2024-04-25 23:11:23, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NM_019195 1952 bp mRNA linear ROD 12-NOV-2023 DEFINITION Rattus norvegicus Cd47 molecule (Cd47), mRNA. ACCESSION NM_019195 VERSION NM_019195.2 KEYWORDS RefSeq; RefSeq Select. SOURCE Rattus norvegicus (Norway rat) ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. REFERENCE 1 (bases 1 to 1952) AUTHORS Takayasu H. TITLE Upregulated TSP1 and CD47 expression in the lung in nitrofen-induced congenital diaphragmatic hernia JOURNAL Pediatr Int 65 (1), e15447 (2023) PUBMED 36528876 REMARK GeneRIF: Upregulated TSP1 and CD47 expression in the lung in nitrofen-induced congenital diaphragmatic hernia. REFERENCE 2 (bases 1 to 1952) AUTHORS Ye F, Hua Y, Keep RF, Xi G and Garton HJL. TITLE CD47 blocking antibody accelerates hematoma clearance and alleviates hydrocephalus after experimental intraventricular hemorrhage JOURNAL Neurobiol Dis 155, 105384 (2021) PUBMED 33945877 REMARK GeneRIF: CD47 blocking antibody accelerates hematoma clearance and alleviates hydrocephalus after experimental intraventricular hemorrhage. REFERENCE 3 (bases 1 to 1952) AUTHORS Gao Y, Zhang D, Yang C, Duan X, Li X and Zhong D. TITLE Two validated liquid chromatography-mass spectrometry methods with different pretreatments for the quantification of an anti-CD47 monoclonal antibody in rat and cynomolgus monkey serum compared with an electrochemiluminescence method JOURNAL J Pharm Biomed Anal 175, 112792 (2019) PUBMED 31377653 REMARK GeneRIF: For the quantification of an anti-CD47 monoclonal antibody. REFERENCE 4 (bases 1 to 1952) AUTHORS Li Y, Zhao K, Zong P, Fu H, Zheng Y, Bao D, Yin Y, Chen Q, Lu L, Dai Y, Hou D and Kong X. TITLE CD47 deficiency protects cardiomyocytes against hypoxia/reoxygenation injury by rescuing autophagic clearance JOURNAL Mol Med Rep 19 (6), 5453-5463 (2019) PUBMED 31059044 REMARK GeneRIF: The CD47 antibody or SiCD47 can protect cardiomyocytes against H/R injury through increasing autophagic flux and autophagic clearance. CD47 deficiency may offer a potential therapeutic approach for preventing myocardial I/R injury. REFERENCE 5 (bases 1 to 1952) AUTHORS Bitar MS. TITLE Diabetes Impairs Angiogenesis and Induces Endothelial Cell Senescence by Up-Regulating Thrombospondin-CD47-Dependent Signaling JOURNAL Int J Mol Sci 20 (3), 673 (2019) PUBMED 30720765 REMARK GeneRIF: Evidence linking the overexpression of TSP1-CD47 signaling in diabetes to a number of parameters associated with endothelial dysfunction including impaired angiogenesis, cellular senescence and a heightened state of oxidative stress was found. Publication Status: Online-Only REFERENCE 6 (bases 1 to 1952) AUTHORS de Vries HE, Hendriks JJ, Honing H, De Lavalette CR, van der Pol SM, Hooijberg E, Dijkstra CD and van den Berg TK. TITLE Signal-regulatory protein alpha-CD47 interactions are required for the transmigration of monocytes across cerebral endothelium JOURNAL J Immunol 168 (11), 5832-5839 (2002) PUBMED 12023387 REFERENCE 7 (bases 1 to 1952) AUTHORS Latour S, Tanaka H, Demeure C, Mateo V, Rubio M, Brown EJ, Maliszewski C, Lindberg FP, Oldenborg A, Ullrich A, Delespesse G and Sarfati M. TITLE Bidirectional negative regulation of human T and dendritic cells by CD47 and its cognate receptor signal-regulator protein-alpha: down-regulation of IL-12 responsiveness and inhibition of dendritic cell activation JOURNAL J Immunol 167 (5), 2547-2554 (2001) PUBMED 11509594 REFERENCE 