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Previous release (v1)
2024-04-29 16:49:13, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NM_138845 17543 bp mRNA linear ROD 22-MAR-2023
DEFINITION Rattus norvegicus trinucleotide repeat containing adaptor 6B
(Tnrc6b), mRNA.
ACCESSION NM_138845 XM_001077084 XM_576311
VERSION NM_138845.4
KEYWORDS RefSeq; RefSeq Select.
SOURCE Rattus norvegicus (Norway rat)
ORGANISM Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
REFERENCE 1 (bases 1 to 17543)
AUTHORS Edwards TL, Hartmann KE and Velez Edwards DR.
TITLE Variants in BET1L and TNRC6B associate with increasing fibroid
volume and fibroid type among European Americans
JOURNAL Hum Genet 132 (12), 1361-1369 (2013)
PUBMED 23892540
REFERENCE 2 (bases 1 to 17543)
AUTHORS Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein
C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J and
Hentze MW.
TITLE Insights into RNA biology from an atlas of mammalian mRNA-binding
proteins
JOURNAL Cell 149 (6), 1393-1406 (2012)
PUBMED 22658674
REFERENCE 3 (bases 1 to 17543)
AUTHORS Ender C and Meister G.
TITLE Argonaute proteins at a glance
JOURNAL J Cell Sci 123 (Pt 11), 1819-1823 (2010)
PUBMED 20484662
REMARK Review article
REFERENCE 4 (bases 1 to 17543)
AUTHORS Fabian MR, Mathonnet G, Sundermeier T, Mathys H, Zipprich JT,
Svitkin YV, Rivas F, Jinek M, Wohlschlegel J, Doudna JA, Chen CY,
Shyu AB, Yates JR 3rd, Hannon GJ, Filipowicz W, Duchaine TF and
Sonenberg N.
TITLE Mammalian miRNA RISC recruits CAF1 and PABP to affect
PABP-dependent deadenylation
JOURNAL Mol Cell 35 (6), 868-880 (2009)
PUBMED 19716330
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
JACYVU010000186.1.
On Feb 10, 2021 this sequence version replaced NM_138845.3.
Sequence Note: The RefSeq transcript and protein were derived from
genomic sequence to make the sequence consistent with the reference
genome assembly. The genomic coordinates used for the transcript
record were based on alignments.
##Evidence-Data-START##
RNAseq introns :: single sample supports all introns SAMD00132285,
SAMD00132291 [ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
inferred exon combination :: based on alignments, homology
RefSeq Select criteria :: based on conservation, expression
##RefSeq-Attributes-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-200 JACYVU010000186.1 5495135-5495334
201-269 JACYVU010000186.1 5535797-5535865
270-360 JACYVU010000186.1 5548886-5548976
361-428 JACYVU010000186.1 5569584-5569651
429-516 JACYVU010000186.1 5639181-5639268
517-538 JACYVU010000186.1 5645136-5645157
539-880 JACYVU010000186.1 5653296-5653637
881-3223 JACYVU010000186.1 5655650-5657992
3224-3382 JACYVU010000186.1 5659715-5659873
3383-3558 JACYVU010000186.1 5661008-5661183
3559-3630 JACYVU010000186.1 5663746-5663817
