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Previous release (v1)
2024-04-29 06:37:37, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NM_001395151 2894 bp mRNA linear ROD 22-FEB-2022
DEFINITION Rattus norvegicus protection of telomeres 1 (Pot1), mRNA.
ACCESSION NM_001395151 XM_006236161
VERSION NM_001395151.1
KEYWORDS RefSeq.
SOURCE Rattus norvegicus (Norway rat)
ORGANISM Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
REFERENCE 1 (bases 1 to 2894)
AUTHORS Yin H, Hardikar S, Lindstroem S, Hsu L, Anderson KE, Banbury BL,
Berndt SI, Chan AT, Giovanucci EL, Harrison TA, Joshi AD, Nan H,
Potter JD, Sakoda LC, Slattery ML, Schoen RE, White E, Peters U and
Newcomb PA.
TITLE Telomere Maintenance Variants and Survival after Colorectal Cancer:
Smoking- and Sex-Specific Associations
JOURNAL Cancer Epidemiol Biomarkers Prev 29 (9), 1817-1824 (2020)
PUBMED 32586834
REFERENCE 2 (bases 1 to 2894)
AUTHORS Ishigaki K, Akiyama M, Kanai M, Takahashi A, Kawakami E, Sugishita
H, Sakaue S, Matoba N, Low SK, Okada Y, Terao C, Amariuta T, Gazal
S, Kochi Y, Horikoshi M, Suzuki K, Ito K, Koyama S, Ozaki K, Niida
S, Sakata Y, Sakata Y, Kohno T, Shiraishi K, Momozawa Y, Hirata M,
Matsuda K, Ikeda M, Iwata N, Ikegawa S, Kou I, Tanaka T, Nakagawa
H, Suzuki A, Hirota T, Tamari M, Chayama K, Miki D, Mori M,
Nagayama S, Daigo Y, Miki Y, Katagiri T, Ogawa O, Obara W, Ito H,
Yoshida T, Imoto I, Takahashi T, Tanikawa C, Suzuki T, Sinozaki N,
Minami S, Yamaguchi H, Asai S, Takahashi Y, Yamaji K, Takahashi K,
Fujioka T, Takata R, Yanai H, Masumoto A, Koretsune Y, Kutsumi H,
Higashiyama M, Murayama S, Minegishi N, Suzuki K, Tanno K, Shimizu
A, Yamaji T, Iwasaki M, Sawada N, Uemura H, Tanaka K, Naito M,
Sasaki M, Wakai K, Tsugane S, Yamamoto M, Yamamoto K, Murakami Y,
Nakamura Y, Raychaudhuri S, Inazawa J, Yamauchi T, Kadowaki T, Kubo
M and Kamatani Y.
TITLE Large-scale genome-wide association study in a Japanese population
identifies novel susceptibility loci across different diseases
JOURNAL Nat Genet 52 (7), 669-679 (2020)
PUBMED 32514122
REFERENCE 3 (bases 1 to 2894)
AUTHORS Yu Y, Tan R, Ren Q, Gao B, Sheng Z, Zhang J, Zheng X, Jiang Y, Lan
L and Mao Z.
TITLE POT1 inhibits the efficiency but promotes the fidelity of
nonhomologous end joining at non-telomeric DNA regions
JOURNAL Aging (Albany NY) 9 (12), 2529-2543 (2017)
PUBMED 29227966
REFERENCE 4 (bases 1 to 2894)
AUTHORS Poojary SS, Mishra G, Singh TD, Gupta S, Shrivastav BR and Tiwari
PK.
