LOCUS       NM_013173               4398 bp    mRNA    linear   ROD 08-NOV-2023
DEFINITION  Rattus norvegicus solute carrier family 11 member 2 (Slc11a2),
            transcript variant 1, mRNA.
ACCESSION   NM_013173
VERSION     NM_013173.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4398)
  AUTHORS   Irollo E, Nash B, Luchetta J, Brandimarti R and Meucci O.
  TITLE     The Endolysosomal Transporter DMT1 is Required for Morphine
            Regulation of Neuronal Ferritin Heavy Chain
  JOURNAL   J Neuroimmune Pharmacol 18 (3), 495-508 (2023)
   PUBMED   37661197
  REMARK    GeneRIF: The Endolysosomal Transporter DMT1 is Required for
            Morphine Regulation of Neuronal Ferritin Heavy Chain.
REFERENCE   2  (bases 1 to 4398)
  AUTHORS   Wolff NA, Garrick MD, Zhao L, Garrick LM, Ghio AJ and Thevenod F.
  TITLE     A role for divalent metal transporter (DMT1) in mitochondrial
            uptake of iron and manganese
  JOURNAL   Sci Rep 8 (1), 211 (2018)
   PUBMED   29317744
  REMARK    GeneRIF: DMT1 mediates mitochondrial Fe2+ and Mn2+ acquisition.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4398)
  AUTHORS   Naito Y, Sawada H, Oboshi M, Okuno K, Yasumura S, Okuhara Y, Eguchi
            A, Nishimura K, Soyama Y, Asakura M, Ishihara M, Tsujino T and
            Masuyama T.
  TITLE     Altered expression of intestinal duodenal cytochrome b and divalent
            metal transporter 1 might be associated with cardio-renal anemia
            syndrome
  JOURNAL   Heart Vessels 32 (11), 1410-1414 (2017)
   PUBMED   28669019
  REMARK    GeneRIF: impaired intestinal expression of Dcyt-b and DMT-1 might
            be associated with the reduction of an iron uptake in CKD. Taken
            together, impaired these intestinal iron transporters may become a
            novel therapeutic target for cardio-renal anemia syndrome.
REFERENCE   4  (bases 1 to 4398)
  AUTHORS   Han M, Chang J and Kim J.
  TITLE     Loss of divalent metal transporter 1 function promotes brain copper
            accumulation and increases impulsivity
  JOURNAL   J Neurochem 138 (6), 918-928 (2016)
   PUBMED   27331785
  REMARK    GeneRIF: Mutations in the divalent metal transporter 1 (DMT1)
            decrease body iron status and up-regulate copper absorption
REFERENCE   5  (bases 1 to 4398)
  AUTHORS   Mackenzie K, Foot NJ, Anand S, Dalton HE, Chaudhary N, Collins BM,
            Mathivanan S and Kumar S.
  TITLE     Regulation of the divalent metal ion transporter via membrane
            budding
  JOURNAL   Cell Discov 2, 16011 (2016)
   PUBMED   27462458
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4398)
  AUTHORS   Fleming MD, Trenor CC 3rd, Su MA, Foernzler D, Beier DR, Dietrich
            WF and Andrews NC.
  TITLE     Microcytic anaemia mice have a mutation in Nramp2, a candidate iron
            transporter gene
  JOURNAL   Nat Genet 16 (4), 383-386 (1997)
   PUBMED   9241278
REFERENCE   7  (bases 1 to 4398)
  AUTHORS   Sassa,S. and Bernstein,S.E.
  TITLE     Studies of erythrocyte protoporphyrin in anemic mutant mice: use of
            a modified hematofluorometer for the detection of heterozygotes for
            hemolytic disease
  JOURNAL   Exp Hematol 6 (5), 479-487 (1978)
   PUBMED   658175
REFERENCE   8  (bases 1 to 4398)
  AUTHORS   Edwards,J.A. and Hoke,J.E.
  TITLE     Red cell iron uptake in hereditary microcytic anemia
  JOURNAL   Blood 46 (3), 381-388 (1975)
   PUBMED   807277
REFERENCE   9  (bases 1 to 4398)
  AUTHORS   Kreimer-Birnbaum,M., Bannerman,R.M., Russell,E.S. and
            Bernstein,S.E.
