LOCUS       NM_001427479            8551 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus slingshot protein phosphatase 1 (Ssh1), mRNA.
ACCESSION   NM_001427479 XM_039090196
VERSION     NM_001427479.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8551)
  AUTHORS   Sparrow,N., Manetti,M.E., Bott,M., Fabianac,T., Petrilli,A.,
            Bates,M.L., Bunge,M.B., Lambert,S. and Fernandez-Valle,C.
  TITLE     The actin-severing protein cofilin is downstream of neuregulin
            signaling and is essential for Schwann cell myelination
  JOURNAL   J Neurosci 32 (15), 5284-5297 (2012)
   PUBMED   22496574
REFERENCE   2  (bases 1 to 8551)
  AUTHORS   Posadas,I., Perez-Martinez,F.C., Guerra,J., Sanchez-Verdu,P. and
            Cena,V.
  TITLE     Cofilin activation mediates Bax translocation to mitochondria
            during excitotoxic neuronal death
  JOURNAL   J Neurochem 120 (4), 515-527 (2012)
   PUBMED   22117609
REFERENCE   3  (bases 1 to 8551)
  AUTHORS   Torres,R.A., Drake,D.A., Solodushko,V., Jadhav,R., Smith,E.,
            Rocic,P. and Weber,D.S.
  TITLE     Slingshot isoform-specific regulation of cofilin-mediated vascular
            smooth muscle cell migration and neointima formation
  JOURNAL   Arterioscler Thromb Vasc Biol 31 (11), 2424-2431 (2011)
   PUBMED   21868701
  REMARK    GeneRIF: The regulation of VSMC migration by cofilin is SSH1
            dependent and that this mechanism potentially contributes to
            neointima formation following vascular injury in vivo.
REFERENCE   4  (bases 1 to 8551)
  AUTHORS   Chiu,T.T., Patel,N., Shaw,A.E., Bamburg,J.R. and Klip,A.
  TITLE     Arp2/3- and cofilin-coordinated actin dynamics is required for
            insulin-mediated GLUT4 translocation to the surface of muscle cells
  JOURNAL   Mol Biol Cell 21 (20), 3529-3539 (2010)
   PUBMED   20739464
REFERENCE   5  (bases 1 to 8551)
  AUTHORS   Yuen,E.Y., Liu,W., Kafri,T., van Praag,H. and Yan,Z.
  TITLE     Regulation of AMPA receptor channels and synaptic plasticity by
            cofilin phosphatase Slingshot in cortical neurons
  JOURNAL   J Physiol 588 (Pt 13), 2361-2371 (2010)
   PUBMED   20442266
  REMARK    GeneRIF: uppressing endogenous Slingshot with small RNA
            interference or function-blocking antibody led to a dramatic
            reduction of AMPA receptor-mediated excitatory postsynaptic
            currents
REFERENCE   6  (bases 1 to 8551)
  AUTHORS   Huang,T.Y., Minamide,L.S., Bamburg,J.R. and Bokoch,G.M.
  TITLE     Chronophin mediates an ATP-sensing mechanism for cofilin
            dephosphorylation and neuronal cofilin-actin rod formation
  JOURNAL   Dev Cell 15 (5), 691-703 (2008)
   PUBMED   19000834
REFERENCE   7  (bases 1 to 8551)
  AUTHORS   Soosairajah,J., Maiti,S., Wiggan,O., Sarmiere,P., Moussi,N.,
            Sarcevic,B., Sampath,R., Bamburg,J.R. and Bernard,O.
  TITLE     Interplay between components of a novel LIM kinase-slingshot
            phosphatase complex regulates cofilin
  JOURNAL   EMBO J 24 (3), 473-486 (2005)
   PUBMED   15660133
REFERENCE   8  (bases 1 to 8551)
  AUTHORS   Nishita,M., Wang,Y., Tomizawa,C., Suzuki,A., Niwa,R., Uemura,T. and
            Mizuno,K.
