LOCUS       NM_001427246            2735 bp    mRNA    linear   ROD 01-JUL-2024
DEFINITION  Rattus norvegicus paired-like homeobox 2b (Phox2b), mRNA.
ACCESSION   NM_001427246 XM_008770167
VERSION     NM_001427246.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2735)
  AUTHORS   Cardani,S., Janes,T.A., Betzner,W. and Pagliardini,S.
  TITLE     Knockdown of PHOX2B in the retrotrapezoid nucleus reduces the
            central CO2 chemoreflex in rats
  JOURNAL   Elife 13, 94653 (2024)
   PUBMED   38727716
  REMARK    GeneRIF: Knockdown of PHOX2B in the retrotrapezoid nucleus reduces
            the central CO2 chemoreflex in rats.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2735)
  AUTHORS   Honzel,E., Hernandez-Morato,I., Joshi,A., Pennington-Fitzgerald,W.,
            Moayedi,Y. and Pitman,M.J.
  TITLE     Temporal Expression of Hox Genes and Phox2b in the Rat Nucleus
            Ambiguus During Development: Implications on Laryngeal Innervation
  JOURNAL   Laryngoscope 133 (12), 3462-3471 (2023)
   PUBMED   37350386
  REMARK    GeneRIF: Temporal Expression of Hox Genes and Phox2b in the Rat
            Nucleus Ambiguus During Development: Implications on Laryngeal
            Innervation.
REFERENCE   3  (bases 1 to 2735)
  AUTHORS   Kajiwara,R., Nakamura,S., Ikeda,K., Onimaru,H., Yoshida,A.,
            Tsutsumi,Y., Nakayama,K., Mochizuki,A., Dantsuji,M., Nishimura,A.,
            Tachikawa,S., Iijima,T. and Inoue,T.
  TITLE     Intrinsic properties and synaptic connectivity of Phox2b-expressing
            neurons in rat rostral parvocellular reticular formation
  JOURNAL   Neurosci Res 178, 41-51 (2022)
   PUBMED   34973291
  REMARK    GeneRIF: Intrinsic properties and synaptic connectivity of
            Phox2b-expressing neurons in rat rostral parvocellular reticular
            formation.
REFERENCE   4  (bases 1 to 2735)
  AUTHORS   Ikeda,K., Kaneko,R., Yanagawa,Y., Ogawa,M., Kobayashi,K., Arata,S.,
            Kawakami,K. and Onimaru,H.
  TITLE     Analysis of the neuronal network of the medullary respiratory
            center in transgenic rats expressing archaerhodopsin-3 in
            Phox2b-expressing cells
  JOURNAL   Brain Res Bull 144, 39-45 (2019)
   PUBMED   30448454
  REMARK    GeneRIF: Findings showed that Phox2b-expressing pFRG/Pre-I neurons
            are involved in the maintenance of the basic respiratory rhythm in
            neonatal rat.
REFERENCE   5  (bases 1 to 2735)
  AUTHORS   Nagoya,K., Nakamura,S., Ikeda,K., Onimaru,H., Yoshida,A.,
            Nakayama,K., Mochizuki,A., Kiyomoto,M., Sato,F., Kawakami,K.,
            Takahashi,K. and Inoue,T.
  TITLE     Distinctive features of Phox2b-expressing neurons in the rat
            reticular formation dorsal to the trigeminal motor nucleus
  JOURNAL   Neuroscience 358, 211-226 (2017)
   PUBMED   28673717
  REMARK    GeneRIF: These results suggest that Phox2b(+) RdV neurons have
            distinct neurotransmitter phenotypes and firing properties from
            Phox2b(-) RdV neurons and might play important roles in
            feeding-related functions including suckling and possibly
            mastication.
REFERENCE   6  (bases 1 to 2735)
  AUTHORS   Young,H.M., Ciampoli,D., Hsuan,J. and Canty,A.J.
  TITLE     Expression of Ret-, p75(NTR)-, Phox2a-, Phox2b-, and tyrosine
            hydroxylase-immunoreactivity by undifferentiated neural
            crest-derived cells and different classes of enteric neurons in the
            embryonic mouse gut
  JOURNAL   Dev Dyn 216 (2), 137-152 (1999)
   PUBMED   10536054
REFERENCE   7  (bases 1 to 2735)
  AUTHORS   Yokoyama,M., Watanabe,H. and Nakamura,M.