TITLE Telomere length variation and expression analysis of shelterin
complex genes during gallbladder carcinogenesis
JOURNAL J Cancer Res Ther 13 (2), 235-239 (2017)
PUBMED 28643740
REFERENCE 5 (bases 1 to 2894)
AUTHORS Karami S, Han Y, Pande M, Cheng I, Rudd J, Pierce BL, Nutter EL,
Schumacher FR, Kote-Jarai Z, Lindstrom S, Witte JS, Fang S, Han J,
Kraft P, Hunter DJ, Song F, Hung RJ, McKay J, Gruber SB, Chanock
SJ, Risch A, Shen H, Haiman CA, Boardman L, Ulrich CM, Casey G,
Peters U, Amin Al Olama A, Berchuck A, Berndt SI, Bezieau S,
Brennan P, Brenner H, Brinton L, Caporaso N, Chan AT, Chang-Claude
J, Christiani DC, Cunningham JM, Easton D, Eeles RA, Eisen T, Gala
M, Gallinger SJ, Gayther SA, Goode EL, Gronberg H, Henderson BE,
Houlston R, Joshi AD, Kury S, Landi MT, Le Marchand L, Muir K,
Newcomb PA, Permuth-Wey J, Pharoah P, Phelan C, Potter JD, Ramus
SJ, Risch H, Schildkraut J, Slattery ML, Song H, Wentzensen N,
White E, Wiklund F, Zanke BW, Sellers TA, Zheng W, Chatterjee N,
Amos CI and Doherty JA.
CONSRTM GECCO and the GAME-ON Network: CORECT, DRIVE, ELLIPSE, FOCI, and
TRICL
TITLE Telomere structure and maintenance gene variants and risk of five
cancer types
JOURNAL Int J Cancer 139 (12), 2655-2670 (2016)
PUBMED 27459707
REFERENCE 6 (bases 1 to 2894)
AUTHORS Kelleher C, Kurth I and Lingner J.
TITLE Human protection of telomeres 1 (POT1) is a negative regulator of
telomerase activity in vitro
JOURNAL Mol Cell Biol 25 (2), 808-818 (2005)
PUBMED 15632080
REFERENCE 7 (bases 1 to 2894)
AUTHORS Liu D, O'Connor MS, Qin J and Songyang Z.
TITLE Telosome, a mammalian telomere-associated complex formed by
multiple telomeric proteins
JOURNAL J Biol Chem 279 (49), 51338-51342 (2004)
PUBMED 15383534
REFERENCE 8 (bases 1 to 2894)
AUTHORS Liu D, Safari A, O'Connor MS, Chan DW, Laegeler A, Qin J and
Songyang Z.
TITLE PTOP interacts with POT1 and regulates its localization to
telomeres
JOURNAL Nat Cell Biol 6 (7), 673-680 (2004)
PUBMED 15181449
REFERENCE 9 (bases 1 to 2894)
AUTHORS Loayza D and De Lange T.
TITLE POT1 as a terminal transducer of TRF1 telomere length control
JOURNAL Nature 423 (6943), 1013-1018 (2003)
PUBMED 12768206
REFERENCE 10 (bases 1 to 2894)
AUTHORS Colgin LM, Baran K, Baumann P, Cech TR and Reddel RR.
TITLE Human POT1 facilitates telomere elongation by telomerase
JOURNAL Curr Biol 13 (11), 942-946 (2003)
PUBMED 12781132
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
JACYVU010000141.1.
On Jun 4, 2021 this sequence version replaced XM_006236161.3.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
RNAseq introns :: mixed/partial sample support SAMD00132261,
SAMD00132262 [ECO:0000350]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-43 JACYVU010000141.1 43883226-43883268 c
44-109 JACYVU010000141.1 43880007-43880072 c
110-331 JACYVU010000141.1 43875642-43875863 c
332-378 JACYVU010000141.1 43872602-43872648 c
379-493 JACYVU010000141.1 43867626-43867740 c
