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Previous release (v1)
2024-04-19 02:40:24, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NM_022528 2065 bp mRNA linear ROD 23-AUG-2023
DEFINITION Rattus norvegicus hypoxia inducible factor 3 subunit alpha (Hif3a),
transcript variant 1, mRNA.
ACCESSION NM_022528
VERSION NM_022528.3
KEYWORDS RefSeq.
SOURCE Rattus norvegicus (Norway rat)
ORGANISM Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
REFERENCE 1 (bases 1 to 2065)
AUTHORS Xu Y, Hu T, Ding H, Yuan Y and Chen R.
TITLE miR-485-5p alleviates obstructive sleep apnea syndrome with
hypertension by inhibiting PI3K/AKT signaling pathway via
downregulating HIF3A expression
JOURNAL Sleep Breath 27 (1), 109-119 (2023)
PUBMED 35132534
REMARK GeneRIF: miR-485-5p alleviates obstructive sleep apnea syndrome
with hypertension by inhibiting PI3K/AKT signaling pathway via
downregulating HIF3A expression.
REFERENCE 2 (bases 1 to 2065)
AUTHORS Yang M, Yan X, Yuan FZ, Ye J, Du MZ, Mao ZM, Xu BB, Chen YR, Song
YF, Fan BS and Yu JK.
TITLE MicroRNA-210-3p Promotes Chondrogenic Differentiation and Inhibits
Adipogenic Differentiation Correlated with HIF-3alpha Signalling in
Bone Marrow Mesenchymal Stem Cells
JOURNAL Biomed Res Int 2021, 6699910 (2021)
PUBMED 33937412
REMARK GeneRIF: MicroRNA-210-3p Promotes Chondrogenic Differentiation and
Inhibits Adipogenic Differentiation Correlated with HIF-3alpha
Signalling in Bone Marrow Mesenchymal Stem Cells.
Publication Status: Online-Only
REFERENCE 3 (bases 1 to 2065)
AUTHORS Coelho NR, Tomkiewicz C, Correia MJ, Goncalves-Dias C, Barouki R,
Pereira SA, Coumoul X and Monteiro EC.
TITLE First evidence of aryl hydrocarbon receptor as a druggable target
in hypertension induced by chronic intermittent hypoxia
JOURNAL Pharmacol Res 159, 104869 (2020)
PUBMED 32416216
REFERENCE 4 (bases 1 to 2065)
AUTHORS Drevytska T, Gonchar E, Okhai I, Lynnyk O, Mankovska I, Klionsky D
and Dosenko V.
TITLE The protective effect of Hif3a RNA interference and HIF-prolyl
hydroxylase inhibition on cardiomyocytes under anoxia-reoxygenation
JOURNAL Life Sci 202, 131-139 (2018)
PUBMED 29660430
REMARK GeneRIF: Hif3a RNA interference and HIF-prolyl hydroxylase
inhibition protect cardiomyocytes against anoxia-reoxygenation
injury via the HIF signaling pathway
REFERENCE 5 (bases 1 to 2065)
AUTHORS Cuomo F, Coppola A, Botti C, Maione C, Forte A, Scisciola L,
Liguori G, Caiafa I, Ursini MV, Galderisi U, Cipollaro M, Altucci L
and Cobellis G.
TITLE Pro-inflammatory cytokines activate hypoxia-inducible factor 3alpha
via epigenetic changes in mesenchymal stromal/stem cells
JOURNAL Sci Rep 8 (1), 5842 (2018)
PUBMED 29643458
REMARK GeneRIF: Study in human mesenchymal stromal/stem cells revealed
robust hypermethylation of histone H3 across HIF3A locus driven by
pro-inflammatory cytokines. Experiments in a murine model of
arteriotomy highlighted the activation of Hif3alpha expression in
infiltrated inflammatory cells, suggesting a new role for Hif3alpha
in inflammation in vivo.
Erratum:[Sci Rep. 2020 Apr 17;10(1):6776. PMID: 32303693]
Publication Status: Online-Only
REFERENCE 6 (bases 1 to 2065)
AUTHORS Li QF and Dai AG.
