2024-11-01 08:35:41, GGRNA.v2 : RefSeq release 226 (Sep, 2024)
LOCUS NM_001107754 2753 bp mRNA linear ROD 03-APR-2024 DEFINITION Rattus norvegicus TNF receptor associated factor 6 (Traf6), mRNA. ACCESSION NM_001107754 XM_001079281 XM_230377 VERSION NM_001107754.2 KEYWORDS RefSeq; RefSeq Select. SOURCE Rattus norvegicus (Norway rat) ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. REFERENCE 1 (bases 1 to 2753) AUTHORS Yang,P., Wang,Y., Ge,W., Jing,Y., Hu,H., Yin,J., Xue,M., Wang,Y., Li,X., Li,X., Shi,Y., Tan,J., Li,Y. and Yan,S. TITLE m6A methyltransferase METTL3 contributes to sympathetic hyperactivity post-MI via promoting TRAF6-dependent mitochondrial ROS production JOURNAL Free Radic Biol Med 209 (Pt 2), 342-354 (2023) PUBMED 37898386 REMARK GeneRIF: m6A methyltransferase METTL3 contributes to sympathetic hyperactivity post-MI via promoting TRAF6-dependent mitochondrial ROS production. REFERENCE 2 (bases 1 to 2753) AUTHORS Wei,B., Su,Z., Yang,H., Feng,Y., Meng,C. and Liang,Z. TITLE Inhibition of TRAF6 improves hyperlipidemic acute pancreatitis by alleviating pyroptosis in vitro and in vivo rat models JOURNAL Biol Direct 18 (1), 23 (2023) PUBMED 37165439 REMARK GeneRIF: Inhibition of TRAF6 improves hyperlipidemic acute pancreatitis by alleviating pyroptosis in vitro and in vivo rat models. Publication Status: Online-Only REFERENCE 3 (bases 1 to 2753) AUTHORS Xia,P., Marjan,M., Liu,Z., Zhou,W., Zhang,Q., Cheng,C., Zhao,M., Tao,Y., Wang,Z. and Ye,Z. TITLE Chrysophanol postconditioning attenuated cerebral ischemia-reperfusion injury induced NLRP3-related pyroptosis in a TRAF6-dependent manner JOURNAL Exp Neurol 357, 114197 (2022) PUBMED 35932799 REMARK GeneRIF: Chrysophanol postconditioning attenuated cerebral ischemia-reperfusion injury induced NLRP3-related pyroptosis in a TRAF6-dependent manner. REFERENCE 4 (bases 1 to 2753) AUTHORS Zhang,T. and Ge,J. TITLE Mechanism of CREB1 in cardiac function of rats with heart failure via regulating the microRNA-376a-3p/TRAF6 axis JOURNAL Mamm Genome 33 (3), 490-501 (2022) PUBMED 35217880 REMARK GeneRIF: Mechanism of CREB1 in cardiac function of rats with heart failure via regulating the microRNA-376a-3p/TRAF6 axis. REFERENCE 5 (bases 1 to 2753) AUTHORS Wei,B., Wu,Q., Yang,X., Lai,C., Su,Z. and Liang,Z. TITLE Effect of TRAF6 in acute pancreatitis-induced intestinal barrier injury via TLR4/NF-kappaB signal pathway JOURNAL Tissue Cell 76, 101792 (2022) PUBMED 35405432 REMARK GeneRIF: Effect of TRAF6 in acute pancreatitis-induced intestinal barrier injury via TLR4/NF-kappaB signal pathway. REFERENCE 6 (bases 1 to 2753) AUTHORS Zapata,J.M., Pawlowski,K., Haas,E., Ware,C.F., Godzik,A. and Reed,J.C. TITLE A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains JOURNAL J Biol Chem 276 (26), 24242-24252 (2001) PUBMED 11279055 REFERENCE 7 (bases 1 to 2753) AUTHORS Lomaga,M.A., Henderson,J.T., Elia,A.J., Robertson,J., Noyce,R.S., Yeh,W.C. and Mak,T.W. TITLE Tumor necrosis factor receptor-associated factor 6 (TRAF6) deficiency results in exencephaly and is required for apoptosis within the developing CNS JOURNAL J Neurosci 20 (19), 7384-7393 (2000) PUBMED 11007897 REFERENCE 8 (bases 1 to 2753) AUTHORS Naito,A., Azuma,S., Tanaka,S., Miyazaki,T., Takaki,S., Takatsu,K., Nakao,K., Nakamura,K., Katsuki,M., Yamamoto,T. and Inoue,J. TITLE Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice JOURNAL Genes Cells 4 (6), 353-362 (1999) PUBMED 10421844 REFERENCE 9 (bases 1 to 2753) AUTHORS Lomaga,M.A., Yeh,W.C., Sarosi,I., Duncan,G.S., Furlonger,C., Ho,A., Morony,S., Capparelli,C., Van,G., Kaufman,S., van der