2024-11-01 08:29:14, GGRNA.v2 : RefSeq release 226 (Sep, 2024)
LOCUS NM_001106524 3595 bp mRNA linear ROD 26-FEB-2024 DEFINITION Rattus norvegicus acyl-CoA synthetase short-chain family member 1 (Acss1), mRNA; nuclear gene for mitochondrial product. ACCESSION NM_001106524 XM_215897 VERSION NM_001106524.1 KEYWORDS RefSeq; RefSeq Select. SOURCE Rattus norvegicus (Norway rat) ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. REFERENCE 1 (bases 1 to 3595) AUTHORS Lakhter AJ, Hamilton J, Konger RL, Brustovetsky N, Broxmeyer HE and Naidu SR. TITLE Glucose-independent Acetate Metabolism Promotes Melanoma Cell Survival and Tumor Growth JOURNAL J Biol Chem 291 (42), 21869-21879 (2016) PUBMED 27539851 REFERENCE 2 (bases 1 to 3595) AUTHORS Sakakibara I, Fujino T, Ishii M, Tanaka T, Shimosawa T, Miura S, Zhang W, Tokutake Y, Yamamoto J, Awano M, Iwasaki S, Motoike T, Okamura M, Inagaki T, Kita K, Ezaki O, Naito M, Kuwaki T, Chohnan S, Yamamoto TT, Hammer RE, Kodama T, Yanagisawa M and Sakai J. TITLE Fasting-induced hypothermia and reduced energy production in mice lacking acetyl-CoA synthetase 2 JOURNAL Cell Metab 9 (2), 191-202 (2009) PUBMED 19187775 REFERENCE 3 (bases 1 to 3595) AUTHORS Watkins PA, Maiguel D, Jia Z and Pevsner J. TITLE Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome JOURNAL J Lipid Res 48 (12), 2736-2750 (2007) PUBMED 17762044 REFERENCE 4 (bases 1 to 3595) AUTHORS Hallows WC, Lee S and Denu JM. TITLE Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases JOURNAL Proc Natl Acad Sci U S A 103 (27), 10230-10235 (2006) PUBMED 16790548 REFERENCE 5 (bases 1 to 3595) AUTHORS Schwer B, Bunkenborg J, Verdin RO, Andersen JS and Verdin E. TITLE Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2 JOURNAL Proc Natl Acad Sci U S A 103 (27), 10224-10229 (2006) PUBMED 16788062 REFERENCE 6 (bases 1 to 3595) AUTHORS Fujino T, Kondo J, Ishikawa M, Morikawa K and Yamamoto TT. TITLE Acetyl-CoA synthetase 2, a mitochondrial matrix enzyme involved in the oxidation of acetate JOURNAL J Biol Chem 276 (14), 11420-11426 (2001) PUBMED 11150295 REFERENCE 7 (bases 1 to 3595) AUTHORS Barth,C., Sladek,M. and Decker,K. TITLE The subcellular distribution of short-chain fatty acyl-CoA synthetase activity in rat tissues JOURNAL Biochim Biophys Acta 248 (1), 24-33 (1971) PUBMED 4334748 COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH474050.2. On Oct 4, 2007 this sequence version replaced XM_215897.4. ##Evidence-Data-START## RNAseq introns :: mixed sample support SAMEA5756307, SAMEA5760383 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## FEATURES Location/Qualifiers source 1..3595 /organism="Rattus norvegicus" /mol_type="mRNA" /db_xref="taxon:10116" /chromosome="3" /map="3q41" gene 1..3595 /gene="Acss1" /gene_synonym="Acas2l" /note="acyl-CoA synthetase short-chain family member 1" /db_xref="GeneID:296259" /db_xref="RGD:1306246" exon 1..345 /gene="Acss1" /gene_synonym="Acas2l" /inference="alignment:Splign:2.1.0" CDS 33..2081 /gene="Acss1" /gene_synonym="Acas2l" /EC_number="6.2.1.1" /note="acetyl-Coenzyme A synthetase 2 (AMP forming)-like" /codon_start=1 /product="acetyl-coenzyme A synthetase 2-like, mitochondrial" /protein_id="NP_001099994.1" /db_xref="GeneID:296259" /db_xref="RGD:1306246" /translation="