TITLE Differential expression of three hypoxia-inducible factor-alpha
subunits in pulmonary arteries of rat with hypoxia-induced
hypertension
JOURNAL Acta Biochim Biophys Sin (Shanghai) 37 (10), 665-672 (2005)
PUBMED 16215633
REMARK GeneRIF: HIF-1alpha, HIF-2alpha and HIF-3alpha may not only confer
different target genes, but also play key pathogenetic roles in
hypoxic-induced pulmonary hypertension.
REFERENCE 7 (bases 1 to 2065)
AUTHORS Heidbreder M, Frohlich F, Johren O, Dendorfer A, Qadri F and
Dominiak P.
TITLE Hypoxia rapidly activates HIF-3alpha mRNA expression
JOURNAL FASEB J 17 (11), 1541-1543 (2003)
PUBMED 12824304
REMARK GeneRIF: Hypoxia rapidly activates HIF-3alpha mRNA expression
REFERENCE 8 (bases 1 to 2065)
AUTHORS Hara S, Hamada J, Kobayashi C, Kondo Y and Imura N.
TITLE Expression and characterization of hypoxia-inducible factor
(HIF)-3alpha in human kidney: suppression of HIF-mediated gene
expression by HIF-3alpha
JOURNAL Biochem Biophys Res Commun 287 (4), 808-813 (2001)
PUBMED 11573933
REFERENCE 9 (bases 1 to 2065)
AUTHORS Kietzmann T, Cornesse Y, Brechtel K, Modaressi S and Jungermann K.
TITLE Perivenous expression of the mRNA of the three hypoxia-inducible
factor alpha-subunits, HIF1alpha, HIF2alpha and HIF3alpha, in rat
liver
JOURNAL Biochem J 354 (Pt 3), 531-537 (2001)
PUBMED 11237857
REFERENCE 10 (bases 1 to 2065)
AUTHORS Gu YZ, Moran SM, Hogenesch JB, Wartman L and Bradfield CA.
TITLE Molecular characterization and chromosomal localization of a third
alpha-class hypoxia inducible factor subunit, HIF3alpha
JOURNAL Gene Expr 7 (3), 205-213 (1998)
PUBMED 9840812
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
JACYVU010000033.1.
On Nov 25, 2020 this sequence version replaced NM_022528.2.
Sequence Note: The RefSeq transcript and protein were derived from
genomic sequence to make the sequence consistent with the reference
genome assembly. The genomic coordinates used for the transcript
record were based on alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AJ277827.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
SAMD00132261, SAMD00132273
[ECO:0000350]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-23 JACYVU010000033.1 1620955-1620977 c
24-214 JACYVU010000033.1 1620642-1620832 c
215-360 JACYVU010000033.1 1619128-1619273 c
361-445 JACYVU010000033.1 1616751-1616835 c
446-558 JACYVU010000033.1 1615871-1615983 c
559-767 JACYVU010000033.1 1615303-1615511 c
768-874 JACYVU010000033.1 1613116-1613222 c
875-1022 JACYVU010000033.1 1612714-1612861 c
1023-1135 JACYVU010000033.1 1609228-1609340 c
1136-1326 JACYVU010000033.1 1608245-1608435 c
1327-1428 JACYVU010000033.1 1606035-1606136 c
1429-1700 JACYVU010000033.1 1604036-1604307 c
1701-1812 JACYVU010000033.1 1602553-1602664 c
1813-1894 JACYVU010000033.1 1600954-1601035 c
1895-2065 JACYVU010000033.1 1599425-1599595 c