  TITLE     Pyrrole pigments in normal and congenitally anaemic mice (+:+, W-W
            v, ha-ha, nb-nb, mk-mk, f-f and sla-Y)
  JOURNAL   Comp Biochem Physiol A Comp Physiol 43 (1), 21-30 (1972)
   PUBMED   4404581
REFERENCE   10 (bases 1 to 4398)
  AUTHORS   Bannerman,R.M., Edwards,J.A., Kreimer-Birnbaum,M., McFarland,E. and
            Russell,E.S.
  TITLE     Hereditary microcytic anaemia in the mouse; studies in iron
            distribution and metabolism
  JOURNAL   Br J Haematol 23 (2), 235-245 (1972)
   PUBMED   5070129
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF008439.1.
            
            On Aug 3, 2012 this sequence version replaced NM_013173.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF008439.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4398              AF008439.1         12-4409
FEATURES             Location/Qualifiers
     source          1..4398
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..4398
                     /gene="Slc11a2"
                     /gene_synonym="Dmt1; Nramp2"
                     /note="solute carrier family 11 member 2"
                     /db_xref="GeneID:25715"
                     /db_xref="RGD:3684"
     CDS             1..1779
                     /gene="Slc11a2"
                     /gene_synonym="Dmt1; Nramp2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     DMT-1; NRAMP 2; divalent cation transporter 1; natural
                     resistance-associated macrophage protein 2; solute carrier
                     family 11 (proton-coupled divalent metal ion
                     transporters), member 2; Solute carrier family 11 member 2
                     (natural resistance-associated macrophage protein 2);
                     divalent metal transporter 1; solute carrier family 11
                     (proton-coupled divalent metal ion transporter), member 2"
                     /codon_start=1
                     /product="natural resistance-associated macrophage protein
                     2 isoform 1"
                     /protein_id="NP_037305.2"
                     /db_xref="GeneID:25715"
                     /db_xref="RGD:3684"
                     /translation="

MGKKQPRAAASAAPNCELKSYSKSTDPQVSTMVLDPEEKIPDDGASGDHGDSASLGAINPAYSNSSLPHSTGDSEEPFTTYFDEKIPIPEEEYSCFSFRKLWAFTGPGFLMSIAYLDPGNIESDLQSGAVAGFKLLWVLLLATIVGLLLQRLAARLGVVTGLHLAEVCHRQYPKVPRIILWLMVELAIIGSDMQEVIGSAIAINLLSAGRVPLYGGVLITIADTFVFLFLDKYGLRKLEAFFGFLITIMALTFGYEYVTVKPSQSQVLRGMFVPSCSGCHTPQVEQAVGIVGAVIMPHNMYLHSALVKSRQVNRANKQEVREANKYFFIESCIALFVSFIINVFVVSVFAEAFFEKTNEQVVEVCRNSSSPHADLFPNDNSTLAVDIYKGGVVLGCYFGPAALYIWAVGILAAGQSSTMTGTYSGQFVMEGFLNLKWSRFARVILTRSIAIIPTLLVAVFQDVEHLTGMNDFLNVLQSLQLPFALIPILTFTSLRPVMSEFSNGIGWRIAGGILVLLVCSINMYFVVVYVQELGHVALYVVAAVVSVAYLGFVFYLGWQCLIALGLSFLDCGRSVSISKVLLSEDTSGGNTK"

     misc_feature    295..1494
                     /gene="Slc11a2"
                     /gene_synonym="Dmt1; Nramp2"
                     /note="NRAMP (natural resistance-associated macrophage
                     protein) metal ion transporters; Region: nramp; TIGR01197"
                     /db_xref="CDD:162246"
     exon            1..55
                     /gene="Slc11a2"
                     /gene_synonym="Dmt1; Nramp2"
                     /inference="alignment:Splign:2.1.0"
     exon            56..127
                     /gene="Slc11a2"
