LOCUS       NM_153726               1420 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus Ly-49 stimulatory receptor 3 (Ly49s3), mRNA.
ACCESSION   NM_153726 XM_579685
VERSION     NM_153726.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1420)
  AUTHORS   Yamada T, Nanashima N, Akita M, Shimizu T, Miura T, Yamana D,
            Sawano T, Sakurai T and Tsuchida S.
  TITLE     Lectin-like receptor Ly49s3 on dendritic cells contributes to the
            differentiation of regulatory T cells in the rat thymus
  JOURNAL   J Immunol 191 (7), 3799-3809 (2013)
   PUBMED   23997226
  REMARK    GeneRIF: Lectin-like receptor Ly49s3 on dendritic cells contributes
            to the differentiation of regulatory T cells in the rat thymus.
REFERENCE   2  (bases 1 to 1420)
  AUTHORS   Kveberg L, Back CJ, Dai KZ, Inngjerdingen M, Rolstad B, Ryan JC,
            Vaage JT and Naper C.
  TITLE     The novel inhibitory NKR-P1C receptor and Ly49s3 identify two
            complementary, functionally distinct NK cell subsets in rats
  JOURNAL   J Immunol 176 (7), 4133-4140 (2006)
   PUBMED   16547249
  REMARK    GeneRIF: NKR-P1C(+) NK cell subset also appears earlier during
            development and shows a tissue distribution distinct from its
            complementary Ly49s3(+) subset
REFERENCE   3  (bases 1 to 1420)
  AUTHORS   Nylenna O, Naper C, Vaage JT, Woon PY, Gauguier D, Dissen E, Ryan
            JC and Fossum S.
  TITLE     The genes and gene organization of the Ly49 region of the rat
            natural killer cell gene complex
  JOURNAL   Eur J Immunol 35 (1), 261-272 (2005)
   PUBMED   15593300
REFERENCE   4  (bases 1 to 1420)
  AUTHORS   Naper C, Hayashi S, Kveberg L, Niemi EC, Lanier LL, Vaage JT and
            Ryan JC.
  TITLE     Ly-49s3 is a promiscuous activating rat NK cell receptor for
            nonclassical MHC class I-encoded target ligands
  JOURNAL   J Immunol 169 (1), 22-30 (2002)
   PUBMED   12077224
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY102036.1.
            
            On Apr 19, 2005 this sequence version replaced XM_579685.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY102036.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1420
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="PVG"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..1420
                     /gene="Ly49s3"
                     /note="Ly-49 stimulatory receptor 3"
                     /db_xref="GeneID:266768"
                     /db_xref="RGD:628683"
     misc_feature    108..110
                     /gene="Ly49s3"
                     /note="upstream in-frame stop codon"
     CDS             138..971
                     /gene="Ly49s3"
                     /codon_start=1
                     /product="Ly-49 stimulatory receptor 3"
                     /protein_id="NP_714948.1"
                     /db_xref="GeneID:266768"
                     /db_xref="RGD:628683"
                     /translation="

MSKQDVPCSTVRFKKSSGLQYQVRPEETQRPREAGWRVPWQLTVIATGILLSLRLVAVAMLVTNIFQYSNENHELQKTHKRQHNSSTMEKDIKLKEEMLRNMSVESVHYNAFLDLINREQNRWYKKTKTVLASPQHTGGCDEMHWFCYGIKCYYFTMDIRIWRECKQTCQNYSLSFLKIDDKDELKFLQDHIIRDNYWIGSSYNNKKKEWAWIDNSPFDLDFVARTLLRKTGYCLYFSMSGLHDDDCGKRYLCICEKGMDKFPAPLCSVKETSHSAV"

     misc_feature    249..602
                     /gene="Ly49s3"
                     /note="Ly49-like protein, N-terminal region; Region: Ly49;
                     pfam08391"
                     /db_xref="CDD:429969"
     misc_feature    561..908
                     /gene="Ly49s3"
                     /note="C-type lectin-like domain (CTLD) of the type found
                     in natural killer cell receptors (NKRs); Region:
                     CLECT_NK_receptors_like; cd03593"
                     /db_xref="CDD:153063"
     misc_feature    order(723..725,807..809,858..860,864..869)
                     /gene="Ly49s3"
                     /note="ligand binding surface [chemical binding]; other
                     site"
                     /db_xref="CDD:153063"
ORIGIN      

atacagaccaggaaaggtcaaggctttctctaattgggagaagagtaccttccaacagaatcactttgggatagagacacagaaaacactcaaggcccgattttaactgaaaacagacttcatacatcattcccaaaatgagtaagcaggatgttccttgctcaactgtgagatttaaaaagtcttcagggttgcagtatcaagtgaggcctgaggagactcaaaggcccagggaagctggctggagagtcccctggcagctcactgtgattgctactggaatcctcctttcccttcggctggttgctgttgcaatgttggtgacaaacatttttcagtacagtaatgaaaaccatgaactacagaaaactcacaaacgtcagcataacagcagcaccatggaaaaggacatcaaattaaaggaagaaatgctgagaaatatgtctgtagagagtgttcactacaatgcttttctagacttaatcaacagagaacaaaacagatggtacaagaaaactaagactgttttagcttcccctcagcacacaggcgggtgtgatgaaatgcactggttctgctatggtataaaatgttattatttcaccatggacataagaatatggcgtgaatgtaaacagacctgtcagaactacagcttgtcctttctgaagatagatgataaggatgaactgaagttccttcaggaccacattattcgtgacaattactggattggatcatcatataataacaaaaaaaaggaatgggcatggattgacaacagcccatttgatcttgattttgtggcaaggactttgctacgaaaaacaggatactgtctgtatttcagtatgtcaggtctacatgatgatgactgtggtaaaagatatctctgtatctgtgaaaagggaatggacaaattccctgccccattgtgcagtgtgaaggaaacgtcacattctgctgtgtgaatagagagatgatctgcaaagggaagaaatcttcgtaaatttggcataacagcagacacagtattccctcttggcacatggaggagcttgcatgtggagaatggacatcttttttccaagacccaaacgtttccctcacattgtttcctgaatgacacacagaacaacatagagaactcaatacataatgcacacatcatatcttctttacgatatttctatagcccttggcttgataccacaattaatgactaatctgccgttgtgggttttcatgtattggttagttattacttggtatttttttttttttttttgatgtacaaaaagttagcattataaaatccttttgagacgaggaactgtggaaaggaggactggagggggtgatgaccggactgttaataaataaaataattttgaaaaccttaaaaaaaaaaaaaaaaaaa

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