LOCUS       NM_001415696            3026 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus Meis homeobox 2 (Meis2), mRNA.
ACCESSION   NM_001415696 XM_006234754
VERSION     NM_001415696.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3026)
  AUTHORS   Sun,C., Liu,H., Si,K., Wu,Y., Zhao,K., Xu,R., Zhou,Z. and Zheng,Z.
  TITLE     Meis2 represses the osteoblastic transdifferentiation of aortic
            valve interstitial cells through the Notch1/Twist1 pathway
  JOURNAL   Biochem Biophys Res Commun 509 (2), 455-461 (2019)
   PUBMED   30594396
REFERENCE   2  (bases 1 to 3026)
  AUTHORS   Verheije,R., Kupchik,G.S., Isidor,B., Kroes,H.Y., Lynch,S.A.,
            Hawkes,L., Hempel,M., Gelb,B.D., Ghoumid,J., D'Amours,G.,
            Chandler,K., Dubourg,C., Loddo,S., Tumer,Z., Shaw-Smith,C.,
            Nizon,M., Shevell,M., Van Hoof,E., Anyane-Yeboa,K., Cerbone,G.,
            Clayton-Smith,J., Cogne,B., Corre,P., Corveleyn,A., De Borre,M.,
            Hjortshoj,T.D., Fradin,M., Gewillig,M., Goldmuntz,E., Hens,G.,
            Lemyre,E., Journel,H., Kini,U., Kortum,F., Le Caignec,C.,
            Novelli,A., Odent,S., Petit,F., Revah-Politi,A., Stong,N.,
            Strom,T.M., van Binsbergen,E., Devriendt,K. and Breckpot,J.
  CONSRTM   DDD study
  TITLE     Heterozygous loss-of-function variants of MEIS2 cause a triad of
            palatal defects, congenital heart defects, and intellectual
            disability
  JOURNAL   Eur J Hum Genet 27 (2), 278-290 (2019)
   PUBMED   30291340
REFERENCE   3  (bases 1 to 3026)
  AUTHORS   Shiga,Y., Akiyama,M., Nishiguchi,K.M., Sato,K., Shimozawa,N.,
            Takahashi,A., Momozawa,Y., Hirata,M., Matsuda,K., Yamaji,T.,
            Iwasaki,M., Tsugane,S., Oze,I., Mikami,H., Naito,M., Wakai,K.,
            Yoshikawa,M., Miyake,M., Yamashiro,K., Kashiwagi,K., Iwata,T.,
            Mabuchi,F., Takamoto,M., Ozaki,M., Kawase,K., Aihara,M., Araie,M.,
            Yamamoto,T., Kiuchi,Y., Nakamura,M., Ikeda,Y., Sonoda,K.H.,
            Ishibashi,T., Nitta,K., Iwase,A., Shirato,S., Oka,Y., Satoh,M.,
            Sasaki,M., Fuse,N., Suzuki,Y., Cheng,C.Y., Khor,C.C., Baskaran,M.,
            Perera,S., Aung,T., Vithana,E.N., Cooke Bailey,J.N., Kang,J.H.,
            Pasquale,L.R., Haines,J.L., Wiggs,J.L., Burdon,K.P.,
            Gharahkhani,P., Hewitt,A.W., Mackey,D.A., MacGregor,S., Craig,J.E.,
            Allingham,R.R., Hauser,M., Ashaye,A., Budenz,D.L., Akafo,S.,
            Williams,S.E.I., Kamatani,Y., Nakazawa,T. and Kubo,M.
  CONSRTM   Japan Glaucoma Society Omics Group (JGS-OG); NEIGHBORHOOD
            Consortium
  TITLE     Genome-wide association study identifies seven novel susceptibility
            loci for primary open-angle glaucoma
  JOURNAL   Hum Mol Genet 27 (8), 1486-1496 (2018)
   PUBMED   29452408
REFERENCE   4  (bases 1 to 3026)
  AUTHORS   Jolma,A., Yin,Y., Nitta,K.R., Dave,K., Popov,A., Taipale,M.,
            Enge,M., Kivioja,T., Morgunova,E. and Taipale,J.
