LOCUS       NM_001179644            2208 bp    mRNA    linear   PLN 17-DEC-2024
DEFINITION  Saccharomyces cerevisiae S288C RNA helicase (DHR2), partial mRNA.
ACCESSION   NM_001179644
VERSION     NM_001179644.1
DBLINK      BioProject: PRJNA128
KEYWORDS    RefSeq.
SOURCE      Saccharomyces cerevisiae S288C
  ORGANISM  Saccharomyces cerevisiae S288C
            Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
            Saccharomycetes; Saccharomycetales; Saccharomycetaceae;
            Saccharomyces.
REFERENCE   1  (bases 1 to 2208)
  AUTHORS   Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M.,
            Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S.,
            Weng,S. and Cherry,J.M.
  TITLE     New data and collaborations at the Saccharomyces Genome Database:
            updated reference genome, alleles, and the Alliance of Genome
            Resources
  JOURNAL   Genetics 220 (4) (2022)
   PUBMED   34897464
REFERENCE   2  (bases 1 to 2208)
  AUTHORS   Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B.,
            Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M.,
            Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and
            Oliver,S.G.
  TITLE     Life with 6000 genes
  JOURNAL   Science 274 (5287), 546 (1996)
   PUBMED   8849441
REFERENCE   3  (bases 1 to 2208)
  AUTHORS   Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V.,
            Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M.,
            Bossier,P. et al.
  TITLE     Complete DNA sequence of yeast chromosome XI
  JOURNAL   Nature 369 (6479), 371-378 (1994)
   PUBMED   8196765
REFERENCE   4  (bases 1 to 2208)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (17-DEC-2024) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   5  (bases 1 to 2208)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (04-MAY-2012) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Protein update by submitter
REFERENCE   6  (bases 1 to 2208)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (31-MAR-2011) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Sequence update by submitter
REFERENCE   7  (bases 1 to 2208)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (14-DEC-2009) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by SGD. This record
            is derived from an annotated genomic sequence (NC_001143).
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: SGD
            Annotation Status   :: Full Annotation
            Annotation Version  :: R64-4-1
            URL                 :: http://www.yeastgenome.org/
            ##Genome-Annotation-Data-END##
            COMPLETENESS: incomplete on both ends.
FEATURES             Location/Qualifiers
     source          1..2208
                     /organism="Saccharomyces cerevisiae S288C"
                     /mol_type="mRNA"
                     /strain="S288C"
                     /db_xref="taxon:559292"
                     /chromosome="XI"
     gene            <1..>2208
                     /gene="DHR2"
                     /locus_tag="YKL078W"
                     /db_xref="GeneID:853784"
     CDS             1..2208
                     /gene="DHR2"
                     /locus_tag="YKL078W"
                     /EC_number="3.6.4.13"
                     /experiment="EXISTENCE:direct assay:GO:0003724 RNA
                     helicase activity [PMID:10982841]"
                     /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus
                     [PMID:10982841]"
                     /experiment="EXISTENCE:direct assay:GO:0042254 ribosome
                     biogenesis [PMID:10982841]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0000462
                     maturation of SSU-rRNA from tricistronic rRNA transcript
                     (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16449634]"
                     /note="Predominantly nucleolar DEAH-box ATP-dependent RNA
                     helicase; required for 18S rRNA synthesis"
                     /codon_start=1
                     /product="RNA helicase"
                     /protein_id="NP_012845.1"
                     /db_xref="GeneID:853784"
                     /db_xref="SGD:S000001561"
                     /translation="

MAANSNSRVASNHTSKKQKVRRNIHPFTNNTRIKRASKIVKFNDSGEGDHVSDQRSNKENVLTYKSLKSRASDLLKMRETLPVYQHKREIMSYIESNPVTVLIGETGSGKSTQIPQFVLEKLYDTKKHGSIAVTQPRRVAAINLATRVAQEHGCKLGEQVGYSVRFDNTTTTRTRLKYLTDGMLLRELMMNSDLREYSVIVIDEAHERTVLTDLILGFLKSLIQGPRPDLRIIVMSATLQAEKFSEFFNNAPILFVEGRKFDVKQYYLKAPTDDIVDAVIRCCIQINQGEELGDILCFLPGQEEIDKAVTIMEKIAKYVSDEAPVPLIVPYPLYAALPAVQQSLVFAPIKGFKRKVVFSTNIAETSVTISGVKFVVDSGLRKVKVWRHQLGLATLLTVPISQASAMQRSGRAGRESEGKSFRLYCESDYVKLPKQSEPEIARSDVTSPVLMLKRYGVDDLLNWTWFENPGKEAIVMGLQELYELGALDTRGKITKRGQQMALLPLQPHLSSVLIKASEVGCLSQVIDIVSCLSVENLLLNPSPEERDEVNERRLSLCNAGKRYGDLIMLKELFDIYFYELGKSQDASSERNDWCKGLCISIRGFKNVIRVRDQLRVYCKRLFSSISEEDEESKKIGEDGELISKILKCFLTGFIKNTAIGMPDRSYRTVSTGEPISIHPSSMLFMNKSCPGIMYTEYVFTTKGYARNVSRIELSWLQEVVTNAAAVAKQKVSDSK"

