LOCUS       NM_001399561            4630 bp    mRNA    linear   ROD 12-JUN-2023
DEFINITION  Rattus norvegicus RNA binding motif protein 15 (Rbm15), mRNA.
ACCESSION   NM_001399561 XM_003749380
VERSION     NM_001399561.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4630)
  AUTHORS   Patil DP, Chen CK, Pickering BF, Chow A, Jackson C, Guttman M and
            Jaffrey SR.
  TITLE     m(6)A RNA methylation promotes XIST-mediated transcriptional
            repression
  JOURNAL   Nature 537 (7620), 369-373 (2016)
   PUBMED   27602518
REFERENCE   2  (bases 1 to 4630)
  AUTHORS   Zhang L, Tran NT, Su H, Wang R, Lu Y, Tang H, Aoyagi S, Guo A,
            Khodadadi-Jamayran A, Zhou D, Qian K, Hricik T, Cote J, Han X, Zhou
            W, Laha S, Abdel-Wahab O, Levine RL, Raffel G, Liu Y, Chen D, Li H,
            Townes T, Wang H, Deng H, Zheng YG, Leslie C, Luo M and Zhao X.
  TITLE     Cross-talk between PRMT1-mediated methylation and ubiquitylation on
            RBM15 controls RNA splicing
  JOURNAL   Elife 4, e07938 (2015)
   PUBMED   26575292
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4630)
  AUTHORS   Xiao N, Laha S, Das SP, Morlock K, Jesneck JL and Raffel GD.
  TITLE     Ott1 (Rbm15) regulates thrombopoietin response in hematopoietic
            stem cells through alternative splicing of c-Mpl
  JOURNAL   Blood 125 (6), 941-948 (2015)
   PUBMED   25468569
REFERENCE   4  (bases 1 to 4630)
  AUTHORS   Horiuchi K, Kawamura T, Iwanari H, Ohashi R, Naito M, Kodama T and
            Hamakubo T.
  TITLE     Identification of Wilms' tumor 1-associating protein complex and
            its role in alternative splicing and the cell cycle
  JOURNAL   J Biol Chem 288 (46), 33292-33302 (2013)
   PUBMED   24100041
REFERENCE   5  (bases 1 to 4630)
  AUTHORS   Baltz AG, Munschauer M, Schwanhausser B, Vasile A, Murakawa Y,
            Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E,
            Bonneau R, Selbach M, Dieterich C and Landthaler M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   6  (bases 1 to 4630)
  AUTHORS   Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein
            C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J and
            Hentze MW.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   7  (bases 1 to 4630)
  AUTHORS   Raffel GD, Chu GC, Jesneck JL, Cullen DE, Bronson RT, Bernard OA
            and Gilliland DG.
  TITLE     Ott1 (Rbm15) is essential for placental vascular branching
            morphogenesis and embryonic development of the heart and spleen
  JOURNAL   Mol Cell Biol 29 (2), 333-341 (2009)
   PUBMED   18981216
REFERENCE   8  (bases 1 to 4630)
  AUTHORS   Ma X, Renda MJ, Wang L, Cheng EC, Niu C, Morris SW, Chi AS and
            Krause DS.
  TITLE     Rbm15 modulates Notch-induced transcriptional activation and
            affects myeloid differentiation
  JOURNAL   Mol Cell Biol 27 (8), 3056-3064 (2007)
   PUBMED   17283045
REFERENCE   9  (bases 1 to 4630)
  AUTHORS   Hiriart E, Gruffat H, Buisson M, Mikaelian I, Keppler S, Meresse P,
            Mercher T, Bernard OA, Sergeant A and Manet E.
  TITLE     Interaction of the Epstein-Barr virus mRNA export factor EB2 with
            human Spen proteins SHARP, OTT1, and a novel member of the family,
            OTT3, links Spen proteins with splicing regulation and mRNA export
  JOURNAL   J Biol Chem 280 (44), 36935-36945 (2005)
   PUBMED   16129689
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000077.1.
