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Previous release (v1)
2025-08-23 20:27:40, GGRNA.v2 : RefSeq release 230 (May, 2025)
LOCUS NM_001436563 3265 bp mRNA linear ROD 17-MAR-2025
DEFINITION Rattus norvegicus piwi-like RNA-mediated gene silencing 4 (Piwil4),
transcript variant 1, mRNA.
ACCESSION NM_001436563 XM_008765980
VERSION NM_001436563.1
KEYWORDS RefSeq; RefSeq Select.
SOURCE Rattus norvegicus (Norway rat)
ORGANISM Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
REFERENCE 1 (bases 1 to 3265)
AUTHORS Henaoui,I.S., Jacovetti,C., Guerra Mollet,I., Guay,C., Sobel,J.,
Eliasson,L. and Regazzi,R.
TITLE PIWI-interacting RNAs as novel regulators of pancreatic beta cell
function
JOURNAL Diabetologia 60 (10), 1977-1986 (2017)
PUBMED 28711973
REFERENCE 2 (bases 1 to 3265)
AUTHORS Sivagurunathan,S., Palanisamy,K., Arunachalam,J.P. and
Chidambaram,S.
TITLE Possible role of HIWI2 in modulating tight junction proteins in
retinal pigment epithelial cells through Akt signaling pathway
JOURNAL Mol Cell Biochem 427 (1-2), 145-156 (2017)
PUBMED 28025795
REFERENCE 3 (bases 1 to 3265)
AUTHORS Yang,Z., Chen,K.M., Pandey,R.R., Homolka,D., Reuter,M.,
Janeiro,B.K., Sachidanandam,R., Fauvarque,M.O., McCarthy,A.A. and
Pillai,R.S.
TITLE PIWI Slicing and EXD1 Drive Biogenesis of Nuclear piRNAs from
Cytosolic Targets of the Mouse piRNA Pathway
JOURNAL Mol Cell 61 (1), 138-152 (2016)
PUBMED 26669262
REFERENCE 4 (bases 1 to 3265)
AUTHORS Pastor,W.A., Stroud,H., Nee,K., Liu,W., Pezic,D., Manakov,S.,
Lee,S.A., Moissiard,G., Zamudio,N., Bourc'his,D., Aravin,A.A.,
Clark,A.T. and Jacobsen,S.E.
TITLE MORC1 represses transposable elements in the mouse male germline
JOURNAL Nat Commun 5, 5795 (2014)
PUBMED 25503965
REMARK Erratum:[Nat Commun. 2015 Jul 10;6:7604. doi: 10.1038/ncomms8604.
PMID: 26159654]
Publication Status: Online-Only
REFERENCE 5 (bases 1 to 3265)
AUTHORS Keam,S.P., Young,P.E., McCorkindale,A.L., Dang,T.H., Clancy,J.L.,
Humphreys,D.T., Preiss,T., Hutvagner,G., Martin,D.I., Cropley,J.E.
and Suter,C.M.
TITLE The human Piwi protein Hiwi2 associates with tRNA-derived piRNAs in
somatic cells
JOURNAL Nucleic Acids Res 42 (14), 8984-8995 (2014)
PUBMED 25038252
REFERENCE 6 (bases 1 to 3265)
AUTHORS Shoji,M., Tanaka,T., Hosokawa,M., Reuter,M., Stark,A., Kato,Y.,
Kondoh,G., Okawa,K., Chujo,T., Suzuki,T., Hata,K., Martin,S.L.,
Noce,T., Kuramochi-Miyagawa,S., Nakano,T., Sasaki,H., Pillai,R.S.,
Nakatsuji,N. and Chuma,S.
TITLE The TDRD9-MIWI2 complex is essential for piRNA-mediated
retrotransposon silencing in the mouse male germline
JOURNAL Dev Cell 17 (6), 775-787 (2009)
PUBMED 20059948
REFERENCE 7 (bases 1 to 3265)
AUTHORS Aravin,A.A., van der Heijden,G.W., Castaneda,J., Vagin,V.V.,
Hannon,G.J. and Bortvin,A.
TITLE Cytoplasmic compartmentalization of the fetal piRNA pathway in mice
JOURNAL PLoS Genet 5 (12), e1000764 (2009)
PUBMED 20011505
REFERENCE 8 (bases 1 to 3265)
AUTHORS Aravin,A.A., Sachidanandam,R., Bourc'his,D., Schaefer,C., Pezic,D.,
Toth,K.F., Bestor,T. and Hannon,G.J.
