LOCUS       NM_031032               1424 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  Rattus norvegicus glia maturation factor, beta (Gmfb), mRNA.
ACCESSION   NM_031032
VERSION     NM_031032.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1424)
  AUTHORS   Shi S, Gu H, Xu J, Sun W, Liu C, Zhu T, Wang J, Gao F, Zhang J, Ou
            Q, Jin C, Xu J, Chen H, Li J, Xu G, Tian H and Lu L.
  TITLE     Glia maturation factor beta deficiency protects against diabetic
            osteoporosis by suppressing osteoclast hyperactivity
  JOURNAL   Exp Mol Med 55 (5), 898-909 (2023)
   PUBMED   37121966
  REMARK    GeneRIF: Glia maturation factor beta deficiency protects against
            diabetic osteoporosis by suppressing osteoclast hyperactivity.
REFERENCE   2  (bases 1 to 1424)
  AUTHORS   Xu FF, Zhang ZB, Wang YY and Wang TH.
  TITLE     Brain-Derived Glia Maturation Factor beta Participates in Lung
            Injury Induced by Acute Cerebral Ischemia by Increasing ROS in
            Endothelial Cells
  JOURNAL   Neurosci Bull 34 (6), 1077-1090 (2018)
   PUBMED   30191459
  REMARK    GeneRIF: This study demonstrated that GMFB is up-regulated in
            astrocytes after Acute Cerebral Ischemia.
REFERENCE   3  (bases 1 to 1424)
  AUTHORS   Lim R, Zaheer A, Khosravi H, Freeman JH Jr, Halverson HE, Wemmie JA
            and Yang B.
  TITLE     Impaired motor performance and learning in glia maturation
            factor-knockout mice
  JOURNAL   Brain Res 1024 (1-2), 225-232 (2004)
   PUBMED   15451385
REFERENCE   4  (bases 1 to 1424)
  AUTHORS   Zaheer A, Fink BD and Lim R.
  TITLE     Expression of glia maturation factor beta mRNA and protein in rat
            organs and cells
  JOURNAL   J Neurochem 60 (3), 914-920 (1993)
   PUBMED   8436977
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081778.1.
            
            On Oct 17, 2004 this sequence version replaced NM_031032.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081778.1, FQ222145.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840105, SAMN12840107
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1424
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p14"
     gene            1..1424
                     /gene="Gmfb"
                     /note="glia maturation factor, beta"
                     /db_xref="GeneID:81661"
                     /db_xref="RGD:70910"
     exon            1..86
                     /gene="Gmfb"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..512
                     /gene="Gmfb"
                     /note="GMF-beta; DNA for thyroid hormone receptor binding
                     site (276bp)"
                     /codon_start=1
                     /product="glia maturation factor beta"
                     /protein_id="NP_112294.1"
                     /db_xref="GeneID:81661"
                     /db_xref="RGD:70910"
                     /translation="

MSESLVVCDVAEDLVEKLRKFRFRKETHNAAIIMKIDKDKRLVVLDEELEGVSPDELKDELPERQPRFIVYSYKYQHDDGRVSYPLCFIFSSPLGCKPEQQMMYAGSKNKLVQTAELTKVFEIRNTEDLTEEWLREKLGFFH"

     misc_feature    87..89
                     /gene="Gmfb"
                     /note="N-acetylserine. /evidence=ECO:0000269|Ref.4;
                     propagated from UniProtKB/Swiss-Prot (Q63228.2);
                     acetylation site"
     misc_feature    108..473
                     /gene="Gmfb"
                     /note="ADF-homology domain of glia maturation factor beta
                     and related proteins; Region: ADF_GMF-beta_like; cd11283"
                     /db_xref="CDD:200439"
     exon            87..183
                     /gene="Gmfb"
                     /inference="alignment:Splign:2.1.0"
     exon            184..233
                     /gene="Gmfb"
                     /inference="alignment:Splign:2.1.0"
     exon            234..283
                     /gene="Gmfb"
                     /inference="alignment:Splign:2.1.0"
     exon            284..366
                     /gene="Gmfb"
                     /inference="alignment:Splign:2.1.0"
     exon            367..440
                     /gene="Gmfb"
                     /inference="alignment:Splign:2.1.0"
     exon            441..1398
                     /gene="Gmfb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

caggaagggaggtggctgcagagccattcttaaaggggcccaagagatcatacggcaacggacggctgacgaccggaaggaaaatgagtgagtctttggtggtttgtgatgttgctgaagatttagtggaaaagctgagaaagtttcgttttcgaaaagaaacccacaatgctgctattataatgaagattgacaaggataaacgcttggtggtgctggatgaggagctcgagggtgtctctccagatgaacttaaagatgaactacctgaacggcaacctcgcttcattgtgtatagttataaataccagcacgacgatggccgggtctcctaccctctgtgctttatcttctccagtcctctggggtgcaaacctgagcagcagatgatgtacgctgggagtaagaacaagctggtccagaccgccgagctaactaaggtatttgaaataagaaacaccgaagacctaactgaagaatggttacgtgagaaacttggatttttccactaatgtgaacttctgtgtttctaaagtatttatgtattaacctgaccatactggaaccagacataaatagttatttatgcctaaaaatgcactgttacttacagtttgtttcctgcagtaaagaaaaattcatttgtgcagtttgaacaaaggggaaatcatcttcatagtaatgaaactttgtgaagtgtttccttgtatctgtcattgttaggtggactacttttctccagggatggttcgcacccttgtgactaatttctataatttatgattcagaatttgttactgttgcagacactataggaaagtgggtatagactgtgatagacaacagttcctccttggccactcctggtactggcatggcagtttgtaagtgccaagagcatttcatcacctatcgcatcattgaggttcactggggctgaagtgtaagtgaccgctctgagccgtgagtggcgatgtagtggaccctctgctgctctcgtcacattcctcctctcttgcattcctgtatcctttcaatcaagtgtagagtcgccatcaatcactcctccttaaggaccgggggcttagttttatggtagagttaggattattagaggttttcttctgatggaacatagtcctagtcttagagactcgtgggctgtataatcaagggcttccgtctaggttatgtcaccagtaggcagctagagcggagcttggtaacagaaagcacctcctaacgtctcgtgagcactgttctggatatgttaacctgtgcctttgatttgtcagctttaacattagcttcagactcctacactgccagtattctagatttggtgagattaatacttttttaaagggttcaaataaaacaattttctaatatgtgtaaaaaaaaaaaaaaaaaaaaaaaaaaaa

//