LOCUS       NM_001415696            3026 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus Meis homeobox 2 (Meis2), mRNA.
ACCESSION   NM_001415696 XM_006234754
VERSION     NM_001415696.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3026)
  AUTHORS   Sun C, Liu H, Si K, Wu Y, Zhao K, Xu R, Zhou Z and Zheng Z.
  TITLE     Meis2 represses the osteoblastic transdifferentiation of aortic
            valve interstitial cells through the Notch1/Twist1 pathway
  JOURNAL   Biochem Biophys Res Commun 509 (2), 455-461 (2019)
   PUBMED   30594396
REFERENCE   2  (bases 1 to 3026)
  AUTHORS   Verheije R, Kupchik GS, Isidor B, Kroes HY, Lynch SA, Hawkes L,
            Hempel M, Gelb BD, Ghoumid J, D'Amours G, Chandler K, Dubourg C,
            Loddo S, Tumer Z, Shaw-Smith C, Nizon M, Shevell M, Van Hoof E,
            Anyane-Yeboa K, Cerbone G, Clayton-Smith J, Cogne B, Corre P,
            Corveleyn A, De Borre M, Hjortshoj TD, Fradin M, Gewillig M,
            Goldmuntz E, Hens G, Lemyre E, Journel H, Kini U, Kortum F, Le
            Caignec C, Novelli A, Odent S, Petit F, Revah-Politi A, Stong N,
            Strom TM, van Binsbergen E, Devriendt K and Breckpot J.
  CONSRTM   DDD study
  TITLE     Heterozygous loss-of-function variants of MEIS2 cause a triad of
            palatal defects, congenital heart defects, and intellectual
            disability
  JOURNAL   Eur J Hum Genet 27 (2), 278-290 (2019)
   PUBMED   30291340
REFERENCE   3  (bases 1 to 3026)
  AUTHORS   Shiga Y, Akiyama M, Nishiguchi KM, Sato K, Shimozawa N, Takahashi
            A, Momozawa Y, Hirata M, Matsuda K, Yamaji T, Iwasaki M, Tsugane S,
            Oze I, Mikami H, Naito M, Wakai K, Yoshikawa M, Miyake M, Yamashiro
            K, Kashiwagi K, Iwata T, Mabuchi F, Takamoto M, Ozaki M, Kawase K,
            Aihara M, Araie M, Yamamoto T, Kiuchi Y, Nakamura M, Ikeda Y,
            Sonoda KH, Ishibashi T, Nitta K, Iwase A, Shirato S, Oka Y, Satoh
            M, Sasaki M, Fuse N, Suzuki Y, Cheng CY, Khor CC, Baskaran M,
            Perera S, Aung T, Vithana EN, Cooke Bailey JN, Kang JH, Pasquale
            LR, Haines JL, Wiggs JL, Burdon KP, Gharahkhani P, Hewitt AW,
            Mackey DA, MacGregor S, Craig JE, Allingham RR, Hauser M, Ashaye A,
            Budenz DL, Akafo S, Williams SEI, Kamatani Y, Nakazawa T and Kubo
            M.
  CONSRTM   Japan Glaucoma Society Omics Group (JGS-OG); NEIGHBORHOOD
            Consortium
  TITLE     Genome-wide association study identifies seven novel susceptibility
            loci for primary open-angle glaucoma
  JOURNAL   Hum Mol Genet 27 (8), 1486-1496 (2018)
   PUBMED   29452408
REFERENCE   4  (bases 1 to 3026)
  AUTHORS   Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M,
            Kivioja T, Morgunova E and Taipale J.
  TITLE     DNA-dependent formation of transcription factor pairs alters their
            binding specificity
  JOURNAL   Nature 527 (7578), 384-388 (2015)
   PUBMED   26550823
REFERENCE   5  (bases 1 to 3026)
  AUTHORS   Wu YH, Zhao H, Zhou LP, Zhao CX, Wu YF, Zhen LX, Li J, Ge DX, Xu L,
            Lin L, Liu Y, Liang DD and Chen YH.
  TITLE     miR-134 Modulates the Proliferation of Human Cardiomyocyte
            Progenitor Cells by Targeting Meis2
  JOURNAL   Int J Mol Sci 16 (10), 25199-25213 (2015)
   PUBMED   26512644
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3026)
  AUTHORS   Fujino T, Yamazaki Y, Largaespada DA, Jenkins NA, Copeland NG,
            Hirokawa K and Nakamura T.
  TITLE     Inhibition of myeloid differentiation by Hoxa9, Hoxb8, and Meis
            homeobox genes
  JOURNAL   Exp Hematol 29 (7), 856-863 (2001)
   PUBMED   11438208
REFERENCE   7  (bases 1 to 3026)
  AUTHORS   Liu Y, MacDonald RJ and Swift GH.
  TITLE     DNA binding and transcriptional activation by a PDX1.PBX1b.MEIS2b
            trimer and cooperation with a pancreas-specific basic
            helix-loop-helix complex
  JOURNAL   J Biol Chem 276 (21), 17985-17993 (2001)
   PUBMED   11279116
REFERENCE   8  (bases 1 to 3026)
  AUTHORS   Skogh C, Eriksson C, Kokaia M, Meijer XC, Wahlberg LU, Wictorin K
            and Campbell K.
  TITLE     Generation of regionally specified neurons in expanded glial
            cultures derived from the mouse and human lateral ganglionic
            eminence
  JOURNAL   Mol Cell Neurosci 17 (5), 811-820 (2001)
   PUBMED   11358480
REFERENCE   9  (bases 1 to 3026)
  AUTHORS   Yang Y, Hwang CK, D'Souza UM, Lee SH, Junn E and Mouradian MM.
  TITLE     Three-amino acid extension loop homeodomain proteins Meis2 and TGIF
            differentially regulate transcription
  JOURNAL   J Biol Chem 275 (27), 20734-20741 (2000)
   PUBMED   10764806
REFERENCE   10 (bases 1 to 3026)
  AUTHORS   Toresson H, Parmar M and Campbell K.
  TITLE     Expression of Meis and Pbx genes and their protein products in the
            developing telencephalon: implications for regional differentiation
  JOURNAL   Mech Dev 94 (1-2), 183-187 (2000)
   PUBMED   10842069
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000118.1.
            
