LOCUS       NM_153472               1334 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus MNAT1 component of CDK activating kinase (Mnat1),
            mRNA.
ACCESSION   NM_153472
VERSION     NM_153472.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1334)
  AUTHORS   Fujii W, Nishimura T, Kano K, Sugiura K and Naito K.
  TITLE     CDK7 and CCNH are components of CDK-activating kinase and are
            required for meiotic progression of pig oocytes
  JOURNAL   Biol Reprod 85 (6), 1124-1132 (2011)
   PUBMED   21778139
REFERENCE   2  (bases 1 to 1334)
  AUTHORS   Egly JM and Coin F.
  TITLE     A history of TFIIH: two decades of molecular biology on a pivotal
            transcription/repair factor
  JOURNAL   DNA Repair (Amst) 10 (7), 714-721 (2011)
   PUBMED   21592869
  REMARK    Review article
REFERENCE   3  (bases 1 to 1334)
  AUTHORS   Sano M, Izumi Y, Helenius K, Asakura M, Rossi DJ, Xie M, Taffet G,
            Hu L, Pautler RG, Wilson CR, Boudina S, Abel ED, Taegtmeyer H,
            Scaglia F, Graham BH, Kralli A, Shimizu N, Tanaka H, Makela TP and
            Schneider MD.
  TITLE     Menage-a-trois 1 is critical for the transcriptional function of
            PPARgamma coactivator 1
  JOURNAL   Cell Metab 5 (2), 129-142 (2007)
   PUBMED   17276355
REFERENCE   4  (bases 1 to 1334)
  AUTHORS   Sandrock B and Egly JM.
  TITLE     A yeast four-hybrid system identifies Cdk-activating kinase as a
            regulator of the XPD helicase, a subunit of transcription factor
            IIH
  JOURNAL   J Biol Chem 276 (38), 35328-35333 (2001)
   PUBMED   11445587
REFERENCE   5  (bases 1 to 1334)
  AUTHORS   Busso D, Keriel A, Sandrock B, Poterszman A, Gileadi O and Egly JM.
  TITLE     Distinct regions of MAT1 regulate cdk7 kinase and TFIIH
            transcription activities
  JOURNAL   J Biol Chem 275 (30), 22815-22823 (2000)
   PUBMED   10801852
REFERENCE   6  (bases 1 to 1334)
  AUTHORS   Wu L, Chen P, Hwang JJ, Barsky LW, Weinberg KI, Jong A and Starnes
            VA.
  TITLE     RNA antisense abrogation of MAT1 induces G1 phase arrest and
            triggers apoptosis in aortic smooth muscle cells
  JOURNAL   J Biol Chem 274 (9), 5564-5572 (1999)
   PUBMED   10026172
REFERENCE   7  (bases 1 to 1334)
  AUTHORS   Kershnar E, Wu SY and Chiang CM.
  TITLE     Immunoaffinity purification and functional characterization of
            human transcription factor IIH and RNA polymerase II from clonal
            cell lines that conditionally express epitope-tagged subunits of
            the multiprotein complexes
  JOURNAL   J Biol Chem 273 (51), 34444-34453 (1998)
   PUBMED   9852112
REFERENCE   8  (bases 1 to 1334)
  AUTHORS   Drapkin R, Le Roy G, Cho H, Akoulitchev S and Reinberg D.
  TITLE     Human cyclin-dependent kinase-activating kinase exists in three
            distinct complexes
  JOURNAL   Proc Natl Acad Sci U S A 93 (13), 6488-6493 (1996)
   PUBMED   8692842
REFERENCE   9  (bases 1 to 1334)
  AUTHORS   Reardon JT, Ge H, Gibbs E, Sancar A, Hurwitz J and Pan ZQ.
  TITLE     Isolation and characterization of two human transcription factor
            IIH (TFIIH)-related complexes: ERCC2/CAK and TFIIH
  JOURNAL   Proc Natl Acad Sci U S A 93 (13), 6482-6487 (1996)
   PUBMED   8692841
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1996 Sep 17;93(19):10538]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC078712.1.
            
