LOCUS       NM_022637               1284 bp    mRNA    linear   ROD 28-JUN-2025
DEFINITION  Rattus norvegicus ventral anterior homeobox 2 (Vax2), mRNA.
ACCESSION   NM_022637
VERSION     NM_022637.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1284)
  AUTHORS   Vacik,T., Stubbs,J.L. and Lemke,G.
  TITLE     A novel mechanism for the transcriptional regulation of Wnt
            signaling in development
  JOURNAL   Genes Dev 25 (17), 1783-1795 (2011)
   PUBMED   21856776
REFERENCE   2  (bases 1 to 1284)
  AUTHORS   Kim,J.W. and Lemke,G.
  TITLE     Hedgehog-regulated localization of Vax2 controls eye development
  JOURNAL   Genes Dev 20 (20), 2833-2847 (2006)
   PUBMED   17043310
REFERENCE   3  (bases 1 to 1284)
  AUTHORS   Mui,S.H., Kim,J.W., Lemke,G. and Bertuzzi,S.
  TITLE     Vax genes ventralize the embryonic eye
  JOURNAL   Genes Dev 19 (10), 1249-1259 (2005)
   PUBMED   15905411
REFERENCE   4  (bases 1 to 1284)
  AUTHORS   Barbieri,A.M., Broccoli,V., Bovolenta,P., Alfano,G.,
            Marchitiello,A., Mocchetti,C., Crippa,L., Bulfone,A., Marigo,V.,
            Ballabio,A. and Banfi,S.
  TITLE     Vax2 inactivation in mouse determines alteration of the eye
            dorsal-ventral axis, misrouting of the optic fibres and eye
            coloboma
  JOURNAL   Development 129 (3), 805-813 (2002)
   PUBMED   11830579
REFERENCE   5  (bases 1 to 1284)
  AUTHORS   Mui,S.H., Hindges,R., O'Leary,D.D., Lemke,G. and Bertuzzi,S.
  TITLE     The homeodomain protein Vax2 patterns the dorsoventral and
            nasotemporal axes of the eye
  JOURNAL   Development 129 (3), 797-804 (2002)
   PUBMED   11830578
REFERENCE   6  (bases 1 to 1284)
  AUTHORS   Schulte,D., Furukawa,T., Peters,M.A., Kozak,C.A. and Cepko,C.L.
  TITLE     Misexpression of the Emx-related homeobox genes cVax and mVax2
            ventralizes the retina and perturbs the retinotectal map
  JOURNAL   Neuron 24 (3), 541-553 (1999)
   PUBMED   10595508
REFERENCE   7  (bases 1 to 1284)
  AUTHORS   Barbieri,A.M., Lupo,G., Bulfone,A., Andreazzoli,M., Mariani,M.,
            Fougerousse,F., Consalez,G.G., Borsani,G., Beckmann,J.S.,
            Barsacchi,G., Ballabio,A. and Banfi,S.
  TITLE     A homeobox gene, vax2, controls the patterning of the eye
            dorsoventral axis
  JOURNAL   Proc Natl Acad Sci U S A 96 (19), 10729-10734 (1999)
   PUBMED   10485894
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Apr 3, 2024 this sequence version replaced NM_022637.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF113516.1, SRR26643286.14066.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760476, SAMN11044071
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-295               JAXUCZ010000004.1  117753180-117753474
            296-483             JAXUCZ010000004.1  117773128-117773315
            484-1284            JAXUCZ010000004.1  117776442-117777242
FEATURES             Location/Qualifiers
     source          1..1284
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     gene            1..1284
                     /gene="Vax2"
                     /note="ventral anterior homeobox 2"
                     /db_xref="GeneID:64572"
                     /db_xref="RGD:621133"
     exon            1..295
                     /gene="Vax2"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..927
                     /gene="Vax2"
                     /note="ventral anterior homeobox containing gene 2"
                     /codon_start=1
                     /product="ventral anterior homeobox 2"
                     /protein_id="NP_072159.2"
                     /db_xref="GeneID:64572"
                     /db_xref="RGD:621133"
                     /translation="

MGDGGAERDRGPKRREEPGGRSGCRGEHRGAEDLRADTGSTSPREIAGTSASSPAGSRESGGDSDGQQALGETDHCRRILVRDAKGTIREIVLPKGLDLDRPKRTRTSFTAEQLYRLEMEFQRCQYVVGRERTELARQLNLSETQVKVWFQNRRTKQKKDQSRDLEKRASSSASEAFATSNVLRLLEQGRLLSVPRAPSLLALSPGLPGLTAGHRGTSLGDPRNSSQRLNPMPSASASSPLPPPLPAVCFSAAPLLDLPASYKLGSSAFEPYSRLEQQKVGSPGQSDKKADI"

     misc_feature    268..351
                     /gene="Vax2"
                     /note="Region: vax upstream domain"
     misc_feature    352..531
                     /gene="Vax2"
                     /note="Region: homeobox"
     misc_feature    355..525
                     /gene="Vax2"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     misc_feature    592..627
                     /gene="Vax2"
                     /note="Region: vax downstream domain"
     misc_feature    682..771
                     /gene="Vax2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JLZ9.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    844..870
                     /gene="Vax2"
                     /note="Region: vax terminal domain"
     exon            296..483
                     /gene="Vax2"
                     /inference="alignment:Splign:2.1.0"
     exon            484..1284
                     /gene="Vax2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gagccaggactagcggctgctgtgggccaggcagcagtggcggcgggcatgggcgatgggggcgcggagcgggaccgcggccccaagcgccgggaggagcctggtggccgcagcgggtgtcgtggggagcaccgcggagcggaagatttgcgtgctgacacgggtagcacgagtccgagggagattgctgggacctccgcctccagccctgcaggctccagggagagcggcggggacagcgacggacaacaggcgctcggtgagacggaccactgccgccgcatcctggtacgagatgccaaggggaccattcgggaaattgtcctgcccaagggcctggacctcgaccgacccaagaggacccgtacctccttcacagcagaacagctgtatcgtttggagatggagttccagcgctgccagtatgtggtgggccgagagcgcacagagctggcccgccagctgaacctctctgagactcaggtgaaggtctggttccagaaccgccgcaccaagcagaagaaggaccagagcagagacctggaaaagcgggcatcctcctccgcctccgaggcctttgccacctccaacgttctgcgacttctggaacagggccggctgctctccgtgcccagagctcccagcctcctagcactgagccctggcctgccaggtctaaccgctggccacaggggcacctccttgggtgaccccaggaactcctcccaacgcctcaatccaatgccctcagcctcagcgtcgtcccctctgccaccccctctgccagccgtctgcttttccgcagctccactcctggacttgcccgccagctacaaactggggtcctcggcttttgagccctacagcagactagaacaacagaaagtaggcagccctggccaaagtgacaagaaagctgacatttaagagtcccatccccgtgtgacactgagtccccagcacagcactaccctagcctcctggcccctgtggactatactgagcaggcctggaagaggaaggatgggcacagcatgagcctctccacctgccctcagctcagagactgaaccaaaatgactttgtactctctgatgtgtgagtgctatgtgcgtgcgtgcgtgtgtgcgtgtgtgtgtgcgtgcgtgtgtgcgtgtgtgtgtgcatgagaaagagagagagagagagagggagagagagagagagagagagagagagagagagagagagagagagaatgtgtcactgaaataaagaagggaactgtcccagcatcaccaactc

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