LOCUS       NM_001414917            7096 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus NOVA alternative splicing regulator 1 (Nova1),
            transcript variant 3, mRNA.
ACCESSION   NM_001414917 XM_039111965
VERSION     NM_001414917.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7096)
  AUTHORS   Liu,Z., Lou,Y., Cui,J.C., Chen,Y., Liu,J.T., Yuan,Y., Han,Y.,
            Huo,Y.L., Qi,Y.X., Jiang,Z.L. and Yao,Q.P.
  TITLE     Circular RNA UVRAG Mediated by Alternative Splicing Factor NOVA1
            Regulates Adhesion and Migration of Vascular Smooth Muscle Cells
  JOURNAL   Genes (Basel) 12 (3), 418 (2021)
   PUBMED   33799408
  REMARK    GeneRIF: Circular RNA UVRAG Mediated by Alternative Splicing Factor
            NOVA1 Regulates Adhesion and Migration of Vascular Smooth Muscle
            Cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7096)
  AUTHORS   Li,H., Lv,B., Kong,L., Xia,J., Zhu,M., Hu,L., Zhen,D., Wu,Y.,
            Jia,X., Zhu,S. and Cui,H.
  TITLE     Nova1 mediates resistance of rat pheochromocytoma cells to
            hypoxia-induced apoptosis via the Bax/Bcl-2/caspase-3 pathway
  JOURNAL   Int J Mol Med 40 (4), 1125-1133 (2017)
   PUBMED   28791345
  REMARK    GeneRIF: Nova1 mediates resistance of rat pheochromocytoma cells to
            hypoxia-induced apoptosis via the Bax/Bcl-2/caspase-3 pathway.
REFERENCE   3  (bases 1 to 7096)
  AUTHORS   Vernia,S., Edwards,Y.J., Han,M.S., Cavanagh-Kyros,J., Barrett,T.,
            Kim,J.K. and Davis,R.J.
  TITLE     An alternative splicing program promotes adipose tissue
            thermogenesis
  JOURNAL   Elife 5, e17672 (2016)
   PUBMED   27635635
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7096)
  AUTHORS   Kapeli,K., Pratt,G.A., Vu,A.Q., Hutt,K.R., Martinez,F.J.,
            Sundararaman,B., Batra,R., Freese,P., Lambert,N.J., Huelga,S.C.,
            Chun,S.J., Liang,T.Y., Chang,J., Donohue,J.P., Shiue,L., Zhang,J.,
            Zhu,H., Cambi,F., Kasarskis,E., Hoon,S., Ares,M. Jr., Burge,C.B.,
            Ravits,J., Rigo,F. and Yeo,G.W.
  TITLE     Distinct and shared functions of ALS-associated proteins TDP-43,
            FUS and TAF15 revealed by multisystem analyses
  JOURNAL   Nat Commun 7, 12143 (2016)
   PUBMED   27378374
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7096)
  AUTHORS   Storchel,P.H., Thummler,J., Siegel,G., Aksoy-Aksel,A., Zampa,F.,
            Sumer,S. and Schratt,G.
  TITLE     A large-scale functional screen identifies Nova1 and Ncoa3 as
            regulators of neuronal miRNA function
  JOURNAL   EMBO J 34 (17), 2237-2254 (2015)
   PUBMED   26105073
  REMARK    GeneRIF: Nova1 and Ncoa3 stimulate miRNA function by different
            mechanisms that converge on Argonaute (Ago) proteins, core
            components of the miRNA-induced silencing complex (miRISC).
REFERENCE   6  (bases 1 to 7096)
  AUTHORS   Eom,T., Zhang,C., Wang,H., Lay,K., Fak,J., Noebels,J.L. and
            Darnell,R.B.
  TITLE     NOVA-dependent regulation of cryptic NMD exons controls synaptic
            protein levels after seizure
  JOURNAL   Elife 2, e00178 (2013)
   PUBMED   23359859
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 7096)
  AUTHORS   Li,H., Sun,C., Wang,Y., Gao,Y., Liu,Y., Gao,Y., Li,X. and Zhang,C.