  TITLE     Phosphoinositide 3-kinase-mediated activation of cofilin
            phosphatase Slingshot and its role for insulin-induced membrane
            protrusion
  JOURNAL   J Biol Chem 279 (8), 7193-7198 (2004)
   PUBMED   14645219
REFERENCE   9  (bases 1 to 8551)
  AUTHORS   Niwa,R., Nagata-Ohashi,K., Takeichi,M., Mizuno,K. and Uemura,T.
  TITLE     Control of actin reorganization by Slingshot, a family of
            phosphatases that dephosphorylate ADF/cofilin
  JOURNAL   Cell 108 (2), 233-246 (2002)
   PUBMED   11832213
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Apr 3, 2024 this sequence version replaced NM_001427479.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.290961.1,
                                           SRR26643287.28455.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-89                JAXUCZ010000012.1  48281756-48281844
            90-130              JAXUCZ010000012.1  48286369-48286409
            131-234             JAXUCZ010000012.1  48306725-48306828
            235-299             JAXUCZ010000012.1  48310943-48311007
            300-421             JAXUCZ010000012.1  48311418-48311539
            422-490             JAXUCZ010000012.1  48317274-48317342
            491-556             JAXUCZ010000012.1  48318433-48318498
            557-751             JAXUCZ010000012.1  48321865-48322059
            752-845             JAXUCZ010000012.1  48323275-48323368
            846-974             JAXUCZ010000012.1  48324886-48325014
            975-1021            JAXUCZ010000012.1  48327836-48327882
            1022-1168           JAXUCZ010000012.1  48328867-48329013
            1169-1369           JAXUCZ010000012.1  48330627-48330827
            1370-1919           JAXUCZ010000012.1  48333577-48334126
            1920-8551           JAXUCZ010000012.1  48337181-48343812
FEATURES             Location/Qualifiers
     source          1..8551
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..8551
                     /gene="Ssh1"
                     /note="slingshot protein phosphatase 1"
                     /db_xref="GeneID:304580"
                     /db_xref="RGD:1306038"
     exon            1..89
                     /gene="Ssh1"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..3143
                     /gene="Ssh1"
                     /note="slingshot 1; slingshot homolog 1"
                     /codon_start=1
                     /product="protein phosphatase Slingshot homolog 1"
                     /protein_id="NP_001414408.1"
                     /db_xref="GeneID:304580"
                     /db_xref="RGD:1306038"
                     /translation="