            On Dec 23, 2022 this sequence version replaced XM_006234754.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5756307, SAMEA5760383
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-340               JACYVU010000118.1  26810314-26810653   c
            341-573             JACYVU010000118.1  26808834-26809066   c
            574-715             JACYVU010000118.1  26806986-26807127   c
            716-766             JACYVU010000118.1  26806217-26806267   c
            767-817             JACYVU010000118.1  26804982-26805032   c
            818-967             JACYVU010000118.1  26804066-26804215   c
            968-1082            JACYVU010000118.1  26794469-26794583   c
            1083-1228           JACYVU010000118.1  26747488-26747633   c
            1229-1305           JACYVU010000118.1  26667869-26667945   c
            1306-1364           JACYVU010000118.1  26615623-26615681   c
            1365-1454           JACYVU010000118.1  26614194-26614283   c
            1455-1550           JACYVU010000118.1  26613730-26613825   c
            1551-3026           JACYVU010000118.1  26609969-26611444   c
FEATURES             Location/Qualifiers
     source          1..3026
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q35"
     gene            1..3026
                     /gene="Meis2"
                     /note="Meis homeobox 2"
                     /db_xref="GeneID:311311"
                     /db_xref="RGD:1305198"
     exon            1..340
                     /gene="Meis2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    287..289
                     /gene="Meis2"
                     /note="upstream in-frame stop codon"
     CDS             329..1513
                     /gene="Meis2"
                     /note="Meis1, myeloid ecotropic viral integration site 1
                     homolog 2"
                     /codon_start=1
                     /product="homeobox protein Meis2"
                     /protein_id="NP_001402625.1"
                     /db_xref="GeneID:311311"
                     /db_xref="RGD:1305198"
                     /translation="

MAQRYDELPHYGGMDGVGVPASMYGDPHAPRPIPPVHHLNHGPPLHATQHYGAHAPHPNVMPASMGSAVNDALKRDKDAIYGHPLFPLLALVFEKCELATCTPREPGVAGGDVCSSDSFNEDIAVFAKQVRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCLKGKMPIDLVIDERDGSSKSDHEELSGSSTNLADHNPSSWRDHDDATSTHSAGTPGPSSGGHASQSGDNSSEQGDGLDNSVASPGTGDDDDPDKDKKRQKKRGIFPKVATNIMRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAVSQGAAYSPEGQPMGSFVLDGQQHMGIRPAGPMSGMGMNMGMDGQWHYM"

     misc_feature    656..910
                     /gene="Meis2"
                     /note="N-terminal of Homeobox Meis and PKNOX1; Region:
                     Meis_PKNOX_N; pfam16493"
                     /db_xref="CDD:435375"
     misc_feature    order(1172..1174,1301..1303,1310..1315,1322..1324)
                     /gene="Meis2"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     misc_feature    1211..1327
                     /gene="Meis2"
                     /note="Homeobox KN domain; Region: Homeobox_KN; pfam05920"
                     /db_xref="CDD:428673"
     exon            341..573
                     /gene="Meis2"
                     /inference="alignment:Splign:2.1.0"
     exon            574..715
                     /gene="Meis2"
                     /inference="alignment:Splign:2.1.0"
     exon            716..766
                     /gene="Meis2"
                     /inference="alignment:Splign:2.1.0"
     exon            767..817
                     /gene="Meis2"
                     /inference="alignment:Splign:2.1.0"
     exon            818..967
                     /gene="Meis2"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1082
                     /gene="Meis2"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1228
                     /gene="Meis2"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1305
                     /gene="Meis2"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1364
                     /gene="Meis2"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1454
                     /gene="Meis2"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1550
                     /gene="Meis2"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..3026
                     /gene="Meis2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

actgagaggaaaagaagagaaagaggggtaaaggaggaccgaagaggaagaggaggggagggggaggaggaggtggaggaggaggaggaggaagatcaggaggaggaggaggaagaagagaaaaaaagagaaaaagaagaaatatcactgaaaaaaaatcttcgttttcttgactgggctttccccacccccctaaaaataacattggaaaattgggagaagtctccttggtttggagaataaggactcttcaacctagctcactttcttatccggactgggatattaaatatacgacacatccaggagtttattggagcgcagactgatggcgcaaaggtacgatgagctgccccattacggcgggatggacggagtaggggttcctgcttccatgtacggagaccctcacgcgccgcggccgattcccccggttcaccacctaaaccacgggccgccgctccacgccacgcagcactacggcgcgcacgccccgcaccccaatgtcatgccagccagcatgggatctgctgtcaacgacgccttgaagagagacaaggacgcgatctacgggcacccgttgtttcctctgttagcgctggtctttgagaagtgcgagctggcgacttgcactccccgggaacccggagtggccggcggagacgtctgttcctctgactccttcaacgaggacatcgcggtcttcgccaagcaggttcgcgccgaaaagcctcttttttcctcaaatccagagctggataatttgatgatacaagcaatacaagtgctaaggtttcatcttctggagttagaaaaggtccacgaactgtgtgataacttctgccaccggtacattagctgtttgaaggggaaaatgcccattgacctcgtgattgatgagagagacggaagctccaagtcagatcatgaagaactttcaggctcctccacaaatctcgccgaccacaacccttcatcctggcgagaccacgatgatgcaacctcaactcactcagcaggcaccccaggaccctccagcgggggccatgcttcccagagtggagacaacagcagtgagcaaggcgacgggctagacaacagtgtagcttcacctggcacaggtgatgacgacgatccagacaaggacaaaaaacgccagaagaaaagaggcatattccccaaagtcgcgacaaatatcatgagagcgtggctcttccagcatctcacacacccgtacccttcagaagagcagaagaagcagttagcacaagacacggggctgacaattctgcaagtgaacaactggtttattaatgccagaagaagaatagtacagcccatgattgaccagtcaaatcgagcagtgagccaaggagcagcgtatagtccagagggtcagcctatggggagctttgtattggatggtcagcaacacatggggatccggcccgcaggacccatgagtggaatgggcatgaatatgggcatggatgggcaatggcactacatgtaaccttcgccatgtaaagcaatcgcaaggcaagggggaagtttgcagagcatgccaggggactacgtttctcagggtggtccagtgggaatgggtatggcccagccgagttacactcctccccagatgaccccacaccctactcagttaagacatggacccccaatgcattcatatttgccaagccatccccaccacccagccatgatgatgcacggaggaccccctacccaccctggaatgactatgtcagcacagagccccacaatgttaaattctgtagatcccaatgttggcggacaggttatggacattcatgcccaatagtataagggaactcaaggaagaaggaaacacacgcaaaaactattgactaagactctccgaactttgaccagatgtgacacttaatatgaaactccagacagctgtgattattttttacttttgtcatttttcatcaagcaacagaggaccaatgggacaagaacacaaatgtgaagcgatgggggtcatcgagacaattttgtccatgcaaagatcctctggagaaagactccgagagttataactactgtagcataaacatagggactaagttaaacttgtacatttctgttgatcactccgttatgttgcctcaaatagttttagaagagaaaaaaatatatccttgttttccacactatgtgtgttgttcccaaaagaatgactgtcttggttcatcagtgaattcactatccagaagagaactgtggtatattttaaatctgttgggccaatgagaaaagaaccacgctgcggagagagatggacacttggctgaacctcatcactaactccagcggctagaatgtgttttcatgcccggcctttgttcccccgtccgtgtgtcctttagtttcaaacagatctttatagtttgtgcttcataagccaattcttattatgattttgggggactgttcttcaaagagcttgccagtgaagatttagagacaaagcgaagacttcttcaagtcccaagccttggctatggacaaagcaatcttaagttggacagcttcctcaacacgcgcacatgtgtgcgcgagcgcacacacacacacacacacacacacacacacacacacacagaaattattcatggtcattgcaccataagattctatcaggaactcaaagcttgggggataaaacggagcaagagaatactgtaacaaacttcgtacagagttcggtcttttaattgtttcatgttagatattctatgtgtttacctcaattgaaaaaaaaaaagaatgtttttgctagtatcagatctgctgtggaattggtattgtatgtccatgggatcctcttttctcagcacgtgttcctcactagaagaaaatgctgttacctttaagctttgtcaaatttacattaaaatacttgtatgaggactgtgacgttatgttaaaaaaaggtgttaagtcacaaaatgcggtaataaatatttcatttttgatttttt

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