FEATURES Location/Qualifiers
source 1..2065
/organism="Rattus norvegicus"
/mol_type="mRNA"
/strain="BN"
/db_xref="taxon:10116"
/chromosome="1"
/map="1q21"
gene 1..2065
/gene="Hif3a"
/gene_synonym="Ipas; Mop7"
/note="hypoxia inducible factor 3 subunit alpha"
/db_xref="GeneID:64345"
/db_xref="RGD:70332"
exon 1..23
/gene="Hif3a"
/gene_synonym="Ipas; Mop7"
/inference="alignment:Splign:2.1.0"
CDS 4..1992
/gene="Hif3a"
/gene_synonym="Ipas; Mop7"
/function="transcription factor"
/note="isoform 1 is encoded by transcript variant 1;
HIF3-alpha; HIF-3-alpha; HIF3-alpha-1; hypoxia inducible
factor 3, alpha subunit; hypoxia inducible factor 3a;
Inhibitory PAS (Per/Arnt/Sim) domain protein;
hypoxia-inducible factor 3-alpha"
/codon_start=1
/product="hypoxia-inducible factor 3-alpha isoform 1"
/protein_id="NP_071973.2"
/db_xref="GeneID:64345"
/db_xref="RGD:70332"
/translation="
MDWDQDRSSTELRKEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMHRLCAAGEWNQVGKEGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELIGHSIFDFIHPCDQEELQDALTPRPSLSKKKSEAATGRHFSLRMKSTLTSRGRTLNLKAATWKVLHCSGHMRAYKPPAQTSPAGSPRSEPPLQCLVLICEAIPHPASLEPPLGRGAFLSRHSLDMKFTYCDERIAEVAGYSPDDLIGCSAYEYIHALDSDAVSRSIHTLLSKGQAVTGQYRFLARTGGYLWTQTQATVVSGGRGPQSESIICVHFLISRVEENGVVLSLEQTEQHTRRPPQLGTSSKKGIPGNSLDPPAPRILAFLHPPALSEASLAADPRRFCSPDLRRLMAPILDGPPTAATPSTPQAARRPQSPLPADLPDQLAVGLENAHRLSTARKNKTMETDLDIAQDPDTLDLEMLAPYISMDDDFQLNSSEQLPKVHRRPPRTARRPRARSFHGLSPPIPEATLLPRWGSDPRLNCSSSSKGDPPTAPLTPRTRKRALAQSSEDKGLELLETKPPKRSPRLEPGSVLLPPLSLSFLLQGRQLPGNQPDPRAPLVDSHEPLGLAPSLLSLYQHEETIQPRNHFLPAAGLAQTH"
misc_feature 4..78
/gene="Hif3a"
/gene_synonym="Ipas; Mop7"
/note="propagated from UniProtKB/Swiss-Prot (Q9JHS2.1);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 31..219
/gene="Hif3a"
/gene_synonym="Ipas; Mop7"
/note="basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS)
domain found in hypoxia-inducible factor 3-alpha (HIF3a)
and similar proteins; Region: bHLH-PAS_HIF3a_PASD7;
cd19729"
/db_xref="CDD:381572"
misc_feature order(40..45,49..57,64..69,73..78,151..156)
/gene="Hif3a"
/gene_synonym="Ipas; Mop7"
/note="putative DNA binding site [nucleotide binding];
other site"
/db_xref="CDD:381572"
misc_feature order(82..87,91..96,103..108,115..120,151..159,166..171,
178..180,187..192,199..201)
/gene="Hif3a"
/gene_synonym="Ipas; Mop7"
/note="putative dimer interface [polypeptide binding];
other site"
/db_xref="CDD:381572"
misc_feature 226..297
/gene="Hif3a"
/gene_synonym="Ipas; Mop7"
/note="propagated from UniProtKB/Swiss-Prot (Q9JHS2.1);
Region: Nuclear localization signal.
/evidence=ECO:0000250|UniProtKB:Q0VBL6"
misc_feature 265..432
/gene="Hif3a"
/gene_synonym="Ipas; Mop7"
/note="PAS domain; Region: PAS; smart00091"
/db_xref="CDD:214512"
misc_feature 685..819
/gene="Hif3a"
/gene_synonym="Ipas; Mop7"
/note="propagated from UniProtKB/Swiss-Prot (Q9JHS2.1);
Region: Nuclear export signal.
