LOCUS       NM_022399               1865 bp    mRNA    linear   ROD 12-NOV-2023
DEFINITION  Rattus norvegicus calreticulin (Calr), mRNA.
ACCESSION   NM_022399
VERSION     NM_022399.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1865)
  AUTHORS   Yoshie M, Kusama K, Tanaka R, Okubo T, Kojima J, Takaesu Y, Isaka
            K, Nishi H and Tamura K.
  TITLE     Possible Roles of Calreticulin in Uterine Decidualization and
            Receptivity in Rats and Humans
  JOURNAL   Int J Mol Sci 22 (19), 10505 (2021)
   PUBMED   34638846
  REMARK    GeneRIF: Possible Roles of Calreticulin in Uterine Decidualization
            and Receptivity in Rats and Humans.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1865)
  AUTHORS   Ye J, Qi L, Du Z, Yu L, Chen K, Li R, Feng R and Zhai W.
  TITLE     Calreticulin: a potential diagnostic and therapeutic biomarker in
            gallbladder cancer
  JOURNAL   Aging (Albany NY) 13 (4), 5607-5620 (2021)
   PUBMED   33591948
REFERENCE   3  (bases 1 to 1865)
  AUTHORS   Sheng W, Wang G, Tang J, Shi X, Cao R, Sun J, Lin YH, Jia C, Chen
            C, Zhou J and Dong M.
  TITLE     Calreticulin promotes EMT in pancreatic cancer via mediating Ca2+
            dependent acute and chronic endoplasmic reticulum stress
  JOURNAL   J Exp Clin Cancer Res 39 (1), 209 (2020)
   PUBMED   33028359
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1865)
  AUTHORS   Zhang X, Wang D, Li Z, Jiao D, Jin L, Cong J, Zheng X and Xu L.
  TITLE     Low-Dose Gemcitabine Treatment Enhances Immunogenicity and Natural
            Killer Cell-Driven Tumor Immunity in Lung Cancer
  JOURNAL   Front Immunol 11, 331 (2020)
   PUBMED   32161598
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1865)
  AUTHORS   Ye D, Zhu J, Zhao Q, Ma W, Xiao Y, Xu G and Zhang Z.
  TITLE     LMP1 Up-regulates Calreticulin to Induce Epithelial-mesenchymal
            Transition via TGF-beta/Smad3/NRP1 Pathway in Nasopharyngeal
            Carcinoma Cells
  JOURNAL   J Cancer 11 (5), 1257-1269 (2020)
   PUBMED   31956372
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1865)
  AUTHORS   Nakamura M, Michikawa Y, Baba T, Okinaga S and Arai K.
  TITLE     Calreticulin is present in the acrosome of spermatids of rat testis
  JOURNAL   Biochem Biophys Res Commun 186 (2), 668-673 (1992)
   PUBMED   1497655
REFERENCE   7  (bases 1 to 1865)
  AUTHORS   Rojiani MV, Finlay BB, Gray V and Dedhar S.
  TITLE     In vitro interaction of a polypeptide homologous to human Ro/SS-A
            antigen (calreticulin) with a highly conserved amino acid sequence
            in the cytoplasmic domain of integrin alpha subunits
  JOURNAL   Biochemistry 30 (41), 9859-9866 (1991)
   PUBMED   1911778
REFERENCE   8  (bases 1 to 1865)
  AUTHORS   Treves S, De Mattei M, Landfredi M, Villa A, Green NM, MacLennan
            DH, Meldolesi J and Pozzan T.
  TITLE     Calreticulin is a candidate for a calsequestrin-like function in
            Ca2(+)-storage compartments (calciosomes) of liver and brain
  JOURNAL   Biochem J 271 (2), 473-480 (1990)
   PUBMED   2241926
REFERENCE   9  (bases 1 to 1865)
  AUTHORS   Murthy KK, Banville D, Srikant CB, Carrier F, Holmes C, Bell A and
            Patel YC.
  TITLE     Structural homology between the rat calreticulin gene product and
            the Onchocerca volvulus antigen Ral-1
  JOURNAL   Nucleic Acids Res 18 (16), 4933 (1990)
   PUBMED   2395661
REFERENCE   10 (bases 1 to 1865)
  AUTHORS   Tuan,R.S. and Cavanaugh,S.T.
  TITLE     Identification and characterization of a calcium-binding protein in
            the mouse chorioallantoic placenta
  JOURNAL   Biochem J 233 (1), 41-49 (1986)
   PUBMED   3513762
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU671467.1, BC062395.1 and AW672583.1.
            