  TITLE     DNA-dependent formation of transcription factor pairs alters their
            binding specificity
  JOURNAL   Nature 527 (7578), 384-388 (2015)
   PUBMED   26550823
REFERENCE   5  (bases 1 to 3026)
  AUTHORS   Wu,Y.H., Zhao,H., Zhou,L.P., Zhao,C.X., Wu,Y.F., Zhen,L.X., Li,J.,
            Ge,D.X., Xu,L., Lin,L., Liu,Y., Liang,D.D. and Chen,Y.H.
  TITLE     miR-134 Modulates the Proliferation of Human Cardiomyocyte
            Progenitor Cells by Targeting Meis2
  JOURNAL   Int J Mol Sci 16 (10), 25199-25213 (2015)
   PUBMED   26512644
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3026)
  AUTHORS   Fujino,T., Yamazaki,Y., Largaespada,D.A., Jenkins,N.A.,
            Copeland,N.G., Hirokawa,K. and Nakamura,T.
  TITLE     Inhibition of myeloid differentiation by Hoxa9, Hoxb8, and Meis
            homeobox genes
  JOURNAL   Exp Hematol 29 (7), 856-863 (2001)
   PUBMED   11438208
REFERENCE   7  (bases 1 to 3026)
  AUTHORS   Liu,Y., MacDonald,R.J. and Swift,G.H.
  TITLE     DNA binding and transcriptional activation by a PDX1.PBX1b.MEIS2b
            trimer and cooperation with a pancreas-specific basic
            helix-loop-helix complex
  JOURNAL   J Biol Chem 276 (21), 17985-17993 (2001)
   PUBMED   11279116
REFERENCE   8  (bases 1 to 3026)
  AUTHORS   Skogh,C., Eriksson,C., Kokaia,M., Meijer,X.C., Wahlberg,L.U.,
            Wictorin,K. and Campbell,K.
  TITLE     Generation of regionally specified neurons in expanded glial
            cultures derived from the mouse and human lateral ganglionic
            eminence
  JOURNAL   Mol Cell Neurosci 17 (5), 811-820 (2001)
   PUBMED   11358480
REFERENCE   9  (bases 1 to 3026)
  AUTHORS   Yang,Y., Hwang,C.K., D'Souza,U.M., Lee,S.H., Junn,E. and
            Mouradian,M.M.
  TITLE     Three-amino acid extension loop homeodomain proteins Meis2 and TGIF
            differentially regulate transcription
  JOURNAL   J Biol Chem 275 (27), 20734-20741 (2000)
   PUBMED   10764806
REFERENCE   10 (bases 1 to 3026)
  AUTHORS   Toresson,H., Parmar,M. and Campbell,K.