/evidence=ECO:0000250|UniProtKB:Q0VBL6"
misc_feature 748..1011
/gene="Hif3a"
/gene_synonym="Ipas; Mop7"
/note="PAS fold; Region: PAS_3; pfam08447"
/db_xref="CDD:430001"
misc_feature order(757..759,769..771,787..789,826..837,913..915,
928..930)
/gene="Hif3a"
/gene_synonym="Ipas; Mop7"
/note="putative active site [active]"
/db_xref="CDD:238075"
misc_feature order(817..819,829..831,853..855,862..867,949..951,
955..957)
/gene="Hif3a"
/gene_synonym="Ipas; Mop7"
/note="heme pocket [chemical binding]; other site"
/db_xref="CDD:238075"
misc_feature 1057..1140
/gene="Hif3a"
/gene_synonym="Ipas; Mop7"
/note="propagated from UniProtKB/Swiss-Prot (Q9JHS2.1);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature <1075..1896
/gene="Hif3a"
/gene_synonym="Ipas; Mop7"
/note="large tegument protein UL36; Provisional; Region:
PHA03247"
/db_xref="CDD:223021"
misc_feature 1231..1242
/gene="Hif3a"
/gene_synonym="Ipas; Mop7"
/note="propagated from UniProtKB/Swiss-Prot (Q9JHS2.1);
Region: LRRLL"
misc_feature 1252..1338
/gene="Hif3a"
/gene_synonym="Ipas; Mop7"
/note="propagated from UniProtKB/Swiss-Prot (Q9JHS2.1);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 1345..1746
/gene="Hif3a"
/gene_synonym="Ipas; Mop7"
/note="propagated from UniProtKB/Swiss-Prot (Q9JHS2.1);
Region: ODD"
misc_feature 1351..1506
/gene="Hif3a"
/gene_synonym="Ipas; Mop7"
/note="propagated from UniProtKB/Swiss-Prot (Q9JHS2.1);
Region: NTAD"
misc_feature 1378..1443
/gene="Hif3a"
/gene_synonym="Ipas; Mop7"
/note="propagated from UniProtKB/Swiss-Prot (Q9JHS2.1);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 1426..1515
/gene="Hif3a"
/gene_synonym="Ipas; Mop7"
/note="Hypoxia-inducible factor-1; Region: HIF-1;
pfam11413"
/db_xref="CDD:431874"
misc_feature 1456..1479
/gene="Hif3a"
/gene_synonym="Ipas; Mop7"
/note="propagated from UniProtKB/Swiss-Prot (Q9JHS2.1);
Region: LAPYISMD"
misc_feature 1462..1464
/gene="Hif3a"
/gene_synonym="Ipas; Mop7"
/note="4-hydroxyproline. /evidence=ECO:0000250; propagated
from UniProtKB/Swiss-Prot (Q9JHS2.1); hydroxylation site"
misc_feature 1501..1788
/gene="Hif3a"
/gene_synonym="Ipas; Mop7"
/note="propagated from UniProtKB/Swiss-Prot (Q9JHS2.1);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
exon 24..214
/gene="Hif3a"
/gene_synonym="Ipas; Mop7"
/inference="alignment:Splign:2.1.0"
exon 215..360
/gene="Hif3a"
/gene_synonym="Ipas; Mop7"
/inference="alignment:Splign:2.1.0"
exon 361..445
/gene="Hif3a"
/gene_synonym="Ipas; Mop7"
/inference="alignment:Splign:2.1.0"
exon 446..558
/gene="Hif3a"
/gene_synonym="Ipas; Mop7"
/inference="alignment:Splign:2.1.0"
exon 559..767
/gene="Hif3a"
/gene_synonym="Ipas; Mop7"
/inference="alignment:Splign:2.1.0"
exon 768..874
/gene="Hif3a"
/gene_synonym="Ipas; Mop7"
/inference="alignment:Splign:2.1.0"
exon 875..1022
/gene="Hif3a"
/gene_synonym="Ipas; Mop7"
/inference="alignment:Splign:2.1.0"
