LOCUS       NM_024355               3216 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus axin 2 (Axin2), mRNA.
ACCESSION   NM_024355 XM_001081593
VERSION     NM_024355.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3216)
  AUTHORS   Qiu Z, Chen W, Liu Y, Jiang B, Yin L and Chen X.
  TITLE     LncRNA AC061961.2 overexpression inhibited endoplasmic reticulum
            stress induced apoptosis in dilated cardiomyopathy rats and
            cardiomyocytes via activating wnt/beta-catenin pathway
  JOURNAL   J Recept Signal Transduct Res 41 (5), 494-503 (2021)
   PUBMED   33092439
REFERENCE   2  (bases 1 to 3216)
  AUTHORS   An YZ, Cho E, Ling J and Zhang X.
  TITLE     The Axin2-snail axis promotes bone invasion by activating
            cancer-associated fibroblasts in oral squamous cell carcinoma
  JOURNAL   BMC Cancer 20 (1), 987 (2020)
   PUBMED   33046030
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3216)
  AUTHORS   Wu Z, Liang Y and Yu S.
  TITLE     Downregulation of microRNA-103a reduces microvascular endothelial
            cell injury in a rat model of cerebral ischemia by targeting AXIN2
  JOURNAL   J Cell Physiol 235 (5), 4720-4733 (2020)
   PUBMED   31650542
REFERENCE   4  (bases 1 to 3216)
  AUTHORS   Otero L, Lacunza E, Vasquez V, Arbelaez V, Cardier F and Gonzalez
            F.
  TITLE     Variations in AXIN2 predict risk and prognosis of colorectal cancer
  JOURNAL   BDJ Open 5, 13 (2019)
   PUBMED   31632692
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3216)
  AUTHORS   Mishra A, Singh S, Tiwari V, Chaturvedi S, Wahajuddin M and Shukla
            S.
  TITLE     Dopamine receptor activation mitigates mitochondrial dysfunction
            and oxidative stress to enhance dopaminergic neurogenesis in 6-OHDA
            lesioned rats: A role of Wnt signalling
  JOURNAL   Neurochem Int 129, 104463 (2019)
   PUBMED   31078578
REFERENCE   6  (bases 1 to 3216)
  AUTHORS   Leung JY, Kolligs FT, Wu R, Zhai Y, Kuick R, Hanash S, Cho KR and
            Fearon ER.
  TITLE     Activation of AXIN2 expression by beta-catenin-T cell factor. A
            feedback repressor pathway regulating Wnt signaling
  JOURNAL   J Biol Chem 277 (24), 21657-21665 (2002)
   PUBMED   11940574
REFERENCE   7  (bases 1 to 3216)
  AUTHORS   Lustig B, Jerchow B, Sachs M, Weiler S, Pietsch T, Karsten U, van
            de Wetering M, Clevers H, Schlag PM, Birchmeier W and Behrens J.
  TITLE     Negative feedback loop of Wnt signaling through upregulation of
            conductin/axin2 in colorectal and liver tumors
  JOURNAL   Mol Cell Biol 22 (4), 1184-1193 (2002)
   PUBMED   11809809
REFERENCE   8  (bases 1 to 3216)
  AUTHORS   Liu W, Dong X, Mai M, Seelan RS, Taniguchi K, Krishnadath KK,
            Halling KC, Cunningham JM, Boardman LA, Qian C, Christensen E,
            Schmidt SS, Roche PC, Smith DI and Thibodeau SN.
  TITLE     Mutations in AXIN2 cause colorectal cancer with defective mismatch
            repair by activating beta-catenin/TCF signalling
  JOURNAL   Nat Genet 26 (2), 146-147 (2000)
   PUBMED   11017067
  REMARK    Erratum:[Nat Genet 2000 Dec;26(4):501]
REFERENCE   9  (bases 1 to 3216)
  AUTHORS   Yamamoto H, Kishida S, Uochi T, Ikeda S, Koyama S, Asashima M and
            Kikuchi A.