            On Jan 24, 2008 this sequence version replaced NM_022399.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D78308.1, FQ210587.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                BU671467.1         1-23
            24-1863             BC062395.1         1-1840
            1864-1865           AW672583.1         365-366
FEATURES             Location/Qualifiers
     source          1..1865
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q11"
     gene            1..1865
                     /gene="Calr"
                     /note="calreticulin"
                     /db_xref="GeneID:64202"
                     /db_xref="RGD:620288"
     exon            1..154
                     /gene="Calr"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    28..30
                     /gene="Calr"
                     /note="upstream in-frame stop codon"
     CDS             64..1314
                     /gene="Calr"
                     /note="CABP3; CALBP; CRP55; ERp60; HACBP; calregulin;
                     calcium-binding protein 3; endoplasmic reticulum resident
                     protein 60"
                     /codon_start=1
                     /product="calreticulin precursor"
                     /protein_id="NP_071794.1"
                     /db_xref="GeneID:64202"
                     /db_xref="RGD:620288"
                     /translation="

MLLSVPLLLGLLGLAAADPAIYFKEQFLDGDAWTNRWVESKHKSDFGKFVLSSGKFYGDQEKDKGLQTSQDARFYALSARFEPFSNKGQTLVVQFTVKHEQNIDCGGGYVKLFPGGLDQKDMHGDSEYNIMFGPDICGPGTKKVHVIFNYKGKNVLINKDIRCKDDEFTHLYTLIVRPDNTYEVKIDNSQVESGSLEDDWDFLPPKKIKDPDAAKPEDWDERAKIDDPTDSKPEDWDKPEHIPDPDAKKPEDWDEEMDGEWEPPVIQNPEYKGEWKPRQIDNPDYKGTWIHPEIDNPEYSPDANIYAYDSFAVLGLDLWQVKSGTIFDNFLITNDEAYAEEFGNETWGVTKAAEKQMKDKQDEEQRLKEEEEDKKRKEEEEAEDKEDEDDRDEDEDEEDEKEEDEEDATGQAKDEL"

     sig_peptide     64..114
                     /gene="Calr"
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
     mat_peptide     115..1311
                     /gene="Calr"
                     /product="Calreticulin. /id=PRO_0000004177"
                     /note="propagated from UniProtKB/Swiss-Prot (P18418.1)"
     misc_feature    115..654
                     /gene="Calr"
                     /note="propagated from UniProtKB/Swiss-Prot (P18418.1);
                     Region: N-domain"
     misc_feature    130..1059
                     /gene="Calr"
                     /note="Calreticulin family; Region: Calreticulin;
                     pfam00262"
                     /db_xref="CDD:425564"
     misc_feature    205..207
                     /gene="Calr"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P27797; propagated from
                     UniProtKB/Swiss-Prot (P18418.1); acetylation site"
     misc_feature    538..540
                     /gene="Calr"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P27797; propagated from
                     UniProtKB/Swiss-Prot (P18418.1); acetylation site"
     misc_feature    634..828
                     /gene="Calr"
                     /note="propagated from UniProtKB/Swiss-Prot (P18418.1);
                     Region: 4 X approximate repeats"
     misc_feature    640..897
                     /gene="Calr"
                     /note="propagated from UniProtKB/Swiss-Prot (P18418.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    655..987
                     /gene="Calr"
                     /note="propagated from UniProtKB/Swiss-Prot (P18418.1);
                     Region: P-domain"
     misc_feature    688..690
                     /gene="Calr"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P27797; propagated from
                     UniProtKB/Swiss-Prot (P18418.1); acetylation site"
     misc_feature    772..873
                     /gene="Calr"
                     /note="propagated from UniProtKB/Swiss-Prot (P18418.1);
                     Region: Interaction with PPIB. /evidence=ECO:0000250"
     misc_feature    838..954
                     /gene="Calr"
                     /note="propagated from UniProtKB/Swiss-Prot (P18418.1);
                     Region: 3 X approximate repeats"
     misc_feature    988..1311
                     /gene="Calr"
                     /note="propagated from UniProtKB/Swiss-Prot (P18418.1);
                     Region: C-domain"
     misc_feature    1111..1311
                     /gene="Calr"
                     /note="propagated from UniProtKB/Swiss-Prot (P18418.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1300..1311
                     /gene="Calr"
                     /note="propagated from UniProtKB/Swiss-Prot (P18418.1);
                     Region: Prevents secretion from ER"
     exon            155..256
                     /gene="Calr"
                     /inference="alignment:Splign:2.1.0"
     exon            257..460
                     /gene="Calr"
                     /inference="alignment:Splign:2.1.0"
     exon            461..555
                     /gene="Calr"
                     /inference="alignment:Splign:2.1.0"
     exon            556..765
                     /gene="Calr"
                     /inference="alignment:Splign:2.1.0"
     exon            766..879
                     /gene="Calr"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1023
                     /gene="Calr"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1116
                     /gene="Calr"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1865
                     /gene="Calr"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