  TITLE     Genomic structure and functional characterization of NBPhox
            (PMX2B), a homeodomain protein specific to catecholaminergic cells
            that is involved in second messenger-mediated transcriptional
            activation
  JOURNAL   Genomics 59 (1), 40-50 (1999)
   PUBMED   10395798
REFERENCE   8  (bases 1 to 2735)
  AUTHORS   Pattyn,A., Morin,X., Cremer,H., Goridis,C. and Brunet,J.F.
  TITLE     The homeobox gene Phox2b is essential for the development of
            autonomic neural crest derivatives
  JOURNAL   Nature 399 (6734), 366-370 (1999)
   PUBMED   10360575
REFERENCE   9  (bases 1 to 2735)
  AUTHORS   Young,H.M., Hearn,C.J., Ciampoli,D., Southwell,B.R., Brunet,J.F.
            and Newgreen,D.F.
  TITLE     A single rostrocaudal colonization of the rodent intestine by
            enteric neuron precursors is revealed by the expression of Phox2b,
            Ret, and p75 and by explants grown under the kidney capsule or in
            organ culture
  JOURNAL   Dev Biol 202 (1), 67-84 (1998)
   PUBMED   9758704
REFERENCE   10 (bases 1 to 2735)
  AUTHORS   Pattyn,A., Morin,X., Cremer,H., Goridis,C. and Brunet,J.F.
  TITLE     Expression and interactions of the two closely related homeobox
            genes Phox2a and Phox2b during neurogenesis
  JOURNAL   Development 124 (20), 4065-4075 (1997)
   PUBMED   9374403
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Jan 16, 2024 this sequence version replaced XM_008770167.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN14984021,
                              SAMN17050745 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-356               JAXUCZ010000014.1  41420011-41420366
            357-544             JAXUCZ010000014.1  41421216-41421403
            545-2735            JAXUCZ010000014.1  41422325-41424515
FEATURES             Location/Qualifiers
     source          1..2735
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p11"
     gene            1..2735
                     /gene="Phox2b"
                     /gene_synonym="NBPhox"
                     /note="paired-like homeobox 2b"
                     /db_xref="GeneID:364152"
                     /db_xref="RGD:1560582"
     exon            1..356
                     /gene="Phox2b"
                     /gene_synonym="NBPhox"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    23..25
                     /gene="Phox2b"
                     /gene_synonym="NBPhox"
                     /note="upstream in-frame stop codon"
     CDS             116..1060
                     /gene="Phox2b"
                     /gene_synonym="NBPhox"
                     /note="neuroblastoma Phox"
                     /codon_start=1
                     /product="paired mesoderm homeobox protein 2B"
                     /protein_id="NP_001414175.1"
                     /db_xref="GeneID:364152"
                     /db_xref="RGD:1560582"
                     /translation="

MYKMEYSYLNSSAYESCMAGMDTSSLASAYADFSSCSQASGFQYNPIRTTFGATSGCPSLTPGSCSLGTLRDHQSSPYAAVPYKLFTDHGGLNEKRKQRRIRTTFTSAQLKELERVFAETHYPDIYTREELALKIDLTEARVQVWFQNRRAKFRKQERAAAAAAAAAKNGSSGKKSDSSRDDESKEAKSTDPDSTGGPGPNPNPTPSCGANGGGGGGPSPAGAPGAAGPGGPGGEPGKGGAAAAAAAAAAAAAAAAAAAAGGLAAAGGPGQGWAPGPGPITSIPDSLGGPFASVLSSLQRPNGAKAALVKSSMF"

