LOCUS       NM_172085               5909 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus POU class 3 homeobox 2 (Pou3f2), mRNA.
ACCESSION   NM_172085 XM_001059735 XM_345510
VERSION     NM_172085.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5909)
  AUTHORS   Wapinski OL, Vierbuchen T, Qu K, Lee QY, Chanda S, Fuentes DR,
            Giresi PG, Ng YH, Marro S, Neff NF, Drechsel D, Martynoga B, Castro
            DS, Webb AE, Sudhof TC, Brunet A, Guillemot F, Chang HY and Wernig
            M.
  TITLE     Hierarchical mechanisms for direct reprogramming of fibroblasts to
            neurons
  JOURNAL   Cell 155 (3), 621-635 (2013)
   PUBMED   24243019
REFERENCE   2  (bases 1 to 5909)
  AUTHORS   Ellmann L, Joshi MB, Resink TJ, Bosserhoff AK and Kuphal S.
  TITLE     BRN2 is a transcriptional repressor of CDH13 (T-cadherin) in
            melanoma cells
  JOURNAL   Lab Invest 92 (12), 1788-1800 (2012)
   PUBMED   23069940
REFERENCE   3  (bases 1 to 5909)
  AUTHORS   Arnold SJ, Huang GJ, Cheung AF, Era T, Nishikawa S, Bikoff EK,
            Molnar Z, Robertson EJ and Groszer M.
  TITLE     The T-box transcription factor Eomes/Tbr2 regulates neurogenesis in
            the cortical subventricular zone
  JOURNAL   Genes Dev 22 (18), 2479-2484 (2008)
   PUBMED   18794345
REFERENCE   4  (bases 1 to 5909)
  AUTHORS   Hoser M, Potzner MR, Koch JM, Bosl MR, Wegner M and Sock E.
  TITLE     Sox12 deletion in the mouse reveals nonreciprocal redundancy with
            the related Sox4 and Sox11 transcription factors
  JOURNAL   Mol Cell Biol 28 (15), 4675-4687 (2008)
   PUBMED   18505825
REFERENCE   5  (bases 1 to 5909)
  AUTHORS   Dy P, Penzo-Mendez A, Wang H, Pedraza CE, Macklin WB and Lefebvre
            V.
  TITLE     The three SoxC proteins--Sox4, Sox11 and Sox12--exhibit overlapping
            expression patterns and molecular properties
  JOURNAL   Nucleic Acids Res 36 (9), 3101-3117 (2008)
   PUBMED   18403418
REFERENCE   6  (bases 1 to 5909)
  AUTHORS   Malik KF, Jaffe H, Brady J and Young WS 3rd.
  TITLE     The class III POU factor Brn-4 interacts with other class III POU
            factors and the heterogeneous nuclear ribonucleoprotein U
  JOURNAL   Brain Res Mol Brain Res 45 (1), 99-107 (1997)
   PUBMED   9105675
REFERENCE   7  (bases 1 to 5909)
  AUTHORS   Brunekreef GA, van Genesen ST and Lubsen NH.
  TITLE     Sp1- and octamer-consensus sequence binding proteins during lens
            fibre differentiation
  JOURNAL   Exp Eye Res 64 (3), 295-299 (1997)
   PUBMED   9196379
REFERENCE   8  (bases 1 to 5909)
  AUTHORS   Suzuki T, Kim HS, Kurabayashi M, Hamada H, Fujii H, Aikawa M,
            Watanabe M, Watanabe N, Sakomura Y, Yazaki Y and Nagai R.
  TITLE     Preferential differentiation of P19 mouse embryonal carcinoma cells
            into smooth muscle cells. Use of retinoic acid and antisense
            against the central nervous system-specific POU transcription
            factor Brn-2
  JOURNAL   Circ Res 78 (3), 395-404 (1996)
   PUBMED   8593698
REFERENCE   9  (bases 1 to 5909)
  AUTHORS   Schonemann MD, Ryan AK, McEvilly RJ, O'Connell SM, Arias CA, Kalla
            KA, Li P, Sawchenko PE and Rosenfeld MG.
  TITLE     Development and survival of the endocrine hypothalamus and
            posterior pituitary gland requires the neuronal POU domain factor
            Brn-2
  JOURNAL   Genes Dev 9 (24), 3122-3135 (1995)
   PUBMED   8543156
REFERENCE   10 (bases 1 to 5909)
  AUTHORS   Li P, He X, Gerrero MR, Mok M, Aggarwal A and Rosenfeld MG.
