LOCUS       NM_022512               1748 bp    mRNA    linear   ROD 15-SEP-2023
DEFINITION  Rattus norvegicus acyl-CoA dehydrogenase short chain (Acads), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_022512
VERSION     NM_022512.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1748)
  AUTHORS   Zhong X, Li Z, Xu Q, Peng H, Su Y, Le K, Shu Z, Liao Y, Ma Z, Pan
            X, Xu S and Zhou S.
  TITLE     Short-chain acyl-CoA dehydrogenase is a potential target for the
            treatment of vascular remodelling
  JOURNAL   J Hypertens 41 (5), 775-793 (2023)
   PUBMED   36883465
  REMARK    GeneRIF: Short-chain acyl-CoA dehydrogenase is a potential target
            for the treatment of vascular remodelling.
REFERENCE   2  (bases 1 to 1748)
  AUTHORS   Zeng Z, Huang Q, Shu Z, Liu P, Chen S, Pan X, Zang L and Zhou S.
  TITLE     Effects of short-chain acyl-CoA dehydrogenase on cardiomyocyte
            apoptosis
  JOURNAL   J Cell Mol Med 20 (7), 1381-1391 (2016)
   PUBMED   26989860
  REMARK    GeneRIF: the role of SCAD in tert-butyl hydroperoxide
            (tBHP)-induced cardiomyocyte apoptosis, is reported.
REFERENCE   3  (bases 1 to 1748)
  AUTHORS   Huang J, Xu L, Huang Q, Luo J, Liu P, Chen S, Yuan X, Lu Y, Wang P
            and Zhou S.
  TITLE     Changes in short-chain acyl-coA dehydrogenase during rat cardiac
            development and stress
  JOURNAL   J Cell Mol Med 19 (7), 1672-1688 (2015)
   PUBMED   25753319
  REMARK    GeneRIF: the down-regulated expression of SCAD in pathological
            cardiac hypertrophy may be responsible for 'the recapitulation of
            foetal energy metabolism'.
REFERENCE   4  (bases 1 to 1748)
  AUTHORS   Huang Q, Huang J, Zeng Z, Luo J, Liu P, Chen S, Liu B, Pan X, Zang
            L and Zhou S.
  TITLE     Effects of ERK1/2/PPARalpha/SCAD signal pathways on cardiomyocyte
            hypertrophy induced by insulin-like growth factor 1 and
            phenylephrine
  JOURNAL   Life Sci 124, 41-49 (2015)
   PUBMED   25636810
  REMARK    GeneRIF: the phosphorylation of ERK1/2 inhibited the expression and
            activity of SCAD through the PPARalpha signaling pathway, which
            induced the development of pathological cardiomyocyte hypertrophy.
REFERENCE   5  (bases 1 to 1748)
  AUTHORS   de Mateo S, Castillo J, Estanyol JM, Ballesca JL and Oliva R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   6  (bases 1 to 1748)
  AUTHORS   Matsubara Y, Indo Y, Naito E, Ozasa H, Glassberg R, Vockley J,
            Ikeda Y, Kraus J and Tanaka K.
  TITLE     Molecular cloning and nucleotide sequence of cDNAs encoding the
            precursors of rat long chain acyl-coenzyme A, short chain
            acyl-coenzyme A, and isovaleryl-coenzyme A dehydrogenases. Sequence
            homology of four enzymes of the acyl-CoA dehydrogenase family
  JOURNAL   J Biol Chem 264 (27), 16321-16331 (1989)
   PUBMED   2777793
REFERENCE   7  (bases 1 to 1748)
  AUTHORS   Finocchiaro,G., Ito,M. and Tanaka,K.
  TITLE     Purification and properties of short chain acyl-CoA, medium chain
            acyl-CoA, and isovaleryl-CoA dehydrogenases from human liver
  JOURNAL   J Biol Chem 262 (17), 7982-7989 (1987)
   PUBMED   3597357
REFERENCE   8  (bases 1 to 1748)
  AUTHORS   Ikeda,Y., Keese,S.M., Fenton,W.A. and Tanaka,K.
  TITLE     Biosynthesis of four rat liver mitochondrial acyl-CoA
            dehydrogenases: in vitro synthesis, import into mitochondria, and
            processing of their precursors in a cell-free system and in
            cultured cells
  JOURNAL   Arch Biochem Biophys 252 (2), 662-674 (1987)
   PUBMED   3813556
REFERENCE   9  (bases 1 to 1748)
  AUTHORS   Coulson,A.
  TITLE     Treatment of metritis in cattle with prostaglandin F2 alpha
  JOURNAL   Vet Rec 103 (16), 359 (1978)
   PUBMED   734878
REFERENCE   10 (bases 1 to 1748)
  AUTHORS   Dabrowski,Z., Gregorczyk,J., Samochowiec,L., Wojcicki,J.,
            Lawczynski,L., Antoszczyk,M., Chrzanowska-Ansilewska,K., Jurek,D.
            and Sych,Z.
  TITLE     [Effect of truncal vagotomy on the exocrine function of the
            pancreas in the dog]
  JOURNAL   Pol Tyg Lek 33 (28), 1093-1095 (1978)
   PUBMED   704405
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from J05030.1.
            