3631-3676 JACYVU010000186.1 5664657-5664702
3677-3813 JACYVU010000186.1 5665954-5666090
3814-3939 JACYVU010000186.1 5671157-5671282
3940-4071 JACYVU010000186.1 5678361-5678492
4072-4167 JACYVU010000186.1 5678756-5678851
4168-4390 JACYVU010000186.1 5678984-5679206
4391-4528 JACYVU010000186.1 5684638-5684775
4529-4705 JACYVU010000186.1 5687767-5687943
4706-4852 JACYVU010000186.1 5689115-5689261
4853-4948 JACYVU010000186.1 5689509-5689604
4949-5173 JACYVU010000186.1 5695578-5695802
5174-5244 JACYVU010000186.1 5696216-5696286
5245-5384 JACYVU010000186.1 5699063-5699202
5385-17543 JACYVU010000186.1 5700414-5712572
FEATURES Location/Qualifiers
source 1..17543
/organism="Rattus norvegicus"
/mol_type="mRNA"
/strain="BN"
/db_xref="taxon:10116"
/chromosome="7"
/map="7q34"
gene 1..17543
/gene="Tnrc6b"
/gene_synonym="Cbl27"
/note="trinucleotide repeat containing adaptor 6B"
/db_xref="GeneID:192178"
/db_xref="RGD:621428"
exon 1..200
/gene="Tnrc6b"
/gene_synonym="Cbl27"
/inference="alignment:Splign:2.1.0"
exon 201..269
/gene="Tnrc6b"
/gene_synonym="Cbl27"
/inference="alignment:Splign:2.1.0"
misc_feature 226..228
/gene="Tnrc6b"
/gene_synonym="Cbl27"
/note="upstream in-frame stop codon"
exon 270..360
/gene="Tnrc6b"
/gene_synonym="Cbl27"
/inference="alignment:Splign:2.1.0"
CDS 316..5772
/gene="Tnrc6b"
/gene_synonym="Cbl27"
/note="androgen receptor-related apoptosis-associated
protein CBL27; trinucleotide repeat containing 6B"
/codon_start=1
/product="trinucleotide repeat-containing gene 6B protein"
/protein_id="NP_620200.2"
/db_xref="GeneID:192178"
/db_xref="RGD:621428"
/translation="
MHTNEGEVEEESSSQVEQEDFVMEGHGKTPPPGEESKQEKEQEREEQLMEDKKRKKEDKKKKEATQKVTEQKTKVPEVTKPSLSQPTAASPIGSSPSPPVNGGNNAKRVAVPNGQPPSAARYMPREVPPRFRCQQDHKVLLKRGQPPPPSCMLLGGGAGPPPCTAPGANPNNAQVTGALLQSESGTAPESTLGGAAASNYANSTWGPGASSNNGASPNPIHIWDKVIVDGSDMEEWPCIASKDTESSSENTTDNNSASNPGSEKSALPGSTTSNKGKGSQCQSASSGNECNLGVWKSDPKAKSVQSPNSTSDSNNGLGTWRSTSGQDRIGPGSGFSNFNPNSNPSAWPALVQEGTCRKGVLEAEGSSSSAQVSTVGQASREQQSKMENAGVNFVVSGREQAQIHNTDGPKNGNTNSLNLSSPNPMENKGMPFGMGLGNTSRSTDAPSQSTGDRKTGSVGSWGAARGPSGADTVSGQSNSGNNGNNGKDREDSWKGASVPKPTGSQSDSWDNNNRSTGGSWNFGPQDSNDNKWGEGNKMTSGVSQGEWKQPTGSDELKIGEWSGPNQPNSSTGAWDNQKGHPLPENQGNAQAPCWGRSSSSAGSEVGGQSTGSNHKAGSSDSHNSGRRSYRPAHPDCQAVLQTLLSRTDLDPRVLSNTGWGQTQIKQDTVWDIEEVPRPEGKSDKGTEGWESAATQTKNSGGWGDAPSQSNQMKSGWGELSASTEWKDPKSTGGWNDYKNNNSSNWGGGRADEKTPSSWNESSCKDQGWGGGRQPNQGWTSGKNGWGEEVDQVKNNNWESSANKPVSGWGEGGQSEIGTWGNGGNTNLASKGGWEDCKRSPAWNETGRQPNSWNKQHQQQQQQPPPPQPEASGSWGGPPPPPQGNVRPSNSNWSSGPQPATPKDDEPSGWEEPSPQSISRKMDIDDGTSAWGDPNSYNYKNVNLWDKNSQGGPAPREPNLPTPMTGKSASVWSKSTPPAPDNGTSAWGEPNESSPGWGEMDDAGASATGWGNTPASAPNAMKPNSKSMQDGWGESDGPVTGARHPSWEEEDDGGVWNTAGSQGSTSSHNSASWGQGGKKQMKCSIKGNNDSWMNPLAKQFSNMGLLSQTEDNPSSKMDLSVDKKFDVDKRTMNLGDFNDIMRKDRPGFRPPNSKDLGTTDSGPYFEKGGSHGLFGNSTAQSRGLHTPVQPLSSSPGLRAQVPPQFISPQVSASMLKQFPNSGLNPGLFNVGPQLSPQQIAMLSQLPQIPQFQLACQLLLQQQQQQQLLQNQRKISQAVRQQQEQQLARMVSALQQQQQQQQQQQQQQQQQQQQQRQPSMKHSPSHPVGPKPHLDNMVPNTLNVGLPDLPTKGPIPGYGSGFSSGGMDYGMVGGKEAGTESRFKQWTSMMEGLPSVATQEATMHKNGAIVAPGKTRGGSPYNQFDIIPGDTLGGHTGPAGDSWLPAKSPPTNKIGSKSSNASWPPEFQPGVPWKGIQNIDPESDPYVTPGSVLGGTATSPIVDTDHQLLRDNTTGSNSSLNTSLPSPGAWPYSASDNSFTNVHSTSAKFPDYKSTWSPDPIGHNPTHLSNKMWKNHISSRNTTPLPRPPPGLTNPKPASPWSSTAPRSVRGWGTQDSRIASASTWSDGGSVRPSYWLVLHNLTPQIDGSTLRTICMQHGPLLTFHLNLTQGTALIRYSTKQEAAKAQTALHMCVLGNTTILAEFATEDEVSRFLAQAQPPTPAATPSAPATGWQSLETSQNQADPVGPALNLFGGSTGLGQWSSSAGGSSGADLAGTSLWGPPNYSSSLWGVPTVEDPHRMGSPAPLLPGDLLGGGSDSI"
misc_feature 3181..3594
/gene="Tnrc6b"
/gene_synonym="Cbl27"
/note="Argonaute hook; Region: Ago_hook; pfam10427"
/db_xref="CDD:431279"
misc_feature 4369..5205
/gene="Tnrc6b"
/gene_synonym="Cbl27"
/note="TNRC6-PABC binding domain; Region: TNRC6-PABC_bdg;
pfam16608"
/db_xref="CDD:435458"
misc_feature 5209..5457
/gene="Tnrc6b"
/gene_synonym="Cbl27"
/note="RNA recognition motif (RRM) found in vertebrate
trinucleotide repeat-containing gene 6B protein (TNRC6B);
Region: RRM_TNRC6B; cd12712"
/db_xref="CDD:410111"
exon 361..428
/gene="Tnrc6b"
/gene_synonym="Cbl27"
/inference="alignment:Splign:2.1.0"
exon 429..516
/gene="Tnrc6b"
/gene_synonym="Cbl27"
/inference="alignment:Splign:2.1.0"
exon 517..538
/gene="Tnrc6b"
/gene_synonym="Cbl27"
/inference="alignment:Splign:2.1.0"
exon 539..880
/gene="Tnrc6b"
/gene_synonym="Cbl27"
/inference="alignment:Splign:2.1.0"
exon 881..3223
/gene="Tnrc6b"
/gene_synonym="Cbl27"
/inference="alignment:Splign:2.1.0"
exon 3224..3382
/gene="Tnrc6b"
/gene_synonym="Cbl27"
/inference="alignment:Splign:2.1.0"
exon 3383..3558
/gene="Tnrc6b"
/gene_synonym="Cbl27"
/inference="alignment:Splign:2.1.0"
exon 3559..3630
/gene="Tnrc6b"
/gene_synonym="Cbl27"
/inference="alignment:Splign:2.1.0"
exon 3631..3676
/gene="Tnrc6b"
/gene_synonym="Cbl27"
/inference="alignment:Splign:2.1.0"
exon 3677..3813
/gene="Tnrc6b"
/gene_synonym="Cbl27"
/inference="alignment:Splign:2.1.0"
exon 3814..3939
/gene="Tnrc6b"
/gene_synonym="Cbl27"
/inference="alignment:Splign:2.1.0"
exon 3940..4071
/gene="Tnrc6b"
/gene_synonym="Cbl27"
/inference="alignment:Splign:2.1.0"
exon 4072..4167
/gene="Tnrc6b"
/gene_synonym="Cbl27"
/inference="alignment:Splign:2.1.0"
exon 4168..4390
/gene="Tnrc6b"
/gene_synonym="Cbl27"
/inference="alignment:Splign:2.1.0"
exon 4391..4528
/gene="Tnrc6b"
/gene_synonym="Cbl27"
/inference="alignment:Splign:2.1.0"
exon 4529..4705
/gene="Tnrc6b"
/gene_synonym="Cbl27"
/inference="alignment:Splign:2.1.0"
exon 4706..4852
/gene="Tnrc6b"
/gene_synonym="Cbl27"
/inference="alignment:Splign:2.1.0"
exon 4853..4948
/gene="Tnrc6b"
/gene_synonym="Cbl27"
/inference="alignment:Splign:2.1.0"
exon 4949..5173
