LOCUS       NM_001178441            1404 bp    mRNA    linear   PLN 17-DEC-2024
DEFINITION  Saccharomyces cerevisiae S288C acid phosphatase PHO5 (PHO5),
            partial mRNA.
ACCESSION   NM_001178441
VERSION     NM_001178441.3
DBLINK      BioProject: PRJNA128
KEYWORDS    RefSeq.
SOURCE      Saccharomyces cerevisiae S288C
  ORGANISM  Saccharomyces cerevisiae S288C
            Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
            Saccharomycetes; Saccharomycetales; Saccharomycetaceae;
            Saccharomyces.
REFERENCE   1  (bases 1 to 1404)
  AUTHORS   Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M.,
            Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S.,
            Weng,S. and Cherry,J.M.
  TITLE     New data and collaborations at the Saccharomyces Genome Database:
            updated reference genome, alleles, and the Alliance of Genome
            Resources
  JOURNAL   Genetics 220 (4) (2022)
   PUBMED   34897464
REFERENCE   2  (bases 1 to 1404)
  AUTHORS   Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B.,
            Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M.,
            Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and
            Oliver,S.G.
  TITLE     Life with 6000 genes
  JOURNAL   Science 274 (5287), 546 (1996)
   PUBMED   8849441
REFERENCE   3  (bases 1 to 1404)
  AUTHORS   Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C.,
            Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al.
  TITLE     Complete DNA sequence of yeast chromosome II
  JOURNAL   EMBO J. 13 (24), 5795-5809 (1994)
   PUBMED   7813418
REFERENCE   4  (bases 1 to 1404)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (17-DEC-2024) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   5  (bases 1 to 1404)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (04-MAY-2012) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Protein update by submitter
REFERENCE   6  (bases 1 to 1404)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (31-MAR-2011) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Sequence update by submitter
REFERENCE   7  (bases 1 to 1404)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (11-DEC-2009) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by SGD. This record
            is derived from an annotated genomic sequence (NC_001134).
            
            On Jul 30, 2012 this sequence version replaced NM_001178441.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: SGD
            Annotation Status   :: Full Annotation
            Annotation Version  :: R64-4-1
            URL                 :: http://www.yeastgenome.org/
            ##Genome-Annotation-Data-END##
            COMPLETENESS: incomplete on both ends.
FEATURES             Location/Qualifiers
     source          1..1404
                     /organism="Saccharomyces cerevisiae S288C"
                     /mol_type="mRNA"
                     /strain="S288C"
                     /db_xref="taxon:559292"
                     /chromosome="II"
     gene            <1..>1404
                     /gene="PHO5"
                     /locus_tag="YBR093C"
                     /db_xref="GeneID:852390"
     CDS             1..1404
                     /gene="PHO5"
                     /locus_tag="YBR093C"
                     /EC_number="3.1.3.2"
                     /experiment="EXISTENCE:direct assay:GO:0003993 acid
                     phosphatase activity [PMID:8817921]"
                     /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type
                     cell wall [PMID:3537693]"
                     /experiment="EXISTENCE:direct assay:GO:0071944 cell
                     periphery [PMID:26928762]"
                     /experiment="EXISTENCE:genetic interaction:GO:0017111
                     ribonucleoside triphosphate phosphatase activity
                     [PMID:16278456]"
                     /experiment="EXISTENCE:genetic interaction:GO:0047429
                     nucleoside triphosphate diphosphatase activity
                     [PMID:16278456]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0006796
                     phosphate-containing compound metabolic process
                     [PMID:16278456]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0008361
                     regulation of cell size [PMID:12089449]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0016036
                     cellular response to phosphate starvation [PMID:16278456]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0017111
                     ribonucleoside triphosphate phosphatase activity
                     [PMID:16278456]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0047429
                     nucleoside triphosphate diphosphatase activity
                     [PMID:16278456]"
                     /note="Repressible acid phosphatase; 1 of 3 repressible
                     acid phosphatases that also mediates extracellular
                     nucleotide-derived phosphate hydrolysis; secretory pathway
                     derived cell surface glycoprotein; induced by phosphate
                     starvation and coordinately regulated by PHO4 and PHO2"
                     /codon_start=1
                     /product="acid phosphatase PHO5"
                     /protein_id="NP_009651.3"
                     /db_xref="GeneID:852390"
                     /db_xref="SGD:S000000297"
                     /translation="

