LOCUS       NM_138838               2981 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus POU class 3 homeobox 1 (Pou3f1), mRNA.
ACCESSION   NM_138838
VERSION     NM_138838.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2981)
  AUTHORS   Iwafuchi-Doi M, Matsuda K, Murakami K, Niwa H, Tesar PJ, Aruga J,
            Matsuo I and Kondoh H.
  TITLE     Transcriptional regulatory networks in epiblast cells and during
            anterior neural plate development as modeled in epiblast stem cells
  JOURNAL   Development 139 (21), 3926-3937 (2012)
   PUBMED   22992956
  REMARK    Erratum:[Development. 2012 Dec;139(24):4675]
REFERENCE   2  (bases 1 to 2981)
  AUTHORS   Jagalur NB, Ghazvini M, Mandemakers W, Driegen S, Maas A, Jones EA,
            Jaegle M, Grosveld F, Svaren J and Meijer D.
  TITLE     Functional dissection of the Oct6 Schwann cell enhancer reveals an
            essential role for dimeric Sox10 binding
  JOURNAL   J Neurosci 31 (23), 8585-8594 (2011)
   PUBMED   21653862
  REMARK    GeneRIF: we propose that Sox10-dependent activation of Oct6 defines
            a feedforward regulatory module that serves to time and amplify the
            onset of myelination in the peripheral nervous system.
REFERENCE   3  (bases 1 to 2981)
  AUTHORS   Wolf M, Lommes P, Sock E, Reiprich S, Friedrich RP, Kriesch J,
            Stolt CC, Bermingham JR Jr and Wegner M.
  TITLE     Replacement of related POU transcription factors leads to severe
            defects in mouse forebrain development
  JOURNAL   Dev Biol 332 (2), 418-428 (2009)
   PUBMED   19527706
REFERENCE   4  (bases 1 to 2981)
  AUTHORS   Hoser M, Potzner MR, Koch JM, Bosl MR, Wegner M and Sock E.
  TITLE     Sox12 deletion in the mouse reveals nonreciprocal redundancy with
            the related Sox4 and Sox11 transcription factors
  JOURNAL   Mol Cell Biol 28 (15), 4675-4687 (2008)
   PUBMED   18505825
REFERENCE   5  (bases 1 to 2981)
  AUTHORS   Friedrich RP, Schlierf B, Tamm ER, Bosl MR and Wegner M.
  TITLE     The class III POU domain protein Brn-1 can fully replace the
            related Oct-6 during schwann cell development and myelination
  JOURNAL   Mol Cell Biol 25 (5), 1821-1829 (2005)
   PUBMED   15713637
REFERENCE   6  (bases 1 to 2981)
  AUTHORS   Malik KF, Jaffe H, Brady J and Young WS 3rd.
  TITLE     The class III POU factor Brn-4 interacts with other class III POU
            factors and the heterogeneous nuclear ribonucleoprotein U
  JOURNAL   Brain Res Mol Brain Res 45 (1), 99-107 (1997)
   PUBMED   9105675
REFERENCE   7  (bases 1 to 2981)
  AUTHORS   Jaegle M, Mandemakers W, Broos L, Zwart R, Karis A, Visser P,
            Grosveld F and Meijer D.
  TITLE     The POU factor Oct-6 and Schwann cell differentiation
  JOURNAL   Science 273 (5274), 507-510 (1996)
   PUBMED   8662541
REFERENCE   8  (bases 1 to 2981)
  AUTHORS   He X, Gerrero R, Simmons DM, Park RE, Lin CJ, Swanson LW and
            Rosenfeld MG.
  TITLE     Tst-1, a member of the POU domain gene family, binds the promoter
            of the gene encoding the cell surface adhesion molecule P0
  JOURNAL   Mol Cell Biol 11 (3), 1739-1744 (1991)
   PUBMED   1705013
REFERENCE   9  (bases 1 to 2981)
  AUTHORS   Monuki ES, Kuhn R, Weinmaster G, Trapp BD and Lemke G.
  TITLE     Expression and activity of the POU transcription factor SCIP
  JOURNAL   Science 249 (4974), 1300-1303 (1990)
   PUBMED   1975954
REFERENCE   10 (bases 1 to 2981)
  AUTHORS   He X, Treacy MN, Simmons DM, Ingraham HA, Swanson LW and Rosenfeld
            MG.
  TITLE     Expression of a large family of POU-domain regulatory genes in
            mammalian brain development
  JOURNAL   Nature 340 (6228), 35-41 (1989)
   PUBMED   2739723
  REMARK    Erratum:[Nature 1989 Aug 24;340(6235):662]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JACYVU010000162.1.
            
