LOCUS       NM_152849               1785 bp    mRNA    linear   ROD 04-OCT-2024
DEFINITION  Rattus norvegicus homeobox and leucine zipper encoding (Homez),
            mRNA.
ACCESSION   NM_152849
VERSION     NM_152849.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1785)
  AUTHORS   Bayarsaihan,D., Enkhmandakh,B., Makeyev,A., Greally,J.M.,
            Leckman,J.F. and Ruddle,F.H.
  TITLE     Homez, a homeobox leucine zipper gene specific to the vertebrate
            lineage
  JOURNAL   Proc Natl Acad Sci U S A 100 (18), 10358-10363 (2003)
   PUBMED   12925734
  REMARK    GeneRIF: Homez is a homeobox leucine zipper gene specific to the
            vertebrate lineage.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC084701.1.
            
            On Oct 28, 2005 this sequence version replaced NM_152849.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC084701.1, BC085694.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1785              BC084701.1         1-1785
FEATURES             Location/Qualifiers
     source          1..1785
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p13"
     gene            1..1785
                     /gene="Homez"
                     /note="homeobox and leucine zipper encoding"
                     /db_xref="GeneID:260325"
                     /db_xref="RGD:628904"
     exon            1..50
                     /gene="Homez"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..1687
                     /gene="Homez"
                     /note="homeodomain leucine zipper-containing factor;
                     homeodomain leucine zipper-encoding; homeodomain-leucine
                     zipper protein HOMEZ"
                     /codon_start=1
                     /product="homeobox and leucine zipper protein Homez"
                     /protein_id="NP_690062.3"
                     /db_xref="GeneID:260325"
                     /db_xref="RGD:628904"
                     /translation="

MRTRHPERAVSEGYKSEQVMSPNKDSSSLNSSGAGLVCLPPVSEELQLVWTQAVQTSELDGNEHLLQAFSYFPYPSLADIALLCLRHGLQMEKVKTWFMAQRLRCGISWSSEEIEETRARVVYHRDQLLFKSLLSFTHHAVRPPQEMPPVTPPEQVALGLRPLALSEPTQMKGLKVEPEEPFQVSQLPLNHQKVKEPLMMGSRTLNHQSDCQDLQISGLSKEQAGGGPDQSCGGGTASWNHSIAVHQPDKSPLISLLDNSCKEESEPSGTPPSSSASSPFQVLANGTTATPKPLQPLGYIPQSFSPSEQALSPQVEPLWSQRLRNNSVPSRVGPTEYLSPDMQHQRKTKRKTKEQLAILKSFFLQCQWARREDYHKLEQITGLPRPEIIQWFGDTRYALKHGQLKWFRDNAVLGTPSFQDPAISTSSTRSLKEWAKTPPLPAPPPPPDIRPLERYWAAHQQLQEADILKLSQASRLSTQQVLDWFDSRLPKPAEVVVCLDEEEEEEDEELPEDGEEEEEEEEEEDDDGLSCGQKDHGLLTNGAVERGSLLTVG"

     misc_feature    209..352
                     /gene="Homez"
                     /note="Homeodomain; DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:238039"
     misc_feature    1061..1234
                     /gene="Homez"
                     /note="Homeodomain; DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:238039"
     misc_feature    order(1061..1072,1076..1078,1127..1129,1145..1147,
                     1184..1186,1190..1195,1202..1207,1211..1219,1223..1228)
                     /gene="Homez"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     misc_feature    order(1064..1066,1073..1075,1193..1195,1202..1207,
                     1214..1216)
                     /gene="Homez"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     misc_feature    1367..1510
                     /gene="Homez"
                     /note="Homeodomain leucine-zipper encoding, Homez; Region:
                     Homez; pfam11569"
                     /db_xref="CDD:463297"
     exon            51..1606
                     /gene="Homez"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..1759
                     /gene="Homez"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gtacatatgtgaaggaagagtcagcatgaggactagacacccagagagagctgtctctgaagggtacaaatcagagcaggtcatgagtccgaataaagactccagcagtctcaacagctcgggagcagggcttgtctgcctcccgccagtctccgaggagctacagcttgtgtggactcaagcggtccaaaccagtgagctggacggaaatgagcacctgctacaggctttcagctacttcccctacccaagcctggcagatatcgctctcctctgcctgcggcatgggctgcagatggagaaggtaaagacctggttcatggcccaacgtctccgctgtggcattagctggtcatctgaagagatagaagagactcgagccagagtggtgtaccaccgagatcagctccttttcaagtctcttctgtctttcacacatcacgcagtgaggcccccacaggagatgcctccagtgacccctccagaacaggttgctcttggactgcgtcctctggcgcttagcgagcccactcagatgaaaggattgaaggttgagcctgaggagccctttcaggtatcacagctgccactgaatcatcagaaagttaaggagcctttgatgatgggcagcagaacattgaaccaccaatcagattgtcaggatcttcagatcagtggcctctctaaggagcaggcaggcgggggtcctgaccagtcatgtggtggaggaactgcttcctggaatcactccatagctgtccatcagccagataagtccccattgatctcattacttgataatagttgtaaggaggaatccgaacctagtggaacacctccatcttcctctgcctcttctcctttccaggtactggctaatggaaccactgccacccctaaacccctccagcctttgggttatatcccacagtcattctcacctagtgagcaggcactgtctccacaagtagaaccactctggtcccaaaggctacggaataactcagtaccgagcagggttggccccaccgaatacctttccccagatatgcaacaccagcgaaagactaagcgtaaaaccaaagaacagttggccatccttaaatcctttttcctgcagtgccaatgggcacgacgagaagattaccataagttagaacagatcactggtttacctcgccctgagatcattcaatggtttggtgatacacgctatgccttgaagcatggacagctgaaatggtttcgggacaatgcagtacttggtactcctagttttcaagatccagccatttctacatcatcaactcgttccttgaaagaatgggccaagacaccacctctaccagccccaccgcccccaccagatatacgacctttggagaggtactgggcagcccaccagcagctgcaggaagctgatatccttaaactgagtcaggcatcaagactaagcactcagcaagtgctggactggtttgactctcgattgcccaagccagcagaagtggtagtttgtttagatgaagaggaagaggaggaggatgaagaactgccagaagatggtgaggaagaagaggaggaggaggaggaagaagatgatgatggtctgtcttgtggacagaaggaccatggtcttctaactaatggtgctgtagaacggggatcactgctaacagttggttagtcatctgaaagtagagtgtaagccccagttgctaagataataaaaaggccaaaaataaaattgtttctcttcaaaaaaaaaaaaaaaaaaaaaaaaaa

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