MAARSLGSGVGRLLRGLHGHSGQSGWLLSLSRWTTTRFLGSVPAAAQLGSYPALSAQAAQEPAAFWGPLARDTLVWDTPYHTVWDCDFRTGKIGWFLGGQLNVSVNCLDQHVQKSPDTIALIWERDEPGTEVRITYRELLETTCRLANTLKRHGVHRGDRVAIYMPVSPLAVAAMLACARIGAIHTVVFAGFSAESLAGRINDAKCKVVITFNQGLRGGRVVELKKIVDEAVKNCPTVQHVLVAHRTDTKVPMGNLDIPLEQEMANEAPVCTPESMNSEDMLFMLYTSGSTGTPKGLVHTQAGYLLYAAMTHKLVFDYHPGDVFGCVADIGWITGHSYVVYGPLCNGATTVLFESTPVYPDAGRYWETVQRLKINQFYGAPTAVRLLLKFGDAWVKKYDRSSLRTLGSVGEPINHEAWEWLHKVVGDGRCTLVDTWWQTETGGICIAPRPSEDGAEILPGMAMRPFFGIVPALMDEKGNVVEGGDVSGALCISQAWPGMARTIYGDHQRFVDAYFRTYPGYYFTGDGAHRTEGGYYQITGRMDDVINISGHRLGTAEIEDAMADHPAVPETAVIGYPHDIKGEAAFAFIVLKDDVRDANVVVNELKLAVATKIAKYAVPDQILVVKRLPKTRSGKVMRRLLRKIITSRGQDLGDTTTLEDPSVITEIMSAFREYEEQRAATN"
misc_feature 165..2042 /gene="Acss1" /gene_synonym="Acas2l" /note="acetate--CoA ligase; Region: Ac_CoA_lig_AcsA; TIGR02188" /db_xref="CDD:274022" misc_feature order(597..605,681..683,690..692,696..698,1014..1016, 1029..1034,1098..1106,1176..1181,1188..1190,1257..1268, 1332..1349,1608..1610,1644..1646,1653..1655,1677..1688, 1860..1862,1875..1880) /gene="Acss1" /gene_synonym="Acas2l" /note="active site" /db_xref="CDD:341270" misc_feature order(597..605,681..683,690..692,696..698,1014..1016, 1032..1034,1098..1106,1176..1181,1188..1190,1677..1685, 1860..1862,1875..1877) /gene="Acss1" /gene_synonym="Acas2l" /note="CoA binding site [chemical binding]; other site" /db_xref="CDD:341270" misc_feature order(882..884,891..908,912..917) /gene="Acss1" /gene_synonym="Acas2l" /note="acyl-activating enzyme (AAE) consensus motif; other site" /db_xref="CDD:341270" misc_feature order(1029..1034,1257..1268,1332..1349,1608..1610, 1644..1646,1653..1655,1686..1688) /gene="Acss1" /gene_synonym="Acas2l" /note="AMP binding site [chemical binding]; other site" /db_xref="CDD:341270" misc_feature order(1029..1034,1257..1262,1341..1343) /gene="Acss1" /gene_synonym="Acas2l" /note="acetate binding site [chemical binding]; other site" /db_xref="CDD:341270" exon 346..442 /gene="Acss1" /gene_synonym="Acas2l" /inference="alignment:Splign:2.1.0" exon 443..642 /gene="Acss1" /gene_synonym="Acas2l" /inference="alignment:Splign:2.1.0" exon 643..818 /gene="Acss1" /gene_synonym="Acas2l" /inference="alignment:Splign:2.1.0" exon 819..971 /gene="Acss1" /gene_synonym="Acas2l" /inference="alignment:Splign:2.1.0" exon 972..1119 /gene="Acss1" /gene_synonym="Acas2l" /inference="alignment:Splign:2.1.0" exon 1120..1257 /gene="Acss1" /gene_synonym="Acas2l" /inference="alignment:Splign:2.1.0" exon 1258..1350 /gene="Acss1" /gene_synonym="Acas2l" /inference="alignment:Splign:2.1.0" exon 1351..1463 /gene="Acss1" /gene_synonym="Acas2l" /inference="alignment:Splign:2.1.0" exon 1464..1590 /gene="Acss1" /gene_synonym="Acas2l" /inference="alignment:Splign:2.1.0" exon 1591..1718 /gene="Acss1" /gene_synonym="Acas2l" /inference="alignment:Splign:2.1.0" exon 1719..1782 /gene="Acss1" /gene_synonym="Acas2l" /inference="alignment:Splign:2.1.0" exon 1783..1901 /gene="Acss1" /gene_synonym="Acas2l" /inference="alignment:Splign:2.1.0" exon 1902..3595 /gene="Acss1" /gene_synonym="Acas2l" /inference="alignment:Splign:2.1.0" ORIGIN