MALVTLQRSPTPSAASSSASNSELEAGSDEDRKLNLSLSESFFMVKGAALFLQQGNSPQGQRSLQHPHKHAGDLPQHLQVMINLLRCEDRIKLAVRLESVWTDRVRYMVVVYTSGRQDTEENILLGVDFSSKESKSCTIGMVLRLWSDTKIHLDGDGGFSVSTAGRMHIFKPVSVQAMWSALQVLHKACEVARRHNYFPGGVALIWATYYESCISSEQSCINEWNAMQDLESTRPDSPALFVDKPTEGERTERLIKAKLRSIMMSQDLENVTSKEIRNELEKQMNCNLKEFKEFIDNEMLLILGQMDKPSLIFDHLYLGSEWNASNLEELQGSGVDYILNVTREIDNFFPGLFAYHNIRVYDEETTDLLAHWNEAYQFINKAKRNHSKCLVHCKMGVSRSASTVIAYAMKEFGWPLEKAFNYVKQKRSITRPNAGFMRQLSEYEGILDASKQRHNKLWRQQPADDTIAEPSEFLPETLDGALDTQLPCLEDATHPGLPRSLPSGGPSLPCCFRRLSDPLLLPHRDGAGGLVHLEDLERDALLEDEAQPVEVRKLVPSSQEGDRLCEKDVKRKLEFGSPKARSGSLPQVEELEKDGSPRPGRWRRASTQLERGLLDQENLNNNNSKRSCPDDFERDAVFGILSKVKPPYTSCADCMYPAAGAPEAFMERHEDPSSSAICTQPTFLPHVTSSPMAHTSNRSRAPERPTSGPANTSPFLLPAGSRKPDVSGSGAGVAPEPPASLPEPSRETSKALQKSLLSKNSHCDKNAANTEAAAKEELSTKKDPKPSKDLRLLFSQEGEKPTANSYLMQHQESIIQLQKAGLVRKHTKELERLKSLPSDSPSTCRDSAASRLEASIPEEGQEPAHPALDSQAGTEEKPVGGASQKSPPPTLLLRLDHTSKDFSKDFLKSACYTPTPSSISSNLTRSSSSDSIHSVRGKPGLVKQRAQEIETRLRLAGLTVSSPLKRSHSLAKLGSLNFSTEDLSSEADTSTIADSQDAKCTLSSFLPEPQAAPRNPSATSKPSGKSAPENLKIPVRVNKS"

     exon            90..130
                     /gene="Ssh1"
                     /inference="alignment:Splign:2.1.0"
     exon            131..234
                     /gene="Ssh1"
                     /inference="alignment:Splign:2.1.0"
     exon            235..299
                     /gene="Ssh1"
                     /inference="alignment:Splign:2.1.0"
     exon            300..421
                     /gene="Ssh1"
                     /inference="alignment:Splign:2.1.0"
     exon            422..490
                     /gene="Ssh1"
                     /inference="alignment:Splign:2.1.0"
     exon            491..556
                     /gene="Ssh1"
                     /inference="alignment:Splign:2.1.0"
     exon            557..751
                     /gene="Ssh1"
                     /inference="alignment:Splign:2.1.0"
     exon            752..845
                     /gene="Ssh1"
                     /inference="alignment:Splign:2.1.0"
     exon            846..974
                     /gene="Ssh1"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1021
                     /gene="Ssh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1168
                     /gene="Ssh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1369
                     /gene="Ssh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1919
                     /gene="Ssh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1920..8551
                     /gene="Ssh1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