494-624 JACYVU010000141.1 43854342-43854472 c
625-915 JACYVU010000141.1 43851067-43851357 c
916-1071 JACYVU010000141.1 43847694-43847849 c
1072-1241 JACYVU010000141.1 43842178-43842347 c
1242-1327 JACYVU010000141.1 43839064-43839149 c
1328-1390 JACYVU010000141.1 43837855-43837917 c
1391-1547 JACYVU010000141.1 43835199-43835355 c
1548-1753 JACYVU010000141.1 43833439-43833644 c
1754-1889 JACYVU010000141.1 43832629-43832764 c
1890-1978 JACYVU010000141.1 43830593-43830681 c
1979-2070 JACYVU010000141.1 43828931-43829022 c
2071-2176 JACYVU010000141.1 43827218-43827323 c
2177-2894 JACYVU010000141.1 43825551-43826268 c
FEATURES Location/Qualifiers
source 1..2894
/organism="Rattus norvegicus"
/mol_type="mRNA"
/strain="BN"
/db_xref="taxon:10116"
/chromosome="4"
/map="4q22"
gene 1..2894
/gene="Pot1"
/gene_synonym="Pot1a"
/note="protection of telomeres 1"
/db_xref="GeneID:500054"
/db_xref="RGD:1562696"
exon 1..43
/gene="Pot1"
/gene_synonym="Pot1a"
/inference="alignment:Splign:2.1.0"
exon 44..109
/gene="Pot1"
/gene_synonym="Pot1a"
/inference="alignment:Splign:2.1.0"
exon 110..331
/gene="Pot1"
/gene_synonym="Pot1a"
/inference="alignment:Splign:2.1.0"
exon 332..378
/gene="Pot1"
/gene_synonym="Pot1a"
/inference="alignment:Splign:2.1.0"
misc_feature 340..342
/gene="Pot1"
/gene_synonym="Pot1a"
/note="upstream in-frame stop codon"
CDS 370..2286
/gene="Pot1"
/gene_synonym="Pot1a"
/note="protection of telomeres 1A; protection of telomeres
1 homolog"
/codon_start=1
/product="protection of telomeres protein 1"
/protein_id="NP_001382080.1"
/db_xref="GeneID:500054"
/db_xref="RGD:1562696"
/translation="
MSLVPVTPYTYTPLNLLKEGAVANVYGVVKFFKPPYLSKGTDYCSVVTIVDPTNVKLTCMLFSGNYEALPIIYKVGDIVRFHRLKIQVYKNELQGINSSGFASLTFEGTLGTPVTARTSSKVFSFTSQDQKMVEALRVWASKHIAASSSLVQLCDAQPLQYYDLTCQLLGKAEVDGTAFLLKVWDGTRTMFPSWRVSIQNLTFEGDLSHIQRLQSLVIDILVYDNHVQVAKSLKIGSFIRIYSLHTKLQSVDSETSKSLLRLEFHLHGGTSYGRGIRVLPDESSCVDQLKKDLECADSAVTQPSNGICQSKNEDSFVLSSSASGSVSLYEEERCQQVSSTILTDHQHLEKTPLCAVLKQKAPQQYRVRAKLRSYLPRRLPQSVKLICPQCHSLQEVPHEDSLDKLLQDAATKAPDIRLQGTSLYESKIWTTEGQGGRQVAVHFVKKDGVLPLSSECLILIEGGRLCEVSKLSSKFHSVIPVRSGPEDLELLDISAPFLIQGKLHHYGCKQCSSLKPIQNLNSLLNKGPWIPSSVAKVLGIVPLQYVFVMTFTLDDGTGVLDTYLKDSENFFKIPASEVLTDDNLQRNLEAIMDMICPPGIKVDAYPWLECLIKSYNVTIGTEQRICYQIFDTTVAEDV"
misc_feature 400..792
/gene="Pot1"
/gene_synonym="Pot1a"
/note="Telomeric single stranded DNA binding POT1/CDC13;
Region: Telo_bind; smart00976"
/db_xref="CDD:214949"
misc_feature order(439..441,601..603,607..609,613..615,679..681)
/gene="Pot1"
/gene_synonym="Pot1a"
/note="generic binding surface II [active]"
/db_xref="CDD:239943"
misc_feature order(460..471,475..477,511..513,577..579,583..585,
589..594,694..696)
/gene="Pot1"
/gene_synonym="Pot1a"
/note="OB1/OB2 interface [polypeptide binding]; other
site"
/db_xref="CDD:239943"
misc_feature order(466..468,475..477,481..483,493..495,511..513,
547..549,553..555,559..561,628..630,634..636,649..651)
/gene="Pot1"
/gene_synonym="Pot1a"
/note="ssDNA binding site [nucleotide binding]; other