MFKSVVYSILAASLANAGTIPLGKLADVDKIGTQKDIFPFLGGAGPYYSFPGDYGISRDLPEGCEMKQLQMVGRHGERYPTVSLAKTIKSTWYKLSNYTRQFNGSLSFLNDDYEFFIRDDDDLEMETTFANSDDVLNPYTGEMNAKRHARDFLAQYGYMVENQTSFAVFTSNSKRCHDTAQYFIDGLGDQFNITLQTVSEAESAGANTLSACNSCPAWDYDANDDIVNEYDTTYLDDIAKRLNKENKGLNLTSTDASTLFSWCAFEVNAKGYSDVCDIFTKDELVHYSYYQDLHTYYHEGPGYDIIKSVGSNLFNASVKLLKQSEIQDQKVWLSFTHDTDILNFLTTAGIIDDKNNLTAEYVPFMGNTFHRSWYVPQGARVYTEKFQCSNDTYVRYVINDAVVPIETCSTGPGFSCEINDFYDYAEKRVAGTDFLKVCNVSSVSNSTELTFYWDWNTTHYNASLLRQ"

     misc_feature    193..1197
                     /gene="PHO5"
                     /locus_tag="YBR093C"
                     /note="Histidine phosphatase superfamily (branch 2);
                     Region: His_Phos_2; pfam00328"
                     /db_xref="CDD:395259"
     misc_feature    order(220..225,232..234,523..525,1009..1014)
                     /gene="PHO5"
                     /locus_tag="YBR093C"
                     /note="catalytic core [active]"
                     /db_xref="CDD:132717"
ORIGIN      

atgtttaaatctgttgtttattcaattttagccgcttctttggccaatgcaggtaccattcccttaggcaaactagccgatgtcgacaagattggtacccaaaaagatatcttcccatttttgggtggtgccggaccatactactctttccctggcgactatggtatttctcgtgatttgcctgaaggttgtgaaatgaagcaactgcaaatggttggtagacatggtgaaagataccctactgtcagtctggctaagactatcaagagtacatggtataagttgagcaattacactcgtcaattcaacggctcattgtcattcttgaacgatgattacgagtttttcatccgtgatgacgatgatttggaaatggaaaccacttttgccaactcggacgatgttttgaacccatacactggtgaaatgaacgccaagagacatgctcgtgacttcttggctcaatacggttacatggtcgaaaaccaaaccagtttcgccgtttttacctctaattctaagagatgtcatgacactgctcaatatttcattgatggtttaggtgaccaattcaacatcaccttgcagactgtcagtgaagctgaatccgctggtgccaacactttgagtgcttgtaactcatgtcctgcttgggactacgatgccaatgatgacattgtaaatgaatacgacacaacctacttggatgacattgccaagagattgaacaaggaaaacaagggtttgaacttgacctcaactgacgctagtactttattctcgtggtgtgcatttgaagtgaacgctaaaggttacagtgatgtctgtgatattttcaccaaggatgaattagtccattactcctactaccaagacttgcacacttattaccatgagggtccaggttacgacattatcaagtctgtcggttccaacttgttcaatgcctcagtcaaattattaaagcaaagtgagattcaagaccaaaaggtttggttgagttttacccacgataccgatatcctaaactttttgaccaccgctggtataattgacgacaaaaacaacttaactgccgaatacgttccattcatgggcaacactttccacagatcctggtacgttcctcaaggtgctcgtgtctacaccgaaaaattccaatgttctaacgacacctacgtcagatacgtcattaacgatgctgttgttccaattgaaacctgttccactggtccagggttctcttgtgaaatcaatgacttctacgactatgctgaaaagagagtagccggtactgacttcctaaaggtctgtaacgtcagcagcgtcagtaactctactgaattgaccttctactgggactggaacactactcattacaacgccagtctattgagacaatag

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