LOCUS       NM_031566               9023 bp    mRNA    linear   ROD 12-JAN-2022
DEFINITION  Rattus norvegicus nuclear factor I/B (Nfib), transcript variant 2,
            mRNA.
ACCESSION   NM_031566 XM_001059586 XM_001059704 XM_001059759 XM_001059813
            XM_001059879 XM_001059950 XM_001060012 XM_001064131 XM_342854
VERSION     NM_031566.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 9023)
  AUTHORS   Zhang WQ, Feng L, Wang HJ, Du XF, Hao XL, Li YZ and Cheng L.
  TITLE     Inhibition of microRNA-495 inhibits hypoxia-induced apoptosis in
            H9c2 cells via targeting NFIB
  JOURNAL   Eur Rev Med Pharmacol Sci 25 (1), 335-343 (2021)
   PUBMED   33506922
  REMARK    GeneRIF: Inhibition of microRNA-495 inhibits hypoxia-induced
            apoptosis in H9c2 cells via targeting NFIB.
REFERENCE   2  (bases 1 to 9023)
  AUTHORS   Yang B, Dong R and Zhao H.
  TITLE     Inhibition of microRNA-346 inhibits myocardial inflammation and
            apoptosis after myocardial infarction via targeting NFIB
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (22), 11752-11760 (2020)
   PUBMED   33275244
  REMARK    GeneRIF: Inhibition of microRNA-346 inhibits myocardial
            inflammation and apoptosis after myocardial infarction via
            targeting NFIB.
REFERENCE   3  (bases 1 to 9023)
  AUTHORS   Schanze I, Bunt J, Lim JWC, Schanze D, Dean RJ, Alders M, Blanchet
            P, Attie-Bitach T, Berland S, Boogert S, Boppudi S, Bridges CJ, Cho
            MT, Dobyns WB, Donnai D, Douglas J, Earl DL, Edwards TJ, Faivre L,
            Fregeau B, Genevieve D, Gerard M, Gatinois V, Holder-Espinasse M,
            Huth SF, Izumi K, Kerr B, Lacaze E, Lakeman P, Mahida S, Mirzaa GM,
            Morgan SM, Nowak C, Peeters H, Petit F, Pilz DT, Puechberty J,
            Reinstein E, Riviere JB, Santani AB, Schneider A, Sherr EH,
            Smith-Hicks C, Wieland I, Zackai E, Zhao X, Gronostajski RM, Zenker
            M and Richards LJ.
  TITLE     NFIB Haploinsufficiency Is Associated with Intellectual Disability
            and Macrocephaly
  JOURNAL   Am J Hum Genet 103 (5), 752-768 (2018)
   PUBMED   30388402
REFERENCE   4  (bases 1 to 9023)
  AUTHORS   Mellas RE, Kim H, Osinski J, Sadibasic S, Gronostajski RM, Cho M
            and Baker OJ.
  TITLE     NFIB regulates embryonic development of submandibular glands
  JOURNAL   J Dent Res 94 (2), 312-319 (2015)
   PUBMED   25403566
REFERENCE   5  (bases 1 to 9023)
  AUTHORS   Archambaud C, Nahori MA, Soubigou G, Becavin C, Laval L, Lechat P,
            Smokvina T, Langella P, Lecuit M and Cossart P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   6  (bases 1 to 9023)
  AUTHORS   Grunder A, Ebel TT, Mallo M, Schwarzkopf G, Shimizu T, Sippel AE
            and Schrewe H.
  TITLE     Nuclear factor I-B (Nfib) deficient mice have severe lung
            hypoplasia
  JOURNAL   Mech Dev 112 (1-2), 69-77 (2002)
   PUBMED   11850179
REFERENCE   7  (bases 1 to 9023)
  AUTHORS   Baumeister H, Gronostajski RM, Lyons GE and Margolis FL.
