LOCUS       NM_001414936            3635 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus RAS protein activator like 3 (Rasal3), transcript
            variant 1, mRNA.
ACCESSION   NM_001414936 XM_006241059
VERSION     NM_001414936.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3635)
  AUTHORS   Saito S, Kawamura T, Higuchi M, Kobayashi T, Yoshita-Takahashi M,
            Yamazaki M, Abe M, Sakimura K, Kanda Y, Kawamura H, Jiang S, Naito
            M, Yoshizaki T, Takahashi M and Fujii M.
  TITLE     RASAL3, a novel hematopoietic RasGAP protein, regulates the number
            and functions of NKT cells
  JOURNAL   Eur J Immunol 45 (5), 1512-1523 (2015)
   PUBMED   25652366
REFERENCE   2  (bases 1 to 3635)
  AUTHORS   Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M and
            Stoorvogel W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   3  (bases 1 to 3635)
  AUTHORS   Ghosh D, Lippert D, Krokhin O, Cortens JP and Wilkins JA.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000177.1.
            
            On Dec 15, 2022 this sequence version replaced XM_006241059.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132291, SAMD00132301
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-501               JACYVU010000177.1  6569795-6570295     c
            502-641             JACYVU010000177.1  6566354-6566493     c
            642-720             JACYVU010000177.1  6566149-6566227     c
            721-782             JACYVU010000177.1  6565993-6566054     c
            783-853             JACYVU010000177.1  6562873-6562943     c
            854-980             JACYVU010000177.1  6562359-6562485     c
            981-1079            JACYVU010000177.1  6562178-6562276     c
            1080-1616           JACYVU010000177.1  6561238-6561774     c
            1617-1761           JACYVU010000177.1  6560650-6560794     c
            1762-1906           JACYVU010000177.1  6559875-6560019     c
            1907-2143           JACYVU010000177.1  6558858-6559094     c
            2144-2345           JACYVU010000177.1  6558560-6558761     c
            2346-2464           JACYVU010000177.1  6558350-6558468     c
            2465-2855           JACYVU010000177.1  6557205-6557595     c
            2856-3013           JACYVU010000177.1  6556850-6557007     c
            3014-3077           JACYVU010000177.1  6556160-6556223     c
            3078-3635           JACYVU010000177.1  6555502-6556059     c
FEATURES             Location/Qualifiers
     source          1..3635
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..3635
                     /gene="Rasal3"
                     /gene_synonym="RGD1309019"
                     /note="RAS protein activator like 3"
                     /db_xref="GeneID:314596"
                     /db_xref="RGD:1309019"
     exon            1..501
                     /gene="Rasal3"
                     /gene_synonym="RGD1309019"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..3233
                     /gene="Rasal3"
                     /gene_synonym="RGD1309019"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="RAS protein activator like-3 isoform 1"
                     /protein_id="NP_001401865.1"
                     /db_xref="GeneID:314596"
                     /db_xref="RGD:1309019"
                     /translation="

MKTECGQTTRRSVTFWSCSRDSAMDPPLQNEDSQTQPSPLTSYRWHTGGRGEKIAGGFRWGRFAGWGRALSHQEPMVSSQPAPRSLFRRVLSAPPKESRPNRLRFSKSLWGRHKNVVPLEPKLNPKAPEPELELEGAPDLRAAHIPEPPAPDMPVWNIDGFALLEGRLVMLGEEEGPRQIRMGSASSESSMQAALGNLKDPVRTPGKIEPEATGSNQVHNVRKLLKRLKEKKRAKSELGAHTPRDGPSSALGSRESLATLSELDLGVERDVRVWPLHPSLLGEPYCFQVTWAGGSRCFSCRSSAERDRWIEDLRRQFQPSQDNVERQETWLTVWVHEAKGLPRAAAPGVRAELWLDGALLARTAPRAGPDQLFWAERFHFEALPPARRLSLRLRGAGPAGATVGRVVLELDEVSIPRAPAAGLERWFPVLGAPAGAVLRARIRVRCLRVLPSERYKELAEFLTFHYARLCMALEPALSAQAKEELAAAMVRVLRATGRAQALVTDLGTAELERCGGREALLFRENTLATKAIDEYMKLVAQEYLQETLGQVVRSLCASTEDCEVDPSKCPTPELPKCQARLRSSCEEVFENIIHSYNYFPAELGTVFSNWREACKARGSEALGPRLVCASLFLRLLCPAILAPSLFGLAPEHPAPGPARTLTLIAKVIQNLANCAPFGEKEAYMVFMNSFLEDHGPAMRHFLDQVAMVDTDTTPSGYQGSGDLALQLAVLHVQLCTIFAELDQKTRDSLEPLPTILQAIEEGRPVPVSVPMRLPLNTAHVQSSFSSGEKPGFLAPRDLPKHTPLISKSQSLRSFQGAGSWARRRPDGERPQRRPRPVLRTQSVPARRPTHHRPAAGSKPRPKGSLRTGPATSGRAWARTSTSLPRKPSVPWQRQLDQPGDRYQTPGTHRPVGKLAEIQCEVAALREEQKALSHLVESLSTHIQALTEQQEQLRCQLQDLDSRLGAGISKLDSKGGLPSNGSLGLKSLEHRMTEMECSQNQLRDTLQSLQLLSKTPGSRSQPPPLKAPCVNGADLSMGT"