TITLE A piRNA pathway primed by individual transposons is linked to de
novo DNA methylation in mice
JOURNAL Mol Cell 31 (6), 785-799 (2008)
PUBMED 18922463
REFERENCE 9 (bases 1 to 3265)
AUTHORS Kuramochi-Miyagawa,S., Watanabe,T., Gotoh,K., Totoki,Y., Toyoda,A.,
Ikawa,M., Asada,N., Kojima,K., Yamaguchi,Y., Ijiri,T.W., Hata,K.,
Li,E., Matsuda,Y., Kimura,T., Okabe,M., Sakaki,Y., Sasaki,H. and
Nakano,T.
TITLE DNA methylation of retrotransposon genes is regulated by Piwi
family members MILI and MIWI2 in murine fetal testes
JOURNAL Genes Dev 22 (7), 908-917 (2008)
PUBMED 18381894
REFERENCE 10 (bases 1 to 3265)
AUTHORS Carmell,M.A., Girard,A., van de Kant,H.J., Bourc'his,D.,
Bestor,T.H., de Rooij,D.G. and Hannon,G.J.
TITLE MIWI2 is essential for spermatogenesis and repression of
transposons in the mouse male germline
JOURNAL Dev Cell 12 (4), 503-514 (2007)
PUBMED 17395546
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
JAXUCZ010000008.1.
On Mar 14, 2025 this sequence version replaced XM_008765980.4.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR26643293.43905.1,
SRR26643429.29219.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA5760383, SAMEA5760434
[ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
RefSeq Select criteria :: based on conservation, expression,
longest protein
##RefSeq-Attributes-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-194 JAXUCZ010000008.1 19861134-19861327 c
195-258 JAXUCZ010000008.1 19860137-19860200 c
259-390 JAXUCZ010000008.1 19857313-19857444 c
391-605 JAXUCZ010000008.1 19854407-19854621 c
606-727 JAXUCZ010000008.1 19849931-19850052 c
728-808 JAXUCZ010000008.1 19848140-19848220 c
809-1006 JAXUCZ010000008.1 19844447-19844644 c
1007-1118 JAXUCZ010000008.1 19842929-19843040 c
1119-1242 JAXUCZ010000008.1 19835733-19835856 c
1243-1360 JAXUCZ010000008.1 19833845-19833962 c
1361-1472 JAXUCZ010000008.1 19831229-19831340 c
1473-1657 JAXUCZ010000008.1 19829442-19829626 c
1658-1730 JAXUCZ010000008.1 19826182-19826254 c
1731-1931 JAXUCZ010000008.1 19824687-19824887 c
1932-2035 JAXUCZ010000008.1 19823626-19823729 c
2036-2106 JAXUCZ010000008.1 19823388-19823458 c
2107-2260 JAXUCZ010000008.1 19822130-19822283 c
2261-2389 JAXUCZ010000008.1 19819948-19820076 c
2390-2537 JAXUCZ010000008.1 19819279-19819426 c
2538-3265 JAXUCZ010000008.1 19817985-19818712 c
FEATURES Location/Qualifiers
source 1..3265
/organism="Rattus norvegicus"
/mol_type="mRNA"
/strain="BN"
/db_xref="taxon:10116"
/chromosome="8"
/map="8q12"
gene 1..3265
/gene="Piwil4"
/note="piwi-like RNA-mediated gene silencing 4"
/db_xref="GeneID:689972"
/db_xref="RGD:1311015"
exon 1..194
/gene="Piwil4"
/inference="alignment:Splign:2.1.0"
CDS 108..2654
/gene="Piwil4"
/note="isoform 1 is encoded by transcript variant 1;
piwi-like protein 4; piwi-like 4"
/codon_start=1
/product="piwi-like protein 4 isoform 1"
/protein_id="NP_001423492.1"
/db_xref="GeneID:689972"
/db_xref="RGD:1311015"
/translation="
