LOCUS       NM_182842               2367 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus calcium/calmodulin-dependent protein kinase IG
            (Camk1g), mRNA.
ACCESSION   NM_182842 XM_341177
VERSION     NM_182842.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2367)
  AUTHORS   Davare MA, Fortin DA, Saneyoshi T, Nygaard S, Kaech S, Banker G,
            Soderling TR and Wayman GA.
  TITLE     Transient receptor potential canonical 5 channels activate
            Ca2+/calmodulin kinase Igamma to promote axon formation in
            hippocampal neurons
  JOURNAL   J Neurosci 29 (31), 9794-9808 (2009)
   PUBMED   19657032
  REMARK    GeneRIF: These results are consistent with a model in which highly
            localized calcium influx through the TRPC5 channels activates CaMKK
            and CaMKI, which subsequently promote axon formation.
REFERENCE   2  (bases 1 to 2367)
  AUTHORS   Nishimura H, Sakagami H, Uezu A, Fukunaga K, Watanabe M and Kondo
            H.
  TITLE     Cloning, characterization and expression of two alternatively
            splicing isoforms of Ca2+/calmodulin-dependent protein kinase I
            gamma in the rat brain
  JOURNAL   J Neurochem 85 (5), 1216-1227 (2003)
   PUBMED   12753081
  REMARK    GeneRIF: findings suggest that both alternatively splicing isoforms
            of CaMKI gamma may be involved in Ca2+ signal transduction in the
            cytoplasmic compartment of certain neuronal population
REFERENCE   3  (bases 1 to 2367)
  AUTHORS   Takemoto-Kimura S, Terai H, Takamoto M, Ohmae S, Kikumura S, Segi
            E, Arakawa Y, Furuyashiki T, Narumiya S and Bito H.
  TITLE     Molecular cloning and characterization of CLICK-III/CaMKIgamma, a
            novel membrane-anchored neuronal Ca2+/calmodulin-dependent protein
            kinase (CaMK)
  JOURNAL   J Biol Chem 278 (20), 18597-18605 (2003)
   PUBMED   12637513
REFERENCE   4  (bases 1 to 2367)
  AUTHORS   Yokokura H, Terada O, Naito Y and Hidaka H.
  TITLE     Isolation and comparison of rat cDNAs encoding
            Ca2+/calmodulin-dependent protein kinase I isoforms
  JOURNAL   Biochim Biophys Acta 1338 (1), 8-12 (1997)
   PUBMED   9074610
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB101231.1.
            
            On Dec 17, 2003 this sequence version replaced XM_341177.1.
            
            Sequence Note: This sequence has been modified as follows: removed
            25 bp suspected to be vector contamination from the 3' end.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB101231.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMD00132261, SAMD00132268
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2367              AB101231.1         1-2367
FEATURES             Location/Qualifiers
     source          1..2367
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q27"
     gene            1..2367
                     /gene="Camk1g"
                     /note="calcium/calmodulin-dependent protein kinase IG"
                     /db_xref="GeneID:171358"
                     /db_xref="RGD:621800"
     exon            1..51
                     /gene="Camk1g"
                     /inference="alignment:Splign:2.1.0"
     exon            52..172
                     /gene="Camk1g"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..1511
                     /gene="Camk1g"
                     /EC_number="2.7.11.17"
                     /note="caMKIG; CLICK III; caM-KI gamma; caM kinase IG;
                     caMKI gamma; caM kinase I gamma; caMK-like CREB kinase
                     III; calcium/calmodulin-dependent protein kinase I gamma"
                     /codon_start=1
                     /product="calcium/calmodulin-dependent protein kinase type
                     1G"
                     /protein_id="NP_878262.1"
                     /db_xref="GeneID:171358"
                     /db_xref="RGD:621800"
                     /translation="

MGRKEEEDCSSWKKQTTNIRKTFIFMEVLGSGAFSEVFLVKQRVTGKLFALKCIKKSPAFRDSSLENEIAVLKRIKHENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGVMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAKDFICHLLEKDPNERYTCEKALRHPWIDGNTALHRDIYPSVSLQIQKNFAKSKWRQAFNAAAVVHHMRKLHMNLHSPSVRQEVENRPPVSPAPEVSRPGSHDSSITEAPILDPSTPLPALTRLPCSHSSRPSAPGGRSLNCLVNGSLRISSSLVPMQQGPLATGPCGCCSSCLNIGNKGKSSYCSEPTLFRKANKKQNFKSEVMVPVKAGGSTHCRAGQTGVCLIM"