  TITLE     Identification of NFI-binding sites and cloning of NFI-cDNAs
            suggest a regulatory role for NFI transcription factors in
            olfactory neuron gene expression
  JOURNAL   Brain Res Mol Brain Res 72 (1), 65-79 (1999)
   PUBMED   10521600
REFERENCE   8  (bases 1 to 9023)
  AUTHORS   Osada S, Matsubara T, Daimon S, Terazu Y, Xu M, Nishihara T and
            Imagawa M.
  TITLE     Expression, DNA-binding specificity and transcriptional regulation
            of nuclear factor 1 family proteins from rat
  JOURNAL   Biochem J 342 (Pt 1), 189-198 (1999)
   PUBMED   10432316
REFERENCE   9  (bases 1 to 9023)
  AUTHORS   Liu Y, Bernard HU and Apt D.
  TITLE     NFI-B3, a novel transcriptional repressor of the nuclear factor I
            family, is generated by alternative RNA processing
  JOURNAL   J Biol Chem 272 (16), 10739-10745 (1997)
   PUBMED   9099724
REFERENCE   10 (bases 1 to 9023)
  AUTHORS   Chaudhry AZ, Lyons GE and Gronostajski RM.
  TITLE     Expression patterns of the four nuclear factor I genes during mouse
            embryogenesis indicate a potential role in development
  JOURNAL   Dev Dyn 208 (3), 313-325 (1997)
   PUBMED   9056636
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000162.1.
            
            On Dec 28, 2021 this sequence version replaced NM_031566.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB012231.2 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1049              JACYVU010000162.1  11522252-11523300   c
            1050-1581           JACYVU010000162.1  11515826-11516357   c
            1582-1635           JACYVU010000162.1  11399545-11399598   c
            1636-1704           JACYVU010000162.1  11377876-11377944   c
            1705-1825           JACYVU010000162.1  11371830-11371950   c
            1826-1944           JACYVU010000162.1  11368895-11369013   c
            1945-2079           JACYVU010000162.1  11349550-11349684   c
            2080-2264           JACYVU010000162.1  11347006-11347190   c
            2265-2403           JACYVU010000162.1  11343037-11343175   c
            2404-2486           JACYVU010000162.1  11339731-11339813   c
            2487-9023           JACYVU010000162.1  11308507-11315043   c
FEATURES             Location/Qualifiers
     source          1..9023
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q31"
     gene            1..9023
                     /gene="Nfib"
                     /note="nuclear factor I/B"
                     /db_xref="GeneID:29227"
                     /db_xref="RGD:62015"
     exon            1..1049
                     /gene="Nfib"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    1008..1010
                     /gene="Nfib"
                     /note="upstream in-frame stop codon"
     CDS             1020..2504
                     /gene="Nfib"
                     /note="isoform 2 is encoded by transcript variant 2;