     misc_feature    410..580
                     /gene="Phox2b"
                     /gene_synonym="NBPhox"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     exon            357..544
                     /gene="Phox2b"
                     /gene_synonym="NBPhox"
                     /inference="alignment:Splign:2.1.0"
     exon            545..2735
                     /gene="Phox2b"
                     /gene_synonym="NBPhox"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

aggccagtttggaggcaggcgttgagctgtgcacatcttcccactccagctaccgtctccacatccatcttttatttcatttttccacttggctgagccatccagaaccttttcaatgtataaaatggaatattcttacctcaattcctctgcctacgagtcctgtatggccgggatggacacctcgagcctggcttcagcttatgcagacttcagttcctgcagccaggccagtggcttccagtataacccgataaggaccacttttggggccacgtccggctgcccgtccctcacgccgggatcctgcagcctgggcaccctcagggaccaccagagcagtccgtacgccgcagttccatacaaactcttcaccgaccacggtggcctcaacgagaaacgcaagcagcggcgcatccgcaccaccttcacaagcgcgcagctcaaagagttggagagggtcttcgctgagacacactaccccgacatctacacccgggaggagctagcgctgaagatcgacctcaccgaggcgagagtccaggtgtggttccagaaccgtcgggccaagtttcgaaagcaggagcgcgccgccgccgcagccgccgccgcagccaaaaacggctcctccgggaagaagtcggactcctcccgggatgacgagagcaaagaagccaagagcaccgatcccgatagcactgggggcccgggacccaaccccaacccgacccccagctgcggggcaaatggcggcggcggcggagggcccagcccagccggagctccgggggcggcgggcccggggggcccgggaggcgaacccggcaagggcggggcggctgcggcggctgctgcagcggcggcggcggcagcggcggctgcggccgcggcggcgggaggcctggctgcggccgggggccccggacaaggctgggctcccggcccgggccctatcacctccatcccggattcgcttggaggtcccttcgccagcgtcttatcttcgctccaaagacccaacggtgccaaagccgccttagtgaagagcagtatgttctgatctgcgatccgaggcggcggcgggcgagcccggggtccgggctggcgagtgggcgagtgggtagacccaaggctagtatcgctgctgtcagtggctttttccatcgaaggcctaaaatgatcgcgattcgaaaaaacgagaaaatgacgtcgctcccatttcaaccccacttctatcccctatctcccctcccaacaaaacaaaaacaaaaacaaaacaaaaattatccctggcttcgcacctgcctcgggctgcgcataggacagggctccacccaagggatgtgagcctggacttcggggcactctcagggggctgtgtctgagtgacgggtgtctgtctgtctcggagaatgtgtgtctgtggccccaagtaaatgatagggagagatgagggtggccacaaccaactcagtgacttcttagaaaaaaaaatgttggaaagcagcaacgacataaaagcaaaaatgaaataaatcaaaaaagtttaaaaagatccaaatggaaggaacaatttgaaaatacaaaggggcgagggaggactgtgtctggagctgaggatttgatcttgcgaacccctaaattctcgcgctcgcgactgcacagactgtcttgtggttcctctttaggaaagagtactgatggctgtccggcccggttcccctcaggtccttgtgttctggccactgcagagatggctcactcagactgtcctggcagccaaagtgactttctggagccctgcttgcctgtccccaactcgctggaaaccatctcgccattagcgcaactgatcccccacaccgttgctatgcccgaaccgaatcttcgcagccgcttggccctgaaagatgccctgtacaagagataccttttcatcctcaaactctgcaaaccgtgtctcatatttcacagcgctccttttttcctctcccgccacccccaccggcattttcttcttccaccagcttttatggaactttttggcactgctttgctttggagtcagttgcagcccacatagctggctgcagagaaataaatctacccgacaaggggaaggcacacacacgtttgcagaaagtgtctcggctcgcgtttctgattgagtgatccgagctgaactcatcctgtagggtggacggactgtatattgatgattccttctatgcgcagtttagacatctctgttgggctttttttttaatttttattttaaaaggcacaaactatagatattagttgaatgttgaggctttaacttttcagtgtctttcgacagctgtgttctgtgactcaattgtatcgtgttactatcagtacagcgtctcctctacgtgaccgtataatgtttttctcttcttgtagtctctatggtgtgtctttatgacgtaataaggttctcacgggttcgattcctttgtgtttagagagaccaggttcagacaatggtatatatttttgttatcaggtgcatgtctgtctgatttccttttcttctcctttggactatgtttgtgaacatgagcgtcataagttatgtttcagaatttcaaatttatttatacgtgttataatgaatgcttctatttaaaggggaaatatttctacatgtgcatatagttttccaagagtgtaccattaacttgattgttaataaaaaaaaaaagcaagtc

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