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Previous release (v1)
2024-11-22 06:48:36, GGRNA.v2 : RefSeq release 226 (Sep, 2024)
LOCUS NM_001394371 6621 bp mRNA linear ROD 03-APR-2024
DEFINITION Rattus norvegicus argonaute RISC component 4 (Ago4), mRNA.
ACCESSION NM_001394371 XM_006238862
VERSION NM_001394371.2
KEYWORDS RefSeq; RefSeq Select.
SOURCE Rattus norvegicus (Norway rat)
ORGANISM Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
REFERENCE 1 (bases 1 to 6621)
AUTHORS Gu,S., Jin,L., Huang,Y., Zhang,F. and Kay,M.A.
TITLE Slicing-independent RISC activation requires the argonaute PAZ
domain
JOURNAL Curr Biol 22 (16), 1536-1542 (2012)
PUBMED 22795694
REFERENCE 2 (bases 1 to 6621)
AUTHORS Modzelewski,A.J., Holmes,R.J., Hilz,S., Grimson,A. and Cohen,P.E.
TITLE AGO4 regulates entry into meiosis and influences silencing of sex
chromosomes in the male mouse germline
JOURNAL Dev Cell 23 (2), 251-264 (2012)
PUBMED 22863743
REFERENCE 3 (bases 1 to 6621)
AUTHORS Ender,C. and Meister,G.
TITLE Argonaute proteins at a glance
JOURNAL J Cell Sci 123 (Pt 11), 1819-1823 (2010)
PUBMED 20484662
REMARK Review article
REFERENCE 4 (bases 1 to 6621)
AUTHORS Yoda,M., Kawamata,T., Paroo,Z., Ye,X., Iwasaki,S., Liu,Q. and
Tomari,Y.
TITLE ATP-dependent human RISC assembly pathways
JOURNAL Nat Struct Mol Biol 17 (1), 17-23 (2010)
PUBMED 19966796
REFERENCE 5 (bases 1 to 6621)
AUTHORS Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
TITLE Defining the membrane proteome of NK cells
JOURNAL J Mass Spectrom 45 (1), 1-25 (2010)
PUBMED 19946888
REFERENCE 6 (bases 1 to 6621)
AUTHORS Rybak,A., Fuchs,H., Hadian,K., Smirnova,L., Wulczyn,E.A.,
Michel,G., Nitsch,R., Krappmann,D. and Wulczyn,F.G.
TITLE The let-7 target gene mouse lin-41 is a stem cell specific E3
ubiquitin ligase for the miRNA pathway protein Ago2
JOURNAL Nat Cell Biol 11 (12), 1411-1420 (2009)
PUBMED 19898466
REFERENCE 7 (bases 1 to 6621)
AUTHORS Chi,S.W., Zang,J.B., Mele,A. and Darnell,R.B.
TITLE Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps
JOURNAL Nature 460 (7254), 479-486 (2009)
PUBMED 19536157
REFERENCE 8 (bases 1 to 6621)
AUTHORS Wu,L., Fan,J. and Belasco,J.G.
TITLE Importance of translation and nonnucleolytic ago proteins for
on-target RNA interference
JOURNAL Curr Biol 18 (17), 1327-1332 (2008)
PUBMED 18771919
REFERENCE 9 (bases 1 to 6621)
AUTHORS Meister,G., Landthaler,M., Patkaniowska,A., Dorsett,Y., Teng,G. and
Tuschl,T.
TITLE Human Argonaute2 mediates RNA cleavage targeted by miRNAs and
siRNAs
JOURNAL Mol Cell 15 (2), 185-197 (2004)
PUBMED 15260970
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
JAXUCZ010000005.1.
On Apr 3, 2024 this sequence version replaced NM_001394371.1.
Sequence Note: The RefSeq transcript and protein were derived from
genomic sequence to make the sequence consistent with the reference
genome assembly. The genomic coordinates used for the transcript
record were based on alignments.
