LOCUS       NM_012592               1783 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus isovaleryl-CoA dehydrogenase (Ivd), mRNA; nuclear
            gene for mitochondrial product.
ACCESSION   NM_012592
VERSION     NM_012592.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1783)
  AUTHORS   Liu,X., Wu,L., Deng,G., Chen,G., Li,N., Chu,X. and Li,D.
  TITLE     Comparative studies of Acyl-CoA dehydrogenases for monomethyl
            branched chain substrates in amino acid metabolism
  JOURNAL   Bioorg Chem 47, 1-8 (2013)
   PUBMED   23474214
  REMARK    GeneRIF: Isovaleryl-CoA dehydrogenase has relatively broader
            substrate specificity than those of the other two enzymes in
            accommodating various substrate analogs.
REFERENCE   2  (bases 1 to 1783)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   3  (bases 1 to 1783)
  AUTHORS   Vockley,J., Rogan,P.K., Anderson,B.D., Willard,J., Seelan,R.S.,
            Smith,D.I. and Liu,W.
  TITLE     Exon skipping in IVD RNA processing in isovaleric acidemia caused
            by point mutations in the coding region of the IVD gene
  JOURNAL   Am J Hum Genet 66 (2), 356-367 (2000)
   PUBMED   10677295
REFERENCE   4  (bases 1 to 1783)
  AUTHORS   Tiffany,K.A., Roberts,D.L., Wang,M., Paschke,R., Mohsen,A.W.,
            Vockley,J. and Kim,J.J.
  TITLE     Structure of human isovaleryl-CoA dehydrogenase at 2.6 A
            resolution: structural basis for substrate specificity,
  JOURNAL   Biochemistry 36 (28), 8455-8464 (1997)
   PUBMED   9214289
REFERENCE   5  (bases 1 to 1783)
  AUTHORS   Mohsen,A.W. and Vockley,J.
  TITLE     Identification of the active site catalytic residue in human
            isovaleryl-CoA dehydrogenase
  JOURNAL   Biochemistry 34 (32), 10146-10152 (1995)
   PUBMED   7640268
REFERENCE   6  (bases 1 to 1783)
  AUTHORS   Vockley,J., Parimoo,B. and Tanaka,K.
  TITLE     Molecular characterization of four different classes of mutations
            in the isovaleryl-CoA dehydrogenase gene responsible for isovaleric
            acidemia
  JOURNAL   Am J Hum Genet 49 (1), 147-157 (1991)
   PUBMED   2063866
REFERENCE   7  (bases 1 to 1783)
  AUTHORS   Matsubara,Y., Indo,Y., Naito,E., Ozasa,H., Glassberg,R.,
            Vockley,J., Ikeda,Y., Kraus,J. and Tanaka,K.
  TITLE     Molecular cloning and nucleotide sequence of cDNAs encoding the
            precursors of rat long chain acyl-coenzyme A, short chain
            acyl-coenzyme A, and isovaleryl-coenzyme A dehydrogenases. Sequence
            homology of four enzymes of the acyl-CoA dehydrogenase family
  JOURNAL   J Biol Chem 264 (27), 16321-16331 (1989)
   PUBMED   2777793
REFERENCE   8  (bases 1 to 1783)
  AUTHORS   Kraus,J.P., Matsubara,Y., Barton,D., Yang-Feng,T.L., Glassberg,R.,
            Ito,M., Ikeda,Y., Mole,J., Francke,U. and Tanaka,K.
  TITLE     Isolation of cDNA clones coding for rat isovaleryl-CoA
            dehydrogenase and assignment of the gene to human chromosome 15
  JOURNAL   Genomics 1 (3), 264-269 (1987)
   PUBMED   3446585
REFERENCE   9  (bases 1 to 1783)
  AUTHORS   Finocchiaro,G., Ito,M. and Tanaka,K.
  TITLE     Purification and properties of short chain acyl-CoA, medium chain
            acyl-CoA, and isovaleryl-CoA dehydrogenases from human liver
  JOURNAL   J Biol Chem 262 (17), 7982-7989 (1987)
   PUBMED   3597357
REFERENCE   10 (bases 1 to 1783)
  AUTHORS   Ikeda,Y., Keese,S.M., Fenton,W.A. and Tanaka,K.
  TITLE     Biosynthesis of four rat liver mitochondrial acyl-CoA
            dehydrogenases: in vitro synthesis, import into mitochondria, and
            processing of their precursors in a cell-free system and in
            cultured cells
  JOURNAL   Arch Biochem Biophys 252 (2), 662-674 (1987)
   PUBMED   3813556
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC088401.1.
            