cgcagagccgctgcttgaagatcgttttaaagggccagtgtgccgccgccccctcggcccgccatgctcctttcggtgccgctcctgcttggcctcctcggcctggctgccgcagaccctgccatctatttcaaagagcagttcttggacggagatgcctggaccaaccgctgggtcgaatccaaacataagtctgattttggcaaattcgtcctcagttctggcaaattctacggggaccaggagaaggataaagggttgcagacaagccaagatgcccgattttacgcgctgtccgccagattcgaacccttcagcaacaagggccagacactggtggtacagttcaccgtgaagcatgagcagaatatcgactgtgggggcggctacgtgaagctgtttccgggtggcttggaccagaaggacatgcatggagactcagaatataacatcatgtttggtccggacatctgcggtcctggcaccaagaaggttcatgtcatctttaactacaagggcaagaacgtgctgatcaacaaggatatccggtgtaaggatgatgaattcacacatctatacacgctgattgtgcggccagacaacacctacgaggtgaaaattgacaacagccaggtggagtcgggctccttggaggatgattgggactttctgccgcccaagaagattaaggatcctgacgctgccaagccagaagactgggatgaacgagccaagattgatgaccccacagattccaagcctgaggactgggacaagccagagcacatccctgaccctgatgctaagaagcctgaggactgggacgaagagatggatggagagtgggaaccaccagtgattcaaaatcctgaatacaagggcgaatggaagccacgtcaaattgacaacccagattacaagggtacctggatacacccagagattgacaatcctgaatactcccccgatgcgaatatctatgcctatgatagttttgctgtactgggcttagacctctggcaggtcaagtctggcacaatttttgacaacttcctcatcaccaatgatgaggcctatgcagaggagtttggcaatgagacctggggtgtcaccaaggctgcagagaagcagatgaaggacaagcaggatgaggagcagaggcttaaggaagaagaagaagacaagaagcgtaaagaggaagaggaggccgaggataaagaggatgaggatgacagagatgaagatgaagatgaagaggatgagaaggaagaagatgaggaggatgccactggccaagccaaggatgagctgtagaggccacaccacctgcctccagggctggactgaggcctgaacaccccgccacagagctggctgctcccaataatgtctctatgagactcaagaacttttcattttttttccaggcaggttcaggtctggggtggattctgatttttgttcccctgcctccccatcctccccaccccccttttttttttactggtgtttgtctttaattcttcagccctcacctcctggcctctcatttttgaatcaacattttttctttctgtccctttctccatctcttggtcactatcctccaactctaggaacaggtatggaggaaaagccctaggcttgagatttcatctgctctcctttctgaatctcagaggagggtaggagaagggggtggtatcttccctccccccagcactgaggaagaatggggctcttcccctttctcccttgcccccaggactgggccatttgtggggcagccagttctagcacagctcacactgagagtgtaagaactacaaacaaaatttctattaaattaagttttgtgtcttccc

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