LOCUS       NM_001401069            2307 bp    mRNA    linear   ROD 06-OCT-2023
DEFINITION  Rattus norvegicus ring finger protein 41 (Rnf41), transcript
            variant 3, mRNA.
ACCESSION   NM_001401069 XM_006240775
VERSION     NM_001401069.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2307)
  AUTHORS   Zhu J, Zhu Z, Ren Y, Dong Y, Li Y and Yang X.
  TITLE     Role of the Nrdp1 in Brain Injury Induced by Chronic Intermittent
            Hypoxia in Rats via Regulating the Protein Levels of ErbB3
  JOURNAL   Neurotox Res 38 (1), 124-132 (2020)
   PUBMED   32200526
  REMARK    GeneRIF: Role of the Nrdp1 in Brain Injury Induced by Chronic
            Intermittent Hypoxia in Rats via Regulating the Protein Levels of
            ErbB3.
REFERENCE   2  (bases 1 to 2307)
  AUTHORS   Fragoza R, Das J, Wierbowski SD, Liang J, Tran TN, Liang S, Beltran
            JF, Rivera-Erick CA, Ye K, Wang TY, Yao L, Mort M, Stenson PD,
            Cooper DN, Wei X, Keinan A, Schimenti JC, Clark AG and Yu H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2307)
  AUTHORS   Zheng J, Min S, Hu B, Liu Q and Wan Y.
  TITLE     Nrdp1 is involved in hippocampus apoptosis in cardiopulmonary
            bypass-induced cognitive dysfunction via the regulation of ErbB3
            protein levels
  JOURNAL   Int J Mol Med 43 (4), 1747-1757 (2019)
   PUBMED   30720051
  REMARK    GeneRIF: Nrdp1 serves an important role in regulating the apoptosis
            induced by cardiopulmonary bypass in vivo and in vitro through
            regulating ErbB3 and phosphoAKT protein levels.
REFERENCE   4  (bases 1 to 2307)
  AUTHORS   Hatakeyama J, Wald JH, Rafidi H, Cuevas A, Sweeney C and Carraway
            KL 3rd.
  TITLE     The ER structural protein Rtn4A stabilizes and enhances signaling
            through the receptor tyrosine kinase ErbB3
  JOURNAL   Sci Signal 9 (434), ra65 (2016)
   PUBMED   27353365
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2307)
  AUTHORS   Zhang Y, Su L and Zhang K.
  TITLE     Transcriptional Effects of E3 Ligase Nrdp1 on Hypertrophy in
            Neonatal Rat Cardiomyocytes by Microarray and Integrated Gene
            Network Analysis
  JOURNAL   Cardiology 135 (4), 203-215 (2016)
   PUBMED   27428330
  REMARK    GeneRIF: Pathway network analysis identified myocardial metabolism,
            DNA replication, and the cell cycle as the most important pathways
            targeted by Nrdp1.
REFERENCE   6  (bases 1 to 2307)
  AUTHORS   Zhang Y, Zeng Y, Wang M, Tian C, Ma X, Chen H, Fang Q, Jia L, Du J
            and Li H.
  TITLE     Cardiac-specific overexpression of E3 ligase Nrdp1 increases
            ischemia and reperfusion-induced cardiac injury
  JOURNAL   Basic Res Cardiol 106 (3), 371-383 (2011)
   PUBMED   21312039
REFERENCE   7  (bases 1 to 2307)
  AUTHORS   Jing X, Infante J, Nachtman RG and Jurecic R.
  TITLE     E3 ligase FLRF (Rnf41) regulates differentiation of hematopoietic
            progenitors by governing steady-state levels of cytokine and
            retinoic acid receptors
  JOURNAL   Exp Hematol 36 (9), 1110-1120 (2008)
   PUBMED   18495327
REFERENCE   8  (bases 1 to 2307)
  AUTHORS   Yu F and Zhou J.
  TITLE     Parkin is ubiquitinated by Nrdp1 and abrogates Nrdp1-induced
            oxidative stress
  JOURNAL   Neurosci Lett 440 (1), 4-8 (2008)
   PUBMED   18541373
REFERENCE   9  (bases 1 to 2307)
  AUTHORS   Yen L, Cao Z, Wu X, Ingalla ER, Baron C, Young LJ, Gregg JP,
            Cardiff RD, Borowsky AD, Sweeney C and Carraway KL 3rd.
  TITLE     Loss of Nrdp1 enhances ErbB2/ErbB3-dependent breast tumor cell
            growth
  JOURNAL   Cancer Res 66 (23), 11279-11286 (2006)
   PUBMED   17145873
REFERENCE   10 (bases 1 to 2307)
  AUTHORS   Qiu XB, Markant SL, Yuan J and Goldberg AL.
  TITLE     Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel
            pathway for triggering apoptosis
  JOURNAL   EMBO J 23 (4), 800-810 (2004)
   PUBMED   14765125
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000171.1.
            
            On Feb 1, 2022 this sequence version replaced XM_006240775.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR8487227.212281.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132263, SAMD00132264
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                JACYVU010000171.1  838212-838301
            91-182              JACYVU010000171.1  840354-840445
            183-365             JACYVU010000171.1  841866-842048
            366-478             JACYVU010000171.1  853554-853666
            479-750             JACYVU010000171.1  859932-860203
            751-886             JACYVU010000171.1  861073-861208
            887-990             JACYVU010000171.1  861554-861657
            991-2307            JACYVU010000171.1  862307-863623
FEATURES             Location/Qualifiers
     source          1..2307
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..2307
                     /gene="Rnf41"
                     /note="ring finger protein 41"
                     /db_xref="GeneID:362814"
                     /db_xref="RGD:1309557"
     exon            1..90
                     /gene="Rnf41"
                     /inference="alignment:Splign:2.1.0"
     exon            91..182
                     /gene="Rnf41"
                     /inference="alignment:Splign:2.1.0"
     exon            183..365
                     /gene="Rnf41"
                     /inference="alignment:Splign:2.1.0"
     exon            366..478
                     /gene="Rnf41"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    383..385
                     /gene="Rnf41"
                     /note="upstream in-frame stop codon"
     CDS             389..1342
                     /gene="Rnf41"
                     /EC_number="6.3.2.38"
                     /note="isoform 1 is encoded by transcript variant 3; E3
                     ubiquitin-protein ligase NRDP1"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase NRDP1 isoform 1"
                     /protein_id="NP_001387998.1"
                     /db_xref="GeneID:362814"
                     /db_xref="RGD:1309557"
                     /translation="

MGYDVTRFQGDVDEDLICPICSGVLEEPVQAPHCEHAFCNACITQWFSQQQTCPVDRSVVTVAHLRPVPRIMRNMLSKLQIACDNAVFGCSAVVRLDSLMSHLSDCEHNPKRPVTCEQGCGLEMPKDELPNHNCIKHLRSVVQQQQTRIAELEKTSAEHKHQLAEQKRDIQLLKAYMRAIRSVNPNLQNLEETIEYNEILEWVNSLQPARVTRWGGMISTPDAVLQAVIKRSLVESGCPASIVNELIENAHERSWPQGLATLETRQMNRRYYENYVAKRIPGKQAVVVMACENQHMGDDMVQEPGLVMIFAHGVEEI"

     misc_feature    431..559
                     /gene="Rnf41"
                     /note="Modified RING finger, HC subclass (C3HC3D-type),
                     found in neuregulin receptor degradation protein-1 (Nrdp1)
                     and similar proteins; Region: mRING-HC-C3HC3D_Nrdp1;
                     cd16634"
                     /db_xref="CDD:438296"
     misc_feature    797..1333
                     /gene="Rnf41"
                     /note="USP8 interacting; Region: USP8_interact; pfam08941"
                     /db_xref="CDD:430333"
     exon            479..750
                     /gene="Rnf41"
                     /inference="alignment:Splign:2.1.0"
     exon            751..886
                     /gene="Rnf41"
                     /inference="alignment:Splign:2.1.0"
     exon            887..990
                     /gene="Rnf41"
                     /inference="alignment:Splign:2.1.0"
     exon            991..2307
                     /gene="Rnf41"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

