2024-11-01 08:14:04, GGRNA.v2 : RefSeq release 226 (Sep, 2024)
LOCUS NM_001113542 2028 bp mRNA linear ROD 03-APR-2024 DEFINITION Rattus norvegicus WT1 associated protein (Wtap), transcript variant 1, mRNA. ACCESSION NM_001113542 XM_001068104 XM_574313 VERSION NM_001113542.1 KEYWORDS RefSeq; RefSeq Select. SOURCE Rattus norvegicus (Norway rat) ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. REFERENCE 1 (bases 1 to 2028) AUTHORS Wang,H., Fu,L., Li,Y., Wei,L., Gu,X., Li,H., Li,J. and Wen,S. TITLE m6A methyltransferase WTAP regulates myocardial ischemia reperfusion injury through YTHDF1/FOXO3a signaling JOURNAL Apoptosis 28 (5-6), 830-839 (2023) PUBMED 36894806 REMARK GeneRIF: m6A methyltransferase WTAP regulates myocardial ischemia reperfusion injury through YTHDF1/FOXO3a signaling. REFERENCE 2 (bases 1 to 2028) AUTHORS Du,Y., Hou,G., Zhang,H., Dou,J., He,J., Guo,Y., Li,L., Chen,R., Wang,Y., Deng,R., Huang,J., Jiang,B., Xu,M., Cheng,J., Chen,G.Q., Zhao,X. and Yu,J. TITLE SUMOylation of the m6A-RNA methyltransferase METTL3 modulates its function JOURNAL Nucleic Acids Res 46 (10), 5195-5208 (2018) PUBMED 29506078 REFERENCE 3 (bases 1 to 2028) AUTHORS Scholler,E., Weichmann,F., Treiber,T., Ringle,S., Treiber,N., Flatley,A., Feederle,R., Bruckmann,A. and Meister,G. TITLE Interactions, localization, and phosphorylation of the m6A generating METTL3-METTL14-WTAP complex JOURNAL RNA 24 (4), 499-512 (2018) PUBMED 29348140 REFERENCE 4 (bases 1 to 2028) AUTHORS Wen,J., Lv,R., Ma,H., Shen,H., He,C., Wang,J., Jiao,F., Liu,H., Yang,P., Tan,L., Lan,F., Shi,Y.G., He,C., Shi,Y. and Diao,J. TITLE Zc3h13 Regulates Nuclear RNA m6A Methylation and Mouse Embryonic Stem Cell Self-Renewal JOURNAL Mol Cell 69 (6), 1028-1038 (2018) PUBMED 29547716 REFERENCE 5 (bases 1 to 2028) AUTHORS Yue,Y., Liu,J., Cui,X., Cao,J., Luo,G., Zhang,Z., Cheng,T., Gao,M., Shu,X., Ma,H., Wang,F., Wang,X., Shen,B., Wang,Y., Feng,X., He,C. and Liu,J. TITLE VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation JOURNAL Cell Discov 4, 10 (2018) PUBMED 29507755 REMARK Publication Status: Online-Only REFERENCE 6 (bases 1 to 2028) AUTHORS Horiuchi,K., Kawamura,T., Iwanari,H., Ohashi,R., Naito,M., Kodama,T. and Hamakubo,T. TITLE Identification of Wilms' tumor 1-associating protein complex and its role in alternative splicing and the cell cycle JOURNAL J Biol Chem 288 (46), 33292-33302 (2013) PUBMED 24100041 REFERENCE 7 (bases 1 to 2028) AUTHORS Ahmed,F., Torrado,M., Zinovieva,R.D., Senatorov,V.V., Wistow,G. and Tomarev,S.I. TITLE Gene expression profile of the rat eye iridocorneal angle: NEIBank expressed sequence tag analysis JOURNAL Invest Ophthalmol Vis Sci 45 (9), 3081-3090 (2004) PUBMED 15326124 REFERENCE 8 (bases 1 to 2028) AUTHORS Niksic,M., Slight,J., Sanford,J.R., Caceres,J.F. and Hastie,N.D. TITLE The Wilms' tumour protein (WT1) shuttles between nucleus and cytoplasm and is present in functional polysomes JOURNAL Hum Mol Genet 13 (4), 463-471 (2004) PUBMED 14681305 REFERENCE 9 (bases 1 to 2028) AUTHORS Little,N.A., Hastie,N.D. and Davies,R.C. TITLE Identification of WTAP, a novel Wilms' tumour 1-associating protein JOURNAL Hum Mol Genet 9 (15), 2231-2239 (2000) PUBMED 11001926 REFERENCE 10 (bases 1 to 2028) AUTHORS Hoja,M.R., Wahlestedt,C. and Hoog,C. TITLE A visual intracellular classification strategy for uncharacterized human proteins JOURNAL Exp Cell Res 259 (1), 239-246 (2000) PUBMED 10942595 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CK478322.1, CO561762.1, DV714133.1 and AA900399.1. On or before Jan 18, 2008 this sequence version replaced XM_001068104.1, XM_574313.