     misc_feature    714..1154
                     /gene="Rasal3"
                     /gene_synonym="RGD1309019"
                     /note="Pleckstrin homology-like domain; Region: PH-like;
                     cl17171"
                     /db_xref="CDD:450165"
     misc_feature    1071..1469
                     /gene="Rasal3"
                     /gene_synonym="RGD1309019"
                     /note="C2 domain; Region: C2; cl14603"
                     /db_xref="CDD:449331"
     misc_feature    1443..2414
                     /gene="Rasal3"
                     /gene_synonym="RGD1309019"
                     /note="Ras-GTPase Activating Domain of DAB2IP and similar
                     proteins; Region: RasGAP_DAB2IP; cd05136"
                     /db_xref="CDD:213338"
     misc_feature    order(1560..1562,1671..1673,1677..1679,1683..1688,
                     1692..1694,1701..1703,1713..1715,1989..1991,2013..2018,
                     2025..2030,2037..2039,2100..2102,2109..2114,2121..2123,
                     2133..2135,2139..2141,2154..2159)
                     /gene="Rasal3"
                     /gene_synonym="RGD1309019"
                     /note="putative RAS interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:213338"
     exon            502..641
                     /gene="Rasal3"
                     /gene_synonym="RGD1309019"
                     /inference="alignment:Splign:2.1.0"
     exon            642..720
                     /gene="Rasal3"
                     /gene_synonym="RGD1309019"
                     /inference="alignment:Splign:2.1.0"
     exon            721..782
                     /gene="Rasal3"
                     /gene_synonym="RGD1309019"
                     /inference="alignment:Splign:2.1.0"
     exon            783..853
                     /gene="Rasal3"
                     /gene_synonym="RGD1309019"
                     /inference="alignment:Splign:2.1.0"
     exon            854..980
                     /gene="Rasal3"
                     /gene_synonym="RGD1309019"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1079
                     /gene="Rasal3"
                     /gene_synonym="RGD1309019"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1616
                     /gene="Rasal3"
                     /gene_synonym="RGD1309019"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..1761
                     /gene="Rasal3"
                     /gene_synonym="RGD1309019"
                     /inference="alignment:Splign:2.1.0"
     exon            1762..1906
                     /gene="Rasal3"
                     /gene_synonym="RGD1309019"
                     /inference="alignment:Splign:2.1.0"
     exon            1907..2143
                     /gene="Rasal3"
                     /gene_synonym="RGD1309019"
                     /inference="alignment:Splign:2.1.0"
     exon            2144..2345
                     /gene="Rasal3"
                     /gene_synonym="RGD1309019"
                     /inference="alignment:Splign:2.1.0"
     exon            2346..2464
                     /gene="Rasal3"
                     /gene_synonym="RGD1309019"
                     /inference="alignment:Splign:2.1.0"
     exon            2465..2855
                     /gene="Rasal3"
                     /gene_synonym="RGD1309019"
                     /inference="alignment:Splign:2.1.0"
     exon            2856..3013
                     /gene="Rasal3"
                     /gene_synonym="RGD1309019"
                     /inference="alignment:Splign:2.1.0"
     exon            3014..3077
                     /gene="Rasal3"
                     /gene_synonym="RGD1309019"
                     /inference="alignment:Splign:2.1.0"
     exon            3078..3635
                     /gene="Rasal3"
                     /gene_synonym="RGD1309019"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

acagacggctgctggttctggactggccaggaaatcaaggtaagagagggtgtacgtgtggcaccctcaagtgtgttctgtcctttggaggcaaagctgagaagagactggggaagatgaagacagaatgtgggcagacaacgcgcagaagtgtcaccttttggtcttgtagcagagactccgccatggacccaccgctgcagaatgaagattcccaaacgcagccctcgccgctgacgtcctatcgttggcacactggaggcagaggggagaagattgctggagggttccgctggggccgcttcgcaggctggggaagggccctgagccatcaggagcccatggtgagcagccagccagcccctagatctctgtttcgtcgggtcctctctgcacctcctaaggagtcacgacccaatcgcctccggttttccaagagcctgtgggggaggcacaagaacgtggtaccgctggaacccaagctaaatccgaaggccccagagccagagctggagttggagggagccccagacctgcgcgctgcacatatccctgagcctcccgcccctgacatgcctgtttggaacattgatggctttgccctgctcgaaggaagactggtgatgctcggtgaggaggagggtcctcgccaaatccgaatgggaagtgccagctcggaaagcagcatgcaggcagccttggggaacctcaaagacccagttcggactcctgggaaaattgagccggaagctactggttccaaccaggtccacaatgttcggaagttactcaagaggctgaaggagaagaaaagggccaagtcggaactgggagcccacactcctcgagatggaccctccagtgctcttggttccagagaatcgctggccacactctctgagctggacctaggcgttgagagggatgtgagagtctggccgctgcatcctagcctcctgggggagccatattgcttccaggtaacgtgggcaggtgggagccgctgtttctcttgtcgctcgagcgctgagagagaccgttggattgaggaccttcgtcggcagttccagcctagccaggacaatgtggaacgacaagagacctggctgacagtgtgggtgcacgaagccaaagggcttccccgagcagctgcacccggagtgcgtgcggagctgtggttggacggcgcgctactggcgcgcactgcccctcgggcgggccctgaccaactcttctgggccgaacgcttccacttcgaggcgttgccacctgcccgtcgcctgtcgctgcggctgcgcggagcaggcccggcaggggcaaccgtgggcagggtggtactagaactggacgaggtgagcatcccccgcgcgcctgccgcaggcctggagcgctggttccccgtgctcggggctccggcgggtgcggtgctacgggcgcggatcagggtacgatgtctgcgcgtgctgccgtcggagcgctataaggagttagcggagttcctcaccttccactacgcgcgcctgtgcatggcgctggagcccgcgctgtctgctcaggccaaggaggagctggcagcagccatggtgcgcgtgctacgagccactggccgagcgcaggcattggtgacagacctaggaaccgcagagctggagcgctgtggaggccgtgaagcgctgctattccgagaaaataccttagccacaaaggccattgatgaatacatgaaactggtggcacaggagtacctccaggagaccctgggccaggttgtgcggagtctctgtgcctccaccgaggactgtgaagtggaccccagcaagtgcccaacaccggagctgccaaaatgccaagctagactgcgaagcagttgtgaggaggtttttgaaaacatcatccactcttacaactatttcccagcagagctgggcaccgtgttctcaaattggcgggaagcatgcaaagcacgaggctctgaggcactgggcccccggctggtgtgtgcttctctcttcctaaggctcctatgccccgccatcttggcacctagcctctttggcctggcaccagagcaccccgccccaggcccagccagaactcttacactcatcgccaaggtcatccagaatcttgccaactgtgctccgtttggtgagaaggaagcctacatggtctttatgaatagcttcctggaagatcatggaccggccatgcgacacttcctggatcaggtagctatggtggacacagataccacacccagtggctaccagggaagtggagacctggccctccagttggcagttcttcatgtccagctctgcacaatctttgctgaacttgaccagaaaactcgagacagcttggaaccactacccaccatccttcaagccattgaggagggtcggcctgtcccagtgtctgtaccaatgcgtcttcccctgaacactgctcatgtccaatccagcttctcttcaggggagaaacccggcttcctggcaccccgagacctccccaagcacactcctctcatttccaagagccagtctttgcgcagctttcaaggggcaggaagctgggcccgtcggcggccagatggggagcggccccagcggcggccgcggccagtgctgcgcacacagagcgtccctgccagacgccctacccaccatcgccctgctgcgggttccaagcctcgacccaaaggctctctacgcactggtcctgcgacttccggacgggcctgggctaggacttccacctctctacctcggaagccatcggtgccttggcagcgccaactggaccagcccggggaccgataccaaactccgggaacgcaccgaccagtgggcaagctagcagagatacaatgcgaggtagctgcactccgcgaggaacagaaagccctgtcccatctggtggagtcgctgagtacccacatccaggccttgacggagcagcaagagcagctccgctgtcagctgcaggatctggactccagactgggagctgggatctcaaagttggattctaagggtggtctcccaagcaacggtagcctcgggctgaaaagtctggagcaccgcatgactgagatggaatgttctcagaaccagctgagggataccctccaaagcctacagcttctttcaaaaactccaggatctcggagccagcccccgcctctcaaagcaccatgtgtcaatggagctgatctgtcgatgggcacctgagtatttcaccccactccatacagtctggaagccaggagagccactacagaggattttctgactacctcagtccttcatggcccttagtaggggacagagtgggaggtgtcaatcactctggtaactgtgaggttgcccagtaaatctccatttcagaaaatcactggtttctctgcccctacaaagattaatgcaagagcatacccagttctctactcagctcccccaaattcttacctaatttgaagtctcccgaagatgaaaatgattagcaaaattgtcctcactattggtgtgatctaaggtcatcactctaaaagactccattctctcttctgtatctaaaaattctctgcatagttaaaggtattcaataaaaggtatttatcattgttgtgggaa

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