  TITLE     Dynamic expression pattern of neuro-oncological ventral antigen 1
            (Nova1) in the rat brain after focal cerebral ischemia/reperfusion
            insults
  JOURNAL   J Histochem Cytochem 61 (1), 45-54 (2013)
   PUBMED   23042482
  REMARK    GeneRIF: Nova1 might mediate neuronal responsiveness, and its
            expression might positively correlate with neural repair after
            ischemia-reperfusion insults in the rat brain.
REFERENCE   8  (bases 1 to 7096)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   9  (bases 1 to 7096)
  AUTHORS   Kumar,D.V., Nighorn,A. and St John,P.A.
  TITLE     Role of Nova-1 in regulating alpha2N, a novel glycine receptor
            splice variant, in developing spinal cord neurons
  JOURNAL   J Neurobiol 52 (2), 156-165 (2002)
   PUBMED   12124753
  REMARK    GeneRIF: Role of Nova-1 in regulating alpha2N, a novel glycine
            receptor splice variant, in developing spinal cord neurons.
REFERENCE   10 (bases 1 to 7096)
  AUTHORS   Jensen,K.B., Dredge,B.K., Stefani,G., Zhong,R., Buckanovich,R.J.,
            Okano,H.J., Yang,Y.Y. and Darnell,R.B.
  TITLE     Nova-1 regulates neuron-specific alternative splicing and is
            essential for neuronal viability
  JOURNAL   Neuron 25 (2), 359-371 (2000)
   PUBMED   10719891
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Dec 14, 2022 this sequence version replaced XM_039111965.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.666436.1,
                                           SRR26360181.200887.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840115 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-157               JAXUCZ010000006.1  69632281-69632437   c
            158-301             JAXUCZ010000006.1  69630546-69630689   c
            302-403             JAXUCZ010000006.1  69580242-69580343   c
            404-570             JAXUCZ010000006.1  69531175-69531341   c
            571-642             JAXUCZ010000006.1  69524090-69524161   c
            643-7096            JAXUCZ010000006.1  69506983-69513436   c
FEATURES             Location/Qualifiers
     source          1..7096
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q21"
     gene            1..7096
                     /gene="Nova1"
                     /gene_synonym="Nova-1"
                     /note="NOVA alternative splicing regulator 1"
                     /db_xref="GeneID:298992"
                     /db_xref="RGD:621345"
     exon            1..157
                     /gene="Nova1"
                     /gene_synonym="Nova-1"
                     /inference="alignment:Splign:2.1.0"
     exon            158..301
                     /gene="Nova1"
                     /gene_synonym="Nova-1"
                     /inference="alignment:Splign:2.1.0"
     exon            302..403
                     /gene="Nova1"
                     /gene_synonym="Nova-1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    385..387
                     /gene="Nova1"
                     /gene_synonym="Nova-1"
                     /note="upstream in-frame stop codon"
     exon            404..570
                     /gene="Nova1"
