2024-03-28 21:02:28, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NM_022671 2360 bp mRNA linear ROD 22-MAR-2023 DEFINITION Rattus norvegicus one cut homeobox 1 (Onecut1), mRNA. ACCESSION NM_022671 VERSION NM_022671.3 KEYWORDS RefSeq; RefSeq Select. SOURCE Rattus norvegicus (Norway rat) ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. REFERENCE 1 (bases 1 to 2360) AUTHORS Peng YC, Lv TH, Du ZK, Cun XN and Yang KM. TITLE Liver Macrophages Stimulate the Expression of Hepatocyte Nuclear Factor-6 and Promote Hepatocyte Proliferation at the Early Stage of Liver Regeneration JOURNAL Bull Exp Biol Med 170 (1), 40-45 (2020) PUBMED 33222081 REMARK GeneRIF: Liver Macrophages Stimulate the Expression of Hepatocyte Nuclear Factor-6 and Promote Hepatocyte Proliferation at the Early Stage of Liver Regeneration. REFERENCE 2 (bases 1 to 2360) AUTHORS Falix FA, Weeda VB, Labruyere WT, Poncy A, de Waart DR, Hakvoort TB, Lemaigre F, Gaemers IC, Aronson DC and Lamers WH. TITLE Hepatic Notch2 deficiency leads to bile duct agenesis perinatally and secondary bile duct formation after weaning JOURNAL Dev Biol 396 (2), 201-213 (2014) PUBMED 25446530 REFERENCE 3 (bases 1 to 2360) AUTHORS Faure AJ, Schmidt D, Watt S, Schwalie PC, Wilson MD, Xu H, Ramsay RG, Odom DT and Flicek P. TITLE Cohesin regulates tissue-specific expression by stabilizing highly occupied cis-regulatory modules JOURNAL Genome Res 22 (11), 2163-2175 (2012) PUBMED 22780989 REFERENCE 4 (bases 1 to 2360) AUTHORS Wang Z and Burke PA. TITLE Hepatocyte nuclear factor-4alpha interacts with other hepatocyte nuclear factors in regulating transthyretin gene expression JOURNAL FEBS J 277 (19), 4066-4075 (2010) PUBMED 20735474 REFERENCE 5 (bases 1 to 2360) AUTHORS Margagliotti S, Clotman F, Pierreux CE, Beaudry JB, Jacquemin P, Rousseau GG and Lemaigre FP. TITLE The Onecut transcription factors HNF-6/OC-1 and OC-2 regulate early liver expansion by controlling hepatoblast migration JOURNAL Dev Biol 311 (2), 579-589 (2007) PUBMED 17936262 REFERENCE 6 (bases 1 to 2360) AUTHORS Vanhorenbeeck V, Jacquemin P, Lemaigre FP and Rousseau GG. TITLE OC-3, a novel mammalian member of the ONECUT class of transcription factors JOURNAL Biochem Biophys Res Commun 292 (4), 848-854 (2002) PUBMED 11944891 REFERENCE 7 (bases 1 to 2360) AUTHORS Jacquemin P, Durviaux SM, Jensen J, Godfraind C, Gradwohl G, Guillemot F, Madsen OD, Carmeliet P, Dewerchin M, Collen D, Rousseau GG and Lemaigre FP. TITLE Transcription factor hepatocyte nuclear factor 6 regulates pancreatic endocrine cell differentiation and controls expression of the proendocrine gene ngn3 JOURNAL Mol Cell Biol 20 (12), 4445-4454 (2000) PUBMED 10825208 REFERENCE 8 (bases 1 to 2360) AUTHORS Lannoy VJ, Burglin TR, Rousseau GG and Lemaigre FP. TITLE Isoforms of hepatocyte nuclear factor-6 differ in DNA-binding properties, contain a bifunctional homeodomain, and define the new ONECUT class of homeodomain proteins JOURNAL