8 (bases 1 to 1952) AUTHORS Verdrengh M, Lindberg FP, Ryden C and Tarkowski A. TITLE Integrin-associated protein (IAP)-deficient mice are less susceptible to developing Staphylococcus aureus-induced arthritis JOURNAL Microbes Infect 1 (10), 745-751 (1999) PUBMED 10816079 REFERENCE 9 (bases 1 to 1952) AUTHORS Huang AM, Wang HL, Tang YP and Lee EH. TITLE Expression of integrin-associated protein gene associated with memory formation in rats JOURNAL J Neurosci 18 (11), 4305-4313 (1998) PUBMED 9592107 REFERENCE 10 (bases 1 to 1952) AUTHORS Nishiyama Y, Tanaka T, Naitoh H, Mori C, Fukumoto M, Hiai H and Toyokuni S. TITLE Overexpression of integrin-associated protein (CD47) in rat kidney treated with a renal carcinogen, ferric nitrilotriacetate JOURNAL Jpn J Cancer Res 88 (2), 120-128 (1997) PUBMED 9119739 COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC085740.1. On Nov 15, 2004 this sequence version replaced NM_019195.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC085740.1, D87659.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA5760400, SAMEA5760476 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## FEATURES Location/Qualifiers source 1..1952 /organism="Rattus norvegicus" /mol_type="mRNA" /db_xref="taxon:10116" /chromosome="11" /map="11q21" gene 1..1952 /gene="Cd47" /gene_synonym="Itgp" /note="Cd47 molecule" /db_xref="GeneID:29364" /db_xref="RGD:2308" exon 1..161 /gene="Cd47" /gene_synonym="Itgp" /inference="alignment:Splign:2.1.0" CDS 116..1027 /gene="Cd47" /gene_synonym="Itgp" /note="leukocyte surface antigen CD47; IAP; integrin-associated protein; CD47 antigen (Rh-related antigen, integrin-associated signal transducer)" /codon_start=1 /product="leukocyte surface antigen CD47 precursor" /protein_id="NP_062068.1" /db_xref="GeneID:29364" /db_xref="RGD:2308" /translation="
MWPLAAALLLGSCCCGSAQLLLSKVKSVEFTSCNDTVVIPCKVLNVEAQSTDEMFVKWKLNKSYIFIYDGNKNSTTREQNFTSAKISVSDLLKGIASLTMDTHEAVVGNYTCEVTELSREGKTVIELKNRPVSWFSTNEKILIVIFPILAILLFWGKFGILTLKYKSSHTNKRIILLLVAGLALTLIVVVGAILFIPGEKPVKNASGLGLIVISTGILILLQYNVFMTAFGMTSFTIAILITQVLGYVLAVVGMCLCIMACEPVHGPLLISGLGIIALAELLGLVYMKFVASNQRTIQPPRNN"
sig_peptide 116..169 /gene="Cd47" /gene_synonym="Itgp" /inference="COORDINATES: ab initio prediction:SignalP:4.0" mat_peptide 170..1024 /gene="Cd47" /gene_synonym="Itgp" /product="Leukocyte surface antigen CD47. /id=PRO_0000042209" /note="propagated from UniProtKB/Swiss-Prot (P97829.1)" misc_feature 170..172 /gene="Cd47" /gene_synonym="Itgp" /note="Pyrrolidone carboxylic acid. /evidence=ECO:0000250|UniProtKB:Q08722, ECO:0000305; propagated from UniProtKB/Swiss-Prot (P97829.1); pyrrolidone-carboxylic-acid site" misc_feature 173..505 /gene="Cd47" /gene_synonym="Itgp" /note="Immunoglobulin variable region (IgV) in Cluster of Differentiation (CD) 47; Region: IgV_CD47; cd16090" /db_xref="CDD:409511" misc_feature 173..247 /gene="Cd47" /gene_synonym="Itgp" /note="FR1 [structural motif]; Region: FR1" /db_xref="CDD:409511" misc_feature 173..184 /gene="Cd47" /gene_synonym="Itgp" /note="Ig strand A [structural motif]; Region: Ig strand A" /db_xref="CDD:409511" misc_feature 191..205 /gene="Cd47" /gene_synonym="Itgp" /note="Ig strand A' [structural motif]; Region: Ig strand A'" /db_xref="CDD:409511" misc_feature 215..217 /gene="Cd47" /gene_synonym="Itgp" /note="N-linked (GlcNAc...) asparagine. /evidence=ECO:0000255; propagated from UniProtKB/Swiss-Prot (P97829.1); glycosylation site" misc_feature 224..247 /gene="Cd47" /gene_synonym="Itgp" /note="Ig strand B [structural motif]; Region: Ig strand B" /db_xref="CDD:409511" misc_feature 248..274 /gene="Cd47" /gene_synonym="Itgp" /note="CDR1 [structural motif]; Region: CDR1" /db_xref="CDD:409511" misc_feature 275..301 /gene="Cd47" /gene_synonym="Itgp" /note="FR2 [structural motif]; Region: FR2" /db_xref="CDD:409511" misc_feature order(278..280,284..286,290..292,452..454,479..481) /gene="Cd47" /gene_synonym="Itgp" /note="SIRP-CD47 complex [polypeptide binding]; other site" /db_xref="CDD:409511" misc_feature 278..295 /gene="Cd47" /gene_synonym="Itgp" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409511" misc_feature 296..298 /gene="Cd47" /gene_synonym="Itgp" /note="N-linked (GlcNAc...) asparagine. /evidence=ECO:0000255; propagated from UniProtKB/Swiss-Prot (P97829.1); glycosylation site" misc_feature 302..346 /gene="Cd47" /gene_synonym="Itgp" /note="CDR2 [structural motif]; Region: CDR2" /db_xref="CDD:409511" misc_feature 302..325 /gene="Cd47" /gene_synonym="Itgp" /note="Ig strand C' [structural motif]; Region: Ig strand C'" /db_xref="CDD:409511" misc_feature 332..346 /gene="Cd47" /gene_synonym="Itgp" /note="Ig strand C' [structural motif]; Region: Ig strand C'" /db_xref="CDD:409511" misc_feature 332..334 /gene="Cd47" /gene_synonym="Itgp" /note="N-linked (GlcNAc...) asparagine. /evidence=ECO:0000255; propagated from UniProtKB/Swiss-Prot (P97829.1); glycosylation site" misc_feature 350..460 /gene="Cd47" /gene_synonym="Itgp" /note="FR3 [structural motif]; Region: FR3" /db_xref="CDD:409511" misc_feature 353..355 /gene="Cd47" /gene_synonym="Itgp" /note="N-linked (GlcNAc...) asparagine. /evidence=ECO:0007744|PubMed:24090084; propagated from UniProtKB/Swiss-Prot (P97829.1); glycosylation site" misc_feature 362..373 /gene="Cd47" /gene_synonym="Itgp" /note="Ig strand D [structural motif]; Region: Ig strand D" /db_xref="CDD:409511" misc_feature 374..376 /gene="Cd47" /gene_synonym="Itgp" /note="Phosphoserine. /evidence=ECO:0007744|PubMed:22673903; propagated from UniProtKB/Swiss-Prot (P97829.1); phosphorylation site" misc_feature 380..382 /gene="Cd47" /gene_synonym="Itgp" /note="Phosphoserine. /evidence=ECO:0007744|PubMed:22673903; propagated from UniProtKB/Swiss-Prot (P97829.1); phosphorylation site" misc_feature 395..415 /gene="Cd47" /gene_synonym="Itgp" /note="Ig strand E [structural motif]; Region: Ig strand E" /db_xref="CDD:409511" misc_feature 440..463 /gene="Cd47" /gene_synonym="Itgp" /note="Ig strand F [structural motif]; Region: Ig strand F" /db_xref="CDD:409511" misc_feature 440..442 /gene="Cd47" /gene_synonym="Itgp" /note="N-linked (GlcNAc...) asparagine. /evidence=ECO:0007744|PubMed:24090084; propagated from UniProtKB/Swiss-Prot (P97829.1); glycosylation site" misc_feature 461..472 /gene="Cd47" /gene_synonym="Itgp" /note="CDR3 [structural motif]; Region: CDR3" /db_xref="CDD:409511" misc_feature 470..502 /gene="Cd47" /gene_synonym="Itgp" /note="Ig strand G [structural motif]; Region: Ig strand G" /db_xref="CDD:409511" misc_feature 473..505 /gene="Cd47" /gene_synonym="Itgp" /note="FR4 [structural motif]; Region: FR4" /db_xref="CDD:409511" misc_feature 536..598 /gene="Cd47" /gene_synonym="Itgp" /note="propagated from UniProtKB/Swiss-Prot (P97829.1); transmembrane region" misc_feature 539..985 /gene="Cd47" /gene_synonym="Itgp" /note="CD47 transmembrane region; Region: CD47; pfam04549" /db_xref="CDD:367985" misc_feature 635..697 /gene="Cd47" /gene_synonym="Itgp" /note="propagated