            On Jun 10, 2007 this sequence version replaced NM_012592.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088401.1, J05031.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1783
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q35"
     gene            1..1783
                     /gene="Ivd"
                     /note="isovaleryl-CoA dehydrogenase"
                     /db_xref="GeneID:24513"
                     /db_xref="RGD:2936"
     exon            1..152
                     /gene="Ivd"
                     /inference="alignment:Splign:2.1.0"
     CDS             6..1280
                     /gene="Ivd"
                     /EC_number="1.3.8.4"
                     /EC_number="1.3.8.1"
                     /note="isovaleryl-CoA dehydrogenase, mitochondrial;
                     isovaleryl coenzyme A dehydrogenase; butyryl-CoA
                     dehydrogenase"
                     /codon_start=1
                     /product="isovaleryl-CoA dehydrogenase, mitochondrial
                     precursor"
                     /protein_id="NP_036724.1"
                     /db_xref="GeneID:24513"
                     /db_xref="RGD:2936"
                     /translation="

MATAVRLLGRRVSSWRLRPLPSPLAVPQRAHSMLPVDDDINGLNEEQKQLRHTISKFVQENLAPKAQEIDQSNDFKNLREFWKQLGSLGVLGITAPVQYGGSGLGYLEHVLVMEEISRASAAVGLSYGAHSNLCINQIVRNGNEAQKEKYLPKLISGEFIGALAMSEPNAGSDVVSMRLKAEKKGDHYVLNGNKFWITNGPDADVLVVYAKTDLTAVPASRGITAFIVEKDMPGFSTSKKLDKLGMRGSNTCELVFEDCKVPAANILSQESKGVYVLMSGLDLERLVLAGGPLGIMQAVLDHTIPYLHVREAFGQKIGQFQLMQGKMADMYTRLMACRQYVYNVARACDEGHITAKDCAGVILYTAECATQVALDGIQCLGGNGYINDFPMGRFLRDAKLYEIGGGTSEVRRLVIGRAFNADFR"

     transit_peptide 6..95
                     /gene="Ivd"
                     /note="Mitochondrion.
                     /evidence=ECO:0000269|PubMed:2777793; propagated from
                     UniProtKB/Swiss-Prot (P12007.2)"
     mat_peptide     96..1277
                     /gene="Ivd"
                     /product="Isovaleryl-CoA dehydrogenase, mitochondrial.
                     /id=PRO_0000000534"
                     /note="propagated from UniProtKB/Swiss-Prot (P12007.2)"
     misc_feature    129..1268
                     /gene="Ivd"
                     /note="Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156"
                     /db_xref="CDD:173845"
     misc_feature    171..173
                     /gene="Ivd"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:Q9JHI5; propagated from
                     UniProtKB/Swiss-Prot (P12007.2); acetylation site"
     misc_feature    198..200
                     /gene="Ivd"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:Q9JHI5; propagated from
                     UniProtKB/Swiss-Prot (P12007.2); acetylation site"
     misc_feature    231..233
                     /gene="Ivd"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:P26440; propagated from
                     UniProtKB/Swiss-Prot (P12007.2); acetylation site"
     misc_feature    order(378..380,390..392,402..404,519..521,597..599,
                     666..668,828..830,849..851,858..860,867..869,1203..1208,
                     1215..1223)
                     /gene="Ivd"
                     /note="substrate binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:173845"
     misc_feature    order(492..494,498..503,516..521,591..593,597..599,
                     1224..1226,1230..1232)
                     /gene="Ivd"
                     /note="FAD binding site [chemical binding]; other site"
                     /db_xref="CDD:173845"
     misc_feature    720..722
                     /gene="Ivd"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q9JHI5; propagated from
                     UniProtKB/Swiss-Prot (P12007.2); acetylation site"
     misc_feature    783..785
                     /gene="Ivd"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:Q9JHI5; propagated from
                     UniProtKB/Swiss-Prot (P12007.2); acetylation site"
     misc_feature    855..857
                     /gene="Ivd"
                     /note="catalytic base [active]"
                     /db_xref="CDD:173845"
     exon            153..242
                     /gene="Ivd"
                     /inference="alignment:Splign:2.1.0"
     exon            243..294
                     /gene="Ivd"
                     /inference="alignment:Splign:2.1.0"
     exon            295..464
                     /gene="Ivd"
                     /inference="alignment:Splign:2.1.0"
     exon            465..558
                     /gene="Ivd"
                     /inference="alignment:Splign:2.1.0"
     exon            559..695
                     /gene="Ivd"
                     /inference="alignment:Splign:2.1.0"
     exon            696..792
                     /gene="Ivd"
                     /inference="alignment:Splign:2.1.0"
     exon            793..886
                     /gene="Ivd"
                     /inference="alignment:Splign:2.1.0"
     exon            887..968
                     /gene="Ivd"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1073
                     /gene="Ivd"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1146
                     /gene="Ivd"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1715
                     /gene="Ivd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

