LOCUS       NM_001178916            1584 bp    mRNA    linear   PLN 17-DEC-2024
DEFINITION  Saccharomyces cerevisiae S288C translation initiation factor eIF2
            subunit gamma (GCD11), partial mRNA.
ACCESSION   NM_001178916
VERSION     NM_001178916.1
DBLINK      BioProject: PRJNA128
KEYWORDS    RefSeq.
SOURCE      Saccharomyces cerevisiae S288C
  ORGANISM  Saccharomyces cerevisiae S288C
            Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
            Saccharomycetes; Saccharomycetales; Saccharomycetaceae;
            Saccharomyces.
REFERENCE   1  (bases 1 to 1584)
  AUTHORS   Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M.,
            Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S.,
            Weng,S. and Cherry,J.M.
  TITLE     New data and collaborations at the Saccharomyces Genome Database:
            updated reference genome, alleles, and the Alliance of Genome
            Resources
  JOURNAL   Genetics 220 (4) (2022)
   PUBMED   34897464
REFERENCE   2  (bases 1 to 1584)
  AUTHORS   Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E.,
            Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E.,
            Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G.,
            Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D.,
            Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al.
  TITLE     The nucleotide sequence of Saccharomyces cerevisiae chromosome V
  JOURNAL   Nature 387 (6632 SUPPL), 78-81 (1997)
   PUBMED   9169868
REFERENCE   3  (bases 1 to 1584)
  AUTHORS   Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B.,
            Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M.,
            Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and
            Oliver,S.G.
  TITLE     Life with 6000 genes
  JOURNAL   Science 274 (5287), 546 (1996)
   PUBMED   8849441
REFERENCE   4  (bases 1 to 1584)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (17-DEC-2024) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   5  (bases 1 to 1584)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (16-JAN-2015) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Protein update by submitter
REFERENCE   6  (bases 1 to 1584)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (29-JUL-2014) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Protein update by submitter
REFERENCE   7  (bases 1 to 1584)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (04-MAY-2012) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Protein update by submitter
REFERENCE   8  (bases 1 to 1584)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (31-MAR-2011) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Sequence update by submitter
REFERENCE   9  (bases 1 to 1584)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (11-DEC-2009) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by SGD. This record
            is derived from an annotated genomic sequence (NC_001137).
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: SGD
            Annotation Status   :: Full Annotation
            Annotation Version  :: R64-4-1
            URL                 :: http://www.yeastgenome.org/
            ##Genome-Annotation-Data-END##
            COMPLETENESS: incomplete on both ends.
FEATURES             Location/Qualifiers
     source          1..1584
                     /organism="Saccharomyces cerevisiae S288C"
                     /mol_type="mRNA"
                     /strain="S288C"
                     /db_xref="taxon:559292"
                     /chromosome="V"
     gene            <1..>1584
                     /gene="GCD11"
                     /locus_tag="YER025W"
                     /gene_synonym="SUI4"
                     /db_xref="GeneID:856746"
     CDS             1..1584
                     /gene="GCD11"
                     /locus_tag="YER025W"
                     /gene_synonym="SUI4"
                     /EC_number="3.6.5.3"
                     /experiment="EXISTENCE:direct assay:GO:0001731 formation
                     of translation preinitiation complex [PMID:12008673]"
                     /experiment="EXISTENCE:direct assay:GO:0005525 GTP binding
                     [PMID:14698289|PMID:16246727]"
                     /experiment="EXISTENCE:direct assay:GO:0005829 cytosol
                     [PMID:26928762]"
                     /experiment="EXISTENCE:direct assay:GO:0016282 eukaryotic
                     43S preinitiation complex [PMID:12008673]"
                     /experiment="EXISTENCE:direct assay:GO:0031369 translation
                     initiation factor binding [PMID:22683627]"
                     /experiment="EXISTENCE:direct assay:GO:0033290 eukaryotic
                     48S preinitiation complex [PMID:17242201]"
                     /experiment="EXISTENCE:direct assay:GO:0043614 multi-eIF
                     complex [PMID:15838098|PMID:11018020]"
                     /experiment="EXISTENCE:direct assay:GO:1990856
                     methionyl-initiator methionine tRNA binding
                     [PMID:16565414]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0000049 tRNA
                     binding [PMID:8947054]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0003743
                     translation initiation factor activity [PMID:23063529]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0005525 GTP
                     binding [PMID:8947054]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0005850
                     eukaryotic translation initiation factor 2 complex
                     [PMID:8417348]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0006413
                     translational initiation [PMID:23063529]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0045903
                     positive regulation of translational fidelity
                     [PMID:9308967]"
                     /experiment="EXISTENCE:physical interaction:GO:0005515
                     protein binding [PMID:22683627]"
                     /note="Gamma subunit of the translation initiation factor
                     eIF2; involved in the identification of the start codon;
                     binds GTP when forming the ternary complex with GTP and
                     tRNAi-Met; mutations in human ortholog cause X-linked
                     intellectual disability (XLID) syndrome"
                     /codon_start=1
                     /product="translation initiation factor eIF2 subunit
                     gamma"
                     /protein_id="NP_010942.1"
                     /db_xref="GeneID:856746"
                     /db_xref="SGD:S000000827"
                     /translation="