caagggctagctcgagaaggcgaggagtggtcggaaccttcttctccatccttctcttccccttcccctacggggaaaggttgagacccgttgtctgagaagggctcctgcctcgtagcctctgctgaccttgagttcacagtgaccttcccaactcagcctcccaggtgttgggattgcagagcgctcctgattgtgacatcacacccacccctgggccatgaaacttgtctctaggaagaaagactcagttggagaatagccaacaagatgggatacttggagtgtctcctgagtggcaccaagcagaggcatcaggggcttggaaccttgtgaacagggaacctgcccccaccacttagaaggacctgggtttcagtgatgagacatggggtatgatgtaacccggttccagggggacgttgacgaggacctcatctgccctatttgcagtggagtcttggaggagccagtacaggcgcctcattgtgagcatgccttctgcaacgcctgcatcacccaatggttctctcagcagcagacgtgtccggtagaccgtagcgttgtcacggttgcccacctgcgcccagtgcctcggatcatgcggaacatgttgtcaaagctgcagattgcctgtgacaacgctgtgtttggctgcagtgctgttgtcaggcttgacagcctcatgtcccacctcagtgactgtgagcacaacccgaagcggcctgtgacctgcgagcagggctgcggcctggagatgcccaaagatgagctgccaaaccacaattgcattaagcacctgcgctccgtggtccagcagcagcagacgcgcatcgcagagctggagaagacatctgctgaacacaagcaccagctggcagaacagaagcgagacattcagttgctgaaggcgtatatgcgagccatccgcagtgtcaaccccaaccttcagaacctggaggagacaatcgagtacaacgagatccttgagtgggtgaactccctacagccggcaagagtgacgcgctggggggggatgatctccactcctgacgctgtgctgcaggctgtaatcaagcgctccctcgtggaaagtggctgcccagcttctatcgtcaacgagctgatcgaaaatgcccatgaacgcagctggccccagggtctggccacactagagacaagacagatgaaccggcgctactatgagaactacgtggccaagcgcatccctggcaagcaggctgtggtggtgatggcctgcgagaaccagcacatgggtgacgacatggtgcaggagccggggctggtcatgatctttgcacatggtgtggaggagatttaagagcgtgactgactatgaggaagaggtagagtgggaacctatggccgctccagcagctgagccctgacctccccacacacaaccctgtgccacggcttgtactggagcctcgcactccctgcttctggcatgaaggaccttgggccacttagctcagcctttcagcggggaacccaagttcctgccttttgctatattcctccccccacaatgtctgtaaattttcagtcagggtggagaaatccccacttctgtatttgctgactaagatccctggttcccaaatattttcagaaagcacaaagacacttgttttccctagagggtcagggtggagtgaggcatttctacacttgatcttagccaaaaggccgagaagcgatgagtgaggcatttctaattgtccctctcttccaaaaccaggggatccaagcaggcaggcttgctggctccatgcagcattgagagagcagctctgacatccagcagaagggctaacagtgtgaccaaagcccctctaactagtgaggccaggacttggtcctcactaacagcccttggggaagacctttgtgctgagcacatccctgtccaggcccctgtgactgtgcaggccttgctgggtgtgcagggaaggaagagggtaggcattggtgttcacgcactcagcaggaaagctgtctggctctgctgaaggaggataccactgccccttgaggcacgtctatgttgcctcgtaggcccctcttcagtcctgtgattgtagttggctggatttcctttggtgtttgtttatattccccaagtctcaaacctcatctgttacccagtcttgttttcatagaatggactggctgtgtctgtcctccgatccagcccagccacattgttggcaatttaatttatttacttttttttttttaagaaaggagaaaagaaaaaaaaatgaagaaaacttaaaacct

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