            
            On Jan 12, 2022 this sequence version replaced XM_003749380.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR8487231.129909.1, DV724526.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132264, SAMD00132266
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3734              JACYVU010000077.1  10479133-10482866   c
            3735-4630           JACYVU010000077.1  10474342-10475237   c
FEATURES             Location/Qualifiers
     source          1..4630
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..4630
                     /gene="Rbm15"
                     /note="RNA binding motif protein 15"
                     /db_xref="GeneID:684233"
                     /db_xref="RGD:1592713"
     exon            1..3734
                     /gene="Rbm15"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    863..865
                     /gene="Rbm15"
                     /note="upstream in-frame stop codon"
     CDS             869..3757
                     /gene="Rbm15"
                     /note="putative RNA-binding protein 15"
                     /codon_start=1
                     /product="RNA-binding protein 15"
                     /protein_id="NP_001386490.1"
                     /db_xref="GeneID:684233"
                     /db_xref="RGD:1592713"
                     /translation="

MRSAGREPLPRRSPRWRRASPLCETSAGWRVSQLRRDDLRRPSTMKGKERSPVKPKRSRGGEDSSSRGERSKKLGGSGGSNGSSSGKTDSGGSRRSLHLDKSSSRGGSREYDTGGGSSSSRLHSYSSPSTKNSSGGGESRSSSRGGGGESRSSGAASSAPGGGDGVEYKTLKISELGSQLSDEAVEDGLFHEFKRFGDVSVKISHLSGSGSGDERVAFVNFRRPEDARAAKHARGRLVLYDRPLKIEAVYVSRRRSRSPLDKDTYAPSSSVVGSSVGSHRHAPGGGGGQRSLSPGGAALGYRDYRLQQLALGRLPPPPPPPLPRELERERDYPFYDRVRPAYSLEPRVGAGAGAAPFREVDEISPEDDQRANRTLFLGNLDITVTENDLRRAFDRFGVITEVDIKRPSRGQTSTYGFLKFENLDMSHRAKIAMSGKIIIRNPIKIGYGKATPTTRLWVGGLGPWVPLAALAREFDRFGTIRTIDYRKGDSWAYIQYESLDAAHAAWTHMRGFPLGGPDRRLRVDFADTEHRYQQQYLQPLPLTHYELVTDTFGHRAPDPLRSARDRTPPLLYRDRDRDLYPDSDWVPPPPPVRERSARAATSAVTAYEPLDSLDRRRDGWSLDRDRGDRDLPSSRDQPRKRRLPEESGGRHLDRSPESDRPRKQRHCTPSPDRSPELSSNRDRYNSDNDRSSRLLLLERPSPVRDRRGSLEKSQSDKRDRKNSASAERDRKHRTAAPTEGKTPLKKEDRSDGNTPSASTSSSKQKPPSQKQDGGTAPVAASSPKLCLAWQGMLLLKNSNFPSNMHLLQGDLQVASSLLVEGSTGGKVAQLKITQRLRLDQPKLDEVTRRIKVAGPNGYAILLAVPGSSDSRSSSSSATSDTAASTQRPLRNLVSYLKQKQAAGVISLPVGGNKDKENTGVLHAFPPCEFSQQFLDSPAKALAKSEEDYLVMIIVRAKLVNIG"

     misc_feature    1370..1618
                     /gene="Rbm15"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     RNA binding motif protein 15 (RBM15); Region: RRM1_RBM15;
                     cd12553"
                     /db_xref="CDD:409969"
     misc_feature    1964..2224
                     /gene="Rbm15"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     RNA binding motif protein 15 (RBM15); Region: RRM2_RBM15;
                     cd12555"