                     olfactory epithelium nuclear factor I-B; nuclear factor 1
                     B-type"
                     /codon_start=1
                     /product="nuclear factor 1 B-type isoform 2"
                     /protein_id="NP_113754.1"
                     /db_xref="GeneID:29227"
                     /db_xref="RGD:62015"
                     /translation="

MMYSPICLTQDEFHPFIEALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTVTGKKHPCCVLSNPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFLAYYVQEQDSGQSGSPSHNDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTISIDENMEPSPTGDFYPSPNSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSTSPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPLPFPTQAILPPAPSSYFSHPTIRYPPHLNPQDTLKNYVPSYDPSSPQTSQPNSSGQVVGKVPGHFTPVLAPSPHPSAVRPVTLTMTDTKPITTSTEAYTASGTSQANRYVGLSPRDPSFLHQQQSWYLG"

     misc_feature    1047..1160
                     /gene="Nfib"
                     /note="Nuclear factor I protein pre-N-terminus; Region:
                     NfI_DNAbd_pre-N; pfam10524"
                     /db_xref="CDD:371114"
     misc_feature    1224..1538
                     /gene="Nfib"
                     /note="N-terminal Mad Homology 1 (MH1) domain; Region:
                     MH1; cl00055"
                     /db_xref="CDD:412134"
     misc_feature    1644..2486
                     /gene="Nfib"
                     /note="CTF/NF-I family transcription modulation region;
                     Region: CTF_NFI; pfam00859"
                     /db_xref="CDD:425913"
     exon            1050..1581
                     /gene="Nfib"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..1635
                     /gene="Nfib"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..1704
                     /gene="Nfib"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..1825
                     /gene="Nfib"
                     /inference="alignment:Splign:2.1.0"
     exon            1826..1944
                     /gene="Nfib"
                     /inference="alignment:Splign:2.1.0"
     exon            1945..2079
                     /gene="Nfib"
                     /inference="alignment:Splign:2.1.0"
     exon            2080..2264
                     /gene="Nfib"
                     /inference="alignment:Splign:2.1.0"
     exon            2265..2403
                     /gene="Nfib"
                     /inference="alignment:Splign:2.1.0"
     exon            2404..2486
                     /gene="Nfib"
                     /inference="alignment:Splign:2.1.0"
     exon            2487..9023
                     /gene="Nfib"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