     misc_feature    135..989
                     /gene="Camk1g"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calcium/calmodulin-dependent protein kinase Type I gamma;
                     Region: STKc_CaMKI_gamma; cd14166"
                     /db_xref="CDD:271068"
     misc_feature    order(165..179,189..191,228..230,234..236,321..323,
                     369..380,390..392,396..398,504..509,513..515,519..524,
                     528..530,567..572,579..581,618..632,636..638)
                     /gene="Camk1g"
                     /note="active site"
                     /db_xref="CDD:271068"
     misc_feature    order(165..176,189..191,228..230,234..236,321..323,
                     369..380,390..392,519..524,528..530,567..572)
                     /gene="Camk1g"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:271068"
     misc_feature    order(177..179,390..392,396..398,504..509,513..515,
                     519..521,579..581,618..632,636..638)
                     /gene="Camk1g"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:271068"
     misc_feature    567..632
                     /gene="Camk1g"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:271068"
     misc_feature    909..1031
                     /gene="Camk1g"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNJ7.1);
                     Region: Autoinhibitory domain"
     misc_feature    969..1034
                     /gene="Camk1g"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNJ7.1);
                     Region: Calmodulin-binding"
     misc_feature    1056..1241
                     /gene="Camk1g"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNJ7.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            173..301
                     /gene="Camk1g"
                     /inference="alignment:Splign:2.1.0"
     exon            302..376
                     /gene="Camk1g"
                     /inference="alignment:Splign:2.1.0"
     exon            377..515
                     /gene="Camk1g"
                     /inference="alignment:Splign:2.1.0"
     exon            516..639
                     /gene="Camk1g"
                     /inference="alignment:Splign:2.1.0"
     exon            640..715
                     /gene="Camk1g"
                     /inference="alignment:Splign:2.1.0"
     exon            716..828
                     /gene="Camk1g"
                     /inference="alignment:Splign:2.1.0"
     exon            829..907
                     /gene="Camk1g"
                     /inference="alignment:Splign:2.1.0"
     exon            908..995
                     /gene="Camk1g"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1420
                     /gene="Camk1g"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1537
                     /gene="Camk1g"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..2367
                     /gene="Camk1g"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

ggctcgctggccaagatcacagactggagcacctttcttgtgagcccctggcttcccaggcagcttcaactctggaggacatggggcgaaaggaggaggaggactgtagctcctggaagaaacagaccaccaacatcaggaaaaccttcatcttcatggaagtgctcggatcaggagcgttctcagaggtgttcctggtgaagcaaagagtgactgggaaactctttgctctgaagtgcatcaagaagtcaccagccttccgggacagtagcctagagaatgagattgctgtgttgaaaaggatcaagcatgaaaacattgtgaccctggaggatatctatgagagcaccacccactactacctggtcatgcagcttgtttctggaggtgagctttttgaccgaatcctagagcgtggtgtctacacagaaaaggatgccagtctggtcatccagcaggtcttgtctgccgtgaaataccttcatgagaatggcatcgttcacagagatctaaagcctgaaaacctgctgtacctcacccctgaggagaactccaagataatgatcactgattttggcctatccaagatggagcagaatggagtcatgtccacagcttgtgggaccccaggctatgtggctccagaagtgctggcccagaagccctacagtaaggctgtggactgctggtccattggtgtcatcacatacatactgctgtgtgggtatccccctttctatgaagaaacagaatcaaagctttttgagaagatcaaagagggttactacgagtttgagtctccattctgggatgacatttctgagtcagccaaggactttatttgccatctgcttgagaaggacccaaatgaacgatacacctgcgagaaagccctcagacacccttggattgacgggaacacagccctgcaccgggacatctacccatctgtcagcctccagattcagaagaactttgccaagagcaagtggaggcaagccttcaatgcggccgccgtggtgcaccacatgaggaaactacacatgaacctgcacagccccagtgtccgccaagaagtggagaacaggccacctgtgtcccctgctcccgaagtctccagaccaggctcccatgacagctccatcacagaggctcccatcctggacccaagcacaccccttcctgcactgacccgacttccctgctcgcatagctctcggccttcagctcctggtggccgctcactcaactgcctggtcaacggttctctgcgcatcagcagtagcctagtgcccatgcaacagggtcccctagccacggggccctgcggctgctgctccagctgtctaaatatagggaacaagggaaagtcttcctattgctctgagcctaccctcttcagaaaagccaacaaaaaacagaacttcaagtcagaggtcatggtaccagtgaaagcaggtggcagcacccactgccgggctgggcagactggggtgtgtctcataatgtgatcccaggagcccgtgtggtttttcaggagacacgtctagctcttctctgcctctctaagctggcgtctgctctgaggaaagggagcagcaaagcagggatagccgaagcggctggtctgaggcagtaggggtgttgctgcctgggcagacactcgcaggaagtccagaggagctccaatcctggacgttctctgaggccacaagcaggatgtgtggtctgcctccagcatcccagcctccaggtctccagacctgcccattcccttccccacatcctatgtgcagtggctctgtgcagtgtccatagatagtgctcatctgggtccgtattgtttgttgtgaaaagctttatgggctggccaggctgtgccactttcttcaagcaaagccatatggagtctaactcagactccctgctctgcatactcactccggcctctctggcctcatggccagattgaacccgttatcatagtacctgcctatccgcatgaatgccagcctgcttcaggggcctgggagcactcacagctctagtcctcccctccaggattagcttcccactgcactgagacccaggccacttcaaagctctccctgcctccgcctaacagcagtgcccccattctccatggtggaacgagaaagctgagactatggactgtgagccttctctcccagccacacacctcacatatccctaactaaggattcggggactatttccatgtcggccaggtctcctctggctccttccattcccctgaaggtcaggtgcattgttctgtctctctgtgttcttaccctcataccctcaagcttcgtgctgtgttgtgctcaaataaaatggacatat

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