2024-04-24 20:19:54, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NM_031700 1501 bp mRNA linear ROD 20-MAR-2023 DEFINITION Rattus norvegicus claudin 3 (Cldn3), mRNA. ACCESSION NM_031700 VERSION NM_031700.2 KEYWORDS RefSeq; RefSeq Select. SOURCE Rattus norvegicus (Norway rat) ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. REFERENCE 1 (bases 1 to 1501) AUTHORS Berndt P, Winkler L, Cording J, Breitkreuz-Korff O, Rex A, Dithmer S, Rausch V, Blasig R, Richter M, Sporbert A, Wolburg H, Blasig IE and Haseloff RF. TITLE Tight junction proteins at the blood-brain barrier: far more than claudin-5 JOURNAL Cell Mol Life Sci 76 (10), 1987-2002 (2019) PUBMED 30734065 REFERENCE 2 (bases 1 to 1501) AUTHORS Wang J, Chen J, Tang Z, Li Y, Hu L and Pan J. TITLE The Effects of Copper on Brain Microvascular Endothelial Cells and Claudin Via Apoptosis and Oxidative Stress JOURNAL Biol Trace Elem Res 174 (1), 132-141 (2016) PUBMED 27038183 REMARK GeneRIF: identified four claudin isoforms (1, 3, 5, and 12) and showed that their expression levels were regulated as a group by copper REFERENCE 3 (bases 1 to 1501) AUTHORS Peng S, Wang SB, Singh D, Zhao PY, Davis K, Chen B, Adelman RA and Rizzolo LJ. TITLE Claudin-3 and claudin-19 partially restore native phenotype to ARPE-19 cells via effects on tight junctions and gene expression JOURNAL Exp Eye Res 151, 179-189 (2016) PUBMED 27593915 REFERENCE 4 (bases 1 to 1501) AUTHORS Milatz S, Piontek J, Schulzke JD, Blasig IE, Fromm M and Gunzel D. TITLE Probing the cis-arrangement of prototype tight junction proteins claudin-1 and claudin-3 JOURNAL Biochem J 468 (3), 449-458 (2015) PUBMED 25849148 REFERENCE 5 (bases 1 to 1501) AUTHORS Martinez CA, de Campos FG, de Carvalho VR, de Castro Ferreira C, Rodrigues MR, Sato DT and Pereira JA. TITLE Claudin-3 and occludin tissue content in the glands of colonic mucosa with and without a fecal stream JOURNAL J Mol Histol 46 (2), 183-194 (2015) PUBMED 25649016 REMARK GeneRIF: Colonic glands without a fecal stream showed a reduction in claudin-3 content independent of the time and reduction in occludin content after 12 weeks of intestinal exclusion. REFERENCE 6 (bases 1 to 1501) AUTHORS Rahner C, Mitic LL and Anderson JM. TITLE Heterogeneity in expression and subcellular localization of claudins 2, 3, 4, and 5 in the rat liver, pancreas, and gut JOURNAL Gastroenterology 120 (2), 411-422 (2001) PUBMED 11159882 REFERENCE 7 (bases 1 to 1501) AUTHORS Furuse M, Sasaki H and Tsukita S. TITLE Manner of interaction of heterogeneous claudin species within and between tight junction strands JOURNAL J Cell Biol 147 (4), 891-903 (1999) PUBMED 10562289 REFERENCE 8 (bases 1 to 1501) AUTHORS Kubota K, Furuse M, Sasaki H, Sonoda N, Fujita K, Nagafuchi A and Tsukita S. TITLE Ca(2+)-independent cell-adhesion activity of claudins, a family of integral membrane proteins localized at tight junctions JOURNAL Curr Biol 9 (18), 1035-1038 (1999) PUBMED 10508613 REFERENCE 9 (bases 1 to 1501) AUTHORS Morita K, Furuse M, Fujimoto K and Tsukita S. TITLE Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands JOURNAL Proc Natl Acad Sci U S A 96 (2), 511-516 (1999) PUBMED 9892664 REFERENCE 10 (bases 1 to 1501) AUTHORS Briehl MM and Miesfeld RL. TITLE Isolation and characterization of transcripts induced by androgen withdrawal and apoptotic cell death in the rat ventral prostate JOURNAL Mol Endocrinol 5 (10), 1381-1388 (1991) PUBMED 1723140 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JACYVU010000227.1 and BC062411.1. On Nov 23, 2005 this sequence version replaced NM_031700.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC062411.1, M74067.