  TITLE     Axil, a member of the Axin family, interacts with both glycogen
            synthase kinase 3beta and beta-catenin and inhibits axis formation
            of Xenopus embryos
  JOURNAL   Mol Cell Biol 18 (5), 2867-2875 (1998)
   PUBMED   9566905
REFERENCE   10 (bases 1 to 3216)
  AUTHORS   Behrens J, Jerchow BA, Wurtele M, Grimm J, Asbrand C, Wirtz R, Kuhl
            M, Wedlich D and Birchmeier W.
  TITLE     Functional interaction of an axin homolog, conductin, with
            beta-catenin, APC, and GSK3beta
  JOURNAL   Science 280 (5363), 596-599 (1998)
   PUBMED   9554852
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF017757.1.
            
            On Jun 25, 2006 this sequence version replaced XM_001081593.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF017757.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3216
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..3216
                     /gene="Axin2"
                     /gene_synonym="axil; axin-2"
                     /note="axin 2"
                     /db_xref="GeneID:29134"
                     /db_xref="RGD:69259"
     exon            1..899
                     /gene="Axin2"
                     /gene_synonym="axil; axin-2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    1..3
                     /gene="Axin2"
                     /gene_synonym="axil; axin-2"
                     /note="upstream in-frame stop codon"
     CDS             85..2601
                     /gene="Axin2"
                     /gene_synonym="axil; axin-2"
                     /note="conductin; axin-like protein; axis inhibition
                     protein 2"
                     /codon_start=1
                     /product="axin-2"
                     /protein_id="NP_077331.1"
                     /db_xref="GeneID:29134"
                     /db_xref="RGD:69259"
                     /translation="

MSSAVLVTLLPDPSSSFREDAPRPPVPGEEGETPPCQPSVGKVQSTKPMPVSSNARRNEDGLGEPEGRASPDSPLTRWTKSLHSLLGDQDGAYLFRTFLEREKCVDTLDFWFACNGFRQMNLKDTKTLRVAKAIYKRYIENNSVVSKQLKPATKTYIRDGIKKQQIGSVMFDQAQTEIQAVMEENAYQVFLTSDIYLEYVRSGGENTAYMSNGGLGSLKVLCGYLPTLNEEEEWTCADLKCKLSPTVVGLSSKTLRATASVRSTETAENGFRSFKRSEPVNPYHVGSGYVFAPATSANDSELSSDALTDDSMSMTDSSVDGIPPYRMGSKKQLQREMHRSVKANGQVSLPHFPRTHRLPKEMTPVEPAAFAAELISRLEKLKLELESRHSLEERLQQIREDEEKEGSEQALSSRDGAPVQHPLALLPSGSYEEDPQTILDDHLSRVLKTPGCQSPGVGRYSPRSRSPDHHHHHHQQCHALLPTGGKLPPEAACPLLGGKSFLTKQTTKHVHHHYIHHHAVPKTKEEIEAEATQRVRCLCPGGTDYYCYSKCKSHSKPPEPLPGEQFCGSRGGTLPKRNTKGTEPGLALPAREGGMSSAAGAPQLPGEEGDRSQDVWQWMLESERQSKSKPHSTQSIRKSYPLESARAPPGERVSRHHLLGASGHPRSAARAHPFTQDPAMPPLTPPNTLAQLEEACRRLAEVSKPQKQRCCVASQQRDRNHPATGQAGPTSFSNPSLASEDHKEPKRLASVHALQASELIVTYFFCGEEIPYRRMLKAQSLTLGHFKEQLSKKGNYRYYFKKASDEFACGAVFEEIWDDETVLPMYEGRILGKVERID"

     misc_feature    85..309
                     /gene="Axin2"
                     /gene_synonym="axil; axin-2"
                     /note="propagated from UniProtKB/Swiss-Prot (O70240.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    112..309
                     /gene="Axin2"
                     /gene_synonym="axil; axin-2"
                     /note="Axin-1 tankyrase binding domain; Region:
                     AXIN1_TNKS_BD; pfam16646"
                     /db_xref="CDD:435487"
     misc_feature    145..174
                     /gene="Axin2"
                     /gene_synonym="axil; axin-2"
                     /note="propagated from UniProtKB/Swiss-Prot (O70240.1);
                     Region: Tankyrase-binding motif"
     misc_feature    328..678
                     /gene="Axin2"
                     /gene_synonym="axil; axin-2"