Heiden,A., Itie,A., Wakeham,A., Khoo,W., Sasaki,T., Cao,Z., Penninger,J.M., Paige,C.J., Lacey,D.L., Dunstan,C.R., Boyle,W.J., Goeddel,D.V. and Mak,T.W. TITLE TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling JOURNAL Genes Dev 13 (8), 1015-1024 (1999) PUBMED 10215628 REFERENCE 10 (bases 1 to 2753) AUTHORS Ninomiya-Tsuji,J., Kishimoto,K., Hiyama,A., Inoue,J., Cao,Z. and Matsumoto,K. TITLE The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway JOURNAL Nature 398 (6724), 252-256 (1999) PUBMED 10094049 COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC168921.1. On Sep 4, 2008 this sequence version replaced NM_001107754.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC168921.1, SRR8487227.172149.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00132263, SAMD00132265 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## FEATURES Location/Qualifiers source 1..2753 /organism="Rattus norvegicus" /mol_type="mRNA" /db_xref="taxon:10116" /chromosome="3" /map="3q31" gene 1..2753 /gene="Traf6" /note="TNF receptor associated factor 6" /db_xref="GeneID:311245" /db_xref="RGD:1306853" exon 1..168 /gene="Traf6" /inference="alignment:Splign:2.1.0" misc_feature 146..148 /gene="Traf6" /note="upstream in-frame stop codon" exon 169..486 /gene="Traf6" /inference="alignment:Splign:2.1.0" CDS 191..1783 /gene="Traf6" /EC_number="2.3.2.27" /note="E3 ubiquitin-protein ligase TRAF6; TNF receptor-associated factor 6, E3 ubiquitin protein ligase; RING-type E3 ubiquitin transferase TRAF6" /codon_start=1 /product="TNF receptor-associated factor 6" /protein_id="NP_001101224.1" /db_xref="GeneID:311245" /db_xref="RGD:1306853" /translation="
MSLLNCENSCASSQSSSDCCAAMANSCSAAMKDDSVSGCVSTGNLSSSFMEEIQGYDVEFDPPLESKYECPICLMALREAVQTPCGHRFCKACITKSIRDAGHKCPVDNEILLENQLFPDNFAKREILSLTVKCPNKGCVQKMELRHLEDHQVHCEFALVICPQCQRFFQKCQINKHIIEDCPRRQVSCVNCAVPMPYEEKEIHDQSCPLANIICEYCGTILIREQMPNHYDLDCPTAPVPCTFSVFGCHEKMQRNHLARHLQENTQLHMRLLAQAVHNVNLSLRPCDASSPSRGCRPEDPNYEETVKQLEGRLVRQDHQIRELTAKMETQSMHVSELKRTIRSLEDKVAEMEAQQCNGIYIWKIGNFGMHLKSQEEERPVVIHSPGFYTGRPGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDSHLPWPFQGTIRLTILDQSEAVIRQNHEEVMDAKPELLAFQRPTIPRNPKGFGYVTFMHLEALRQGTFIKDDTLLVRCEVSTRFDMGGLRKEGFQPRSTDAGV"
misc_feature 191..1276 /gene="Traf6" /note="propagated from UniProtKB/Swiss-Prot (B5DF45.1); Region: Interaction with TAX1BP1. /evidence=ECO:0000250" misc_feature 389..562 /gene="Traf6" /note="Modified RING finger, HC subclass (C3HC3D-type), found in tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6) and similar proteins; Region: mRING-HC-C3HC3D_TRAF6; cd16643" /db_xref="CDD:438305" misc_feature order(389..394,434..436,440..454,542..556) /gene="Traf6" /note="dimer interface [polypeptide binding]; other site" /db_xref="CDD:438305" misc_feature order(395..397,401..415,479..481,488..493,506..508) /gene="Traf6" /note="E2 binding site [polypeptide binding]; other site" /db_xref="CDD:438305" misc_feature <584..847 /gene="Traf6" /note="PRLI-interacting factor K; Provisional; Region: PLN03086" /db_xref="CDD:178635" misc_feature 659..739 /gene="Traf6" /note="TNF receptor-associated factor 6 zinc finger 2; Region: TRAF6_Z2; pfam18048" /db_xref="CDD:436235" misc_feature 800..973 /gene="Traf6" /note="TRAF-type zinc finger; Region: zf-TRAF; pfam02176" /db_xref="CDD:280357" misc_feature 1265..1714 /gene="Traf6" /note="Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF6 subfamily, TRAF domain, C-terminal MATH subdomain; composed of proteins with similarity to human TRAF6, including the Drosophila protein DTRAF2. TRAF molecules serve as adapter...; Region: MATH_TRAF6; cd03776" /db_xref="CDD:239745" misc_feature order(1274..1276,1280..1282,1364..1369,1463..1465, 