  TITLE     Expression of Meis and Pbx genes and their protein products in the
            developing telencephalon: implications for regional differentiation
  JOURNAL   Mech Dev 94 (1-2), 183-187 (2000)
   PUBMED   10842069
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Dec 23, 2022 this sequence version replaced XM_006234754.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.17597.1,
                                           SRR26643297.12436.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-340               JAXUCZ010000003.1  123397412-123397751 c
            341-573             JAXUCZ010000003.1  123395932-123396164 c
            574-715             JAXUCZ010000003.1  123394079-123394220 c
            716-766             JAXUCZ010000003.1  123393310-123393360 c
            767-817             JAXUCZ010000003.1  123392075-123392125 c
            818-967             JAXUCZ010000003.1  123391159-123391308 c
            968-1082            JAXUCZ010000003.1  123381566-123381680 c
            1083-1228           JAXUCZ010000003.1  123334585-123334730 c
            1229-1305           JAXUCZ010000003.1  123254965-123255041 c
            1306-1364           JAXUCZ010000003.1  123202720-123202778 c
            1365-1454           JAXUCZ010000003.1  123201291-123201380 c
            1455-1550           JAXUCZ010000003.1  123200827-123200922 c
            1551-3026           JAXUCZ010000003.1  123197066-123198541 c
FEATURES             Location/Qualifiers
     source          1..3026
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q35"
     gene            1..3026
                     /gene="Meis2"
                     /note="Meis homeobox 2"
                     /db_xref="GeneID:311311"
                     /db_xref="RGD:1305198"
     exon            1..340
                     /gene="Meis2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    287..289
                     /gene="Meis2"
                     /note="upstream in-frame stop codon"
     CDS             329..1513
                     /gene="Meis2"
                     /note="Meis1, myeloid ecotropic viral integration site 1
                     homolog 2"
                     /codon_start=1
                     /product="homeobox protein Meis2"
                     /protein_id="NP_001402625.1"
                     /db_xref="GeneID:311311"
                     /db_xref="RGD:1305198"
                     /translation="

MAQRYDELPHYGGMDGVGVPASMYGDPHAPRPIPPVHHLNHGPPLHATQHYGAHAPHPNVMPASMGSAVNDALKRDKDAIYGHPLFPLLALVFEKCELATCTPREPGVAGGDVCSSDSFNEDIAVFAKQVRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCLKGKMPIDLVIDERDGSSKSDHEELSGSSTNLADHNPSSWRDHDDATSTHSAGTPGPSSGGHASQSGDNSSEQGDGLDNSVASPGTGDDDDPDKDKKRQKKRGIFPKVATNIMRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAVSQGAAYSPEGQPMGSFVLDGQQHMGIRPAGPMSGMGMNMGMDGQWHYM"

     misc_feature    656..910
                     /gene="Meis2"
                     /note="N-terminal of Homeobox Meis and PKNOX1; Region:
                     Meis_PKNOX_N; pfam16493"
                     /db_xref="CDD:465140"
     misc_feature    order(1172..1174,1301..1303,1310..1315,1322..1324)
                     /gene="Meis2"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     misc_feature    1211..1327
                     /gene="Meis2"
                     /note="Homeobox KN domain; Region: Homeobox_KN; pfam05920"
                     /db_xref="CDD:428673"
     exon            341..573
                     /gene="Meis2"
                     /inference="alignment:Splign:2.1.0"
     exon            574..715
                     /gene="Meis2"
                     /inference="alignment:Splign:2.1.0"
     exon            716..766
                     /gene="Meis2"
                     /inference="alignment:Splign:2.1.0"
     exon            767..817
                     /gene="Meis2"