                     /db_xref="CDD:409971"
     misc_feature    2231..2449
                     /gene="Rbm15"
                     /note="RNA recognition motif 3 (RRM3) found in vertebrate
                     RNA binding motif protein 15 (RBM15); Region: RRM3_RBM15;
                     cd12557"
                     /db_xref="CDD:409973"
     misc_feature    2735..>3118
                     /gene="Rbm15"
                     /note="splicing factor, CC1-like family; Region: SF-CC1;
                     TIGR01622"
                     /db_xref="CDD:273721"
     misc_feature    3230..3733
                     /gene="Rbm15"
                     /note="SPOC (Spen paralog and ortholog C-terminal) domain
                     superfamily; Region: SPOC_SF; cl45902"
                     /db_xref="CDD:459247"
     exon            3735..4630
                     /gene="Rbm15"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

aggctgctaactaagatggtgtcggctggacttcccgggacagctgcctaagcggatcgagggccagcagccggaaggaccaccgagcccattgtcccgcccagacaggacagtgcggagcccgcaagttccagactcgaaggaccgaagcacaggcaagtacgccgtaggacctaacaaatgtttaagagaacgccgaaagcgcggggaggcgggcctgactcactgtcaccgtctcgcgacagctaagtgacgtcgcacagcaagcgcgtggtagagtctttcaccttcagactcctcagtttatgggcctactcctttaagtgagtgatggacagcgcttttatccaatcattttcctcgtcaacatccaatcagatttaaactttattcagccgccggagaagttggaagactggggttgaaagagagcgagcgagtgagcgagcgagctctttgtctctcgcgagatccgagagagccaagttctcagggaaaaacgcctgaactgatgtccagacttcccaagtagtgatttaaaggacgtggccataaaccaatgaaagggaagagaaggtgggatcgctgctttcgccgtgctagaagtaccgttacagggcagactttttgtccaatcaacgcttctaggctttgggtcaggtgaccatgaagtgcgaggggcggagctacagcctggcgcgaggaaccgttaagatagacaacgaatataaccaatgaggtactgcgattagggcgttgggaacccaataacagcgtcggggcgggcgccttcccggagcgcggggagatgtaaagacggacaaatagtttttccaatgagaaagctgaagagtgaattaattgaccaatgaggtctgcggggcgggagcctttgccgcggcggagtccaagatggcggcgtgcgagtccgctgtgtgaaacgagcgcggggtggcgggttagtcagctccgcagagacgacctccggcgaccctcaacaatgaaaggaaaggagcgctcgccagtcaagcccaaacgctcccgtggcggtgaggactccagttctcgtggggaacggagcaagaagttagggggctctggcggcagcaatgggagcagcagcgggaagacggacagcggcgggtcgcggcggagccttcatctggacaagtccagcagccgaggcggcagccgcgagtatgataccggtgggggcagctccagtagccgcttgcatagttacagctccccaagcaccaaaaattcctcaggcgggggcgagtcgcgcagcagctcccggggtggaggcggggagtcacgttcctctggggccgcctcctcagcgcctggcggcggggacggcgtggagtacaagaccctgaagataagcgaattggggtcccagctgagtgacgaagcggtggaggacggactgtttcacgagttcaaacgcttcggtgatgtaagtgtcaaaatcagtcatctctcaggttctggcagcggggatgagcgggtagcctttgtgaacttccggaggccagaggacgcgagggcggccaagcatgccagaggccgcctggtgctctatgaccggcctctgaagatagaagccgtgtatgtgagccggcgccgcagccgctccccgttagacaaagatacttacgccccgtcgtccagcgtggtcggaagctctgtaggtagccacaggcacgcccctggaggaggtggaggtcagagatcgctttctcctggcggtgctgctttgggatacagagactaccggttgcagcagttggctcttggccgcctgcctcctccacccccgccaccattgccccgagagctggaaagagaacgagactatccgttctatgacagagtgcggccagcatatagtcttgagccgagggtgggagctggagcaggtgctgctccattccgagaagtggatgagatatcacctgaggatgatcagcgtgccaaccggacacttttcttgggcaacttagatatcactgtgacagaaaatgatctgagaagggcttttgatcgttttggagtcatcacagaagtggacattaagaggccttctcgtggccagaccagtacttacggctttctcaaatttgagaacctagacatgtctcacagggccaaaatagcaatgtctggcaaaattataattcggaatccaatcaagattggttatgggaaagccacacccactacccgactttgggtgggtggtctgggaccttgggtgcctcttgctgccctggcacgagaatttgatcgatttggcaccattcgaaccatagactaccgaaaaggtgacagttgggcatatatacagtatgaaagcttggatgcagctcatgctgcctggacccatatgcgtggattcccacttggtggcccagatcgtcgccttagggtagactttgcagacacagaacatcgttaccagcagcagtatcttcagcctctgcccttaacccattatgaactagtgacagatacttttggacatcgagcacctgaccctttgaggagtgctcgggaccggacaccacccttactatacagagatcgtgatagggacctttatcccgattctgattgggtgccacccccgccaccggttcgggaacgcagtgctcgggctgcaactagtgccgtcactgcttatgagccactggatagcttggatcgaaggagggatggctggtcactggacagggacagaggtgaccgggatttgcctagcagcagggaccagccaaggaagcgaaggctgcctgaggaaagtggaggacggcatcttgatagatcacccgagagtgaccggcctcgaaaacagcgtcactgcactccttctcctgaccgaagtccagaactgagcagtaacagagatcgttacaacagtgacaatgatcgatcatctcgtcttctactcttggaaaggccttccccagtcagagatagacggggcagtttggagaagagccagagtgacaaacgagaccgtaaaaactctgcatcagctgaacgggataggaagcaccggacagctgctcccacagagggaaaaacccctctgaaaaaggaagaccgatctgatggcaatacacccagtgccagcacttcttcatcaaagcagaagccaccttcccagaaacaggatggagggacagctcctgtggcagcatcctctcccaaactctgtttggcttggcagggcatgcttctactgaagaacagcaacttcccttccaacatgcatctattgcagggtgacctccaagttgctagcagtctacttgtggagggttccactggaggcaaagtagcccagctcaagatcactcagcggctccgtttggaccagcccaagttggatgaagtaactcgacgcatcaaagtggcagggcctaatggttatgccattctcctagctgtacctggaagttctgacagccgatcctcctcttcctcagccacatcagacactgccgcctctactcagaggccacttaggaaccttgtgtcctatttaaagcaaaagcaggcagctggggtgatcagcctccctgtgggaggcaataaagacaaggaaaacaccggggttcttcatgccttcccaccttgtgagttctctcagcagttcctggattcccctgccaaggcactggccaaatctgaagaagattacctggtcatgatcattgtccgtgcaaaactggtgaacatcggatgaagatacggaattcaaagctctaatggacctttttgaagagaagtggcttatgtggagtttacatgggcctctgatggaagaaagctaatctgtttagtattttgtgcattttactaaaatggcagcttaacattgtgtatctgctattgtgatgccaatgccggtgttttaagtggaaaaatgacctctttgctttgtgctgtgtacacaagatttctggaaaagtaaagaaaaaccctttttatggctcacacagcttaaaagtagctgtcactcaaacatgggctcacagttgagctgcttttgttttattctaaataaattgtttcttttgaggaaaatgtttttctgcctggaagtgaattgacggcaaaccttgacccctttgtttgcagcggagggggtacttgctgctgctcagatcttgtatgtcttgagcaagaagcagggagatcatcaatttcattttgactatcacggtgtgtcaattctgaaggatcatagtgttacagtgaccccctttgtttgcagtgaaggggatcctttgcttctcggtcctcaacacacgatgagggtgctgtttgctggcatgcaagaagcggggcaagcactctaagcctcccaccacagtgcacgagtcgggggctttgctggttgaagagccggagttcctgaaatttaagttttgatttattttgttcacccatcacgtttggctttagtttcattttttaatttgaagaaaagtttgaagttgcattatcttgcacttttaacatttgcaccaaattgccaaaagaaggagaaatgctccggttgctttttaaatgttaatgatgatgttaataaagcctttcctgacacatttgagga

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