MSGRARVRARGITTGHSAREVERAPRDLMVTSVSPGDNEASSRTSVISQPHELGVSSGDGRRTLVEKRGNGRQDFVDLGVCTREKLTHVKDSKTGSSGIPVQLATNLFHLDLPQDWQLYQYHVTYSPDLASRRLRTALLYNHSILSDKAKAFDGTSLFLSEKLDHKVTELTSETQRGETVKITLTLTSELFPNSPMCIQFFNVIFRKIFKKLSMYQIGRNYYKPSEPVEIPQYKLSLWPGFAISVSRFESKLLFNADVNYKVLRNETVLEFMTDLCLRTDMSCFTETCHKQLVGLIVLTRYNNKTYRIDDIDWSVKPTHAFQKRDGSETTYVDYYKQQYDITLSDLNQPVLVSLLKRRRNDNSEPQMVHLIPELCFLTGLTSQATSDFRLMKAVAEETRLSPMGRQQQLARLADDIQRNQVTRFELETWGLHFGSQLSLTGRVVPSEKILLQDHTCQPAFAADWSKDMRSCKVLSSEPLNTWLIVCCSRAEHLIESFLSCLRRVGGSTGFSVGHPKIIKVDENPAAFLRAIQLHVNPDVQLVMCILPSNQKNYYDSIKRYLSSDCPVPSQCVLTRTLNKQGMMLSVATKIAMQMTCKLGGELWAVEIPLKSLMVVGIDICRDALSKDVAVVGFVASINSRITRWFSRCVLQRTAADIADCLKVCMTGALNKWYKHNHDLPARIIAYRDGVGNGQLKAVLEYEVPQLLSSVTECGSDARSCRLSVVVVRKRCLLRLFAESGHTLQNPPLGTVVDSEATRPEWYDFYLTSQTANRGTVSPTYYNVIYDDNALKPDHMQRLTFKLCHLYYNWQGVISVPAPCQYAHKLTFLVAQSIHKEPSLELANKLFYL"
misc_feature 108..167
/gene="Piwil4"
/note="propagated from UniProtKB/Swiss-Prot (Q4G033.2);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 900..1250
/gene="Piwil4"
/note="PAZ domain, Piwi_like subfamily. In multi-cellular
organisms, the Piwi protein appears to be essential for
the maintenance of germline stem cells. In the Drosophila
male germline, Piwi was shown to be involved in the
silencing of retrotransposons in the...; Region:
PAZ_piwi_like; cd02845"
/db_xref="CDD:239211"
misc_feature order(1035..1037,1074..1076,1098..1100,1110..1112,
1164..1166,1209..1211,1215..1217)
/gene="Piwil4"
/note="nucleic acid-binding interface [nucleotide
binding]; other site"
/db_xref="CDD:239211"
misc_feature 1272..2600
/gene="Piwil4"
/note="PIWI domain, Piwi-like subfamily found in
eukaryotes. This domain is found in Piwi and closely
related proteins, where it is believed to perform a
crucial role in germline cells, via RNA silencing. RNA
silencing refers to a group of related...; Region:
Piwi_piwi-like_Euk; cd04658"
/db_xref="CDD:240016"
misc_feature order(1767..1769,1779..1781,1815..1826,1833..1835,
1863..1865,1872..1874,1884..1886,1896..1898)
/gene="Piwil4"
/note="5' RNA guide strand anchoring site [active]"
/db_xref="CDD:240016"
misc_feature order(1959..1961,1965..1967,2169..2171,2574..2576)
/gene="Piwil4"
/note="active site"
/db_xref="CDD:240016"
exon 195..258
/gene="Piwil4"
/inference="alignment:Splign:2.1.0"
exon 259..390
/gene="Piwil4"
/inference="alignment:Splign:2.1.0"
exon 391..605
/gene="Piwil4"
/inference="alignment:Splign:2.1.0"
exon 606..727
/gene="Piwil4"
/inference="alignment:Splign:2.1.0"
exon 728..808
/gene="Piwil4"
/inference="alignment:Splign:2.1.0"
exon 809..1006
/gene="Piwil4"
/inference="alignment:Splign:2.1.0"
exon 1007..1118
/gene="Piwil4"
/inference="alignment:Splign:2.1.0"
exon 1119..1242
/gene="Piwil4"
/inference="alignment:Splign:2.1.0"
exon 1243..1360
/gene="Piwil4"
/inference="alignment:Splign:2.1.0"
exon 1361..1472
/gene="Piwil4"
/inference="alignment:Splign:2.1.0"
exon 1473..1657
/gene="Piwil4"
/inference="alignment:Splign:2.1.0"
exon 1658..1730
/gene="Piwil4"
/inference="alignment:Splign:2.1.0"
exon 1731..1931
/gene="Piwil4"
/inference="alignment:Splign:2.1.0"
exon 1932..2035
/gene="Piwil4"
/inference="alignment:Splign:2.1.0"
exon 2036..2106
/gene="Piwil4"
/inference="alignment:Splign:2.1.0"
exon 2107..2260
/gene="Piwil4"
/inference="alignment:Splign:2.1.0"
exon 2261..2389
/gene="Piwil4"
/inference="alignment:Splign:2.1.0"
exon 2390..2537
/gene="Piwil4"
/inference="alignment:Splign:2.1.0"
exon 2538..3265
/gene="Piwil4"
/inference="alignment:Splign:2.1.0"
ORIGIN