from UniProtKB/Swiss-Prot (P97829.1); transmembrane region" misc_feature 725..727 /gene="Cd47" /gene_synonym="Itgp" /note="N-linked (GlcNAc...) asparagine. /evidence=ECO:0000255; propagated from UniProtKB/Swiss-Prot (P97829.1); glycosylation site" misc_feature 734..796 /gene="Cd47" /gene_synonym="Itgp" /note="propagated from UniProtKB/Swiss-Prot (P97829.1); transmembrane region" misc_feature 830..892 /gene="Cd47" /gene_synonym="Itgp" /note="propagated from UniProtKB/Swiss-Prot (P97829.1); transmembrane region" misc_feature 914..976 /gene="Cd47" /gene_synonym="Itgp" /note="propagated from UniProtKB/Swiss-Prot (P97829.1); transmembrane region" exon 162..509 /gene="Cd47" /gene_synonym="Itgp" /inference="alignment:Splign:2.1.0" exon 510..599 /gene="Cd47" /gene_synonym="Itgp" /inference="alignment:Splign:2.1.0" exon 600..707 /gene="Cd47" /gene_synonym="Itgp" /inference="alignment:Splign:2.1.0" exon 708..800 /gene="Cd47" /gene_synonym="Itgp" /inference="alignment:Splign:2.1.0" exon 801..893 /gene="Cd47" /gene_synonym="Itgp" /inference="alignment:Splign:2.1.0" exon 894..986 /gene="Cd47" /gene_synonym="Itgp" /inference="alignment:Splign:2.1.0" exon 987..1018 /gene="Cd47" /gene_synonym="Itgp" /inference="alignment:Splign:2.1.0" exon 1019..1942 /gene="Cd47" /gene_synonym="Itgp" /inference="alignment:Splign:2.1.0" ORIGIN
ctgggcggccgttcctgcctatcacggctgcggcgctgctggtcgttctcttgaaggcagcggaggcggcggctgctccagacacctgcggcggcgaccccccggcggcgcggagatgtggcccttggcggcggcgctgttgctgggctcctgctgctgcggttcagctcaactcctgcttagtaaagtcaaatctgtagagttcacgtcatgcaatgacactgtggtcatcccttgcaaagtccttaatgtggaagcccaaagcaccgatgaaatgtttgtgaagtggaagttgaacaaatcgtatattttcatctatgatggaaataaaaatagcactactagagaacaaaactttaccagtgcaaaaatctcggtctcagacttgctcaaaggcattgcctctttgacaatggatacccatgaggctgtggtgggaaactacacctgtgaagtgactgagctttccagagaaggcaaaacagttatagagctgaaaaaccgcccagtttcgtggttttctacaaatgaaaagatcctcattgttattttcccaattttggctatactcctgttctggggaaagtttggtatattaacactcaaatacaagtccagccatacgaataagagaatcattctgctgctggttgccgggctggcgctcacactcatcgtggttgttggcgccatccttttcatcccgggagagaagcccgtgaagaacgcttctggtcttggcctcattgtaatctccacaggaatattaatactgcttcagtacaatgtgtttatgacagcttttggaatgacctctttcaccattgccatattgatcactcaagtgctgggctatgtccttgctgtggtcgggatgtgtctctgcatcatggcttgtgaaccagtgcacggcccccttttgatttcaggtttgggaatcatagctctagcagaattacttggactagtttatatgaagtttgtcgcttccaaccagcggactatacaacctcctaggaataactgaagggaagtgatggactgtaacttgaaagtcagaagtggaagaattcagttgtctgagcaccatggccttcacaactcacagctggaaggaacacacaacagtgactgactttcatctctgaaaaaagtcattgaaccataaatgaatattacagttaagtttatattaaagcagctgtaatttacgtaataaaaaatatatgatgtgctgtgtaaccaatcgaaatccatttttctattgtttctactcaactaggggcaaaagtttcaggggcaacttccaagaatgatgcttgttagatccttgagtctctgaacactgagtttaaatcgattcccagagagactcgccaagcactaaccttcgggttagttacctagagatacctacgagaaacaggggtatccagcaagccttagtaaactcaggttcccagcagctttgccactcatgctgctagctgaataacaagactgccacttctgggtcttagtgacagagactgaagtacaaaaatgaatgtggttgggcaaaccccgtgtggcccctctgtgtgctatgatgttgatggccctgttgtcttcattcttgggcgttgccatcgttcacacacaccccctttgacatacagcgcacccaggttttgaatacttttttttttacagatgtggttttcctttttgcacacaaccctttgcaccctgtcccgtcctgctactttgatttgtgtttcaagatacagtacctttcctcccctttaaacatgatcctgtgacacaattttgtcagttgcagaaaggagccagacttattctcaaagcactgtgctcaaactcttcaaaaaaaaaataaaatagctatggttgtaacatatgtattccagacctctggtttaaaggcaaaaaaaaaaaaaaaaaaaaaaaaa
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Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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