2024-11-01 08:34:04, GGRNA.v2 : RefSeq release 226 (Sep, 2024)
LOCUS NM_022937 1447 bp mRNA linear ROD 30-MAR-2024 DEFINITION Rattus norvegicus double C2 domain alpha (Doc2a), mRNA. ACCESSION NM_022937 VERSION NM_022937.3 KEYWORDS RefSeq; RefSeq Select. SOURCE Rattus norvegicus (Norway rat) ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. REFERENCE 1 (bases 1 to 1447) AUTHORS Yao,J., Gaffaney,J.D., Kwon,S.E. and Chapman,E.R. TITLE Doc2 is a Ca2+ sensor required for asynchronous neurotransmitter release JOURNAL Cell 147 (3), 666-677 (2011) PUBMED 22036572 REFERENCE 2 (bases 1 to 1447) AUTHORS Pang,Z.P., Bacaj,T., Yang,X., Zhou,P., Xu,W. and Sudhof,T.C. TITLE Doc2 supports spontaneous synaptic transmission by a Ca(2+)-independent mechanism JOURNAL Neuron 70 (2), 244-251 (2011) PUBMED 21521611 REFERENCE 3 (bases 1 to 1447) AUTHORS Higashio,H., Nishimura,N., Ishizaki,H., Miyoshi,J., Orita,S., Sakane,A. and Sasaki,T. TITLE Doc2 alpha and Munc13-4 regulate Ca(2+) -dependent secretory lysosome exocytosis in mast cells JOURNAL J Immunol 180 (7), 4774-4784 (2008) PUBMED 18354201 REFERENCE 4 (bases 1 to 1447) AUTHORS Korteweg,N., Denekamp,F.A., Verhage,M. and Burbach,J.P. TITLE Different spatiotemporal expression of DOC2 genes in the developing rat brain argues for an additional, nonsynaptic role of DOC2B in early development JOURNAL Eur J Neurosci 12 (1), 165-171 (2000) PUBMED 10651871 REFERENCE 5 (bases 1 to 1447) AUTHORS Nagano,F., Orita,S., Sasaki,T., Naito,A., Sakaguchi,G., Maeda,M., Watanabe,T., Kominami,E., Uchiyama,Y. and Takai,Y. TITLE Interaction of Doc2 with tctex-1, a light chain of cytoplasmic dynein. Implication in dynein-dependent vesicle transport JOURNAL J Biol Chem 273 (46), 30065-30068 (1998) PUBMED 9804756 REFERENCE 6 (bases 1 to 1447) AUTHORS Verhage,M., de Vries,K.J., Roshol,H., Burbach,J.P., Gispen,W.H. and Sudhof,T.C. TITLE DOC2 proteins in rat brain: complementary distribution and proposed function as vesicular adapter proteins in early stages of secretion JOURNAL Neuron 18 (3), 453-461 (1997) PUBMED 9115738 REFERENCE 7 (bases 1 to 1447) AUTHORS Naito,A., Orita,S., Wanaka,A., Sasaki,T., Sakaguchi,G., Maeda,M., Igarashi,H., Tohyama,M. and Takai,Y. TITLE Molecular cloning of mouse Doc2alpha and distribution of its mRNA in adult mouse brain JOURNAL Brain Res Mol Brain Res 44 (2), 198-204 (1997) PUBMED 9073161 COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAXUCZ010000001.1. On Nov 27, 2020 this sequence version replaced NM_022937.2. ##Evidence-Data-START## Transcript exon combination :: SRR26360194.1008666.1, SRR26643298.5260.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA5760383, SAMEA5760393 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-330 JAXUCZ010000001.1 190888919-190889248 331-410 JAXUCZ010000001.1 190889604-190889683 411-485 JAXUCZ010000001.1 190889861-190889935 486-595 JAXUCZ010000001.1 190890046-190890155 596-722 JAXUCZ010000001.1 190891289-190891415 723-782 JAXUCZ010000001.1 190891495-190891554 783-946 JAXUCZ010000001.1 190891637-190891800 947-1028 JAXUCZ010000001.1 190891888-190891969 1029-1125 JAXUCZ010000001.1 190892059-190892155 1126-1447 JAXUCZ010000001.1 190892238-190892559 FEATURES Location/Qualifiers source 1..1447 /organism="Rattus norvegicus" /mol_type="mRNA" /strain="BN" /db_xref="taxon:10116" /chromosome="1" /map="1q36" gene 1..1447 /gene="Doc2a" /note="double C2 domain alpha" /db_xref="GeneID:65031" /db_xref="RGD:620518" exon 1..330 /gene="Doc2a" /inference="alignment:Splign:2.1.0" CDS 60..1271 /gene="Doc2a" /note="doc2-alpha; double C2, alpha; double C2-like domains, alpha" /codon_start=1 /product="double C2-like domain-containing protein alpha" /protein_id="NP_075226.1" /db_xref="GeneID:65031" /db_xref="RGD:620518" /translation="