                     /inference="alignment:Splign:2.1.0"
     exon            818..967
                     /gene="Meis2"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1082
                     /gene="Meis2"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1228
                     /gene="Meis2"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1305
                     /gene="Meis2"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1364
                     /gene="Meis2"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1454
                     /gene="Meis2"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1550
                     /gene="Meis2"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..3026
                     /gene="Meis2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

actgagaggaaaagaagagaaagaggggtaaaggaggaccgaagaggaagaggaggggagggggaggaggaggtggaggaggaggaggaggaagatcaggaggaggaggaggaagaagagaaaaaaagagaaaaagaagaaatatcactgaaaaaaaatcttcgttttcttgactgggctttccccacccccctaaaaataacattggaaaattgggagaagtctccttggtttggagaataaggactcttcaacctagctcactttcttatccggactgggatattaaatatacgacacatccaggagtttattggagcgcagactgatggcgcaaaggtacgatgagctgccccattacggcgggatggacggagtaggggttcctgcttccatgtacggagaccctcacgcgccgcggccgattcccccggttcaccacctaaaccacgggccgccgctccacgccacgcagcactacggcgcgcacgccccgcaccccaatgtcatgccagccagcatgggatctgctgtcaacgacgccttgaagagagacaaggacgcgatctacgggcacccgttgtttcctctgttagcgctggtctttgagaagtgcgagctggcgacttgcactccccgggaacccggagtggccggcggagacgtctgttcctctgactccttcaacgaggacatcgcggtcttcgccaagcaggttcgcgccgaaaagcctcttttttcctcaaatccagagctggataatttgatgatacaagcaatacaagtgctaaggtttcatcttctggagttagaaaaggtccacgaactgtgtgataacttctgccaccggtacattagctgtttgaaggggaaaatgcccattgacctcgtgattgatgagagagacggaagctccaagtcagatcatgaagaactttcaggctcctccacaaatctcgccgaccacaacccttcatcctggcgagaccacgatgatgcaacctcaactcactcagcaggcaccccaggaccctccagcgggggccatgcttcccagagtggagacaacagcagtgagcaaggcgacgggctagacaacagtgtagcttcacctggcacaggtgatgacgacgatccagacaaggacaaaaaacgccagaagaaaagaggcatattccccaaagtcgcgacaaatatcatgagagcgtggctcttccagcatctcacacacccgtacccttcagaagagcagaagaagcagttagcacaagacacggggctgacaattctgcaagtgaacaactggtttattaatgccagaagaagaatagtacagcccatgattgaccagtcaaatcgagcagtgagccaaggagcagcgtatagtccagagggtcagcctatggggagctttgtattggatggtcagcaacacatggggatccggcccgcaggacccatgagtggaatgggcatgaatatgggcatggatgggcaatggcactacatgtaaccttcgccatgtaaagcaatcgcaaggcaagggggaagtttgcagagcatgccaggggactacgtttctcagggtggtccagtgggaatgggtatggcccagccgagttacactcctccccagatgaccccacaccctactcagttaagacatggacccccaatgcattcatatttgccaagccatccccaccacccagccatgatgatgcacggaggaccccctacccaccctggaatgactatgtcagcacagagccccacaatgttaaattctgtagatcccaatgttggcggacaggttatggacattcatgcccaatagtataagggaactcaaggaagaaggaaacacacgcaaaaactattgactaagactctccgaactttgaccagatgtgacacttaatatgaaactccagacagctgtgattattttttacttttgtcatttttcatcaagcaacagaggaccaatgggacaagaacacaaatgtgaagcgatgggggtcatcgagacaattttgtccatgcaaagatcctctggagaaagactccgagagttataactactgtagcataaacatagggactaagttaaacttgtacatttctgttgatcactccgttatgttgcctcaaatagttttagaagagaaaaaaatatatccttgttttccacactatgtgtgttgttcccaaaagaatgactgtcttggttcatcagtgaattcactatccagaagagaactgtggtatattttaaatctgttgggccaatgagaaaagaaccacgctgcggagagagatggacacttggctgaacctcatcactaactccagcggctagaatgtgttttcatgcccggcctttgttcccccgtccgtgtgtcctttagtttcaaacagatctttatagtttgtgcttcataagccaattcttattatgattttgggggactgttcttcaaagagcttgccagtgaagatttagagacaaagcgaagacttcttcaagtcccaagccttggctatggacaaagcaatcttaagttggacagcttcctcaacacgcgcacatgtgtgcgcgagcgcacacacacacacacacacacacacacacacacacacacagaaattattcatggtcattgcaccataagattctatcaggaactcaaagcttgggggataaaacggagcaagagaatactgtaacaaacttcgtacagagttcggtcttttaattgtttcatgttagatattctatgtgtttacctcaattgaaaaaaaaaaagaatgtttttgctagtatcagatctgctgtggaattggtattgtatgtccatgggatcctcttttctcagcacgtgttcctcactagaagaaaatgctgttacctttaagctttgtcaaatttacattaaaatacttgtatgaggactgtgacgttatgttaaaaaaaggtgttaagtcacaaaatgcggtaataaatatttcatttttgatttttt

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