site"
/db_xref="CDD:239943"
misc_feature 850..1206
/gene="Pot1"
/gene_synonym="Pot1a"
/note="A subfamily of OB folds similar to the second OB
fold (OB2) of human protection of telomeres 1 protein
(hPOT1). POT1 proteins bind to the single-stranded (ss)
3-prime ends of the telomere. hPOT1 binds specifically to
ss telomeric DNA repeats ending with...; Region:
hPOT1_OB2; cd04498"
/db_xref="CDD:239944"
misc_feature order(850..852,1036..1041,1096..1098,1102..1104,
1168..1173,1180..1185,1189..1191)
/gene="Pot1"
/gene_synonym="Pot1a"
/note="ssDNA binding [nucleotide binding]; other site"
/db_xref="CDD:239944"
misc_feature order(1087..1089,1093..1095,1177..1179,1186..1188,
1198..1200)
/gene="Pot1"
/gene_synonym="Pot1a"
/note="binding surface II [active]"
/db_xref="CDD:239944"
misc_feature 1411..2271
/gene="Pot1"
/gene_synonym="Pot1a"
/note="Protection Of Telomeres Protein 1 (POT1) C-terminal
region; Region: Pot1C; cd20374"
/db_xref="CDD:380669"
misc_feature order(1411..1413,1474..1476,1495..1497,1726..1728,
1807..1809,1813..1815,1978..1980,1987..1989,2098..2100,
2143..2145,2155..2157,2251..2253)
/gene="Pot1"
/gene_synonym="Pot1a"
/note="disease mutation sites; other site"
/db_xref="CDD:380669"
misc_feature order(1495..1497,1501..1512,1519..1521,1540..1542,
1546..1548,1552..1557,1561..1563,1642..1644,1648..1650,
1654..1662,1678..1680,1696..1698,1723..1731,1768..1770,
1777..1782,1789..1794,2011..2019,2065..2067,2101..2106,
2113..2115,2122..2124,2206..2208,2212..2214,2218..2220,
2239..2241,2245..2247,2251..2253)
/gene="Pot1"
/gene_synonym="Pot1a"
/note="heterodimer interface [polypeptide binding]; other
site"
/db_xref="CDD:380669"
exon 379..493
/gene="Pot1"
/gene_synonym="Pot1a"
/inference="alignment:Splign:2.1.0"
exon 494..624
/gene="Pot1"
/gene_synonym="Pot1a"
/inference="alignment:Splign:2.1.0"
exon 625..915
/gene="Pot1"
/gene_synonym="Pot1a"
/inference="alignment:Splign:2.1.0"
exon 916..1071
/gene="Pot1"
/gene_synonym="Pot1a"
/inference="alignment:Splign:2.1.0"
exon 1072..1241
/gene="Pot1"
/gene_synonym="Pot1a"
/inference="alignment:Splign:2.1.0"
exon 1242..1327
/gene="Pot1"
/gene_synonym="Pot1a"
/inference="alignment:Splign:2.1.0"
exon 1328..1390
/gene="Pot1"
/gene_synonym="Pot1a"
/inference="alignment:Splign:2.1.0"
exon 1391..1547
/gene="Pot1"
/gene_synonym="Pot1a"
/inference="alignment:Splign:2.1.0"
exon 1548..1753
/gene="Pot1"
/gene_synonym="Pot1a"
/inference="alignment:Splign:2.1.0"
exon 1754..1889
/gene="Pot1"
/gene_synonym="Pot1a"
/inference="alignment:Splign:2.1.0"
exon 1890..1978
/gene="Pot1"
/gene_synonym="Pot1a"
/inference="alignment:Splign:2.1.0"
exon 1979..2070
/gene="Pot1"
/gene_synonym="Pot1a"
/inference="alignment:Splign:2.1.0"
exon 2071..2176
/gene="Pot1"
/gene_synonym="Pot1a"
/inference="alignment:Splign:2.1.0"
exon 2177..2894
/gene="Pot1"
/gene_synonym="Pot1a"
/inference="alignment:Splign:2.1.0"
ORIGIN