MRGRRGDRMTINIQEHMAINVCPGPIRPIRQISDYFPRRGPGPEGGGGGRGFGEAPAHLAPLALAPPAALLGATTPDDGAEVDSYDSDDTTALGTLEFDLLYDQASCMLHCRILRAKGLKPMDFNGLADPYVKLHLLPGACKANKLKTKTQRNTLNPVWNEELTYSGITDDDITHKVLRISVCDEDKLSHNEFIGEIRVPLRRLKPSQKKHFNICLERQVPLPSPSSMSAALRGISCYLKELEQAEQGPGLLEERGRILLSLSYSSRRHGLLVGIVRCAHLAAMDVNGYSDPYVKTYLRPDVDKKSKHKTCVKKKTLNPEFNEEFFYEMELSTLATKTLEVTVWDYDIGKSNDFIGGVSLGPGARGEAQKHWRDCLHQPDTAVERWHTLTSELPPAAGALPLA"
misc_feature 60..335 /gene="Doc2a" /note="propagated from UniProtKB/Swiss-Prot (P70611.1); Region: Interaction with UNC13D and DYNLT1. /evidence=ECO:0000250" misc_feature 336..707 /gene="Doc2a" /note="C2 domain first repeat present in Rabphilin and Double C2 domain; Region: C2A_Rabphilin_Doc2; cd04035" /db_xref="CDD:176000" misc_feature order(426..428,444..446,609..611,615..617,633..635) /gene="Doc2a" /note="Ca2+ binding site [ion binding]; other site" /db_xref="CDD:176000" misc_feature 711..1268 /gene="Doc2a" /note="propagated from UniProtKB/Swiss-Prot (P70611.1); Region: Interaction with UNC13D. /evidence=ECO:0000250" misc_feature 828..1226 /gene="Doc2a" /note="C2 domain second repeat present in Rabphilin and Double C2 domain; Region: C2B_Rabphilin_Doc2; cd08384" /db_xref="CDD:176030" misc_feature order(912..914,930..932,1092..1094,1098..1100,1116..1118) /gene="Doc2a" /note="Ca2+ binding site [ion binding]; other site" /db_xref="CDD:176030" exon 331..410 /gene="Doc2a" /inference="alignment:Splign:2.1.0" exon 411..485 /gene="Doc2a" /inference="alignment:Splign:2.1.0" exon 486..595 /gene="Doc2a" /inference="alignment:Splign:2.1.0" exon 596..722 /gene="Doc2a" /inference="alignment:Splign:2.1.0" exon 723..782 /gene="Doc2a" /inference="alignment:Splign:2.1.0" exon 783..946 /gene="Doc2a" /inference="alignment:Splign:2.1.0" exon 947..1028 /gene="Doc2a" /inference="alignment:Splign:2.1.0" exon 1029..1125 /gene="Doc2a" /inference="alignment:Splign:2.1.0" exon 1126..1447 /gene="Doc2a" /inference="alignment:Splign:2.1.0" ORIGIN
cctacagaccccagccggccactccagctctacacccgtctcccagccagaggtgctgcatgaggggccgcaggggcgatcgcatgaccatcaacatccaggagcacatggccatcaacgtgtgccctggacccatcaggcccatccgccagatctccgactacttccctcgcagggggccaggaccagagggtggcggcggcggcaggggcttcggggaagccccagctcatctggcccctctggctctggccccccctgcggctctccttggggccactacacccgacgatggagctgaggtagacagctacgactcggatgataccactgccctgggcacgctggaatttgaccttctctatgatcaggcttcctgcatgctgcactgtagaatcctcagggccaagggcctcaagcccatggatttcaacggcctggctgacccctatgtaaagctgcacctcctgccaggagcctgcaaggccaataagctaaaaaccaagacacagaggaacacactgaacccagtgtggaacgaggagctgacgtacagtggaatcacagatgacgacatcacccacaaggtgctcaggatctcggtctgtgatgaggacaagctgagtcacaatgaatttattggggagatccgagtgcccctccgccgcctcaagccttcacagaagaagcattttaacatctgccttgagcgtcaggtcccgcttccttcgccctcttcaatgtctgcggcgctgaggggcatatcctgttacctgaaggagctagagcaggcagagcagggacctgggctgttggaagagcgcgggcgcatcctgctgagcctcagctacagctctcggcggcatgggctgctggtgggcattgttcgctgtgctcacctggctgcaatggatgttaacggctactctgacccttatgtgaagacgtacttgagaccagacgtggataagaaatccaagcataagacgtgtgtaaagaagaagacgctgaacccggaatttaatgaggaattcttttatgagatggaactctccactctggctaccaagaccctggaagtcacagtctgggactacgacattggcaaatccaatgacttcataggtggtgtgtctctggggccaggagcccggggagaggcccagaaacactggagagactgtctacatcagccggacacagcagtggagcgctggcataccctgaccagcgagctgcccccagcagcaggggcgttgccgttggcctgaacagactgcagctgcccagcacaggccctctgcggccgggtccagtacccaaccttcgcacgagtgtgttgcacgtttacatgggtgggacgcccctgccccacactacctgtcttatttttgtgagtctctgtgaccgtgggtctatcttcttgtgagggatgtggagagctata
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Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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