            On Nov 27, 2020 this sequence version replaced NM_138838.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: M72711.1, M63712.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2981              JACYVU010000162.1  51459690-51462670
FEATURES             Location/Qualifiers
     source          1..2981
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2981
                     /gene="Pou3f1"
                     /gene_synonym="Oct-6; Otf6; Scip; Testes-1; Tst-1"
                     /note="POU class 3 homeobox 1"
                     /db_xref="GeneID:192110"
                     /db_xref="RGD:619767"
     exon            1..2981
                     /gene="Pou3f1"
                     /gene_synonym="Oct-6; Otf6; Scip; Testes-1; Tst-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..1393
                     /gene="Pou3f1"
                     /gene_synonym="Oct-6; Otf6; Scip; Testes-1; Tst-1"
                     /note="POU domain transcription factor SCIP;
                     octamer-binding transcription factor 6; OTF-6;
                     octamer-binding protein 6; octomer-6; suppressed
                     cAMP-inducible POU; octoamer transcription factor-6"
                     /codon_start=1
                     /product="POU domain, class 3, transcription factor 1"
                     /protein_id="NP_620193.1"
                     /db_xref="GeneID:192110"
                     /db_xref="RGD:619767"
                     /translation="

MATTAQYLPRGPGGGAGGTGPLMHPDAAAAAAAAAAAERLHAGAAYREVQKLMHHEWLGAGAGHPVGLAHPQWLPTGGGGGGDWAGGPHLEHGKAGGGSTGRADDGGGGGGFHARLVHQGAAHAGAAWAQGGTAHHLGPAMSPSPGAGGGHQPQPLGLYAQAAYPGGGGGGLAGMLAAGGGGAGPGLHHALHEDGHEAQLEPSPPPHLGAHGHAHGHAHAGGLHAAAAHLHPGAGGGGSSVGEHSDEDAPSSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEETDSSSGSPTNLDKIAAQGRKRKKRTSIEVGVKGALESHFLKCPKPSAHEITGLADSLQLEKEVVRVWFCNRRQKEKRMTPAAGAGHPPMDDVYAPGELGPGGGGASPPSAPPPPPPAALHHHHHHTLPGSVQ"

     misc_feature    38..100
                     /gene="Pou3f1"
                     /gene_synonym="Oct-6; Otf6; Scip; Testes-1; Tst-1"
                     /note="propagated from UniProtKB/Swiss-Prot (P20267.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    242..379
                     /gene="Pou3f1"
                     /gene_synonym="Oct-6; Otf6; Scip; Testes-1; Tst-1"
                     /note="propagated from UniProtKB/Swiss-Prot (P20267.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    437..499
                     /gene="Pou3f1"
                     /gene_synonym="Oct-6; Otf6; Scip; Testes-1; Tst-1"
                     /note="propagated from UniProtKB/Swiss-Prot (P20267.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    593..796
                     /gene="Pou3f1"
                     /gene_synonym="Oct-6; Otf6; Scip; Testes-1; Tst-1"
                     /note="propagated from UniProtKB/Swiss-Prot (P20267.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    776..1000
                     /gene="Pou3f1"
                     /gene_synonym="Oct-6; Otf6; Scip; Testes-1; Tst-1"
                     /note="Found in Pit-Oct-Unc transcription factors; Region:
                     POU; smart00352"
                     /db_xref="CDD:197673"
     misc_feature    order(1055..1069,1073..1075,1124..1126,1142..1144,
                     1181..1183,1187..1192,1199..1204,1208..1216,1220..1225)
                     /gene="Pou3f1"
                     /gene_synonym="Oct-6; Otf6; Scip; Testes-1; Tst-1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     misc_feature    1061..1222
                     /gene="Pou3f1"
                     /gene_synonym="Oct-6; Otf6; Scip; Testes-1; Tst-1"
                     /note="Homeobox domain; Region: Homeobox; pfam00046"
                     /db_xref="CDD:425441"
     misc_feature    order(1061..1063,1070..1072,1190..1192,1199..1204,
                     1211..1213)
                     /gene="Pou3f1"
                     /gene_synonym="Oct-6; Otf6; Scip; Testes-1; Tst-1"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     misc_feature    1220..1390
                     /gene="Pou3f1"
                     /gene_synonym="Oct-6; Otf6; Scip; Testes-1; Tst-1"
                     /note="propagated from UniProtKB/Swiss-Prot (P20267.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
ORIGIN      