                     /note="Regulator of G protein signaling (RGS) domain found
                     in the Axin protein; Region: RGS_Axin; cd08707"
                     /db_xref="CDD:188662"
     misc_feature    order(340..351,358..360,409..411,418..423,430..435,
                     439..441,469..474,478..486,490..495)
                     /gene="Axin2"
                     /gene_synonym="axil; axin-2"
                     /note="APC binding site [polypeptide binding]; other site"
                     /db_xref="CDD:188662"
     misc_feature    982..1083
                     /gene="Axin2"
                     /gene_synonym="axil; axin-2"
                     /note="propagated from UniProtKB/Swiss-Prot (O70240.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1063..1323
                     /gene="Axin2"
                     /gene_synonym="axil; axin-2"
                     /note="propagated from UniProtKB/Swiss-Prot (O70240.1);
                     Region: Interaction with GSK3B. /evidence=ECO:0000250"
     misc_feature    1276..1389
                     /gene="Axin2"
                     /gene_synonym="axil; axin-2"
                     /note="propagated from UniProtKB/Swiss-Prot (O70240.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1321..1512
                     /gene="Axin2"
                     /gene_synonym="axil; axin-2"
                     /note="propagated from UniProtKB/Swiss-Prot (O70240.1);
                     Region: Interaction with beta-catenin.
                     /evidence=ECO:0000250"
     misc_feature    1381..1488
                     /gene="Axin2"
                     /gene_synonym="axil; axin-2"
                     /note="Axin beta-catenin binding domain; Region:
                     Axin_b-cat_bind; pfam08833"
                     /db_xref="CDD:430248"
     misc_feature    1432..1533
                     /gene="Axin2"
                     /gene_synonym="axil; axin-2"
                     /note="propagated from UniProtKB/Swiss-Prot (O70240.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1786..2130
                     /gene="Axin2"
                     /gene_synonym="axil; axin-2"
                     /note="propagated from UniProtKB/Swiss-Prot (O70240.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2218..2316
                     /gene="Axin2"
                     /gene_synonym="axil; axin-2"
                     /note="propagated from UniProtKB/Swiss-Prot (O70240.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2350..2598
                     /gene="Axin2"
                     /gene_synonym="axil; axin-2"
                     /note="Domain present in Dishevelled and axin; Region:
                     DAX; smart00021"
                     /db_xref="CDD:197474"
     exon            900..1040
                     /gene="Axin2"
                     /gene_synonym="axil; axin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1143
                     /gene="Axin2"
                     /gene_synonym="axil; axin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1284
                     /gene="Axin2"
                     /gene_synonym="axil; axin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1784
                     /gene="Axin2"
                     /gene_synonym="axil; axin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1785..1979
                     /gene="Axin2"
                     /gene_synonym="axil; axin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1980..2210
                     /gene="Axin2"
                     /gene_synonym="axil; axin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2211..2306
                     /gene="Axin2"