##Evidence-Data-START##
RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
[ECO:0006172]
##Evidence-Data-END##
##RefSeq-Attributes-START##
inferred exon combination :: based on alignments, homology
RefSeq Select criteria :: based on conservation, expression,
longest protein
##RefSeq-Attributes-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-402 JAXUCZ010000005.1 144110001-144110402 c
403-568 JAXUCZ010000005.1 144100564-144100729 c
569-689 JAXUCZ010000005.1 144097346-144097466 c
690-871 JAXUCZ010000005.1 144093827-144094008 c
872-1008 JAXUCZ010000005.1 144093526-144093662 c
1009-1143 JAXUCZ010000005.1 144093294-144093428 c
1144-1231 JAXUCZ010000005.1 144092320-144092407 c
1232-1379 JAXUCZ010000005.1 144088046-144088193 c
1380-1499 JAXUCZ010000005.1 144087445-144087564 c
1500-1628 JAXUCZ010000005.1 144087176-144087304 c
1629-1762 JAXUCZ010000005.1 144086853-144086986 c
1763-1947 JAXUCZ010000005.1 144085470-144085654 c
1948-2107 JAXUCZ010000005.1 144083831-144083990 c
2108-2423 JAXUCZ010000005.1 144079961-144080276 c
2424-2558 JAXUCZ010000005.1 144079691-144079825 c
2559-2660 JAXUCZ010000005.1 144071167-144071268 c
2661-2860 JAXUCZ010000005.1 144070709-144070908 c
2861-6621 JAXUCZ010000005.1 144064949-144068709 c
FEATURES Location/Qualifiers
source 1..6621
/organism="Rattus norvegicus"
/mol_type="mRNA"
/strain="BN"
/db_xref="taxon:10116"
/chromosome="5"
/map="5q36"
gene 1..6621
/gene="Ago4"
/gene_synonym="Eif2c4"
/note="argonaute RISC component 4"
/db_xref="GeneID:298533"
/db_xref="RGD:1304583"
exon 1..402
/gene="Ago4"
/gene_synonym="Eif2c4"
/inference="alignment:Splign:2.1.0"
misc_feature 207..209
/gene="Ago4"
/gene_synonym="Eif2c4"
/note="upstream in-frame stop codon"
CDS 384..2969
/gene="Ago4"
/gene_synonym="Eif2c4"
/note="eukaryotic translation initiation factor 2C, 4;
argonaute 4, RISC catalytic component; argonaute RISC
catalytic component 4; protein argonaute-4-like"
/codon_start=1
/product="protein argonaute-4"
/protein_id="NP_001381300.1"
/db_xref="GeneID:298533"
/db_xref="RGD:1304583"
/translation="
MEALGPGPPASLFQPPRRPGLGTVGKPIRLLANHFQVQIPKIDVYHYDVDIKPEKRPRRVNREVVDTMVRHFKMQIFGDRQPGYDGKRNMYTAHPLPIGRDRVDMEVTLPGEGKDQTFKVSVQWVSVVSLQLLLEALAGHLSEVPDDSVQALDVITRHLPSMRYTPVGRSFFSPPEGYYHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYRAQPIIEFMCEVLDIQNINEQTKPLTDSQRVKFTKEIRGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLENGQAMECTVAQYFKQKYNLQLKYSHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLVKSNSVLGGPDPYLKEFGIVVHNEMTELMGRVLPAPMLQYGGRNKTVATPNQGVWDMRGKQFYAGIEIKVWAVACFAPQKQCREDLLKSFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFKHLKMTYVGLQLIVVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVVKTSPQTLSNLCLKINAKLGGINNVLVPHQRPSVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDGHPSRYCATVRVQTSRQEIAQELLFSQEVVQDLTSMARELLIQFYKSTRFKPTRIIYYRGGVSEGQMKQVAWPELIAIRKACISLEEDYRPGITYIVVQKRHHTRLFCADKTERVGKSGNVPAGTTVDSTITHPSEFDFYLCSHAGIQGTSRPSHYQVLWDDNCFTADELQLLTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKDHDSAEGSHVSGQSNGRDPQALAKAVQIHHDTQHTMYFA"
misc_feature 459..848
/gene="Ago4"
/gene_synonym="Eif2c4"
/note="N-terminal domain of argonaute; Region: ArgoN;
pfam16486"
/db_xref="CDD:465134"
misc_feature 879..1031
/gene="Ago4"
/gene_synonym="Eif2c4"
/note="Argonaute linker 1 domain; Region: ArgoL1;
pfam08699"
/db_xref="CDD:462567"
misc_feature 1032..1394
/gene="Ago4"
/gene_synonym="Eif2c4"
/note="PAZ domain, argonaute_like subfamily. Argonaute is
part of the RNA-induced silencing complex (RISC), and is
an endonuclease that plays a key role in the RNA
interference pathway. The PAZ domain has been named after
the proteins Piwi,Argonaut, and Zwille; Region:
PAZ_argonaute_like; cd02846"
/db_xref="CDD:239212"
misc_feature order(1188..1190,1233..1235,1275..1277,1287..1289,
1341..1343,1362..1364,1368..1370)
/gene="Ago4"
/gene_synonym="Eif2c4"
/note="nucleic acid-binding interface [nucleotide
binding]; other site"
/db_xref="CDD:239212"
misc_feature 1533..2840
/gene="Ago4"
/gene_synonym="Eif2c4"
/note="PIWI domain, Argonaute-like subfamily. Argonaute is
the central component of the RNA-induced silencing complex
(RISC) and related complexes. The PIWI domain is the
C-terminal portion of Argonaute and consists of two
subdomains, one of which provides the...; Region:
Piwi_ago-like; cd04657"
/db_xref="CDD:240015"
misc_feature order(1944..1946,1956..1958,1992..2003,2010..2012,
2034..2036,2043..2045,2055..2057,2067..2069)
/gene="Ago4"
/gene_synonym="Eif2c4"
/note="5' RNA guide strand anchoring site [active]"
/db_xref="CDD:240015"
misc_feature order(2148..2150,2154..2156,2394..2396,2808..2810)
/gene="Ago4"
/gene_synonym="Eif2c4"
/note="active site"
/db_xref="CDD:240015"
exon 403..568
/gene="Ago4"
/gene_synonym="Eif2c4"
/inference="alignment:Splign:2.1.0"
exon 569..689
/gene="Ago4"
/gene_synonym="Eif2c4"
/inference="alignment:Splign:2.1.0"
exon 690..871
/gene="Ago4"
/gene_synonym="Eif2c4"
/inference="alignment:Splign:2.1.0"
exon 872..1008
/gene="Ago4"
/gene_synonym="Eif2c4"
/inference="alignment:Splign:2.1.0"
exon 1009..1143
/gene="Ago4"
/gene_synonym="Eif2c4"
/inference="alignment:Splign:2.1.0"
exon 1144..1231
/gene="Ago4"
/gene_synonym="Eif2c4"
/inference="alignment:Splign:2.1.0"
exon 1232..1379
/gene="Ago4"
/gene_synonym="Eif2c4"
/inference="alignment:Splign:2.1.0"
exon 1380..1499
/gene="Ago4"
/gene_synonym="Eif2c4"
/inference="alignment:Splign:2.1.0"
exon 1500..1628
/gene="Ago4"
/gene_synonym="Eif2c4"
/inference="alignment:Splign:2.1.0"
exon 1629..1762
/gene="Ago4"
/gene_synonym="Eif2c4"
/inference="alignment:Splign:2.1.0"
exon 1763..1947
/gene="Ago4"
/gene_synonym="Eif2c4"
/inference="alignment:Splign:2.1.0"
exon 1948..2107
/gene="Ago4"
/gene_synonym="Eif2c4"
/inference="alignment:Splign:2.1.0"
exon 2108..2423
/gene="Ago4"
/gene_synonym="Eif2c4"
/inference="alignment:Splign:2.1.0"
exon 2424..2558
/gene="Ago4"
/gene_synonym="Eif2c4"
/inference="alignment:Splign:2.1.0"
exon 2559..2660
/gene="Ago4"
/gene_synonym="Eif2c4"
/inference="alignment:Splign:2.1.0"
exon 2661..2860
/gene="Ago4"
/gene_synonym="Eif2c4"
/inference="alignment:Splign:2.1.0"
exon 2861..6621
/gene="Ago4"
/gene_synonym="Eif2c4"
/inference="alignment:Splign:2.1.0"
ORIGIN