ggcggcggcggcggcgcggcgcagggcgcggggcggcatggccaccaccgcgcagtatctgccgcggggccccggcggcggagctgggggcaccgggccgctcatgcatcccgatgccgccgcggcggcggcagcggcggcggcggccgagcggctgcacgcgggggccgcgtaccgcgaagtgcagaagctgatgcaccacgagtggctgggcgcgggcgcgggccaccccgtgggcctagcgcaccctcaatggctacccacgggaggaggcggcggcggcgactgggcgggcggcccgcacctggaacacggcaaggcaggcggtggcagtaccggccgagctgacgacggcggcggtggcggaggtttccacgcccgcttggtgcaccaaggggcggcccacgcgggcgcggcatgggcacaaggcggcacagcgcaccacttgggccccgccatgtcgccgtcgcccggggccggcgggggtcaccagccccagccgctcgggctgtacgctcaggcggcctaccccggtggcggcggcggcggcctggccgggatgttggcggcgggaggcggcggcgcgggacccggcctgcaccacgcgctgcacgaggacggccacgaggcacagctggagccgtcgccaccaccgcacctgggcgcacacggacacgcacacggacatgcacacgcgggcggcctgcacgcggcggcggcgcacctgcacccaggcgcgggcggtggtggctcgtcggtgggcgagcactcggacgaggatgctcccagctccgacgacctggagcagttcgccaagcagttcaagcaacgacgcatcaagctgggcttcacccaggccgacgtggggctagcgctgggcaccctctacggtaatgtgttctcgcagaccaccatctgccgcttcgaggccctgcagctgagcttcaagaacatgtgcaagctcaaaccgctgctcaacaagtggctggaggagaccgactcgtccagcggcagccccaccaacctggacaagatcgcggcgcagggccgcaagcgcaagaagcgcacgtccattgaggtgggtgtcaaaggcgcgctcgagagccactttctcaagtgtcccaagccgtctgcgcacgagatcaccggcctggccgacagcctgcaactggagaaggaggtggtgcgtgtctggttctgcaaccggcggcagaaggagaagcgcatgacccccgcggccggcgcgggccacccgcccatggacgacgtttatgcgcctggggagctggggcctggcggaggcggcgcgtcgccaccctctgcgcccccgccacccccgccggccgcgctacaccaccaccatcaccacacactacccggctccgtgcagtgaccctgcggactgggttccccgccggcgcagcggtgcctccggcgcgcagccagcgcgcgcggcctggactctttttgttgtttattcggttgctttggattttacaaaaagaaaaaaggaaaaaaaaaaaagcccagaaacttttaaacaaaaccaaacacccgggaccgacccctctctctggcgagcggcgaaaggcggccgagaggctgtgttgcccgagcccagggagagagcagcgaagatccagaatgcgccaactcactctgggcgccctgcgcccactgcctgctccctatccccatcccctcgacgacccccgcccctgcccccgggctgttcggggccggatcccggcagcggcctccccacagcgaaaggtaacgcggtgcgggattagggattccccgggagaatggacgaaaagaggagagtccccagcagctctcccgggcgcggactccctgtagcctgcaggtcacgggtggggggctgtcactttattctttccgcgcctcttctcgcacctggacgcgccccaccccctcaccttttctccgggcttggttttttacggtttttatttattcgtggagcctctcggctcctggggtccttctaactccgcccgcgcccttaatttaaatcgctgtatactgtatttatcggggccccagaggggaggccgcgagagccgcatctgtgtataaaagcaggaaatagccaaagctttaatctagcctaatttattttccctttctcttcccctctcctccttcaagaacgcaaaacaaaaacaaaaaaaaactaacaaaaaaaatttttttgagtgttcatttttcgtttcgttttaccagagccctcggctcggttcctggcctagcagagagggtctgcgctcccacgcacacccgggtgggaaggggcatcttcacccgcaagatcgagcgcgcaccgcgggccactgcttccccgccgggccctgcccctcctggccttaacgaacgaaacttggaaaagttggaactattttttaactagctgtagaaataaaccgttcccccaagaaccttccgcctgtttccctaccgcttccccctgctctctttccagcccccgcgggatgcaaggatgctgggggaaccctggggagaaactctccaaatttggggtgaggtgggaaccatgtaaatatgtgagatatgtacacaatggcgggggggaagaaacactttgtgcttggtttttattttttggctttctgggttgttctccctccccaccctaaagggttttgtatgcccgactaaaccgaaaaagatattttaatatggtttcctaatttctgacccatctctatttattttctggatgtgtttggagcttccccccttcaccatttcttcatctgtttcttaaggtttgagcgtaatttttttttaaattttttgttattctcagaaaaatgttttggtccattctctttgtatctttattgcaaaaaataataataatgtagactgggaagttccctttatatttatgttatagtaaatattttattactcacataaacatgtaccccagg

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