                     /gene_synonym="axil; axin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2307..2474
                     /gene="Axin2"
                     /gene_synonym="axil; axin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2475..3197
                     /gene="Axin2"
                     /gene_synonym="axil; axin-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

tgagaggaactggaagaagaaaaaggaagaggaaaaaaaaaaagcaaaacaaaacccaaactcagtgagacgctctccctcaccatgagtagcgctgtgttagtgactctccttccagatccaagcagcagcttccgcgaggatgctccgcggcccccggttcccggagaagaaggggagaccccaccgtgtcagcctagcgtgggcaaggtccagtccaccaaacctatgcctgtctcctctaacgctaggcggaatgaagatgggctgggggagcccgaggggcgggcctccccagattcccctctgaccaggtggaccaagtctttgcactccttgttgggggaccaagatggtgcatacctcttccggactttcctggagagggagaaatgtgtggataccctggacttctggtttgcctgcaatgggttcaggcagatgaacttgaaggataccaaaactttgcgagtggccaaagcaatctacaagaggtacattgagaacaacagtgttgtctccaaacagctgaaacccgccaccaagacctacataagagatggcatcaagaagcagcagatcggctcggtcatgtttgaccaggcgcagacggagattcaggcggtgatggaggaaaatgcctatcaggtgttcttgacttctgacatatacctcgaatatgtgaggagtgggggagaaaacacagcttacatgagcaatgggggactggggagcctaaaggtcttatgtggctacctccccaccctgaatgaggaagaggagtggacatgtgccgacctgaagtgcaaactttcacccaccgtggttggcctatccagcaaaactctccgggccacagcgagcgtgagatccacagaaacggctgaaaacggattcagatccttcaagagaagcgaaccggttaatccttatcacgtaggttctggctatgtctttgcaccagccaccagcgccaacgacagcgagttatccagcgacgcgctgaccgacgattccatgtccatgacagacagtagcgtagatggaatccctccttaccgcatggggagtaagaaacaactccagagagagatgcaccgcagtgtgaaggccaatggccaagtgtctctacctcacttcccgagaacccaccgcctgcccaaggagatgacgcccgtggaacctgctgccttcgccgcagagctcatctccaggctggagaagctgaaactggagctggagagccgccacagcctggaggaacggctgcagcagatccgggaggatgaagaaaaggaggggtctgagcaggccctgagctcacgggatggagcaccggtccaacaccccctggccctcttaccctctggcagctatgaagaggacccacaaaccatcttggacgaccacctgtccagggtcctcaagacccccggctgccagtcccctggtgtgggccgctacagcccacgctcccgctcccccgaccaccaccaccaccaccatcagcagtgtcacgcccttcttccaactgggggcaagctgccccccgaggctgcttgcccgctccttggaggcaagagcttcctgaccaaacagacgacgaagcacgtccaccaccactacatccaccaccacgccgtccctaagaccaaggaggagatcgaggcagaagccacacagagagtacgctgcctctgccctggaggcacagattattactgctactccaagtgcaagagccactcgaagcctccagagcccctccctggggagcagttttgtggcagcagaggtggcaccttgccaaaacggaatacgaaaggcacagaaccgggtctggcactgccggccagggaaggagggatgtccagtgcagcaggggcccctcagcttcctggggaagaaggagaccggtcacaggatgtctggcagtggatgttggagagtgagcgtcagagcaagtccaagccccatagtacccaaagcataagaaagagctacccgttggagtctgcccgcgcgcccccaggcgaacgagtcagccggcaccatctgctgggggccagtggacacccccgctcagcggcccgggctcacccatttacccaggaccctgccatgcctcccctaaccccacccaacaccttggcgcagctagaggaagcctgccgcaggctggccgaggtgtcaaagccccagaaacagaggtgctgcgtggccagtcagcagagggacaggaaccacccagccacaggtcaggcaggacccacatccttctccaacccgagcctggcttcagaagatcacaaagagccaaagagactggctagtgtccacgcactccaagccagcgagctgattgttacctactttttctgtggagaagaaattccatacaggaggatgctgaaggcgcagagcttgactctgggccacttcaaggagcagctcagcaaaaagggaaattacaggtattacttcaagaaggcgagtgacgaatttgcctgtggagcagtctttgaggagatctgggatgatgagacagtgctccccatgtacgaaggcaggatcctgggcaaagtggagaggatcgactgagcctcggcctccgccgcgtgcacctccgcgtgcacctccgcgtgcaccacggagccggagcccagagagacctgtctcaggcctacacaacagccatgaaatattttgaaggaaaatgaaaccaattaagaagacaaagcctagggagggactggcccctgggccttcaggagggcgggggtggttggttttcaatatccacgagctgggtactgagatcagaaaagcccgaactatttattcaaaacatgaccactctgggctatagaagatgctgagtgctcgagagactgccatacataatagatggcttcctagggatctgaaatccatagactaagagaaaactgtgtatagcttgcccgaacaggagtccttactgatatttattgaacagtcgattcccctaccccactcccacccccaacccccaacccccagtttatgctgctttaaacctggaaatgagagagagaagtttggtttgctgtctatgcttaagagccaagccgggaacgcattaatcatttcttcgttaacagaggaatccgctctgcatggcatctctccaagtgaagacaggcttctttacaaaaaaaaaaaaaaaaaaaaaaa

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