ggggccgggccagcgccgcgatggccctggtgaccctgcagcgctctcccacgcccagcgccgcgtcgtcctccgcaagcaacagcgagttggaagctggcagcgatgaagaccggaagttgaacctcagcttgagcgagagctttttcatggtgaaaggagcggccctcttcctacagcagggaaacagcccgcagggccagcggagtcttcagcaccctcacaagcatgcaggtgacctgcctcagcacctgcaagtgatgatcaacctcctgcgctgtgaagacagaatcaaactggccgtgcgcctagagagcgtctggactgaccgtgtccgctacatggttgtggtgtacaccagcgggcgccaggacaccgaggagaacatcttgctgggagttgacttttccagtaaggagagcaaaagctgtacaatcgggatggtccttcgactgtggagcgacaccaagatccaccttgatggggacggggggttcagtgtgagcacggcgggcaggatgcacatattcaagccggtgtctgtccaggccatgtggtctgccttgcaagtgcttcacaaggcctgtgaagtggctcggagacataactacttcccggggggagtggcactcatctgggccacctactatgagagctgcatcagctcggagcagagctgcatcaatgaatggaacgccatgcaggacctggagtccacgaggcccgactcccccgcgctgttcgtggacaagccgacagaaggagaaagaactgagcgtctcattaaagccaaactccggagtatcatgatgagccaggaccttgagaatgtgacttctaaggaaatccgaaatgagctggagaagcaaatgaactgcaacctgaaagagttcaaggagttcatcgataacgagatgctgctcatcttgggccagatggacaagccctcccttatctttgaccatctttatcttggctccgagtggaatgcatccaatctggaggagctgcagggctcaggggtcgactacattttaaatgtcactagagaaatcgacaattttttccctggcctgtttgcataccataacatccgagtatatgacgaggagaccacggaccttcttgcccactggaatgaggcctatcagttcataaacaaagcgaaaaggaaccattccaagtgcctggtccattgcaagatgggcgtgagccggtctgcatccacggtcatagcgtacgccatgaaggagtttggctggcccctggagaaagcgtttaactatgtgaaacagaagcgcagcatcacgcggcccaacgcaggctttatgaggcagctgtcggagtatgaaggtatcctggatgcaagcaaacagcgacataacaaactgtggcgccagcagccggcagatgacaccatagcagagcccagtgagttcttgccagagaccttggatggcgccctggatactcagctgccctgtttggaagatgccacccaccccgggctcccgagaagcctgccctcgggaggaccctctctcccctgttgtttccgaagactctcggaccccctcctccttccccaccgtgatggtgcgggtggcctggtccacttagaagaccttgagagggatgctctgttagaggatgaggctcagccagtggaggtgcgcaagctggtcccgagttcccaggaaggtgacaggctgtgtgaaaaggatgtaaagaggaaactggagtttgggagccccaaagcccgcagcggctccttgcctcaggtggaggagctggagaaggatggcagcccaagaccggggaggtggaggcgggcctccacgcagctggagagaggtttgcttgaccaggaaaacctaaataacaacaacagcaagaggagctgtcccgatgactttgagcgtgatgcggtgtttgggatcctcagcaaagtgaagcctccctatacatcctgtgccgactgcatgtacccagcagctggggctcctgaggccttcatggagcggcatgaagaccccagctcctctgccatctgcacccagccgaccttcctcccccacgtcacgtcttccccaatggcccacacgagcaataggtcccgagctccggagaggccaacctcaggtccagctaacacctctccattcctactaccagcgggctccaggaagccagatgtcagtggttctggagccggggttgccccggaaccaccagcaagccttccagagccttccagagagacctcgaaagcccttcagaaatctctcctgtcgaagaattcccactgtgataagaacgcagccaatacggaggcggcggcaaaggaagaactgtcgaccaagaaagatccgaagccctcaaaggacctgaggctcctgttcagtcaagagggggagaagccgaccgccaatagctacctgatgcaacatcaggagtccattatccagttgcagaaggcaggcctggtccgaaagcacaccaaagagctggagaggttgaagagcctgccttcagactcaccatctacttgccgggacagtgccgccagcaggctggaggccagcatccccgaggagggtcaggagcctgcacacccagccctagacagccaagctggaactgaagagaagcctgtgggcggagcctcacagaagagccctccgcctaccctcctcctccgcctagatcacaccagtaaagacttctctaaagacttcctgaagtccgcgtgctacactcccaccccctcctccatcagctccaacctgacccggagctccagcagcgacagcatccacagtgtccgagggaagccagggctggtgaagcagcgggcgcaggagatcgagacgcggctccgcctggccggtctcactgtgtcctccccactgaaacgttcccattccctcgccaagctgggaagtctcaacttctccacggaggacctgtccagtgaggctgacacgtcaaccatcgccgactcacaggatgccaagtgcactctctcttccttcttgcccgaaccccaggccgcacctaggaacccctctgcgacctccaaaccatcagggaaatccgccccagagaacttgaaaatcccagtgagggtgaacaaaagctgactagcttccagctctgcgaggtcttcataatgtcttgatccgctctcgtgtcttgatttgtgttaacgacttcagccttctgagctttccccacctagagcctgtgagggggaacacccaggggtggggcctgggcaacccgggaactgtcagcccggagtaccgttcagatgcatacacacaggctggggctttgtctcagttgttgagagtgtgtacctgacacgcgccaagccctcggtttgattccccagcagcccataaaaccagacaaggctgcatacacccacatcccaacactggaggtggaagcagaaggattagaagttcaaagtcatcttcagctacttggtgagttttaggccagcctggcagagagagtgagagaaaaaaaaaacaaaaaaaactatgtgtgtacatacaaaatactcagtttgcaacgagtaaaggagccacagtggtgaggtccccgctgcccatgttcccggctcaatccggtcctcgagggagaatcctccgaggacaacacaaggcctacctctccgctcactgtgcatttcatttataaaatagtaatgaccgaggctcgatccgaggaacaatgctgtgtccagaagggtttttccaagagaattgtggggggttttgggtttggtttgttttattcttttgagggtggtgacccgcagaagcatcaagactttgaacctgactatcccaagaacagtgaggcaatatcatcagaggaaggcacttagtggcagcgcccgtttaacagtcctggtgcccatgggcggaggcaggggggtcctcagctgctggcttcaagcttacgtcacccaatcacagagaagggcactgctgaagggcactgctgagccttgtctgctgctaacaaggcatcctgtttggaattcagaccacctccggacctcaggacatgaggtcgtggatctgggatgtggttcatcccgctgagacactgtgacccccacccccaaccccacccccacttccacccaaggctctcattcagtgccatctccacatttgttgaaaggaaaggcaggtcagcaacgggtactttcttacaagctgctccccaggagtcactctgagaggagagagtctgttaaaaaaagcttcacagatgtttatgaagtgtcccttctcatggggagaatagaatactgcttccttgtctccagcttgccatgctgtaacgatggggcagaggaggcttggccacagcacaggtatgagtgcaggttagctcaatgaagcagggggcctgggttctgtgttcaaatcatgggcctctcctggtgcccatcgtgaaaagggacaagcagcgaggccgaccgaccagcagaaagccttgacttggtgttcggcaaatggtggcgcacagccctgtgacatcacctgggctctgttggtggttttgggttttggtttggtttggtgttttgagatagggtttctctgtagaccaggctggcctcaaactcagagatctgcctgcctctacctccctagtgctgggattaacagtgtgtgcgaacactggctggctggctgccttccttccttccttcccttcttccttttcttcctcttcttcttcttcctcttcccttccttccttccttccttccttccttccttccttccttccttccttcttaatttgagacaaggtctctctgcagtaccctctgctgccttggaactttctctggagacccggtaggcctcgaactcagcagagacccatctgcctctgcctctcaagggtttggcttttgtttttatttttgaggtagcctctcaccctgtagttcaagctggcctcaaactcacagcaatcctcctgcctcagcctcccaaatgctggtttgatcacaggtgtcatcccttcgtgcccccaggcttagttgtaacatttttaagggtaaacggtctagacttgtgatcctaccctcaggaggccgaggcaggtccatcgtgagttaaagggcagtcggggccacagagtgcgattctacctcagaagtggtaaataaccttgccaccagaagatggcattacctgcttcagatgtcttctctgcgagccccggtagaaagcttgctgactgtttttttgcgatgccccagggctgcttgtaacatggcaggaagacaggggacatatttgaaggctgcctttgctccttggatatctcagaccaaacccttcccgcctacacttcagacttgccagctgtccttttacctcttgagcagacggagtccttgtggaggtgaccacagctccatcctgcggttggctggttcagccagacagttccgtgagaccacaacatctttaaggatacggtgtgttctggaagtacacggatgggggcctccaccgcactggttagaacggagtctcaaaacggccatcctggtgaacgcccaagtgtctctaggatctaggccagttctcttttcattcctctgggggtctttgtgagctctgtctcagaactcttctacctggcgtgactttttttttttttttaatacatgtgcgttattttacagggctttattttcccactactgtcaatggcagtcaccttaaaaagcgatcatccactttttcctgaaaccctgtgggtttcttctattctcccctcggccaacaaaagcaaaaaaaaaaaaaaaaaaggccaagttaatatatgtcgccaagttcaatttcacatggtgggtcaatttttgtgtcaaaataattccctagatttggtaatgataggcttccgctgcgttttttaatcccatctgtaagagcggcaggatttttgaaaaccctcattttgaaaagccgtaatttctgttcaaagagtcaggacaggaggagggcaaactggaggaggtctctggatgctggcagactgcctgcacctgtcttagaagaactggcgcacccagcaacctccccatccttagaaccgaatccctggagtcatggtttccactcctcctggaaggttggctctgtctgtcaacacggatcggcctttaaccagaaaggcttccgtgaaactatcccctcgctaagctaaggcgtacctcagcagcggcatcagctcccgtattgtctcaggaaaagtttgttccagccaggctcggttggtcgcatacacttgtgatggggaggccattggatccctgggttcaaggctgtgtagaaccttgacctccaccccccacccctcccccgaaaatgttagctctgtgagctgctctatgcctggctagtttagctgtgtgtgtgtgtaaccttagcaaacaaaggtacagggacttaggcagcgttgagccaccagtttcgatggctgccaatttcaccgaatgtccttgttgaaagaagagccttctgctctgattgatggtccgggaacttggctgctcttcctcgctctcactcgcctgcacttccatagcttcccaaaagcctgagccatgtggtggccttgtatgtccacacagaaggcttcctgacgtgtaagggagatgggtactgggcaggggggtggggtggggggagtctggatgcccgattgcgtgaactaagagcaaggtgtctttctcaaatcccccacccctcgttctcagtacggaagccctgctggccacatgcagttcatccccgtggctctcacgggttcccagatggctgcactgctctgctcccattgctatagctgaagatccgacccagcatcctctgcccgagaaaagcccggagggtgcctcaggatggaaccaagagagattagatgttgacagccgccctgtacttttgggcaccaatctcagggaccaccccggaaggctctcgaatctcctgctcttcggggaccatttctccttagcaaggacgagaacacaagagacatcacacatcaccgccccttaaaagagttaccttctacacgctggcagttactggtgtgagaattcatttccaaccccagtgggttggctgatgctcagcggcacacctaacgaatgccttcagggtaacccgtgtacctagggtcccttgcccgaccctagctgtgcaatccagcaggaccagggagactctcgctcttccccacattggttgcaatgtcactgctgatgagggaaactctccttcccaccctaaaggctaggttcctgctgaccgtaagggcagatgaaggtcattggtgttcccctacccaaagccccttggttttgttactatggaggtgtgagagtccactgtgtatggacatatgcatataagtatttgcatatgcgctgtgtgtatgtgcgtatgccttgtgtatgcattatacatactatacttaaaagtgtattctactcgatcaaacctggtgtatgctgttcctcacacactgtgggtcctccagctttgcagggaagtcgccctggacccatctgcagtgctgccaccaggggccatctggagaagggttgactaccccgttcccttttgcagtagacaccacagtccctccttcagtccctgtcttagacacacagcctctgccgccctggccccttggcctcgctgcatgagaagacagctgcttcctcctctaccccgtaattattcttttacaactgagtgccttaataatcgtttacaaatactgtgtatttatgcgcagccgttcagctctcatctttcgtggctgggtacttcggtcccggtggttaagattagcacctgagctcgtccctaccccccatccacgtgtgtcactctgctatgcagttgacatcctgggtcctgactactccacccagcctgctgaatccccacaggctatgcggacatcggcaaaccccgaaaacctgaggtaggtagtgaaggacgagatttggtttgccaggcagccgagaggtggtgcaggcccagcgttccctgaaccacagcccaagaccacaccacctgaacctctcaaggtcgccctctagtttacagaggcttgccaacgcctaccctccaccccttcacactccctcctcttctgcctgtgtcctgagctccttgctacatgggtacagctcactccagaggaggagtggcaccagaccgcatccttcacctttcaaacgcccgcagccaccaccgtgccggattccttcgtcacattacaacttcgatggtttttttttttattgtattgtttttcttgttttttatattatatatttaagaggcagtatcttttgtactgtgaattttcagtagaagaggcatagtgcacttttttttttttacttctgttggtgtgtactgtacataatagtctgcgtgcttctcgtgatgagaataaacacttcctttatacatgt

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