exon 1023..1135
/gene="Hif3a"
/gene_synonym="Ipas; Mop7"
/inference="alignment:Splign:2.1.0"
exon 1136..1326
/gene="Hif3a"
/gene_synonym="Ipas; Mop7"
/inference="alignment:Splign:2.1.0"
exon 1327..1428
/gene="Hif3a"
/gene_synonym="Ipas; Mop7"
/inference="alignment:Splign:2.1.0"
exon 1429..1700
/gene="Hif3a"
/gene_synonym="Ipas; Mop7"
/inference="alignment:Splign:2.1.0"
exon 1701..1812
/gene="Hif3a"
/gene_synonym="Ipas; Mop7"
/inference="alignment:Splign:2.1.0"
exon 1813..1894
/gene="Hif3a"
/gene_synonym="Ipas; Mop7"
/inference="alignment:Splign:2.1.0"
exon 1895..2065
/gene="Hif3a"
/gene_synonym="Ipas; Mop7"
/inference="alignment:Splign:2.1.0"
ORIGIN
cacatggactgggaccaagacaggtcgagcaccgagctgcggaaggagaagtcgcgggatgcggcccgcagcaggcgcagccaggagacggaggtgctgtaccaactggcgcacaccctgccctttgcgcgcggcgtcagcgcgcacctggacaaggcctccatcatgcgcctcacaatcagctacttgcgcatgcaccgcctctgcgctgcaggggagtggaaccaggtgggaaaagagggagaaccactggacgcctgctacctgaaggccctggagggtttcgtcatggtgctcaccgctgagggagacatggcttacctgtcggaaaatgtcagcaagcacctgggcctcagtcagctggagctcattggacacagtatctttgattttatccatccctgtgaccaagaggaactccaggatgccctgaccccgagaccaagcctgtcaaagaagaagtcagaagcagcaacaggacgccacttttccctgcgaatgaagagcacactcaccagcagggggcgcacgctgaacctcaaagcggccacctggaaggtgctgcactgctcaggacatatgagggcctacaagccccctgcacagacttcccccgccgggagccctcgctccgagcctcccctgcaatgcctggtgcttatctgtgaagccatcccccacccagccagtctggagcccccactgggccgaggggcctttctcagtcgccacagcctggacatgaagttcacatactgcgacgagaggattgcagaagttgctggctacagccccgatgacctgattggctgttctgcctatgaatacatccacgctttggactctgatgcagtcagcaggagcatccacactttgctgagcaagggccaggcagtaacagggcagtatcgcttcctggcccggactggaggctatctgtggactcagactcaggctacagtggtgtcaggggggcggggcccccagtcggaaagtatcatctgcgtccacttcctgatcagccgtgtagaagagaacggagtggtgctgtccctggaacaaacggagcaacatactcgcagaccccctcagctgggtacctcctcgaagaagggtatcccaggcaacagtctagaccctcccgctccacggatcctggccttcctgcaccctccagccctgagtgaggcctccctggctgctgaccctcgccgtttttgtagcccagacctgcgccgcctcatggcacccatcctggatggacctcccacagccgctacccccagcaccccgcaagctgcacggagaccccaaagtcctcttccggctgatctcccagatcagttggctgtgggcttggagaatgcacacagactctccactgcccggaaaaacaagaccatggagacagatctagatatagctcaggaccctgacactctggacttggagatgttggctccgtacatctccatggatgatgacttccagctcaactccagcgagcaattgcccaaagtccaccgcagacctcccaggacggcccgcaggcctcgtgctcggagcttccatggcctgtcgcctcccatccctgaggccaccctgctgccccgctgggggagtgatccacgactgaactgttccagctcctccaagggggatccccccacagcccccctgacgcctagaactcggaagagggccttggcccagagctcagaggacaaagggttggagctgctggaaacgaagccccccaagcggtccccaagactagaacctggaagtgtcctgctgcctccgctcagcctgagtttccttctgcaaggtcgacaacttccagggaaccagccggatcccagagccccactcgtggattcgcatgagcccttgggcctagctccctcgctgctctctctctaccagcatgaggaaactatccagcccaggaaccacttcctcccagcagcaggcttggcccagacacactgagtcagccttcctctcagccctcttcttctaccccagaaaggactcagccgcactccacaccagcagcctacac
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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