  TITLE     Spacing and orientation of bipartite DNA-binding motifs as
            potential functional determinants for POU domain factors
  JOURNAL   Genes Dev 7 (12B), 2483-2496 (1993)
   PUBMED   8276233
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000161.1.
            
            On Feb 10, 2021 this sequence version replaced NM_172085.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: L27663.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5909              JACYVU010000161.1  11502059-11507967   c
FEATURES             Location/Qualifiers
     source          1..5909
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q21"
     gene            1..5909
                     /gene="Pou3f2"
                     /gene_synonym="Brn-2; oct-7; OTF-7"
                     /note="POU class 3 homeobox 2"
                     /db_xref="GeneID:29588"
                     /db_xref="RGD:61946"
     exon            1..5909
                     /gene="Pou3f2"
                     /gene_synonym="Brn-2; oct-7; OTF-7"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..1408
                     /gene="Pou3f2"
                     /gene_synonym="Brn-2; oct-7; OTF-7"
                     /note="nervous system-specific octamer-binding
                     transcription factor N-Oct-3; brain-specific homeobox/POU
                     domain protein 2; brain-2; protein Brn-2; octamer-binding
                     protein 7; octamer-binding transcription factor 7"
                     /codon_start=1
                     /product="POU domain, class 3, transcription factor 2"
                     /protein_id="NP_742082.2"
                     /db_xref="GeneID:29588"
                     /db_xref="RGD:61946"
                     /translation="

MATAASNHYSLLTSSASIVHAEPPGGMQQGAGGYREAQSLVQGDYGALQSNGHPLSHAHQWITALSHGGSGGGGGGGGGGGGGGGGGGDGSPWSTSPLGQPDIKPSVVVQQGGRGDELHGPGALQQQHQQQQQQQQQQQQQQQQQQQQQQQRPPHLVHHAANHHPGPGAWRSAAAAAHLPPSMGASNGGLLYSQPSFTVNGMLGAGGQPAGLHHHGLRDAHDEPHHADHHPHPHSHPHQQPPPPPPPQGPPGHPGAHHDPHSDEDTPTSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEEADSSSGSPTSIDKIAAQGRKRKKRTSIEVSVKGALESHFLKCPKPSAQEITSLADSLQLEKEVVRVWFCNRRQKEKRMTPPGGTLPGAEDVYGGSRDTPPHHGVQTPVQ"

     misc_feature    257..589
                     /gene="Pou3f2"
                     /gene_synonym="Brn-2; oct-7; OTF-7"
                     /note="propagated from UniProtKB/Swiss-Prot (P56222.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    677..877
                     /gene="Pou3f2"
                     /gene_synonym="Brn-2; oct-7; OTF-7"
                     /note="propagated from UniProtKB/Swiss-Prot (P56222.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    860..1084
                     /gene="Pou3f2"
                     /gene_synonym="Brn-2; oct-7; OTF-7"
                     /note="Found in Pit-Oct-Unc transcription factors; Region:
                     POU; smart00352"
                     /db_xref="CDD:197673"
     misc_feature    1076..1153
                     /gene="Pou3f2"
                     /gene_synonym="Brn-2; oct-7; OTF-7"
                     /note="propagated from UniProtKB/Swiss-Prot (P56222.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1097..1099
                     /gene="Pou3f2"
                     /gene_synonym="Brn-2; oct-7; OTF-7"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P20265; propagated from
                     UniProtKB/Swiss-Prot (P56222.1); phosphorylation site"