            On Aug 31, 2012 this sequence version replaced NM_022512.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J05030.1, BC072545.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1748              J05030.1           2-1749
FEATURES             Location/Qualifiers
     source          1..1748
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..1748
                     /gene="Acads"
                     /gene_synonym="Scad"
                     /note="acyl-CoA dehydrogenase short chain"
                     /db_xref="GeneID:64304"
                     /db_xref="RGD:620514"
     exon            1..78
                     /gene="Acads"
                     /gene_synonym="Scad"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..1271
                     /gene="Acads"
                     /gene_synonym="Scad"
                     /EC_number="1.3.8.1"
                     /note="short-chain specific acyl-CoA dehydrogenase,
                     mitochondrial; butyryl-CoA dehydrogenase; short chain
                     acyl-coenzyme A dehydrogenase; acetyl-Coenzyme A
                     dehydrogenase, short chain; short-chain acyl-CoA
                     dehydrogenase; acyl-Coenzyme A dehydrogenase, short chain;
                     acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain;
                     acyl-CoA dehydrogenase, C-2 to C-3 short chain"
                     /codon_start=1
                     /product="short-chain specific acyl-CoA dehydrogenase,
                     mitochondrial precursor"
                     /protein_id="NP_071957.1"
                     /db_xref="GeneID:64304"
                     /db_xref="RGD:620514"
                     /translation="

MAMAAALLARAGGSLGRALRARDWRRLHTVYQSVELPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVPEELSGAGLDYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDKIGCFALSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQNKGISAFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQTLDMGRIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARLLTWRAAMLKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARITEIYEGTSEIQRLVIAGHLLRSYRS"

     sig_peptide     27..104
                     /gene="Acads"
                     /gene_synonym="Scad"
                     /note="short chain acyl-CoA dehydrogenase signal peptide"
     mat_peptide     105..1268
                     /gene="Acads"
                     /gene_synonym="Scad"
                     /product="short-chain specific acyl-CoA dehydrogenase,
                     mitochondrial"
     misc_feature    138..1256
                     /gene="Acads"
                     /gene_synonym="Scad"
                     /note="Short chain acyl-CoA dehydrogenases and eukaryotic
                     short/branched chain acyl-CoA dehydrogenases; Region:
                     SCAD_SBCAD; cd01158"
                     /db_xref="CDD:173847"
     misc_feature    order(486..488,495..497,513..515,585..587,591..593,
                     1125..1127,1137..1139,1206..1208)
                     /gene="Acads"
                     /gene_synonym="Scad"
                     /note="FAD binding site [chemical binding]; other site"
                     /db_xref="CDD:173847"
     misc_feature    order(501..503,516..518,585..587,714..728,921..923,
                     930..932,957..959,969..974,978..980,987..989,1011..1013,
                     1080..1082,1113..1115,1125..1127,1140..1142,1146..1148,
                     1152..1157,1167..1169,1176..1181,1188..1193,1197..1199,
                     1218..1220,1227..1229,1236..1238)
                     /gene="Acads"
                     /gene_synonym="Scad"
                     /note="homotetramer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:173847"
     misc_feature    order(513..518,825..827,834..839,846..848,930..932,
                     1206..1208)
                     /gene="Acads"
                     /gene_synonym="Scad"
                     /note="substrate binding pocket [chemical binding]; other
                     site"
                     /db_xref="CDD:173847"
     misc_feature    1206..1208
                     /gene="Acads"
                     /gene_synonym="Scad"
                     /note="catalytic base [active]"
                     /db_xref="CDD:173847"
     exon            79..242
                     /gene="Acads"
                     /gene_synonym="Scad"
                     /inference="alignment:Splign:2.1.0"
     exon            243..392
                     /gene="Acads"
                     /gene_synonym="Scad"
                     /inference="alignment:Splign:2.1.0"
     exon            393..504
                     /gene="Acads"
                     /gene_synonym="Scad"
                     /inference="alignment:Splign:2.1.0"
     exon            505..656
                     /gene="Acads"
                     /gene_synonym="Scad"
                     /inference="alignment:Splign:2.1.0"
     exon            657..827
                     /gene="Acads"
                     /gene_synonym="Scad"
                     /inference="alignment:Splign:2.1.0"
     exon            828..965
                     /gene="Acads"
                     /gene_synonym="Scad"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1061
                     /gene="Acads"
                     /gene_synonym="Scad"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1118
                     /gene="Acads"
                     /gene_synonym="Scad"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1748
                     /gene="Acads"
                     /gene_synonym="Scad"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