J Biol Chem 273 (22), 13552-13562 (1998) PUBMED 9593691 REFERENCE 9 (bases 1 to 2360) AUTHORS Samadani U and Costa RH. TITLE The transcriptional activator hepatocyte nuclear factor 6 regulates liver gene expression JOURNAL Mol Cell Biol 16 (11), 6273-6284 (1996) PUBMED 8887657 REFERENCE 10 (bases 1 to 2360) AUTHORS Lemaigre FP, Durviaux SM, Truong O, Lannoy VJ, Hsuan JJ and Rousseau GG. TITLE Hepatocyte nuclear factor 6, a transcription factor that contains a novel type of homeodomain and a single cut domain JOURNAL Proc Natl Acad Sci U S A 93 (18), 9460-9464 (1996) PUBMED 8790352 COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JACYVU010000199.1. On Nov 27, 2020 this sequence version replaced NM_022671.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMD00132263, SAMD00132291 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-1342 JACYVU010000199.1 8214556-8215897 1343-2360 JACYVU010000199.1 8241088-8242105 FEATURES Location/Qualifiers source 1..2360 /organism="Rattus norvegicus" /mol_type="mRNA" /strain="BN" /db_xref="taxon:10116" /chromosome="8" /map="8q24" gene 1..2360 /gene="Onecut1" /gene_synonym="Hnf6" /note="one cut homeobox 1" /db_xref="GeneID:25231" /db_xref="RGD:2811" exon 1..1342 /gene="Onecut1" /gene_synonym="Hnf6" /inference="alignment:Splign:2.1.0" misc_feature 124..126 /gene="Onecut1" /gene_synonym="Hnf6" /note="upstream in-frame stop codon" CDS 238..1635 /gene="Onecut1" /gene_synonym="Hnf6" /note="one cut domain, family member 1; HNF-6" /codon_start=1 /product="hepatocyte nuclear factor 6" /protein_id="NP_073162.2" /db_xref="GeneID:25231" /db_xref="RGD:2811" /translation="
MNAQLTMEAIGELHGVSHEPVPAPADLLGGSPHARSSVGHRGSHLPPAHPRSMGMASLLDGGSGGSDYHHHHRAPEHSLAGPLHPTMTMACETPPGMSMPTTYTTLTPLQPLPPISTVSDKFPHHHHHHHHHHHPHHHQRLAGNVSGSFTLMRDERGLASMNNLYTPYHKDVAGMGQSLSPLSGSGLGSIHNSQQGLPHYAHPGAAMPTDKMLTPNGFEAHHPAMLGRHGEQHLTPTSAGMVPINGLPPHHPHAHLNAQGHGQLLGTAREPNPSVTGAQVSNGSNSGQMEEINTKEVAQRITTELKRYSIPQAIFAQRVLCRSQGTLSDLLRNPKPWSKLKSGRETFRRMWKWLQEPEFQRMSALRLAACKRKEQEHGKDRGNTPKKPRLVFTDVQRRTLHAIFKENKRPSKELQITISQQLGLELSTVSNFFMNARRRSLDKWQDEGSSNSGNSSSSSSTCTKA"
misc_feature 280..489 /gene="Onecut1" /gene_synonym="Hnf6" /note="propagated from UniProtKB/Swiss-Prot (P70512.1); Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite" misc_feature 592..660 /gene="Onecut1" /gene_synonym="Hnf6" /note="propagated from UniProtKB/Swiss-Prot (P70512.1); Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite" misc_feature 1099..1323 /gene="Onecut1" /gene_synonym="Hnf6" /note="CUT domain; Region: CUT; pfam02376" /db_xref="CDD:426745" misc_feature 1390..1557 /gene="Onecut1" /gene_synonym="Hnf6" /note="Homeodomain; Region: HOX; smart00389" /db_xref="CDD:197696" misc_feature order(1393..1407,1411..1413,1462..1464,1480..1482, 1519..1521,1525..1530,1537..1542,1546..1554) /gene="Onecut1" /gene_synonym="Hnf6" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238039" misc_feature order(1399..1401,1408..1410,1528..1530,1537..1542, 1549..1551) /gene="Onecut1" /gene_synonym="Hnf6" /note="specific DNA base contacts [nucleotide binding]; other site" /db_xref="CDD:238039" misc_feature 1561..1632 /gene="Onecut1" /gene_synonym="Hnf6" /note="propagated from UniProtKB/Swiss-Prot (P70512.1); Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite" exon 1343..2360 /gene="Onecut1" /gene_synonym="Hnf6" /inference="alignment:Splign:2.1.0" ORIGIN