aaccatactcccaatctccgagtcacagcctcaccctctccctgcggaagaggaaatcctcctgtagaggtcctgcagccttggaaagccgctgggaaaccaggaacatgagtggacgggcccgtgtgagggcgcgaggcatcaccactggccacagtgccagggaagtggagcgggccccaagagacctcatggtcacatctgtcagtcccggggacaacgaggccagcagtaggacaagcgtcatttcacagccacatgagcttggcgtctcttctggtgatggtagacgtactctcgtggaaaaaagaggcaatggcagacaggacttcgtcgatttgggtgtctgtaccagggagaagttgactcacgtaaaagattctaaaacaggttctagcggaatacctgtgcagctggctacaaatctcttccatttagatttgccccaggattggcagctataccagtaccatgtcacatacagcccggatttagcctctaggaggctgaggactgctctgctgtataaccacagcatactctccgacaaggcaaaggcattcgacggcaccagccttttcctctcagaaaagctggaccacaaagtcacagaactgacaagtgaaacccaaagaggggagactgtgaagataactctcaccctgaccagtgagctgttcccaaactccccgatgtgcattcagtttttcaatgtcatcttcagaaagatctttaaaaagttgagcatgtaccagattggacggaactactataagccttcagagccagtggagatcccccagtacaaattgtccctgtggcctgggtttgccatttctgtgtctcgctttgaaagcaaactcctgttcaatgctgacgtaaactataaagtcctccgcaatgagactgttctggaattcatgactgatctctgcctcagaaccgacatgtcatgcttcactgagacgtgccacaaacagctagtggggctcattgtccttaccaggtacaacaacaaaacatatcgtatcgatgacattgactggtctgtgaagcccacacatgcctttcagaagcgggatggctcagagaccacgtatgtggattactacaagcagcaatatgatatcaccttatctgacctaaatcagccagtgcttgtcagtctgttgaaaagaaggagaaatgataactccgagcctcagatggtccacctgatcccggagctctgctttctcacgggcctgaccagccaagcaacctcagacttccgcttgatgaaggcagtcgctgaagaaactcggctcagtcctatgggaaggcagcagcaactagcccgactggcagatgacatccagagaaaccaagtgactcggtttgagcttgagacctggggattgcattttggaagccagctatccctgaccggccgggttgttccctctgaaaagatcctgctgcaggaccacacatgtcaacctgcatttgctgctgattggtccaaagatatgcgatcttgcaaggttctgagttctgagcctttgaatacatggttgatcgtgtgctgtagcagggctgagcatttgattgaatccttcctgagctgtctgaggagagttggaggttccacgggattcagtgtgggccacccaaaaatcataaaagtggatgaaaaccctgcagcgttccttcgagccatccagctgcacgtcaaccccgatgttcagttggtgatgtgcatcctgccttctaatcagaagaactattacgactccattaaaagatatttgagctccgactgcccggtcccaagccagtgtgtgctgacccggaccttgaacaaacagggaatgatgctgagtgtggccaccaagatcgccatgcaaatgacctgcaaactcgggggcgagctgtgggctgtggagatcccattgaagtcactgatggtcgtgggcatcgacatctgtagagacgccctcagcaaggatgtagcggtcgtcgggtttgtcgccagcattaactccaggatcaccaggtggttttcccgctgtgtcctccagagaacggcagctgatattgcagattgcctgaaagtctgcatgactggtgctctcaacaagtggtacaaacacaaccacgatttgccggcacggataatcgcgtaccgggatggtgtgggcaacggccagctaaaggcagttttggaatacgaagtcccacagctgctgagcagtgtgacagaatgtggctccgacgccaggagctgtagactgtcagtggtcgtggtcaggaagaggtgtctgctgcgtctctttgccgagtctggccatacgctacagaaccccccacttggcactgtcgtggactcagaagcaacacgtccagagtggtatgacttctacctgaccagccagactgctaaccgggggactgttagtcccacctactacaatgtcatctatgacgacaacgctctgaagcctgaccatatgcagcggctgaccttcaaactgtgccacctctactacaactggcagggcgtaatcagtgtccctgctccgtgccagtatgcacacaagctgaccttcctggtggcacaaagcatccacaaggaaccaagtctggaattagccaataagctcttctacctgtgacaagtgggccaatagcatggctcgatggagacgccaaaaagcggttgctatgctttgttcaaatctgcctaatgctcaaggctcctgctgcttaaaggagcttcagcctgattttaagtattgggaaggagagggttttttggtttttgtttttttgttttgttttgttttgttttttgttttctgggttttttttttgttgttgttgttgttgtttttaaagtcatctgaatcagttgaggacaaacctatggggatttttgtctcccctgtgtctaaaaacaacaatgacaaacaaacaaaaacccacagagtgatgggttttcttgtggctctgtcaggcgacattttactttgtcctggtttatcctcgtatttttttttttttaagtaaatgcttgaggtgaattctcacatggtatatacgtgatgatattgggatatatcatcacagctaactggattctaaaacaatattcgtgtggtattgtgatggtgtttaagaggggtttaacttctttcctgacattaccagggttgttctaagtatcgtagagcattttgtagagtgggttaagtaaatactgaaaataaagactccctgagcatcg
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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