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMD00132261, SAMD00132262 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-661 CK478322.1 1-661 662-1250 CO561762.1 58-646 1251-1520 DV714133.1 474-743 1521-2028 AA900399.1 18-525 FEATURES Location/Qualifiers source 1..2028 /organism="Rattus norvegicus" /mol_type="mRNA" /strain="Sprague-Dawley" /db_xref="taxon:10116" /chromosome="1" /map="1q11" gene 1..2028 /gene="Wtap" /gene_synonym="RGD1563824" /note="WT1 associated protein" /db_xref="GeneID:499020" /db_xref="RGD:1563824" exon 1..185 /gene="Wtap" /gene_synonym="RGD1563824" /inference="alignment:Splign:2.1.0" exon 186..223 /gene="Wtap" /gene_synonym="RGD1563824" /inference="alignment:Splign:2.1.0" CDS 194..1381 /gene="Wtap" /gene_synonym="RGD1563824" /note="isoform a is encoded by transcript variant 1; Wilms' tumour 1-associating protein; pre-mRNA-splicing regulator WTAP; Wilms tumor 1 associated protein" /codon_start=1 /product="pre-mRNA-splicing regulator WTAP isoform a" /protein_id="NP_001107014.1" /db_xref="GeneID:499020" /db_xref="RGD:1563824" /translation="
MTNEEPLPKKVRLSETDFKVMARDELILRWKQYEAYVQALEGKYTDLNSNDVTGLRESEEKLKQQQQESARRENILVMRLATKEQEMQECTTQIQYLKQVQQPSVAQLRSTMVDPAINLFFLKMKGELEQTKDKLEQAQNELSAWKFTPDSQTGKKLMAKCRMLIQENQELGRQLSQGRIAQLEAELALQKKYSEELKSSQDELNDFIIQLDEEVEGMQSTILVLQQQLKETRQQLAQYQQQQSQASAPSTSRTTSSEPVDQAEATSKDCSRLANGPSNGSSSRQRTSGSGFHREGSTPEDDFPSSSGNGNKASNSSEERTGRGSSYINPLSAGYESVDSPTGSENSLTHHSNDTDSSHDPQEEKAVSGKGNRTVGSRHVQNGLDSSVNVQGSIL"
misc_feature 395..859 /gene="Wtap" /gene_synonym="RGD1563824" /note="WTAP/Mum2p family; Region: Wtap; pfam17098" /db_xref="CDD:465345" exon 224..279 /gene="Wtap" /gene_synonym="RGD1563824" /inference="alignment:Splign:2.1.0" exon 280..338 /gene="Wtap" /gene_synonym="RGD1563824" /inference="alignment:Splign:2.1.0" exon 339..466 /gene="Wtap" /gene_synonym="RGD1563824" /inference="alignment:Splign:2.1.0" exon 467..645 /gene="Wtap" /gene_synonym="RGD1563824" /inference="alignment:Splign:2.1.0" exon 646..800 /gene="Wtap" /gene_synonym="RGD1563824" /inference="alignment:Splign:2.1.0" exon 801..2021 /gene="Wtap" /gene_synonym="RGD1563824" /inference="alignment:Splign:2.1.0" ORIGIN
ccggctaagcttgcagagcccccacggggcaggtgcgaacctccgcggacggtctcggtgcggctgcggagagccgcttgcccctccgcgccccgagaccccgagcgggccggcctcgcctcgtctcttctggccggaggcaccgggcacggtgaccgaggcggcgcccgagaggcgcgtctcggggtacaagatgaccaacgaagaacctcttcctaaaaaggtccgactgagtgaaacagacttcaaagttatggcacgggatgagttaattctgagatggaaacaatatgaagcatatgttcaagctttggagggaaagtacacagaccttaattcaaacgatgtgactggcttaagggaatctgaagaaaaactaaagcagcaacagcaggaatctgcacgcagggagaacatccttgtcatgcggctagcaaccaaggaacaggagatgcaagagtgcaccactcaaatccagtacctcaagcaagttcagcagccgagtgtagcccaactgagatcaacaatggtagacccagcgatcaacttgtttttcctaaaaatgaaaggtgaactggaacagactaaagacaaactggaacaagcccaaaatgaactgagtgcctggaagtttacgcctgatagccaaacaggcaaaaaattaatggcgaagtgtcgaatgcttatccaggagaaccaagagcttggaaggcagctgtcccagggccgtattgcacagcttgaagccgagttggctttacagaagaaatacagtgaggagcttaaaagcagtcaggatgaactgaatgacttcatcattcaacttgacgaagaagtagagggtatgcagagcaccattctagttcttcagcaacagttgaaggagactcgacagcagttggcacagtaccagcagcagcagtctcaagcttctgctccaagtaccagcaggactacatcttctgaacctgtggatcaggcagaggccacaagcaaagactgcagtcgtctggcaaatggaccaagtaatggcagctcctcccgccagaggacgtctgggtctggatttcacagggaggggagcactcctgaggatgactttccttcttcttcagggaacggtaataaggcctccaacagctcagaggagagaactggcagaggtagtagttacataaacccactcagtgcggggtatgaaagtgtagactctcccacgggcagtgaaaactctctcacacatcactcaaatgacacagactccagtcatgaccctcaagaggagaaagcagtgagtgggaaaggtaatcgaactgtgggttcccgccatgttcagaatggcttggactcaagtgtaaatgtacagggttcaattttgtaatatttttccagcaaatttttatacagtgtcatttaattgggggaaggatactgtcaaaaattaatgcatacttttgtcacaatttatacccttttgtgggtgtgtttttgttttgtttggttcttttttttttttttttaattgcttcaatacctctgctactttgaaaattgtaacagttaattactttgaacattgctaaaaggacattttgtgtagggtcaagttatttttatatgagttaatgtgaagttgtaaatgggaatctatagcagtgacgtctgtataaatctgtctatctagaacctgtgctgtcagggcactcttcctcacgctgttgttactcatgcaccattcagacttgttagagtagatgtgggcttaggaccgccgagtgtgcccagtacagtagttttatcactaaagagttggatgtgagtcctatagtagtttcagcgttagatagtttttccaccatacatctgtgcattcatctttagctgaactgaatgtttaagaaatccgtgtgcatagttactaagtttttatgaattgttgtgtcctgttaatgcatattgccctgtgactccagtatatctcacctgtactgaccaaacctaaataaaaatttttattgtaaaaaaaaa
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Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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