ggatcctttttggaaattaatattaaaaaagaaaaaaaagaaaagaaaaggcagaggggaaggtaggagcaagagagaaggcaagacacacacagagagagcgaaagacacagatccccacagtgagaggaagaaaggccacagtcgcaggcagccgatgtgaagactggactctgtgcgcccctcgccgcctctgcccggccacatcgatgttgcagcccgctcacccgcatcacgatgaacgcacagctgaccatggaggcgatcggcgagctgcacggggtgagccatgagccggtgcccgcccctgctgacctgctgggcgggagccctcacgcgcgcagctccgtggggcaccgcggcagccacctgcctcccgctcacccgcgttccatgggcatggcgtcgctgctggacggcggcagcggaggcagcgattaccaccaccaccaccgcgcccctgagcacagcttggctggccccctgcaccccaccatgaccatggcctgtgaaactcccccaggtatgagcatgcccaccacctacaccaccttaacccctctgcagccgctgccgcccatctccaccgtgtccgacaagttccctcaccaccatcaccaccaccatcaccaccaccacccacatcaccaccagcgcctggcgggcaacgtgagcggtagtttcacacttatgcgggatgagcgcgggctggcctccatgaataacctctataccccctaccacaaggacgtggctggcatgggccagagcctctcgcccctctctggctcgggtctgggcagcattcacaactcccagcaaggacttccccactatgctcatcccggcgcggctatgcccaccgacaagatgctcaccccaaatggctttgaagcccaccaccctgccatgctcggtcgccacggggagcagcacctcacgcccacctcggccggcatggtacccatcaacggccttcctccacaccatccccatgcccacctgaatgcccagggccacggacagctcctgggcacagcccgggagcccaacccttcggtgaccggcgcgcaggtcagcaatggaagtaattcagggcagatggaagagatcaataccaaagaggtggctcagcgtatcaccaccgagctcaaacgttacagcatcccacaggccatcttcgcgcagagggtgctctgccgttcccaggggaccctttcggacctgctgcgaaaccccaagccctggagcaaactcaagtccggtcgggagactttccggaggatgtggaagtggctgcaggagccggagttccagcgcatgtcggcgctccgcttagcagcctgcaaaaggaaagagcaagaacacgggaaggacagaggcaacacccccaaaaagcccaggctggtcttcacagacgtccaacgtcggactctacatgcaatattcaaggaaaataagcgtccgtccaaagaattacaaatcaccatttcccagcagctggggttggagctgagcactgtcagcaacttcttcatgaatgcgagaaggaggagtctggacaaatggcaggacgagggcagctccaattcaggcaactcttcgtcttcatcaagcacttgtaccaaagcatgaaggaagaaccacggactagaacctcggtggaaaagctttaaattaaataaaaaaaagtttttaaagaccaggacctcaagatagcaggtttatacttagaaatatttgaaggaaaacaagtggtatttatagtccaaagaaaccaaagactaaaaagctcacctgcattctgactttgttcagagacacatacttcagcggggcaagactcggcaagaaagatgatggagaaaacgtcggatctcgcgccttcaacccctgcacctcactgtgctcggctgctcagtggctctaagcacagtaatgtttgagccatcgagtggacatcttttaagatcagacgttcttatctgttccaccacactgcaaaggtgtgtagtgtctcaatatcacgtgtgagtatgtgtgtgcatgcgtgcacacgtaaacacacagcaacaccagtgtttagggactcaggcacggctggtcttcaggaagggttgcaccatatgacatgaccaagctggtgtgggatttctaagttcattggatctgagatgtgagttttctcatctaagcctagcgtttgaacctgccaggcccacaacctaaatgcagattcaaacccagcaaagaaaatttgaatggcacctaaaccagtacgctctctttgtttgttaagaaatgttcagatatttttaaaaaaaaaatgaaacaagagtccatccattaaaaaaaaaaaa
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Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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