tcaggaggtcccggaggtctgtgcccatggccatggccgctgcgttgctcgcccgggccggtggctctctcggcagagctctccgcgctcgagattggcgaagattacatactgtttaccagtctgtggaactacctgagacacatcagatgttgcgccagacatgccgggactttgctgagaaggagctggtccccatcgctgcccagctggacaaggaacatctcttccccacatcgcaggtgaagaagatgggggagctcgggctgctggccatggatgtgccagaggagctgagtggtgctggcctggattacctggcctactcgatcgccctggaggagatcagccgtggctgcgcctccaccggagtgatcatgagtgtcaacaactctctctacttgggacccatcctgaagttcggatcctcacagcagaagcagcagtggatcacccctttcaccaacggtgacaaaatcggctgttttgccctcagtgagccaggcaatggcagtgacgcgggggccgcttccaccactgcccgggaagagggtgactcctgggtcctcaacggcaccaaagcctggatcaccaactcctgggaggcttctgccacggtggtgtttgctagcaccgacaggtcccggcagaacaagggtatcagcgctttcctggttcccatgccaactcctgggcttacgctgggcaaaaaggaagacaagctgggcatccgggcctcatctacagctaacctcatctttgaggactgtcgcatccccaaggagaacctgctcggcgagcctgggatgggcttcaagatagccatgcaaaccctggacatgggccgcattggcatcgcctcccaggccctgggtattgcccaggcctccctggattgtgccgtgaagtacgccgagaaccgccatgcctttggggcacccctcacaaagctccaaaacatccagttcaagctggcagacatggccctggccctggagagtgcccgcctgctgacctggcgcgccgccatgttgaaggacaataagaagcctttcaccaaggagtcggccatggccaagctggctgcatcagaggctgctactgccattagccaccaggccatccagatcctgggcggcatggggtacgtgacagagatgccagccgagcgctactaccgagatgcccgcatcactgagatctatgaaggtaccagcgaaatccagagactggtgattgccgggcatctgctccggagctaccggagctgagcccccgcccttcttgggaacttgccagcctgctcagaccatgaagggacctgcctcggtcagcctttctgcccctcactgtagcccccagtcagactaggggaaagtctgtctcagggagagggaaggtcaaccgctgtgacctgtcagctcagaatggggcggcgtggctacctctttaccccccaccaacagtgcctctctctttgagcgacctgctggaggcagggccacagagacctgaatgaccctggccctcccaatgcggatgccgttcccaagagtcctcagaggcaagaacaggaggggcagggcggggtgaggaggggaaggggatggcccagtgcttgagtccccagggttgtcgtgggaaggctggggaaccggatcatagggccctggctagaggtcaagtggccgcaggtggttctgtggctgtagagctgcctgtggtcaataaagctcacctgtgtcctg

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