     misc_feature    235..>1602
                     /gene="DHR2"
                     /locus_tag="YKL078W"
                     /note="HrpA-like RNA helicase [Translation, ribosomal
                     structure and biogenesis]; Region: HrpA; COG1643"
                     /db_xref="CDD:441249"
     misc_feature    1933..2166
                     /gene="DHR2"
                     /locus_tag="YKL078W"
                     /note="Oligonucleotide/oligosaccharide-binding (OB)-fold;
                     Region: OB_NTP_bind; pfam07717"
                     /db_xref="CDD:400182"
ORIGIN      

atggcagcaaatagcaatagtagagttgcatcaaaccatacttctaaaaaacaaaaggttaggaggaatatacatccattcacgaataacactcggattaaaagagctagtaaaatcgtaaagtttaatgattcaggcgagggcgaccatgtttcagaccaacgttcgaacaaggaaaatgtccttacttataaatctttgaaaagtcgggcaagcgatttactcaaaatgagagaaacacttcccgtttaccaacacaagcgagaaataatgtcatatattgaaagcaatcccgttaccgtccttattggtgaaacaggttctggtaaatcaacacaaattccgcaattcgtattagaaaaattatatgatacgaagaagcatgggtcgattgctgtaactcaaccccgtcgtgttgcggccatcaatttggctacacgtgttgctcaagaacatggttgcaaactgggtgaacaagtaggttattctgtcagatttgacaatacgactactacaagaacaagacttaagtatctgactgacggtatgttacttagagaacttatgatgaatagtgaccttagagaatacagcgtcatcgttatcgatgaagcgcatgaaagaactgtgcttacagatttgatattggggttcttaaaatccttgatacaagggccaagacctgatttgagaataattgttatgtctgcaacattgcaagccgaaaaatttagtgagttcttcaataatgccccaatcttatttgtagaaggaagaaaatttgatgtcaaacaatactacttgaaggcgccaacagatgatatagtagacgctgtcatcaggtgttgtatacaaataaaccaaggtgaagaactgggagatatcttatgttttttaccgggccaagaagagattgacaaagcagtgactataatggagaaaattgcaaagtatgtttcagatgaggccccagtaccattaatagttccttatcctttatatgcagctcttcccgcggtccaacagtccttggtcttcgctccgataaagggtttcaagagaaaagtcgtctttagtaccaatattgcagaaacatctgttaccatatccggtgttaaatttgtcgttgattctggtcttcgaaaagtcaaagtttggagacatcagctgggattagccactctacttaccgtacccatttctcaggcaagtgcgatgcagagaagtggtcgtgctggtagagaaagtgaaggaaagagtttcaggctttattgtgagtctgattatgtgaaattacctaaacaaagtgaacctgaaatagccagaagtgacgtcacatctcctgtgttaatgttgaagagatatggtgttgatgacctgctaaactggacctggtttgagaaccctggaaaggaagctatagtaatggggcttcaggaactttatgaattgggtgctcttgacactcgtggaaagataactaaacggggtcaacaaatggctctgttaccgctacaaccgcatttaagtagtgtcttaattaaagccagtgaagtcggatgtttgagtcaggtcattgatatcgtctcttgccttagtgtggaaaatttactgttgaatccgtcaccagaagaaagagatgaggtgaacgagcgtcgtttgtccttatgcaacgctggtaaaaggtatggtgaccttatcatgctgaaagagctttttgatatctatttctacgaactagggaaaagtcaagatgcaagctctgaaagaaatgattggtgtaaaggattgtgtatttcgatacgtgggtttaaaaatgtaattcgtgtcagagaccagttaagagtttattgtaagcgtttgttttcttcaatcagtgaagaggatgaagaatccaaaaagattggtgaagatggcgagctaatttcgaaaattttaaagtgtttcttaactgggtttatcaagaatacagctatagggatgccagacaggtcttatagaactgtttccactggagagccgataagcattcatccatcatctatgctatttatgaataaaagctgccccggtataatgtacacggagtatgtctttactacgaagggatatgccagaaatgttagtaggattgaactttcatggttacaagaagttgtcactaatgcagccgctgtagcaaagcaaaaagtttctgattcaaaataa

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