tgggcgcgtcaatgcagaccttagttgtccgcgggtcttgctgggaaaactcagttgttcttaatgccttgcggaagtaaaacagctgttttgaagattagactttgagaggctgtaggcctaacgatgactgtctgcgtgttggagagactaagaacctcggtcctgttcagccaatctgtttgatgcttcagcagtccctacctggtgctgaaaccctacagtatttctgcagagcgtttggaagactctgaagctgctgtctgatgtcagtaaatgacagcagcagcagcggcagcgggattgacgcactcactagcaggaatgaaaggtttgtgataaatctatgagaggatttcccatcaaacaatgtctttggttccggtaactccctatacatatacacccctgaatctacttaaggaaggtgcagttgccaatgtctatggtgttgtgaaattctttaagcctccatatctcagcaaaggaactgattattgctcagttgtaacaattgtggacccaacaaatgtgaagttaacgtgcatgctctttagtggaaactatgaagcccttccgatcatttacaaagttggagacattgttcgcttccataggctgaagatccaagtatataaaaatgagcttcagggaatcaacagctctgggttcgcgtctttgacatttgaaggaacattagggacacctgtcacagcacgtacttcaagcaaagtttttagcttcacttctcaggaccaaaaaatggtagaagctttgcgagtttgggcatccaagcacattgcagcttcttcaagtttagtgcagctgtgtgacgctcagcccctgcaatattatgacctgacctgtcagcttctgggtaaagcagaagtggatggaacagcctttcttctaaaggtatgggacggaaccaggactatgtttccctcttggagagtctccatacaaaatcttacctttgaaggtgacttgagtcacattcagcggctacagagtctggtgatagacattctagtctatgacaatcatgttcaagtggcaaaatccctcaagattggaagctttattcgaatctatagcctccataccaaacttcagtctgttgattcagaaaccagcaagtcattgttaaggctggagtttcatctccatggagggaccagttatggtcgggggattagggttttgccagatgaaagctcgtgtgtggatcagctgaaaaaagatttagaatgtgcagattcggcagtcactcaaccctcaaatggtatctgtcaatcaaaaaatgaggatagctttgtactttcaagctctgcatcaggctcagtatccctgtatgaggaagaacgatgtcagcaagtctcttctacaatactcacagatcaccagcacttagagaaaactccattgtgtgccgttttgaagcaaaaggctccgcagcaatatcgggtccgtgccaagctgaggtcgtatttgcccaggagacttccccagtctgttaaactgatctgtccgcagtgccattcactacaagaagttccacatgaggacagtttggataaacttttgcaagatgctgcaactaaagcgccagacatcaggctgcaaggtacatctttgtatgaatcaaagatctggaccaccgaaggccagggaggacggcaggtcgctgttcactttgtgaagaaggatggtgttctcccactttcaagtgaatgtctaattttgatagaaggaggaagactctgtgaagtgtccaagctgtccagcaagttccacagtgtgatccctgtgaggtccggccctgaggatctggagctcctcgacatttcagccccattcctcatacagggaaagctgcatcactatggatgtaaacagtgttcaagcttgaaacctatacaaaacctaaattcccttcttaataaaggaccatggattccttcctccgtggcaaaagtcctgggcattgtgcctctgcagtatgtgtttgttatgacgttcactctggatgatggaacaggagtgttggacacttacctcaaggattctgaaaactttttcaagatcccagcatctgaagtcctcactgatgacaaccttcagaggaatctggaagcgatcatggatatgatatgccctcctggaataaaagttgatgcatacccgtggcttgagtgcctcatcaagtcctacaatgtcaccattggaacagaacaacgaatttgctaccagatttttgacaccacggttgcagaagatgtctagtgctgccattcagtgcagtgtgtatggattttacaattttagaaaaggtcatgactctgagattctcagaagacacttggctattgtcaaaagtattgtatccattttcactgtagttcttttgtacagaaaactattttgttatttatgccatcttgtgaacatgtcagaaatcccttgctgctcatcatgtcccagggagtataaaatgagacagcactggttggggagaatgcccactctcatttttaaaacactggtagcaacttctccttctgtgctgtttgattctttttttttttttttttttgtacagaagaatctgcttagcaacttctgaaagaattctccctctacttccacacatgagtatcaggttaactgagtgcttgttgaacagatgccgtctcaccaagcggggatatactaaaaggagggtttcctttcagaagacatggctttgtttgggtgctcttgatgcccatttcaggataaatgtatctctttgaaccaaatagtatgcgtgactttctgcttctctctggaatactagaagctatttaatttcataccaactaataaagtgataggatttatattttcatgaa
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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