agcggggtccagagggtggaaccggtgaatctttcaacttgcaagtttttcaaggaaagaaagcgagagagggagggggaaagcgcccagaacagaaaagaggagtttgcagccaagcgggatcgatcgtttgggatttttttcaggaggtccttccgatcccttccgtgggctgtgggcatcggcaccggcagcggagtccacgctcggcgggtcagacgcggggcgaggcgggcgggcggcggtgtggcggggcaggagcgcagcaaaggcttttccgcccgggagctccgcgcctgcgccccctccctcaccccggcctctccctgctcccccctccccacccccacccggccctctccggcgcgcgccccgccacccgcgcgcactcgcttgcgctccccctcgcgcacacacatggtcggctcgcggcaaagtttcgcctgcgttcgccactcccggatcctgctgcagtattggcggcggtaaccttgaactttcccagcgcggtgacacattctcctcgctttccccaccgcccggcctcctgcgcccccctccccgcctttttttaaaaaaagcatttcaccacccaccaccaccccaatccaacacacgccgaactctcgcgcaccccaagcccccaacaacaacaacaacaacaacaacaacaacaacaacaacaactgcaaaacagaaaacaaatcccctaaaccgggcgaccagcagcctgcaccggcggcggcctcggagagctcggccggcgcgcgcggaccgcaagagggttaaaagtgtagattggatttcaccccgggaaatctagctcgccgagtgaacttgaatctttggctatttaaggaggactgggtttgttgcgaagttgcggtgatccggcgcagagccccgtcctgattgatcgcaccgctgggctcagatgactgtaaaatgaatagatgaaatccttgcttctcgaagattttcttgggcatctccgggaaagtgcgttttaaggcgaagtcatgatgtattctcccatctgtctcactcaggatgaattccacccatttattgaggcgcttcttccacacgtccgtgcaatcgcctatacgtggttcaacctgcaggctcgaaaacgcaagtactttaaaaagcatgagaagcggatgtcgaaggatgaagaaagagcagtcaaagatgagctgctcagtgaaaagcctgaaatcaaacagaagtgggcatccaggctcctggccaagctgcgcaaagatatccgccaggagtaccgcgaggactttgtgcttaccgtgactggcaagaagcacccgtgctgtgtcttatccaatccagaccagaagggtaagattaggaggatcgactgcctgcgacaggcagacaaagtctggcgtctggatctagtcatggtgatcctgttcaaaggcatccctttggagagtaccgatggagagcgacttatgaagtccccacactgcacaaacccagcactttgtgtgcagccgcaccatatcacagtatcagttaaggagcttgacctgtttttggcatactacgtgcaggagcaagattctgggcaatcaggaagtccaagccacaatgatcctgccaagaatcctccagggtacctagaggacagttttgtaaaatccggagtcttcaacgtatcagagcttgtgagagtatccagaacacccataacccaggggactggagtcaacttcccaatcggagaaatccccagccaaccatactatcatgacatgaactctggcgtgaacctgcagaggtcgctgtcttctccaccgagcagcaaaagacccaaaactatatccatagatgaaaatatggagccaagtcctacaggagacttttacccctctccaaattcaccagctgctggaagtcgaacatggcatgagcgagatcaagatatgtcttctccaactacaatgaagaagcctgagaagccactgtttagctctacatctccacaggattcttccccaagattgagcacttttccccagcaccaccatcccggaatacctggagtcgcgcacagtgtcatctcaactcgaactccacctccaccctcaccgttgccatttccaacgcaagctatccttcctccagcaccatcaagttacttttctcatccaacaatcagatatcctcctcacctgaatcctcaggatactctgaagaactatgtaccttcttatgacccgtccagtcctcaaacgagccagcctaacagcagtggtcaagtagtagggaaagtgcctggccatttcacgcctgtcttggcaccctctccccatcccagtgcagtgcgacctgtgaccctgaccatgacagatactaaacccatcactacatccactgaagcctacacagcctcaggcacatctcaagccaatcgatatgtgggactaagcccaagagacccatccttcctgcatcagcaacagtcctggtacctgggctagcttggttccttttcaagtgtcaaataggacacccatcttaccggcaaatgtccaaaattatggtttgaacataattggagaacctttccttcaagcggagacaagcaactgaggggaaagaaacacaaccatagtgtaagaaaattaggggaaaaacacccaacaaaagaaaagaggaagactggacaacagggagaaaggagagaaactgaagaaagaagacgctagaccagcattgcagcacttccggtcactaattcccttaaggttgagactgtagtgacaggaaagggtcaatgacatctcaccgatgctagactgcagcccctgcaccgtagcctttgttccatgaagtccgctgggaaatagatgttctgtctctatgacaatatattttaactgactttctagatgccttaatatttgcatgataagctagttttcttggttagtattcttgttgtttacgcatggagtcactattcctggttatctcaacaacgaaggctaggaggcggcgtcagaggggctggggacagagccatgagccagccattttataagcactctgatttctaaaagttaaaaaaaattatatatatatatatataaaaatctctgtagcctttagttatccgtacagatttattaaattttggcccttaacccagccttttccagtgtgtaacccagtttgaaaatcttaaaaaggaaaaaaaaagaaaactagggaaaaaatggtttgaactcaaaggctctatggaagaaatgcctctaggtgggtaaagggttacctctgcatgcaacagtaaaaattaatataatattttccccacaaaagaaacacttaacagaggcaagtgcaatttataaatttatatctaaaggggaatcatgattataagtccttcagcccttggactctaaattgaggggattaaaaagaatttaaaataattttgagtgaatttattttcccctcagtttttgagggcacttaaaaaggcattaaatcaagacaaatcatgtgcttgaacagaaaaaaataaaaaataaaaaaaaatattgaaaacacagcacttaggttggcttagctgcagcctcctcagaggtcgaattatttatttaaaattactggttgcatcaagaacccatagggtgtacaaatggttctatacaatctgcatagtagagacaaagaggcaggttaatccatgtcacaagggtaaagcttccagtgtacaggctgggaacgccagggcatagaataggaaaacacgctcttcagagaagtgccatcagggtgctgggaacatgcatggtgctttcggacattagccttgttcaacacatttctcgtaatgacagatctatagtgtgcatgggcagacacatgttgcctctatgtctcttaaaattttaattaaaaagtactctttccagtaatcctaatttgcacgaagatataatgtccacattacgtgccttgccttgaaatctaaaaaacaaaagacaaaaaaaaaaaatccacaaaagtgacatcactacacttgttttgctgcatttattatcgttttaaatctttaccatttttatgacaaaatattttgtactccagacgaagaaaaatgtgtgacatcatggattttttagacagttacacctttatctcacatttataaagcatatcatggctgtgtatagttgccgcttaaaaattgtaatcgaccagcaatattttcagtattttggtgttttttctattaacctttcatgtttttcatcttccaattaatatttggggggaggggtttcaaatttatacgaattatgcaataccaagttttgcctatgtaggtagtgcttttagctgtattggttattataggtaagtacacagatttaaaaagaaataatgtatgctttttttgtttgtttgtttatttgtttgtttgttttaattgaccaaagtgggtactgctatttttgcagtgtgatgaggtccttttgtgtactgagagatggacaggggattttttttaatatacatatataaatatatatatattccggggtgggtgggaggatttttaaccctttacagtgtagctgtgaagcactgtaccctgagataggtctgggctgcaaagcgactgttctgcctactgtgacaaacttcaacttagacaggttcccctccccctgcccccactttcccccctggggtgcaagctgaactcatttctggttttcaatctaagaaaccaggaagaaaaagcaagcacagcacagcgaagcctcctagaggcagacttagaagaactgccctgtcttattttagttgttgtcgatagtttttcctgaaagttccgaaaccacagtggaaagtgagcctgtctcatctttggcaaagacatttcttgaagtgcccacatagcagatgttggctgtttcacacttttgagtttaacacaggaatacgcttccttctaccaaacgcattcgcccatctggagggagagcacccctgccccttcctagcgctcctccattttgttaatgacagatatgttgttcctgtgacttactacttcaaatggatggcattgcacttaggattttgttttttggcatccagaaggttgaccagacagaaggttgctcttcttgaatgtatttggaccgatagattaaaatcaaagttcagtttttaaggaacaaaaataagccagtccttttattctacctgcccttgtaaactgagaagtagagcagagggaaatgtagagttttaagcaactgattttcctgtggatgaatttaagcgtgtttgataatgatgggaggaacttcttgtgaaggggtggtacttcaagtatatatttgaattagtttcccctgaggactagaggtgaatggaaaccagttttattttgtcttcccctcactttcacctggtcctgttgagtgtatccattactccaaggagatctttcagaattagtgacatacacagtcagctgccaagaagccttcttgacccccaccccaggccatgccctagtaaatgaactgtcaagtgtatgcatagcagatcgtttaatcgtgagtactttagaccagtgctcagaggcctgagaattgtacctgaccagtccattcagtttcatgtccacgtgctggatagcacagtcggatgctaggatgcaggttccaagaaagtctagccatgtctgcgatatcagctgtgcagataacagatcctctcagccaagctcttggtgtatttctgacctatttgctgaagagtgtgaccctacatgacacagcattctttccaggcagtcccctctccttgtcaccagtgaatgaacaattcatggcacactgtgggcaaccctgccttcctcttgggtacagaggcctagggcaagtgttccttttttttttttttttaaacctagatcaatttttcttttctttgagataaacttattaaaaaagcactactatagaaaatctcaaatccacttttagccttctattttttttttaaaccaggaagtatattctgacgaagggccccacttttgcaggtcttgcacgccccttccttacccagactgcagagcttcaggatggtgaagatcacccaagggcatctgtagggggtggtgtctccagccaccagctcaaggcactgtccagcctgtgttgtatttgctttgcagcccaccactcccagtgcctctgaagtgtgttttccccagagtgacgtgagcagtcgagacttgcctaagggggaacagaaacctgagaggcagtgaaggagactgtacataaagacgtggcaaaccttaagtatagcaatatagttaccgggtgatgttcgggtgggcagctccattataaagagtgtgaatgagtctgtgaagctgcaattagcaagaagaacgtggtcttcttaatgaaccgcctaccttgtagacagtaatttgtacactgtatagttttgttaagaatttttttttaaattaaagttcccatgtttgtaaagctaactttttaacaattataatggaactgtatgttgtttccatttttaaagtaaacaagaatattccttgtttagagactggactcgagttaaaactctccaggctcttaagttatgtattaaaaaaaaaatctgtccatgttaggagatatttcacagattcccatgcttgaaaagcataggacactaatcctttaaaaaaagtgtaaatggagaaaagttatattttatgaaggttattttgttgtatttagtattggaaaagttggttttcagagcatttcagaatgtcggaagcaccactgtccttttattagtatataagatctttagcaaacattttctctcttttttttttaatggttattccatgatggtatttaaggttacgtttcacagagcattcaggataggcagaaaacaaagcagtgctatgtctcacataacgtgtcctcagggagcagaatcttggatttgtgacttgtagcttcaaaaggactcaacggcagagactgcacgggaacatcttgagcagcaaagcagggcatgttctctacctagacgcagattcaatgtactgtgtgaacggatgaaggctgcagaaagttaccccatatcagtggacagtattcattctccgtgaaacaactctacaatcttgctggcagataggccccaagcatgacattcaatatagtttacatgttcctgtcaaggtcttttgttaacattaaccagctgcatgcttcctggactttaaaaattggggtttctatattttaaaaaaaaattttttttatgtgcaggctattcaagttcaatagtaaaaactcaaaattgaatgttctcctccatgctgaaggagctgaaaactgccttcttcatagtttgcactttctggtagtcgccctgttttctctaactccttaaaattgtgtgggtggagtggatccctgcactgggggataacatggaccactgattttgccctttgaccctgcacaatgacctttgcatcagccaaactcattgccatgacaactctttgtactgtgtcgtgccacagatctgttggtcacattgttaatagtaaaggggacaagttggagacggtcaatttttacatttttttttttgttgttgcagtttttcttcaatggttgtaagtagtttttttttttttttaatgataaaagggttcagtagttaatactctttagaaatatctgtgtgttgcaattcaaatgtatgttgagattgtgaaagcgcttcagtggcactagcctacggggaccctagattaagcctttgataacttttattgcatgatacagtaccagtaacaaaaggtggcctaaacacatgaaaagcagtgtaagctagtgacactaaagccagtcttgtattactgtatttttgacagatggttttgaaaactgtgctacagggactgatgtggcaaatatatctctttatgcagaaggaagtctttttttttttttaagaaaaaaagaagtatggcttattatgcattcttcatcgagggcattgaagttgcatggactgataaaagttgatgcaaaatgagaaagaaacaaaaaacaaaaacaaaaaaaaaaaacaaaaaacaaaaaaaccagcaaaatgtttaccaaaaaactcaaacaaatgagcagtgcctgttcaatttcacagtctctgttgagttcagttgtaaatatgtttcaaatgacattttcttgggaaaaaaaaaatctctacaacattgtggaatgtgaggggcaactgtctcccgggcataggcgtctcaaagctgcagtagattgcgccttgatcaggtggttaatttgtgcttttatcacggagaactttgagcatcctgggaagaggtgcccccacctcaatgatatttctctgagaacaacttttgtaggactgtgtgtttctttagatacatttagtacaactgtaggtgacgagtagtcagtgattgcttgctagctacacaccagggttgatccattttaaaacttttggcattttgtcctcgtgggccataaatacagaaccttgtgttttaattagattttcggggggaaaaggaggcacatgcataatctccatgtaacaaacctttagccgtgggatgtattatatgacagttacttaatttctggagttcgggcctctgggataggcccccagacggggccagaatgttagtgaaggttttattgtgcccggttggaggataacgttctttgtgtactttttgtgggtcgcaaatgaactcaattgccacaagttttaaactggtgtaaatcaagcttgacttaatgtgattgttactgttatatccagcctatactgctagcagctgctcatactgcagtcaattactggaagcggatatatttcctatgcaaaaactgtttaaacaataaaatgagctatgctacaga

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