cggagatggcgactgcagtccggctgctggggcggcgagtttccagttggagactgcggcctttaccgtcgccccttgctgtcccgcagcgggcccactcgatgttgcctgtggatgatgatatcaacgggctaaacgaggagcagaagcagcttcgtcatacgatatctaagttcgttcaagagaacctggcccccaaggcccaagagattgatcaaagcaatgacttcaagaacctgagagagttctggaagcagctgggaagcctgggagtcctgggcatcacagcccccgttcagtatggtggctctggcctgggctacctagaacatgtgttggtgatggaagagatatcccgggcttcagcagctgtggggctcagctatggcgctcactccaacctctgcatcaaccagattgtccgcaatgggaatgaggcacagaaagagaaatatcttcccaagctcatcagtggtgagttcatcggagccctggccatgagtgagcccaacgctggctctgacgttgtctccatgaggctgaaagcagagaagaaaggagatcactacgttctgaatggcaacaagttctggatcaccaatggccctgacgctgatgtcctagttgtctatgccaagacagacttgactgctgtgcctgcgtctcggggcatcacagccttcattgtggaaaaggatatgcctggtttcagcacctcgaagaagctggacaagctaggcatgaggggctccaacacctgtgagctagtctttgaagactgcaaggttcctgctgctaacatcctgagccaagagagtaagggtgtctacgtactgatgagcgggctggacctagaacgcctggtgctggcaggtggaccccttgggatcatgcaggctgtcctggaccacaccattccctatttgcatgtgagggaagcctttggccagaagatcggccaattccagctgatgcagggaaagatggctgacatgtacacccgcctcatggcatgtcgacagtatgtctacaatgtcgccagggcctgtgacgagggccacatcactgccaaggactgtgctggtgtgattctgtatacagccgagtgtgccacacaagtagccctggatggcattcaatgtttaggtggaaatggctacatcaatgacttccccatgggccgctttcttcgagatgccaaactgtacgagatcggaggtgggaccagtgaggtgaggcggctagtcattggcagagctttcaacgcagacttccgctaacctggggccatcaccctgctcccagcagcaggagacctttggaagcagagacgtggcagccctctgacttggctaaggaagctctgctgctcaactgccctcctcttgccagccctctgctcttcgtgaagtcggattctccagccgtgccagccagtcaatcaagaaagcctaaaattcggtccccagctccggaaaaaaaaaaaaaaagaaccaaaagaaagcctaaaatggctgctaaaaggactttggcttttctggggtttgcagggagggtaacagtgtctgcgcccttgttctctacttctgaatgtagtaacctcaccctctggggtagcatatgacaggtacccaactccttttcgtgggcaagcctctggcaggggagctctttctgttgcaatgtaacagaggcattgcctctttcaattgtcaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa

//