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-375 JACYVU010000227.1 2979376-2979750 c 376-1501 BC062411.1 1-1126 FEATURES Location/Qualifiers source 1..1501 /organism="Rattus norvegicus" /mol_type="mRNA" /strain="BN" /db_xref="taxon:10116" /chromosome="12" /map="12q12" gene 1..1501 /gene="Cldn3" /note="claudin 3" /db_xref="GeneID:65130" /db_xref="RGD:68425" exon 1..1473 /gene="Cldn3" /inference="alignment:Splign:2.1.0" misc_feature 348..350 /gene="Cldn3" /note="upstream in-frame stop codon" CDS 441..1100 /gene="Cldn3" /note="RVP1; ventral prostate.1 protein" /codon_start=1 /product="claudin-3" /protein_id="NP_113888.2" /db_xref="GeneID:65130" /db_xref="RGD:68425" /translation="
MSMGLEITGTSLAVLGWLCTIVCCALPMWRVSAFIGSSIITAQITWEGLWMNCVVQSTGQMQCKMYDSLLALPQDLQAARALIVVSILLAAFGLLVALVGAQCTNCVQDETAKAKITIVAGVLFLLAAVLTLVPVSWSANTIIRDFYNPLVPEAQKREMGTGLYVGWAAAALQLLGGALLCCSCPPREKYAPTKILYSAPRSTGPGTGTGTAYDRKDYV"
misc_feature 447..941 /gene="Cldn3" /note="PMP-22/EMP/MP20/Claudin family; Region: PMP22_Claudin; cl21598" /db_xref="CDD:451326" misc_feature 465..527 /gene="Cldn3" /note="propagated from UniProtKB/Swiss-Prot (Q63400.2); transmembrane region" misc_feature 681..743 /gene="Cldn3" /note="propagated from UniProtKB/Swiss-Prot (Q63400.2); transmembrane region" misc_feature 786..848 /gene="Cldn3" /note="propagated from UniProtKB/Swiss-Prot (Q63400.2); transmembrane region" misc_feature 924..986 /gene="Cldn3" /note="propagated from UniProtKB/Swiss-Prot (Q63400.2); transmembrane region" misc_feature 1029..1031 /gene="Cldn3" /note="Phosphotyrosine. /evidence=ECO:0007744|PubMed:22673903; propagated from UniProtKB/Swiss-Prot (Q63400.2); phosphorylation site" misc_feature 1032..1034 /gene="Cldn3" /note="Phosphoserine. /evidence=ECO:0007744|PubMed:22673903; propagated from UniProtKB/Swiss-Prot (Q63400.2); phosphorylation site" misc_feature 1092..1097 /gene="Cldn3" /note="propagated from UniProtKB/Swiss-Prot (Q63400.2); Region: Interactions with TJP1, TJP2 and TJP3. /evidence=ECO:0000250" ORIGIN
ccccatccccacccacacgcacacacatatatagttctgcattgaggttggttctagctaattcctttctcccatggtgaagagggttggggagtaccgatcggactggacgggacacacgtcactgtcccctgggccagaagagcgagctccgccctcctcctctgggcaccaagctaagtccaacccaccccatcccagagccaacccagtctcagaaagacgtctccaaagccacaggcaggtgcaggggcagtctccgtgcgagccccgggaaaggagccgttagcgtgctccgtccattgccatccaccggtcgttcccggcgacagacctccgtcaacttttgaaggggagttggttctcaggtccagcggccgcgatccctggtctcccagcctacggagttacccggcggagccggttcaagtccagcagccatgtccatgggcctggagatcaccggcacgtcgctggccgtgctgggctggctgtgcaccatcgtgtgctgcgcccttcccatgtggcgcgtttcggcattcatcggcagcagcatcatcacggcgcagatcacctgggaaggcctgtggatgaactgcgtggtgcagagcaccggccagatgcagtgcaagatgtacgactcgctgctggccctgccgcaggacctccaggccgcccgagctctcatcgtggtgtctatcctactggcagccttcgggctcctcgtggcgctcgtgggggcccagtgtaccaactgcgtacaagatgagacggccaaggccaagatcaccatcgtggcgggagtgcttttcctgttggcggctgtgctcaccttagtgccggtgtcctggtccgccaacaccatcatccgggatttttataacccgctggtacctgaggcccagaagcgagagatgggaactgggttgtacgtgggctgggctgccgccgcgctgcaattgctagggggcgccttgctgtgttgctcctgcccaccacgcgagaagtacgcacccaccaagatcctctattccgcgccgcgatccaccggccctggcaccggtaccggcaccgcctatgaccgtaaggactacgtctgagaggccgggtgcgcgcacaccgcaccatcaccactaccaaccgtcgatgtaccccacccgtccagcgtgcagcctcgcctcagagaccaccccaccttccagatggttacagacgccacgcagtctgcttgctaggctggaagaggacagacagcctggcgtccccttttctccggttgccacctgattacctggcctaggaactgtccaagtcgaatggacaaagacacctcgcccttcccaagtacagggttggggtggccatcgcagctacttgccagccccgcagccagaaggctcatagtgggcagagacaggcaaactataaaaagggccgtttcgtatttttcaataaaagcctttcgtttttgcaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
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Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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