ggctcctgcacccgcgtggggcgtcgggcgagatggcggcgcgcagcctcggcagcggtgtggggcgactgctgcgtggcctgcacgggcactcgggacaatcggggtggttgctgagcctgtcccgctggaccaccacccgattcctgggcagtgttcctgcagcagcgcagctaggctcgtaccccgctttgagcgctcaggcagcccaggagccggccgccttctggggaccgctggcccgtgacacactagtttgggacactccttaccatactgtctgggactgcgacttcaggacgggcaagatcggctggttcctgggaggccagttgaatgtgtctgtcaactgcctggaccagcacgtgcagaagtctcccgacaccatagctttgatttgggagagagatgaacctgggacagaagtgaggatcacttacagggagcttctggagaccacatgccgcctggccaacacgctgaagaggcatggtgtgcaccgaggggaccgtgtggccatctacatgcctgtgtccccactggctgtggcagcgatgctggcctgtgccaggattggagctatccacacagtggtttttgctggctttagtgcagagtccttggccgggaggatcaatgatgccaagtgcaaggttgttatcaccttcaaccaaggactccggggagggcgtgtggtggagctgaagaaaatagtggacgaagctgtgaagaactgcccaacagtgcagcatgtcctagtggctcacaggacggacaccaaggttcccatggggaatctggacatcccccttgagcaggagatggccaatgaggcccctgtgtgtacccctgaaagcatgaacagtgaagatatgctcttcatgctctacacgtctgggagcactgggacacccaagggactcgttcatacacaggcaggctatctgctgtatgccgccatgacgcacaagctcgtgtttgactaccatccaggtgatgtctttggttgtgtggctgacatcggttggatcacaggacacagctatgtggtgtatggacccctctgcaatggagctaccacggtcctttttgagagcaccccagtttaccctgatgctggtcgttactgggagacagtacagaggctaaagatcaaccagttctatggtgccccgacagctgtccgactgctgctgaagttcggggatgcctgggtgaaaaagtatgaccgctcctccctgcgcacactggggtcagtgggagagcccatcaatcatgaggcctgggagtggctccacaaagtggtgggtgatggcagatgtaccctggtggacacttggtggcagacagaaactggaggcatctgcattgcaccacggccctcggaagatggggcagagatcctcccaggcatggccatgaggccgttttttggcattgtccctgcactcatggatgagaagggcaatgttgtggagggtggtgatgtctctggggccctgtgtatttcccaagcttggccaggcatggcaaggaccatctacggtgaccaccagaggttcgtagatgcctacttcagaacgtacccaggttactacttcactggagatggagctcaccggacggagggtggctattaccagatcacagggcgcatggatgatgtcatcaacatcagtggtcatcgcctggggactgcagagattgaggatgcaatggctgaccatcccgctgtcccagaaactgctgtcattgggtaccctcatgacatcaaaggagaagctgcgtttgccttcattgtactgaaagatgacgtccgtgatgcaaacgtggtggtaaatgagctcaagttggcagtggccaccaagatcgccaagtatgctgtgcctgaccagatcctggtggtgaagcgtctccccaaaaccaggtctgggaaggtgatgaggaggctgctgaggaagatcatcaccagcagggggcaggatctaggggacaccactaccctggaggaccccagtgtcatcacggagatcatgagtgcctttcgggagtacgaagagcagcgggctgccaccaactgagaggtgcacctctgtgttgcccagacaaagccgcacaggacccctggtcaccctcagggaaaggagcttcaaagctggcttgtttcatctgagcacatgacccatgtactgccctatttgcagctgaagcccctctttctttctcctggggcctcgagcgctgcctctggaaggggaggcctttgtcctacttctggtttccagaattaagtcataattggaactaaaccagcacggggtaaccagaggtcttagctccagaactgtcatgttttctccagatgtgtgtagatacaaaacacagaatattttatttttttgtactttttctatttggggagagtaacagaacatttgggtataatgtgaacatttagttttgcacgtgcgcgtgcgtatgcacacacacacacacacacacacacacacacacacacacacacacacacacactgtgggaaaatattcttgcctccccagggatgaggataacagaatgtgcttttttaaaaaaattatcattcagtgtgcttgaaattcaaaccatagatgtttgtgcctctgccacataactgtccccatcctactaatccaagtcgccatatccacctcctgtgtctatttcatatttggttcacttggtttattttgtgatagaacagactggacgattcttatatttacgtttcgcaccttagggattgcactcagggcctcctgaacactaggcaagcactctacctctgagctgcacaccagcacctttaatccccaagagacggagtgaatgtcctctcctttacttgtgaaatcatttgggttcgcttctctaagctgtgatctggaaggagcttctttccccagggaatatgacctcataggaggtcatattgcttcaaacgtgtggttgttcgtggcaaccggtgaaaactcaggtgtcttactaaggctctggtcccattggggctcttgaagactctgcctgccctttctcttgtgattggggcaacaagagccactgtggtccaatgacaacacttggtgctcttgagcgagttctctctcgatgtgccttaagtcctctggacactggtgagtgtcacaaaccgtgaagtctggaaaacgtattctgtagcttggttgtggctaagcatgggagggcttgaaggggtggcagctctgtgagcagggcccctgggggcagaggaagatggttctggctggtccacagaactcagctctatgggtgtttcttagttactgcacacctactgtctgtcctgacttcttgggtaatggggtaaatattctgatactcccgggaggtggagtggttgtagtatgcacaaatattaatagtcctttgttacagtcagcggtaaagagccatgtgatggatttacttggctgactacagttactttagggaatggcctaggtttccaggttactgatagaacctatcagaatgatttatagaaatattcaaataaagctttattttgttcagtgtc
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If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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