/gene="Tnrc6b"
/gene_synonym="Cbl27"
/inference="alignment:Splign:2.1.0"
exon 5174..5244
/gene="Tnrc6b"
/gene_synonym="Cbl27"
/inference="alignment:Splign:2.1.0"
exon 5245..5384
/gene="Tnrc6b"
/gene_synonym="Cbl27"
/inference="alignment:Splign:2.1.0"
exon 5385..17543
/gene="Tnrc6b"
/gene_synonym="Cbl27"
/inference="alignment:Splign:2.1.0"
ORIGIN
cggaggggaaagtttgtttattttgtttttagtttctggggtccccgagcttcgggaaggtgaagcgagcgacagtgacccccctagcctctcagcctccccgcgacgtcgcctctacagcttgcggagaagcggagaccgcggtcaccgctgggctccacagcggaacgacgcgctctcggagccggcgcggctcagcgggtcttgggttttttgcactgaatgtaacctagactgatcgtctcagttgccccaggatactgtcagaggcagtgtctgtgtgtgtctgcagagctttgcacagaatctgttcccatgcacaccaatgagggagaagtagaggaagagagcagctcccaggtggaacaggaggattttgtaatggaagggcatggcaagactccacctcctggagaagaaagcaaacaagagaaggagcaagaaagggaagaacagttaatggaagacaagaaaaggaagaaagaggataaaaagaaaaaagaagccacccagaaggtcacggaacaaaaaaccaaagtgcccgaagtgacgaaaccaagtttaagccaaccaacggccgccagcccaattggcagctctccatcgccaccagtcaatggtggcaacaatgccaaaagggtggcagtgccgaacggacaaccgccaagcgccgcccgctacatgcctcgggaggtgccaccgcgattccgttgccagcaggaccacaaagtgttactaaaacgtgggcagccccctccaccgtcctgcatgctcctagggggtggggcggggcctcctccctgcacagcacctggagcaaaccccaacaacgcacaagtgacaggagcgctgctgcagagcgagagtgggacggcaccagagtcaacccttggaggtgctgctgcttcaaattatgcaaattccacttggggcccgggagcctcctccaacaacggcgcctcccccaacccaattcacatctgggacaaggtgattgtagacgggtctgacatggaagagtggccttgtattgccagcaaagacactgaatcttcttccgaaaacaccaccgataacaacagtgcctcgaaccctggctctgagaagagcgctctgccaggaagcaccactagtaacaaaggcaaagggagccagtgccagtctgcaagttctgggaatgaatgtaatcttggggtctggaaatctgaccctaaggctaaatctgttcagtctcccaactctacttcagatagcaacaatggactaggaacctggaggagtaccagtggtcaagatagaattggacctggctctggcttcagcaactttaacccaaatagcaacccatctgcctggccagcattggtccaagaaggaacttgtaggaaaggggtgttggaggcagaaggtagcagttccagtgcacaagtcagcacagtaggtcaggcatccagggaacagcagtcaaagatggagaatgcgggtgttaattttgttgtctctggcagagaacaggctcagattcataacactgatggaccaaaaaacggaaacactaactccttgaacttaagttcaccaaaccccatggaaaataagggaatgccctttggaatgggcttggggaacacctccaggagcactgatgccccttcacaaagcactggagatcgaaagactgggagtgttgggtcttggggcgcagctagggggccttctggagctgacacagtctctggacaaagcaattctggaaacaatgggaacaatggaaaagacagagaggactcctggaaaggagcttccgttccaaaaccaactgggtcacaaagtgactcttgggacaacaataacaggtctacgggtgggtcctggaattttggccctcaggactctaatgacaacaaatggggtgaagggaacaaaatgacatctggggtctctcagggagaatggaaacagccgactgggtctgatgagttgaaaattggagaatggagtggtccaaaccaaccaaattctagcactggagcatgggacaatcaaaagggccaccccctcccagaaaaccaaggcaatgcccaggctccctgttggggaagatcttccagctccgcaggaagtgaagttggaggtcaaagcactggaagcaaccacaaagcaggaagtagcgacagtcataattctggtcgtcggtcatacaggcccgcacatcctgattgccaggctgtcttgcagactcttttgagccggactgatttggaccctagggtgctctcaaacactggctggggccaaactcaaattaagcaggacacagtgtgggatattgaagaggtgccaaggcctgaggggaaatctgacaaaggaactgaggggtgggagagcgctgccacacagaccaagaactcagggggctggggagatgcacccagccaaagcaatcaaatgaagtctggatggggggagctctcagcctcaacagagtggaaagaccccaagagtacaggaggctggaatgactacaagaacaacaactcttctaactggggaggaggacgagcggatgaaaagacaccttcctcttggaatgagagttcttgtaaggatcaggggtggggaggtgggcgccagcccaaccaaggatggacttctgggaagaatggttggggcgaggaggttgatcaagtgaaaaataacaattgggaaagttctgccaataagcctgtgtctgggtggggtgaaggagggcagagtgaaattggaacttggggcaatggtgggaatacaaacctcgcttcaaaaggtgggtgggaagattgcaaaagatcccctgcatggaatgagactggcagacagcctaattcctggaataaacaacaccaacagcagcagcagcagccaccgccaccacagccagaggcttctggttcatggggaggcccacccccaccacctcaaggcaatgttcgaccttctaattccaactggagcagtgggccccaacctgcaacccctaaggatgatgaacccagtggttgggaggagccatccccacagtcaattagtcgaaaaatggacatcgatgatggcacttcagcttggggagaccctaacagttataactacaagaatgtgaacctttgggataagaattctcaagggggcccagcacctcgagaaccaaacctgcctaccccgatgaccggaaaatcagcatcagtctggagcaaaagcacaccacctgctccagataatgggacttcagcctggggtgagccaaatgaaagcagtcctgggtggggtgagatggatgatgcaggagcatcagccacaggctggggaaacacacctgccagcgctcccaatgccatgaaacccaattccaaatctatgcaagacggctggggggagagtgatggcccagtcacaggagctcgccatcctagctgggaagaggaagatgatggaggagtctggaacaccgccggctctcagggaagcacttcctcccacaactcagcaagctggggacaaggaggaaagaaacaaatgaagtgctcgataaaaggaaacaatgattcgtggatgaatcctcttgccaaacagttttcaaatatgggattgctgagtcaaactgaggataacccaagcagcaaaatggatttgtctgtagataagaaatttgatgtggacaagagaacaatgaatctcggggattttaatgatatcatgaggaaggatcgacctgggttccgtccacctaattccaaagacttgggaaccacagacagtgggccttattttgagaagggcggcagtcatggtttgtttggaaacagcacagcacagtcaagaggcctgcacactccagtgcagccactgagttcttctcctggtctccgggcgcaagtgcctccccagtttatctccccccaggtttctgcctcaatgctcaagcagttccccaacagtggcctgaatccaggtctctttaatgtggggccccagttatctcctcaacaaattgccatgctgagccagcttccacagattccccagtttcagttggcttgtcagcttcttctgcagcagcagcagcagcagcagttgctacagaaccagagaaagatctctcaagcagtgcgccagcagcaagagcagcagctggcaagaatggtgagtgctctccagcagcagcagcagcagcagcagcagcagcagcagcagcagcagcagcagcagcagcagcagaggcaacctagcatgaagcattcaccttctcatcctgttgggcctaagccacatttggacaacatggtacccaacacgctgaatgtggggctcccagaccttccgaccaaaggaccaatccctggatatggttctggctttagctctggtggaatggactatggtatggttggtggcaaggaggctggaactgagtctcgcttcaaacagtggacctccatgatggaagggctgccatctgtggccacacaagaagctaccatgcacaaaaacggcgctatagtggcccctggtaagacccgaggagggtcaccatacaaccagtttgatataatcccaggtgacacactgggtggccatacgggtcctgctggtgatagctggttacctgccaaatctccaccgactaataaaatcggaagtaaatccagcaatgccagttggcctccagaattccaaccaggagtgccatggaaaggtatccaaaatatcgaccctgaatctgacccctatgtcaccccaggaagtgtgctggggggcacagccacatcgcccattgtagatactgaccaccaactgctgcgggataacaccacagggtctaattcttccctcaacacctcgctgccttcacctggtgcctggccctacagtgcctctgacaactcctttaccaacgttcatagcacttcagcaaagttccctgattacaaatccacgtggtccccagatcccataggacacaa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//
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@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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