                     /gene_synonym="Nova-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             490..1647
                     /gene="Nova1"
                     /gene_synonym="Nova-1"
                     /note="isoform 3 is encoded by transcript variant 3;
                     RNA-binding protein Nova-1; neuro-oncological ventral
                     antigen 1"
                     /codon_start=1
                     /product="RNA-binding protein Nova-1 isoform 3"
                     /protein_id="NP_001401846.1"
                     /db_xref="GeneID:298992"
                     /db_xref="RGD:621345"
                     /translation="

MPQNVAKTEPVSILQPQTTVNPDRIKQTLPSSPTTTKSSPSDPMTTSRANQVKIIVPNSTAGLIIGKGGATVKAIMEQSGAWVQLSQKPDGINLQERVVTVSGEPEQNRKAVELIIQKIQEDPQSGSCLNISYANVTGPVANSNPTGSPYANTAEVLPTAAAAAGLLGHANLAGVAAFPAVLSGFTGNDLVAITSALNTLASYGYNLNTLGLGLSQAAATGALAAAAASANPAAAAANLLATYASEASASGSTAGGTAGTFALGSLAAATAATNGYFGAASPLAASAILGTEKSTDGSKDVVEIAVPENLVGAILGKGGKTLVEYQELTGARIQISKKGEFVPGTRNRKVTITGTPAATQAAQYLITQRITYEQGVRAANPQKVG"

     misc_feature    637..846
                     /gene="Nova1"
                     /gene_synonym="Nova-1"
                     /note="second type I K homology (KH) RNA-binding domain
                     found in the family of neuro-oncological ventral antigen
                     (Nova); Region: KH-I_NOVA_rpt2; cd22436"
                     /db_xref="CDD:411864"
     misc_feature    order(670..678,682..696,703..708,736..744,748..756,
                     778..780)
                     /gene="Nova1"
                     /gene_synonym="Nova-1"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:411864"
     misc_feature    1387..1599
                     /gene="Nova1"
                     /gene_synonym="Nova-1"
                     /note="third type I K homology (KH) RNA-binding domain
                     found in the family of neuro-oncological ventral antigen
                     (Nova); Region: KH-I_NOVA_rpt3; cd09031"
                     /db_xref="CDD:411807"
     misc_feature    order(1411..1416,1420..1428,1432..1446,1453..1458,
                     1486..1506,1510..1512,1525..1527,1531..1533)
                     /gene="Nova1"
                     /gene_synonym="Nova-1"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:411807"
     exon            571..642
                     /gene="Nova1"
                     /gene_synonym="Nova-1"
                     /inference="alignment:Splign:2.1.0"
     exon            643..7096
                     /gene="Nova1"
                     /gene_synonym="Nova-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gcagcggcaggaactgcaagcatgatggcggcagctcccattcagcagaacgggacccatacgggggttcccatagatctggacccgccggactcgcggaaaaggccgcttgaagcgccccctgaagccggcagcaccaagaggaccaacacgggcgaagacggccagtactttctaaaggtcctcatacctagttatgctgctggatctataattgggaagggaggacagacaattgttcagttgcaaaaggaaacgggagccacgatcaagctgtctaagtccaaagatttttatccaggtgctgccagctgcagaagagattgtacatgggcctgtacagaaggtatttctccactgtgccatctgcagagtgacactgactaggagtactacatagactgtactactgagagggtttgcttgatccagggaacgattgaagcactgaatgcagttcatggattcattgcagaaaaaattcgagaaatgccccaaaatgttgccaagacagaaccagtcagtatcctgcaacctcagaccaccgttaaccctgatcgcatcaaacaaacattgccatcttccccaactaccaccaagtcctctccatctgaccccatgaccacctccagagccaatcaggtaaagattatagttcccaacagcacagcaggtctgataatagggaagggaggtgctactgtgaaggctataatggagcagtcaggggcttgggtgcagctttcccagaaacctgatgggatcaacttgcaagagagggttgtcactgtgagtggagaacctgaacaaaaccgaaaagctgttgaacttatcatccagaagatacaagaggatccacagagtggcagctgtctcaatatcagttatgccaatgtgacaggtccagtggcaaattccaatccaaccggatctccttatgcaaacactgctgaagtgttaccaactgccgcagccgccgcagggctattaggacatgctaaccttgccggtgttgcggccttcccagcagttttatctggcttcacaggcaatgacctggtggccatcacctctgcacttaatacattagccagctatggatataatctcaacacattaggtttaggtctcagccaagcagcagcaacgggggctttggctgccgcagctgccagtgccaacccagcagcagcagcagccaatttgttggccacctatgccagtgaagcctcagccagcggcagcacagctggtggaacggcggggacatttgcattaggtagcctggctgctgctactgctgcaaccaatggatactttggagctgcctcacccctagctgccagtgccattctagggacagagaaatccacagatggatcaaaggatgtagttgaaatagcagttccagaaaacttagttggtgcaatacttggcaaaggagggaaaaccttagtggaataccaggagttgactggtgcaaggatacagatctccaaaaagggagagttcgtacctggcacacggaatcggaaggtaaccattactggaacaccagctgcaacacaggctgctcagtatttaattacacagaggatcacatatgagcaaggagtgcgggccgccaatcctcagaaagtgggttgagtgccccgattatacgtcagattgttttaacccctcctttaccccattttcaagaaggatgtactgtactttgcagaagtgaagtttttctgttattaatatataattatgcaaatgaatgcgactatgttgacaatgtgtatatgtaaataatatgtgttttaccagatgtttcatagaattttttcttgacctgttttgttctctatactttgcttgtgtatatttgtcagaggtgtttctagtgtaagatttaagcctgccattttaccagcattattgtagtttaatgattgaatgtagacagggatatgcgtatagttttcagtcttagttctagataacactaaattaactactgttaggttgagtatggtggggtcagtgacctaaactggagtgaggccaaagcactgtcatgtatgtcttacttcctgcttagggcacagagaagtaggaaacaatattttgaaaataagttttaaatttaaaatgatcaaaaagcaatatagttgcataaaagcactgtaaaatatttaaaaggttaaaactgtggaaaattacattggtaagtttacagatcaataaaagcacctgttctccatctgaactagacaatggaaataatgctgcatgctggccatggcccattcttcatcatttgtaagttcaacaaaagttctcacatggagtcccacctcttcagaggtttgtacattcgtttttaagcactgaattcactactgatcccatcgcctggccagtagaacagtcattactccattaacatcttcactgtttagacacataactgtggtacagtgtattggaaattttataaacaaacgtgaaagtgccaacacattattgatagctgataatgtttcattatctgcaactgctggataagtacgttgcattttaagagcttataattgtgtataatttgttaacactagaaacctattagtattgtgaatgtagattttactgtgaagctatctgtgatttagctgtttgctccatgacggagtccttgcagcatggcgctagcagccagtgcagtttctaatactcggtaatttgcatgttttgtggagcatttttatgtcaccaaccagacagtatttcctgcatgcttatttagaagaggcagtttatcttgagaggtagtgtgatctacctttgtcaggctttttgacaggtcatttcagagtaagcctttgttcccaagacccaacaactgtcaccctcttctgtacctctcctgagtgccaactgtccaggccatttgacacaccatctgttaacctctgagtttgcccgctcaaggccactcataggggcatccatccccaagcacctcctcatgctgtgcatgcagtcttaaattcaatggacaaaaataaaatgctggctacctctggatcatctggctgagcaactgaattacaaaagagaattacttccatctcaacttccgcccattggttacgtccatcctagcaagctaaatggcatcccagctgctcctttctgtgcaaccaattaaagaacaatgagtgtgatgctccatgtctgaatttcgtccagcctctctctgaactgtgatctttgtcctcatgaactttcccttttgttcattgaactatatggactcttcatttcatattgatttactgtgcaatttacttttggacattgagaacttgaaattatttcctgatcccttccccttccactattaataattcatttctgtcaaactgtaagagtaggactcattttttttttttagtttttaacattggactgttatttcatttagagttctctatctctaaatatttatttagagaatgattttcaaagggaatgatatgcttgtttaaatgaaagagaaaagctgtagtaaactgtgttaattggtaatgactatttatcgtcgatactctgtagctgtgtaagttttgacaaatagtgtatctcgtggaatcagtggttagcattgccgctattatatttactcattttatcattataaatgtgcttagttcatcatgtagcatcacttgtctcccgtctcattttttccttgcatgtcacaagtctcagatcatttataatacattaacagtaaataatatctatgtaaatttctttcaccatgctgtctcagagtcagcagtgaagaaaggcaaagattggggccccactcattggaagaagggaaaggaagcgatctaggatgtgtattagaagcatttcaaatgtcgggtctttaaaatgttttgttcagtattagcaaacctttaatctttttttcaaaattccagtagtccactgtggagcccatacatttcatctggaatttaatgtttctttgaagccaaaccatttagcagttatgtgtattttattagctagcgtggctgacagtgcactcagttcaattttaattgtaaatgggaattccaaacttttcctacttggcatggttatctgttagttaaaaccaaaagctaaattggagatatttacattttaatttatggtaacaaatatgggtttgtatgcattatgtgtaaatcagcttcatgctgtttaaaaaaacgtactgaaatttatagaccatgtagaattgatttgtgatgcgatgctttaatttattgcaagaaaattagtatggcttcagactgccacaggtcggcgtgtgacgatggctgttcagccatactgatccaaagtggggaaaactggtgacacaaggcaaaacatctcatgaaatgcaactatttatagtcttgtttcgctataaggaggctggtgaacacgctgaatacgaattacctcagttctgcagctttctgtgtctttttaatgcattctgtttcagggtcactttcaatcaatatttcatttacttactgagattgaatgggcgctctgagacacagtgtgctgtttatcatacagattggacacctcattctagatccgagatcttttcctcaacactgggagctgtcctttcagcaccacaaaattactgcttgaagctgcattgcagtttattttctttgttttggtttttgtttggttctttgtttttgtttttggttgtttctttggttcttttgttttgttttgttttctgttttcactgggagcttttctttcagcaccacattgcacctagactttttaacggctgccttcctctttgcactgaagaccaatttcgtctgcacttccagttatttgctattacctgtaggactttcaatcctacttcacctcacccagcccactcccaaaacagtaaatgtatctatttctgtggaaatcatttctcattgaatgatcagaaagaatgataagttctaacctgtaacggctcatttcgactcattgcttacagtagacctaagctctgttttcctgcttattcgactccttccagcttcccatcacatctgtaacaaactctcaaaatgatattgccacaccgccatgcacaagcctacctgcacagtagagatagattattccatcgcattcagatggttaacagaggttagcaagtcctgtattatatatttatatcgctttctaagaaagtgcatattaatgtttactttaagaatgtgtaaatggtgctatcaagaatctgataaattttatcccagttttttgtgtaccacttctaatgtatgagatttatttttttattggaaaaaataaacagtatgaaagcattaaattggtagattttagtaatttgacaatgaatggaatccccatgttacaggccctatcttttcttagaaattttaatggtggtaatagacttcaacagaggtactggttacaacattccttttaatccattcttatggtacattcttgattcatataatgattcctcactgagtccttaagtaaattttgtttactgtaattcttctccaagaagggaattcttgctttccaaggcagcaattgaaaggagatgaaaatacaatttaacattctacatccacaaacacaatttaagaccagttactctgttagtagcagaaattcattgatcatcaaattcagggcaagcatggctataagtaataattttgagtgcaatgtaatcttagaaatttaatatatacactttatttaaatgatgcaaacagccatatgaaattctttatgattagaaaacaggatgaactcattttgcctcctgcttggtttctcataaacatgagtacatgctattgttgtgcactgttgtccatagatgtctttttacataaagggtaagtatcattactttacaattatttttggaattttgcatgttatttttgtttcatcagatatgtgcccccaattaaataacgtttttgcgaaaaaagaaagtatcagaaacttgtgttaattttcaaaacaaagcaaagtgtagaacattattagataggatgtcattccactggtctataaaaacaaaaagcaactgttcttgaaaattgaagcattaccttgtataattaataaagtacatcaaatcagatttgtaaataaaatattgtttaaatctaaagtattcaatattttgattagattatttttttaaggaaaatatttaacgtgtatgtgctgaatttttttttaaatagttttttataattgcgatggaagggcaattgtctcattaaaagtggtgcagaggccaatacttgggttgccattagatatataaacaagtgaaaactgtggaacaagttttaagctcattttggaaaaaaaaacagttctgtagaaatgcatatttgtatttgtttctctaataaatctgcaaatagctttaaacacaaattagttttaattatttaaacatgagttctgttaagtaacttaatatctgttttgccttacattgtgtgaaaacattgtcctgtggaaatgaatacaggcttatagtgaaaatcaaggtaggtctgcatttatttgaaaaaaccaagcatttagcacttaggtgtgcttaccgctatgaaatcattggagaatttgcatagaagacagtactgccccatatcacaccagctaatctactgctgaaatcaatagaggaccagtttgaatctgctttaactcagtatcaagtaagagacgaacaagtaagtgcaatcacatctgaatgtttgataccggaaccctgatggtgccagtgctcttcgtcaatagagcgaggaagtaatgtggcttctcactgcagagacctggtcttcttcaatgtgttttacacacaattaaaaatattgtccctggtaacatgtattccatgaaatagtatgaaatgttttaggataacatacagttgtctctctgttgttaatatagcatctccactttgaaaatgcttgaaggagataaatatacatgaaaatca

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