1472..1474,1523..1525) /gene="Traf6" /note="trimer interface [polypeptide binding]; other site" /db_xref="CDD:239745" misc_feature 1277..1780 /gene="Traf6" /note="propagated from UniProtKB/Swiss-Prot (B5DF45.1); Region: Interaction with TANK. /evidence=ECO:0000250|UniProtKB:Q9Y4K3" misc_feature order(1388..1390,1442..1444,1580..1588,1616..1630) /gene="Traf6" /note="TNFR binding site [active]" /db_xref="CDD:239745" exon 487..637 /gene="Traf6" /inference="alignment:Splign:2.1.0" exon 638..796 /gene="Traf6" /inference="alignment:Splign:2.1.0" exon 797..868 /gene="Traf6" /inference="alignment:Splign:2.1.0" exon 869..946 /gene="Traf6" /inference="alignment:Splign:2.1.0" exon 947..2707 /gene="Traf6" /inference="alignment:Splign:2.1.0" ORIGIN
cgcggctggggctgaggctccggccgtcggcggacgcagtagccgcggcccaggaaccgggagtttggcgtcggagacacttgatctcggagtgctgcgtgtataggcggcgcgtggcggcccgggggagctttctagtcggttgtgaagcctctgcgtgtgcgatcgattgactgacaacaaagctactatgagtctcttaaactgtgaaaacagctgtgcgtccagccagtcttcaagcgactgctgtgctgccatggccaactcctgcagtgctgccatgaaagatgacagtgtgagtggctgtgtcagcacggggaacctgtccagctccttcatggaggagatccagggatatgatgtggagtttgacccacctttggaaagcaagtatgagtgccccatctgcttgatggctttacgggaagcagtgcaaacaccatgtggccacaggttctgcaaagcctgcatcaccaagtccataagggatgcaggtcacaagtgcccagttgacaatgaaatactgctggaaaatcaactgtttcctgacaattttgcaaagcgagagattctttccctgacggtaaagtgtccaaataaaggctgtgtgcaaaagatggagctgagacatctcgaggatcatcaagtacattgtgaattcgctctagtgatttgtccccaatgccaacgttttttccaaaagtgccagattaataaacacattatcgaggattgtcccaggagacaggtttcttgtgtaaactgtgctgtgcccatgccgtatgaagagaaagagatccacgatcaaagctgtcctctggcaaatatcatctgtgaatactgtggtacaatcctcataagagaacagatgcctaatcattatgatctagactgcccaacagctccagtcccctgcacattcagtgtgtttggctgtcacgaaaagatgcagaggaatcacttggcacggcacttgcaagagaacacccagttgcacatgagactgttggcccaggctgttcataatgttaacctctctttgcggccatgcgatgcctcctctccatcccggggatgtcgtcctgaggacccaaattatgaggaaacggtcaaacagttggaggggcgcctagtaagacaggaccatcaaatccgggagctgaccgccaaaatggaaacgcagagcatgcatgtgagcgagctcaagcggaccattcgaagcctcgaggacaaagttgccgagatggaagcacagcagtgtaatggcatttacatttggaagattggcaactttgggatgcacttgaaatcccaagaagaggaaagacctgtggtcattcatagccctggattctacacaggcagacctgggtacaagctgtgcatgcgcctgcacctccagctaccgacggctcagcgctgtgcaaactacatttccctctttgtccacacaatgcaaggagagtatgacagccacctcccctggcccttccagggtacaatacgcctcacgatccttgatcagtctgaagcagtaataaggcaaaaccacgaagaggtcatggatgctaagccagaactgcttgcctttcagcggcccaccatcccacggaaccccaaaggttttggctatgtgacattcatgcacctggaagccttaagacagggaaccttcatcaaggatgatacgttattagtgcgctgtgaagtctctacccgctttgacatggggggccttcggaaggaggggttccagccacggagtactgatgcaggcgtgtagcctccacttacctgtgttcaaaaactaggagccatatggaaaaaccgtgccttccgcacctggtccagtaaacaaacggtgggagaggtgtaaggccagcagcagatgtcatcagcgaggtcacattacacttcttaccgttaaccaatatctggggcaattcccatggggacctccgtgtcccctgtgtcttcagaaccttaacatttgaagggccagacgctcatcaatttgtcagggaacctcttcactgtgcttccatgggcttttttgtccatgtactttactgaaaaaaaaaaaggccagaattaatgtactggagctcaatcgtttaatactggtgccttaaacacttaaagtgcttttagggcatgtattaaacgtgaggatcaccattgcctgtgctgctgccagtggaaaggttactgctctggtgttgagttctcatttagttgacccctgtgaatttcagaggctttgaaccatgatccctggaaagctgaagttctcatgtactccctcctccattgaccagggactggtttaacccttacttataaatagcacgaatgtattgtccattgaacaccaagggtttctcccctgccttcattgttgaaatatgctctaggcagcatcttcccggtttgtaagactgtggtcatgtggttgccaactgttcagtgtgactgtcatgtaacctttcttgtctgttcagtatagcttggtttccacagcctgtcgcacatcttctgttgcttgcaaacacaaaatcgccagcctaaacaagtgatcagctcaccagccattaaatggcatctcatggatgatgacagcaattcttatagccaggaaacttcagccctcttaactaccttccaatttagcttagttgattgaaataaaactgatttcctcaaggggaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
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Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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