                     /gene_synonym="Dmt1; Nramp2"
                     /inference="alignment:Splign:2.1.0"
     exon            128..276
                     /gene="Slc11a2"
                     /gene_synonym="Dmt1; Nramp2"
                     /inference="alignment:Splign:2.1.0"
     exon            277..402
                     /gene="Slc11a2"
                     /gene_synonym="Dmt1; Nramp2"
                     /inference="alignment:Splign:2.1.0"
     exon            403..522
                     /gene="Slc11a2"
                     /gene_synonym="Dmt1; Nramp2"
                     /inference="alignment:Splign:2.1.0"
     exon            523..629
                     /gene="Slc11a2"
                     /gene_synonym="Dmt1; Nramp2"
                     /inference="alignment:Splign:2.1.0"
     exon            630..700
                     /gene="Slc11a2"
                     /gene_synonym="Dmt1; Nramp2"
                     /inference="alignment:Splign:2.1.0"
     exon            701..768
                     /gene="Slc11a2"
                     /gene_synonym="Dmt1; Nramp2"
                     /inference="alignment:Splign:2.1.0"
     exon            769..924
                     /gene="Slc11a2"
                     /gene_synonym="Dmt1; Nramp2"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1083
                     /gene="Slc11a2"
                     /gene_synonym="Dmt1; Nramp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1170
                     /gene="Slc11a2"
                     /gene_synonym="Dmt1; Nramp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1290
                     /gene="Slc11a2"
                     /gene_synonym="Dmt1; Nramp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1440
                     /gene="Slc11a2"
                     /gene_synonym="Dmt1; Nramp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1514
                     /gene="Slc11a2"
                     /gene_synonym="Dmt1; Nramp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1668
                     /gene="Slc11a2"
                     /gene_synonym="Dmt1; Nramp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..4320
                     /gene="Slc11a2"
                     /gene_synonym="Dmt1; Nramp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

atggggaagaagcagccgagggcagcagcaagtgctgctccaaactgtgagctaaaatcctattctaagagcacagatcctcaggtatctaccatggtgttggatcctgaagaaaagattccagacgatggtgcttctggggaccatggagactcggccagcctcggtgccatcaaccctgcttacagcaactcttccctcccacattccaccggggattctgaggagcccttcaccacctactttgatgagaaaatccccattcctgaggaggagtactcttgttttagtttccgtaaactctgggccttcacaggacctggttttcttatgagcattgcctacctggatccaggaaacattgaatctgatttacagtctggagcagtggctggatttaagttgctctgggtgctcctgctggccactattgtggggctgctgctccagcgtctcgcagctcgactgggagtggtcaccggcttgcaccttgctgaagtgtgtcaccgtcagtatcccaaggtcccacggatcatcctgtggctaatggtggagttggcaatcattggttctgatatgcaggaagtcattggctcagccatcgccatcaatctcctgtctgccggaagggttcccctgtatggtggagtcctcatcaccatcgcagatacttttgtatttctctttttggacaaatatggcttgcggaagctggaagcattttttggctttctcatcactatcatggccctcacatttggatatgagtatgttacagtgaaacccagccaaagccaagtactcaggggcatgttcgtgccatcctgttcaggctgccacacccctcaggtggagcaggcggtgggcatcgtgggagctgtgatcatgccacacaacatgtacctgcactctgccttagtcaagtctagacaagtgaaccgggccaataagcaggaagttcgagaagccaataagtacttcttcatcgagtcctgcattgcactctttgtttccttcatcatcaatgtctttgtcgtctccgtctttgctgaagcattttttgagaaaaccaatgagcaggtggttgaggtctgcagaaatagcagcagcccccatgctgacctctttcctaacgacaactctaccctggctgtggacatctacaaagggggtgttgtgcttggatgttacttcgggcctgcggccctctacatctgggcggtggggatcctggctgctggacagagctccaccatgactggaacctattctggccagtttgtcatggagggattcctgaacctaaaatggtcgcgctttgcccgcgtgatcctgaccaggtctattgccatcatccctaccctgcttgttgctgtcttccaagatgtggagcatctgacagggatgaatgatttcctgaatgttctgcagagcctacagctcccctttgccctcatccctatcctcaccttcacaagcctgcggccagtgatgagtgagttctccaacggaataggctggaggatcgcaggcggcatcttggtccttctcgtctgctccatcaacatgtactttgtcgtggtctacgtccaggagctagggcatgtggcactgtatgtggtggctgcagtggttagcgtggcttatctgggctttgtgttctacttgggttggcagtgtttgattgcgttgggcctgtcgttcctggactgtgggcgctcggtaagcatctctaaagtcctgctgagcgaagataccagcggtggcaatactaagtaaacactgggtcagcctgtctgtctgtctttgcagggagccatcagagccagtgtgtttctatggtttactgtgtgaacatagccacaagtatgtgccgttgcacagactgcatttagggaccaactgttagttgggaaacactggggtgggtgtgtggtgtgtgtgtgtgtgttgtttccttctgtctttgtcaaatagcatgctgctattaaatgcttggtggcctaaaactctgtgtagcctaggctgccttcaaacttacagcaatcctcctggctcagcctcctgggtgctgggattccaggcatgtctaccgctcctggctgtcacgagtgcttacaagatgactggttttgtcaggggaggtcttaccctgtagcattaggcagcaccttgaaaaggtgagccttgagctgttttgaacactaaattcctaaatagctgtccaaggccatggctcggttttagttctgagaaacccaaccagactgttgtcatcatttgaattgcagaattagagaccgctatttttgagttcaggatttctgtttgtttggtgcatttcattttgtttttcaagacaagggtttcttccttgttgtcctggaacttactctgtagaccagcctggctttgaactcacagagatcctcctgcctctgcctctgcttcccgactgctaggattagaggcatacaccaccactgccctgctaagctcagagttttttatttctactttggaattcctcagtggaaagaaaggtagagcaggagagggggtgtggtcaagtgatggctcccctccaggtccttgcaggtttaccttaaggagtggagcttagcagggcttcatctgtagtcctgaggctagtgacttccctgttaatagcaagcatcccgatagtgtttcatctcgagtacacacagtcctggaatctccgccttcctctcctgagagagtgcggatggcaaaagactactgtagcacttgtgaactggctcacagcaaatcccagagctgaccgcactactcccgaaagtacccttcaccaaatcttggctctgacccaccgctgtttcatgcccaagataactcagaaggcaacctcaggagctctggacccaaaccttgcaaagtcagtagttgtcactgtgatgcaaagtcctctccctgcaaggtgggactaggctgcctcctcacagcccttccctcggagagaaagcctcttgagaccaggctgcggagctctggagattcagcacgggactacagaactgctgctctcagttcagccacttctgtcctggcacgtgggagacatgattctgtcacatcaagtcctgtctgtttgctggaaaggaataatacaagtttgtataatcattgccttggtggcaacaggagctacagtgacttcgaaggatgtcgtcctctttgccgctttcccagttcgactgtcccgacaaatgacctgcattgtggtgccactgtggcattagtgctagcatttcacacagtcagaagctcagcctgcatagagtcctgtgaggcatgaagggtaaatgcagtttcactcagcctggttgacctcagccccacagctaacacaacacagtcaggccgcgggtccctcactgcggcattctcaacccctgggttgccacccatttgcagcccctatatccaaaaccatttacattatgatttataacagtagcagcattagttgtgaaatagcaaagattttatggttgggggttaccaccacaaagggtcgcagcagcaggaagtttgagaaccctgcaccacagggtccatctcacacctgcctctgccaccattgttcccaaaactgactggaaactgagcttttgaaactgtctcgatgtggtgcttgagggccagattgacagtagcagaattactggaatggatgctctagtgacatctgcatttgtacaggggcggggttgggcggggcggggcggggttgggcagggtgtgttcagagtcactgtacttacagtccagcccagagctgctggcagtcatgcccaggggtctgccttgtgcgtgctagcaaggctgtgctgcagatctcacttcctgccccagagttctgctgtagtatgttcgtttacagtgatagacggttccattgtgtacgacggtctctgactctatgcctacagtatttacagtgtcaaagattaaaagtgtcgcctgtccatttggccgtcactgggaaacagtgcttccaacagtgctctgtacgtaacctgtaagcatttcaaccccgccacgccagtgtggcctggcgttacgttggcgagccatcttgtacgttctcacttggtcctcgttcttctgcgacctgaaatagttgttccctctgctctgggagctggcggctggggaacagcagcagcttgtcttgtaaggtcctgccaggagggcaacaagtgactataaggaggctgttagtgagcctctgacagcttgtgaacttgctgtaattaaaacaaaaacttccctgttaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa

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