            On Aug 8, 2004 this sequence version replaced NM_153472.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078712.1, AY135567.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1334
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q24"
     gene            1..1334
                     /gene="Mnat1"
                     /note="MNAT1 component of CDK activating kinase"
                     /db_xref="GeneID:266713"
                     /db_xref="RGD:628874"
     exon            1..143
                     /gene="Mnat1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    43..45
                     /gene="Mnat1"
                     /note="upstream in-frame stop codon"
     CDS             55..984
                     /gene="Mnat1"
                     /note="menage a trois 1; menage a trois homolog 1, cyclin
                     H assembly factor; MNAT CDK-activating kinase assembly
                     factor 1; MNAT1, CDK activating kinase assembly factor"
                     /codon_start=1
                     /product="CDK-activating kinase assembly factor MAT1"
                     /protein_id="NP_703202.1"
                     /db_xref="GeneID:266713"
                     /db_xref="RGD:628874"
                     /translation="

MDDQGCPRCKTTKYRNPSLKLMVNVCGHTLCESCVDLLFVRGAGNCPECGTPLRKSNFRVQLFEDPTVDKEVEIRKKVLKIYNKREEDFPSLREYNDFLEEVEEIVFNLTNNVDLENTKKKMEIYQKENKDVIQKNKLKLTREQEELEEALEVERQESEQRRLFIQKEEELQQILKRKNKQAFLDELESSDLPVALLLAQHKDRSTQLEMQLEKPKSMKPVTFSTGIKMGQQISLAPIQKLEEALYEYQPLQIETCGPQVPEQELLGRLGYLNHVRAASPQDLAGGYTSSLACHRALQDAFSGLFWQPR"

     misc_feature    55..978
                     /gene="Mnat1"
                     /note="CDK-activating kinase assembly factor MAT1; Region:
                     cdk7; TIGR00570"
                     /db_xref="CDD:129661"
     exon            144..296
                     /gene="Mnat1"
                     /inference="alignment:Splign:2.1.0"
     exon            297..370
                     /gene="Mnat1"
                     /inference="alignment:Splign:2.1.0"
     exon            371..474
                     /gene="Mnat1"
                     /inference="alignment:Splign:2.1.0"
     exon            475..615
                     /gene="Mnat1"
                     /inference="alignment:Splign:2.1.0"
     exon            616..741
                     /gene="Mnat1"
                     /inference="alignment:Splign:2.1.0"
     exon            742..863
                     /gene="Mnat1"
                     /inference="alignment:Splign:2.1.0"
     exon            864..1302
                     /gene="Mnat1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gtggcagtggctgaagctggcgttggggggaaaatccaaagctgaggagacgccatggacgaccagggctgccccaggtgtaagaccaccaaataccggaacccttctttgaagctgatggtgaacgtgtgcggacacacactgtgtgagagttgtgtggacttactgtttgtaagaggagctggaaactgtccggagtgtggcactccactgagaaagagcaactttagggtacagctctttgaagatcccactgttgacaaggaggttgaaattcggaaaaaagtactaaagatatacaataaaagggaagaagattttcctagtttaagagagtataatgattttctggaagaagtggaggaaatcgttttcaatttgaccaacaacgtggatttggagaacactaaaaagaaaatggaaatatatcaaaaagaaaacaaagatgtcattcagaaaaataaattaaagctgactcgggagcaggaggaattggaggaagcattggaggtagaacgccaagaaagtgaacaacgacgactgtttattcaaaaggaagaagagctgcagcagattctgaaaaggaagaacaagcaggcctttttagatgagctggagagctccgacctccctgtcgctctgctcttggctcagcataaagacagatctacccagctggaaatgcagcttgagaagcccaaatccatgaagccggtgacattttccacaggaattaaaatgggtcaacagatttcgttagcaccaatccaaaagcttgaggaagctctctatgaataccagcccctgcagatagagacctgtggaccccaagttcctgaacaagagctgctaggaagacttgggtatttgaaccacgtccgagctgcatctccacaggatctagctggcggctatacttcttctcttgcttgtcacagagcgctacaggatgcattcagtgggcttttctggcagcccagatagcctgtattttctcatttataaaatctggatcttggaaccaaaccaaggggtttggaagtaaagaaatttgtaaagtcccagcccacgcagctgcacagcacaccaccgctggctgctgtgttcaggtgtttatggcagtctggaccaagctgagaaatgtgttgcatatagattcatggaagagatttattttttacttctattcttcagacagggatcgaagcattgaacctcatataacaagaaagaaataaatgatttgcctatgtatggtgttgacatacattttttaaaacaataaagcttgactttatgataaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa

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