     misc_feature    order(1139..1153,1157..1159,1208..1210,1226..1228,
                     1265..1267,1271..1276,1283..1288,1292..1300,1304..1309)
                     /gene="Pou3f2"
                     /gene_synonym="Brn-2; oct-7; OTF-7"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     misc_feature    1145..1306
                     /gene="Pou3f2"
                     /gene_synonym="Brn-2; oct-7; OTF-7"
                     /note="Homeobox domain; Region: Homeobox; pfam00046"
                     /db_xref="CDD:425441"
     misc_feature    order(1145..1147,1154..1156,1274..1276,1283..1288,
                     1295..1297)
                     /gene="Pou3f2"
                     /gene_synonym="Brn-2; oct-7; OTF-7"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     misc_feature    1301..1405
                     /gene="Pou3f2"
                     /gene_synonym="Brn-2; oct-7; OTF-7"
                     /note="propagated from UniProtKB/Swiss-Prot (P56222.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
ORIGIN      

ccaaggcagaaaagtaactgtcaaatgcgcggctcctttaaccagagcgcccagtccggctccgagagtcatggcgaccgcagcgtctaaccactacagcctgctcacctccagcgcctccatcgtgcacgccgagccgcctggcggcatgcagcagggcgcggggggctaccgcgaggcacagagcctggtgcagggcgactacggtgcgctgcagagcaacgggcacccgctcagccacgctcaccagtggatcaccgcgctgtcccacggcggcagcggcgggggcggcggcggtggtggaggaggcgggggaggcggcgggggaggcggcgacggctccccgtggtccaccagccccctaggccagccggacatcaagccctcggtggtggtacagcagggtggccgaggcgacgagctgcacgggccaggagcgctgcagcagcagcaccaacagcaacagcagcagcagcaacagcaacagcagcaacaacagcaacagcagcagcagcaacaacagcgaccgccacatctggtgcaccacgctgccaaccaccatcccgggcccggggcatggcggagtgcggcggctgcagctcaccttcctccctccatgggagcttccaacggtggtttgctctattcgcagcccagcttcacggtgaacggcatgctgggcgcaggagggcagccggctgggctgcaccaccacggcctgagggacgcccacgatgagccccatcatgcagaccaccacccgcatccgcactctcacccgcaccagcaaccgcccccgccacctcccccacaaggcccaccgggccacccaggcgcgcaccacgacccgcactcggacgaggacacgccgacctcagacgacctggagcagttcgccaagcaattcaagcagaggcggatcaaactaggatttactcaagcagacgtggggctggcgcttggcaccctgtacggcaacgtcttctcgcagaccaccatctgcaggtttgaggccctgcagctgagcttcaagaacatgtgcaagctgaagcctttgttgaacaagtggttggaagaggcagactcatcctcgggcagccccaccagcatagacaagatcgctgcgcaagggcgcaaacggaaaaagcggacctccatcgaggtgagcgtcaagggggctctggagagccatttcctcaaatgccctaagccctcggcccaggagatcacctccctcgcggacagcttacagctggagaaggaggtggtgagagtttggttttgtaacaggagacagaaagagaaaaggatgacccctcccggagggactctgccgggcgccgaggatgtgtatggggggagtagggacacgccaccacaccacggggtgcagacgcccgtccagtgaactcaagcaggggaggggcagagcttggggctcccctcccctttggtccacagtcttaactgggacctctgttccccctgtaacttctgattgtttttttttttttaattattattttcccggtcccttaaaaagagaaaaaaatagagaaattaaggagaaaggaaagtaaaagtaaaacactggactaacctatagcaggtagcaggtgtattcatgggttttgacctttgcaagcgagtacccaggcaatgaagtagaatgtctcctagtaagagtgaagtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtctgtgtgtgagagagagagagagagagagagagagagagagagagagagagagagagagagggagggaggagtcctggtaaaactaaataaattaccaaaaagaaaaaaaatccaccaaaccgtacacaacacaaaactgcagcttcccatgctcaaagttgacacgtgctgctgtgtttatttaatatggtccccatcaggaaagagggaaaaatacactttttaaaactattggcaaaatttaagcacacgaatttgcactgcaagaaaattgaagtttacattgacaagttcaaccctttttttttttttctcttaatacccactgttaaatttgaagctgtcctttgggttctgttctgttctgccttatccagtggagaggacagaagccagctcctggccaccctccattccagcgttctgatgccccttgttcttattgcttgtaaactttgttttcttcaacgccccagacctggtgtaacacttattggctcttttcaccaaagcgaaatgattggcttcacacaaaataaataaatgtttgcattcaggaaatgtgtatggtttgcccgctttatgcaaggcaggaatatcgttggaaatacaaatataagtgttgagcactgttttttgtttggttggttttttttgtttttttttgtttttgtttttgtttttgtttttgtaaaccacacagtaaacttcatcttcaggcagtatttctgggtaggagagaaaaaggaaaatcaatagtgagtgatcagtcacttcatttttttcaggcagggctattgtgaaagaactaaaaaaacaaacagaaaaaaacctgtgaggttaaatatattgtccaacagacagaaattaaggactctgagaacttggaaacacactgggttctctgcctttgggtttaataacttaattataagggattagttgtgatgacagcagtggttaaactttgttcctctactaggttttattttttaacataaagaaaataacccaggaactcgatatatcatatgcacactgtgtttcttaacacagaaatgcatatactataatgcatatatatatatatatatatatattggatagacaggtttttgtacccaacagttcaattgtttatgaagtcatattttgggctttacaccatcttcccccataagttattgcagaaaaacatcagttcagattggacaaaattccccccactttcattaaaacagacaaatgaaggggagggggcattttcaatgatttctttctccccctttgttaataaattttcagtgcatttttttttaccttgtctaaatgggaaatggtttacacccaacacaatagaatattctggaaggtgtaggtaagaaaacaaaaacagaaaaggctatggctaaactgaaattaacaccattaaaactgtgatcagtttaaaaaattaaatagttatcagcacaaaagggcgctaaaagggaaaaaaaccttaaatagttggggttttatttctttgttaggtatcagataaatgttatgttaaaaaagtaaattctcactaccataaattgatggctcagcatcggattagcattgcactccgtagttaaggttttaggtaatatgctttatcaagtattgtctttagaaactcctgtgattgtttcattttcgatgtttttacaagataaatggtgacttataatgggcatatttatttgcctgtatttcatttcccccaatgaatgtcacaggagatgccatagagctatttcaggttatatcacactgcttcttcctgatgtgtggggactggccttcagtaaagcaacccagaggagggcagatggccaatggtaaaaggaggaaatgaatttgcagatacttattaccaagtaggtaaggtcaggaagctggggttccggggatgtgcctacatcttctcttgctctcttaggcttacaaatatgaaagttaccactgaaccttaccatatgtatatatgtttaatatctgtcttttgaaatgcagaaatagtttaaatgtttctttgtctatttttccttttgtttttaatgctacccagggaaatattttcatatcgttttacgtggcctgcctcaatgtatatttatttctttggagaaaaaaaaaggttctgaaaactggttttctgtagctttaaatgagtaggtagcaagatctatatgggatgtcatttttttgttcagtttctttaaaaaaatgctttgttttgatacatttggttgtgcttgtggggaaaataaaagcgcagagatccttatatatttatgttaaagtaatattttattattacataaaacagaaatgcacaataccttcatagtttgttctaattattgaaatatctttattttatttttaaagatagtgccaagttctaagaggtgaggaagccctacctagaccttatactgactgagctgtgtataaaatacttcccttcctttatacgtcataaagttttggaataaattttatgcatatattgccagctttcatgtttataacttccagaggcattttcttagttttttttttttaaagaggagtgttcagacttttctttgcagaaactaccatggggcccaaatattgtcttcactgccttgtagaattcaatcaaatcagtcattgggtttcagctccaatttgttggccatttcctgaacaaacgaaaaaaaaatacttgccttgtaaatacatgcccaggtccctacaccttccctccaggttagctgctctttgccaatggattgttaaggatagcatcagtgggactagatggaccttaacctctgccacatgtccttaggtaaactggtaccttcagaaaagtgaggcttagacagaaattattattcattattaacaaatatccctcaacaacaaaaactcttaacgatatgcaatatatatgtttaccaactgattaaaagtagataccacacattagtcctcttaggtttacaggggaaagatactttttttacaacagtgtatctctctcaccaggcaaacaaacaaacaaaccacatcaagatctacattaaaagaagagggaaagaatgtattggagagatacaagccatggtttgtttcagaaggttttagataaagcactgcacttaaaacaacagcaaacaagcaaaaagatagtctttaatgttggtgaagtgtttatatatttgttggtgtatttaaagtcctccttggaacactgacttaaaatataaatgtccatttaggaaaggagtttctgggcttattacttctgatcatcttttctaattcctagtcaatattacatgggtcccaaacagattctgccaaatgatcttatcaatagtctgaacaagaagtgacagaaagaagaagtgttttgtgaccacagacatgctgatgggtaaaatgtttaagctaggtatagatttgagttctgggtcaatatccctcctctgaaggaggaaagcgagcctcatctgccctctgcagggcgtttcagtggaccctgagaaggcatttttttttcctttcctcaggcactgtgaacagacctggaaacatcatatattaaacagacacactatgttcctgacttgtgttggtcactggggtcctcaagctgctctggtagcttccatgccagtcttagaatgtattcccacttaaaaaaaaaaaagactgcagagtcattaatacaaatctgtggggacaattgtcagatatcgacaagccatctctatcctaaaggcaaaaatgcagtgtttgtgtttgctcaaaacatgccatattttagatttttatatatacagacatactggggaagaaaagattgtatatgaaagagtatgtgaaggtcataaggatggaatggccacaactaatattatgcttggtgtgtgtggttttttttaaacattcttagttcccctgaagaaatgtcctttatgtttcagatagtaccagtaaaacagctgtcctcgttcctctccctcctgctcttacagagaaggccacacgctgtcagaattttctggtgaaatgtttttaattaaggcacttgtctctctatcttattccttcaaaaataaaaaccaataaaacaacataacagcaaa

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