MSDLQDQEPSIIINGNLEPVGEPDIVEETEVVAQETQETQDADKPKKKVAFTGLEEDGETEEEKRKREFEEGGGLPEQPLNPDFSKLNPLSAEIINRQATINIGTIGHVAHGKSTVVRAISGVQTVRFKDELERNITIKLGYANAKIYKCQEPTCPEPDCYRSFKSDKEISPKCQRPGCPGRYKLVRHVSFVDCPGHDILMSTMLSGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHVIILQNKVDLMREESALEHQKSILKFIRGTIADGAPIVPISAQLKYNIDAVNEFIVKTIPVPPRDFMISPRLIVIRSFDVNKPGAEIEDLKGGVAGGSILNGVFKLGDEIEIRPGIVTKDDKGKIQCKPIFSNIVSLFAEQNDLKFAVPGGLIGVGTKVDPTLCRADRLVGQVVGAKGHLPNIYTDIEINYFLLRRLLGVKTDGQKQAKVRKLEPNEVLMVNIGSTATGARVVAVKADMARLQLTSPACTEINEKIALSRRIEKHWRLIGWATIKKGTTLEPIA"

     misc_feature    220..1572
                     /gene="GCD11"
                     /locus_tag="YER025W"
                     /gene_synonym="SUI4"
                     /note="eukaryotic translation initiation factor 2 gamma
                     subunit; Provisional; Region: PTZ00327"
                     /db_xref="CDD:240362"
ORIGIN      

atgagtgacttacaagaccaagaacctagcattattatcaacggtaatttggaaccagttggtgaaccagatatcgttgaagaaacggaagttgtagctcaagaaacacaagaaacacaagatgctgataagccaaagaagaaagtcgccttcactggcttggaagaagacggggaaactgaagaagaaaaaaggaaaagggaatttgaagaaggtggtggtttgcccgaacaaccattaaaccctgatttttcaaaattaaacccactatccgccgaaattatcaacaggcaagctacaataaacatcggtaccatcggtcatgtcgcccacggtaaatccacagtagttagggctatttcaggtgtccaaacagtccgttttaaggatgaattagaacgtaacattactattaagttaggttacgctaatgctaaaatttataaatgtcaagagcctacatgtcccgaacctgattgttatagatcattcaaatctgataaagaaatcagtcctaaatgtcaaagaccaggttgtccggggcgttacaaattggtccgtcacgtttcttttgttgactgtcccggtcacgatatcttaatgagtactatgttatcaggtgctgctgttatggatgctgcgttactgttgattgcaggtaatgaatcttgtccacaacctcaaacctcagagcatttagctgccattgaaatcatgaaattaaagcacgtcatcatcttacagaataaggtcgatttaatgcgtgaagaaagtgccttagaacaccaaaaatccatcttgaagttcatcagaggtaccattgctgacggtgctcctattgtaccaatatccgctcagttgaagtataacatcgacgcagttaatgaatttattgtcaagactattcccgtaccaccaagagattttatgatttctccaaggttaattgttattcgttcatttgatgttaataagccaggtgctgaaatcgaggacctgaaaggtggtgttgccggtggttctattttgaatggtgttttcaaattaggtgatgaaattgagattagaccaggtattgtcaccaaggatgataagggtaaaattcaatgtaaaccaatcttttctaacattgtctccttatttgccgaacaaaatgacttgaagtttgctgttcccggtggtctgattggtgttggtactaaagttgatcctaccttgtgtagagctgatcgtcttgtcggtcaagtcgtcggtgctaagggtcatttgccaaacatttatactgatatcgaaatcaactactttttgctacgtcgtctattaggtgtcaaaacagatggtcaaaagcaagccaaagtcagaaaattagagccaaatgaagttcttatggtcaacattggttctaccgctacgggggctcgtgtggttgccgttaaagctgatatggcaagattacagttaacgtcgcccgcttgtactgaaattaacgagaagattgctttgtcgagacgtatcgaaaagcattggcgtttgattggttgggcaaccattaaaaagggtactacattggaacccatcgcttaa

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