accccgccccctgcctcggacctgctcgctggaccctgcgcgtgccgggctgcgcacgcccccttcgccagccgggaccccggaccgcacgcgcctggcgccccctccctgcccggcgggcgcgcgccgcctcccgctcccgctccagctggcggcggcggcggcggcccggattgtttttgttgttgccgaggccggaagagccgtgagagagccgggtccctgtccccggaccgggcactgccgccgccccttgcccagcgctcgcgtcttcgcggcgccgcttcagcgccaatattccggagagcaagcgttacgcggcggcggcggggcccggagcgggaggcgccggggaccggggcgaggcggcccccgccgccgccatggaggcgctgggacccggacctccagccagcctcttccagccaccccggcgtcctggccttggcactgttgggaaaccaatccgactgttagccaatcattttcaggttcagattcctaaaatagatgtgtatcactatgatgtggatattaaaccggaaaaacggcctcgtagagtcaacagggaggtagtagacactatggtgcgacacttcaagatgcagatatttggagatcggcagcctggctatgatggcaaaagaaacatgtacacagcacatccactgccaatcggacgggatagggttgatatggaggtgaccctcccaggtgagggcaaggaccaaacgttcaaagtgtcagtgcaatgggtgtcagttgtgagccttcagctgcttttagaagctttagctggacacctgagtgaagtcccagatgactcagtacaagcccttgacgtgattacaaggcatctcccctctatgaggtacactccagtaggccggtcttttttctcacctcctgaaggttactaccaccctctgggagggggcagagaggtctggttcggctttcaccagtctgtgcgccctgccatgtggaagatgatgctcaacattgatgtatctgcaactgctttctaccgggctcagcccatcattgagttcatgtgtgaggttttagacatccagaacatcaacgagcagacgaaacctctaacagactcccagcgtgtcaagtttaccaaagaaatcaggggtcttaaagttgaggtgactcactgtggacagatgaaacgaaaatatcgagtttgtaatgtgacaagacgaccagccagtcatcaaaccttccctttgcagctagaaaatggtcaagctatggaatgtacagtagctcagtattttaagcaaaaatataatctgcagctgaaatactcccatcttccctgccttcaagtgggacaagagcaaaagcatacatacctgccacttgaggtctgtaatatagtagcagggcagagatgtataaagaagctcacagacaaccagacatccaccatgatcaaagccacagcgagatctgctcctgacagacaggaggaaatcagtagactggtgaagagcaacagcgtgctgggtggacctgacccatacctgaaggaatttgggatcgttgtgcacaatgagatgacggaactcatgggcagggtgcttccggcgccaatgctgcagtatggaggccggaataaaacagtagccacacccaaccagggtgtctgggacatgcgaggaaagcagttttatgctggcattgaaattaaagtatgggcagtggcttgttttgcgcctcagaaacaatgtagggaagatttgctaaagagcttcactgaccaacttcgtaaaatctccaaggatgcagggatgcccatccagggtcaaccatgtttctgcaaatatgctcaaggtgcagacagtgtggagcccatgtttaaacatctgaaaatgacatatgtgggcctgcagctaatagtggtgattttgcctgggaagacaccagtatatgcggaggtgaagcgtgttggagataccctcctaggtatggccacgcagtgtgtccaggtcaaaaatgttgtgaagacctcgccacaaaccctttccaacctttgtctgaagataaacgcaaagcttggaggaattaacaacgtacttgtgcctcatcaaaggccctcagtgttccagcagcctgtcatcttcctgggagcagatgtcactcatccacctgctggggatgggaagaagccttctattgcagcggtggtgggcagcatggatggccatcccagtcggtactgtgccactgtccgggtgcagacatctcgccaggagattgcccaggagctcctgttcagtcaggaggtcgtgcaggacctgacgagcatggctcgggagctgctgattcagttctataagtccacgcgcttcaagcccacgcgtatcatctactaccgcggaggggtatccgagggacagatgaaacaggtagcttggccagaactaatagcaattcgaaaggcatgtataagtctggaggaagactaccggccaggaataacctacattgtggtacaaaagcgacatcacacacgactcttctgtgcagataaaacagaaagggtggggaaaagtggcaatgtcccagcaggcactacggtggatagcaccatcacacatccatcggagtttgacttttacctctgcagtcatgcaggaattcagggaaccagtcgtccttcacattaccaggtcctgtgggatgacaactgctttaccgcggatgaactgcagctgctgacctaccagctctgccacacctacgtgaggtgcacacgctcagtctccattcctgcccctgcatattatgcccggcttgtagcattccgggcaaggtatcatttggtggacaaagatcatgacagtgcggaaggcagtcacgtgtcaggacagagcaacggccgggatcctcaagccttggctaaggcggtgcagatccaccatgatacccagcacactatgtattttgcctgagagtcttggaaaagaactcaaccaatttggcatcccacgcatcctcaaaatgtttcagatgcctactgcctctcttagtgcacagtgatttcaggtggtccctaccagcagctcagaaaagttgcactgaatctgtactctgtagccctgtctgatgcatcaacaaaatcgagcctttttttttttttaagaaatagatactcatagattatgttttctgatgcactgggcagaatttttacctcaacgtgcgaaggctgattagccttgactttctaaaggactttccaagaagggtttctgtggaatattttgctagctgtggtattcaccgcatctagtcttataagaggagtatttccttttttctgtgttattgactggagtgtgtacataagaacatttggaagagagaaaccaaacgacctggatcatttccatgtaactttttaattgagtgggtccgtagacttcttaatggagatttcttactttgccactgcaaatgcctttgaggagcattaagttttgaaagttttccagaactctgttaccttcactgcgttatctgactgacctctccgggcctgcgctgtagagtacaggctgcctggtgattgcactaatacttggctgagatttgaacaggcagctcccttccttggctggcttttgtgaatctgtgacataagcagatgtgatgtgtgtcacagggacagataacactgccaatggtaaaaagtacccatgttctccatatttgggaaaaaaaagaattagtttttagtatttttccacattttcaaaagtgcccattttatgctgctgtgtggtgtgttagatctaaacgatctttaaacttctctcatagaaaattaactttggcaataagcatttttaaggtctctgctctttttcctcctgacatagttttctagataagatttcagtatgattttatcaactatttcttgtatctcataactgggatattctgaaaccagtttataaagacatggatttccatgtcctttaaataattgtttttttaaaaaacaaaacaaacctattttatagtcagtgtcctgtcactttaaaaaaaaaaaaaagctggaaccaggatgctttctgattggtcaggctttgctgacgtataaggctcattgagcagtactgcacttgaaaagaaagtaccagccagtaaaaaaatagtttccctgggaatcaaggctgcacacacagctgcttacaagacagcctgaagtgtgcttggctttgcccatctctctctcaactaaaactctgtagaagttgatttttttttctctctctctgtaatagattctggattccctcacaggaagacaggacttcttttcttgtcgtaacaaagggagttgatgtaaagcaagtatcagttagaatgaagggaaaatgtatcctgtatttagtgtagatagtacttggtaaaggacaagcgttacatagtcaaggtagtcctacctgcggtttccagcgcacagttactccaacctggaagggtaaggagtgaaaggcaagaggctctatgtagagccacactcctcatggctgaggagggtgctgggaagagacagacgcaatatgctagagtcaattttgcagtctctctgtagaaaccgttggtgggaaacactgggtcagatgataaagggtgtttgcttgaaccctttagttggtccaaggtccaaatctgttaaacgggccctctcaatcccagcaatataaaacactgtttcccttcagtcttttaaacaagtgtgtagatacattaaatgtttacatttccgtgtgctgtcgtcgctcagcggtgccaccagtgtttgctgagactggtctccaagagagtttccaatgtccatctaatcctatagcacgtgagggtgggtgcagacccccttaatctgcagaccgtgggaaaaagcaagtcctgaggctgaagcacaacatagcagtgaagagacagcagacgtctgttctctgagattttccttttctgcaaatacctcacatggattatacaaatcaggacatgttgatgaatggctgactgccacttttattcacacctgttcagggaaagcacagaaaatactctgcagcccagccactctggacccaagaagagggaaaaaacaaaaggaagctttttcagaaaaaggaaaacttgcctggagtctgtgaggcgaagaaccaagagggggctggcagctagccagagggcaccgtacctgcactggagtgcctagggctcgcttgttaacaatacacagaagaaactcttgggatcttccgacataatggaacagtgagcaagccgtgtgcccagacgctccatccaccttcccgcagttggcttcgaggtttgcccatgaacaatgtatctgaatataccgtcagccctcgtatgcaaggccctgggttcggtccccagctccggaaaaaaagaaccaaaaaaaaaaaaaaaaaaaaaaaaaaacaacagaattgcagtcataccatcgcaagccaatctgaatgcatagttttaattgaacaagagttggcaattcaaatagataccccccccccaaaactgactgaattgttatgcatgtgtcaatcaatgggaggtgtgcattctctagaagtagaattaggttgtttggttttttaaaacacagcctatttaggtcctgtcatatagcgaggaagatttcagtgtagcgactctaaggagtgactatttggggctaaggagcacaggaccttacggatgggaaaggcccagatgtcgaaccaattatgttttgttgttgttgatgtgttgtcgttagttgttgaaacccgagctgtttataaagggaagcagccggcttggtgtagccagtgttctgggcaggtgaaccacattcattctcgctgtaaattctacgtgctgcttccaaaggcgatggttcacaagcaggtgtggcctaagtggtctgtaccttaggatctggtgtctggcccatatcctacatgaaaacctgcccacctggctcagctacccactccttcccatggacaaagataaagcactgttttaaccaggctcaccccgtctcccccgccatggttaccctccctccgaggacgctctgagactcccttgcttagtacaaggtggctgctctgctttcattttgagaaagcagaggttagggcgggcgccatattaatactgcttcaacatcaaccattttcttaccccttcctgccgacactcacattctttctgcatccaccagccaaaagtgcttgtgttcatctgaccgatggtgtggtttctgtttctgtatgcttagacttgtaatgctttaaaatgcattttactaatttggactggatgtctgtctccagcgatgcgaggtactttctaagctatgaaggaagggtttgtatccttatgtgagatgagtaacggttgtttaaattttgcagaggttcttgttactgttactggtttggggttttttggtttttggggggggttttgtttgtttgtttgtttgtttgttttggcttgcagggatattttgtgttcatgtgtctgaaaagtggggaggggaataaatggcattcttgtgctaaa
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
[Full Text]