2024-05-04 18:53:30, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NM_001394371 6622 bp mRNA linear ROD 23-MAR-2023 DEFINITION Rattus norvegicus argonaute RISC component 4 (Ago4), mRNA. ACCESSION NM_001394371 XM_006238862 VERSION NM_001394371.1 KEYWORDS RefSeq; RefSeq Select. SOURCE Rattus norvegicus (Norway rat) ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. REFERENCE 1 (bases 1 to 6622) AUTHORS Gu S, Jin L, Huang Y, Zhang F and Kay MA. TITLE Slicing-independent RISC activation requires the argonaute PAZ domain JOURNAL Curr Biol 22 (16), 1536-1542 (2012) PUBMED 22795694 REFERENCE 2 (bases 1 to 6622) AUTHORS Modzelewski AJ, Holmes RJ, Hilz S, Grimson A and Cohen PE. TITLE AGO4 regulates entry into meiosis and influences silencing of sex chromosomes in the male mouse germline JOURNAL Dev Cell 23 (2), 251-264 (2012) PUBMED 22863743 REFERENCE 3 (bases 1 to 6622) AUTHORS Ender C and Meister G. TITLE Argonaute proteins at a glance JOURNAL J Cell Sci 123 (Pt 11), 1819-1823 (2010) PUBMED 20484662 REMARK Review article REFERENCE 4 (bases 1 to 6622) AUTHORS Yoda M, Kawamata T, Paroo Z, Ye X, Iwasaki S, Liu Q and Tomari Y. TITLE ATP-dependent human RISC assembly pathways JOURNAL Nat Struct Mol Biol 17 (1), 17-23 (2010) PUBMED 19966796 REFERENCE 5 (bases 1 to 6622) AUTHORS Ghosh D, Lippert D, Krokhin O, Cortens JP and Wilkins JA. TITLE Defining the membrane proteome of NK cells JOURNAL J Mass Spectrom 45 (1), 1-25 (2010) PUBMED 19946888 REFERENCE 6 (bases 1 to 6622) AUTHORS Rybak A, Fuchs H, Hadian K, Smirnova L, Wulczyn EA, Michel G, Nitsch R, Krappmann D and Wulczyn FG. TITLE The let-7 target gene mouse lin-41 is a stem cell specific E3 ubiquitin ligase for the miRNA pathway protein Ago2 JOURNAL Nat Cell Biol 11 (12), 1411-1420 (2009) PUBMED 19898466 REFERENCE 7 (bases 1 to 6622) AUTHORS Chi SW, Zang JB, Mele A and Darnell RB. TITLE Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps JOURNAL Nature 460 (7254), 479-486 (2009) PUBMED 19536157 REFERENCE 8 (bases 1 to 6622) AUTHORS Wu L, Fan J and Belasco JG. TITLE Importance of translation and nonnucleolytic ago proteins for on-target RNA interference JOURNAL Curr Biol 18 (17), 1327-1332 (2008) PUBMED 18771919 REFERENCE 9 (bases 1 to 6622) AUTHORS Meister G, Landthaler M, Patkaniowska A, Dorsett Y, Teng G and Tuschl T. TITLE Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs JOURNAL Mol Cell 15 (2), 185-197 (2004) PUBMED 15260970 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JACYVU010000162.1. On Aug 31, 2021 this sequence version replaced XM_006238862.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMD00132261, SAMD00132262 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## inferred exon combination :: based on alignments, homology RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-402 JACYVU010000162.1 53374796-53375197 c 403-568 JACYVU010000162.1 53365359-53365524 c 569-689 JACYVU010000162.1 53362141-53362261 c 690-871 JACYVU010000162.1 53358642-53358823 c 872-1008 JACYVU010000162.1 53358341-53358477 c 1009-1143 JACYVU010000162.1 53358109-53358243 c 1144-1231 JACYVU010000162.1 53357135-53357222 c 1232-1379 JACYVU010000162.1 53352859-53353006 c 1380-1499 JACYVU010000162.1 53352245-53352364 c 1500-1628 JACYVU010000162.1 53351976-53352104 c 1629-1762 JACYVU010000162.1 53351653-53351786 c 1763-1947 JACYVU010000162.1 53350270-53350454 c 1948-2107 JACYVU010000162.1 53348631-53348790 c 2108-2423 JACYVU010000162.1 53344761-53345076 c 2424-2558 JACYVU010000162.1 53344491-53344625 c 2559-2660 JACYVU010000162.1 53335965-53336066 c 2661-2860 JACYVU010000162.1 53335507-53335706 c 2861-6622 JACYVU010000162.1 53329745-53333506 c FEATURES Location/Qualifiers source 1..6622 /organism="Rattus norvegicus" /mol_type="mRNA" /strain="BN" /db_xref="taxon:10116" /chromosome="5" /map="5q36" gene 1..6622 /gene="Ago4" /gene_synonym="Eif2c4" /note="argonaute RISC component 4" /db_xref="GeneID:298533" /db_xref="RGD:1304583" exon 1..402 /gene="Ago4" /gene_synonym="Eif2c4" /inference="alignment:Splign:2.1.0" misc_feature 207..209 /gene="Ago4" /gene_synonym="Eif2c4" /note="upstream in-frame stop codon" CDS 384..2969 /gene="Ago4" /gene_synonym="Eif2c4" /note="eukaryotic translation initiation factor 2C, 4; argonaute 4, RISC catalytic component; argonaute RISC catalytic component 4; protein argonaute-4-like" /codon_start=1 /product="protein argonaute-4" /protein_id="NP_001381300.1" /db_xref="GeneID:298533" /db_xref="RGD:1304583" /translation="
MEALGPGPPASLFQPPRRPGLGTVGKPIRLLANHFQVQIPKIDVYHYDVDIKPEKRPRRVNREVVDTMVRHFKMQIFGDRQPGYDGKRNMYTAHPLPIGRDRVDMEVTLPGEGKDQTFKVSVQWVSVVSLQLLLEALAGHLSEVPDDSVQALDVITRHLPSMRYTPVGRSFFSPPEGYYHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYRAQPIIEFMCEVLDIQNINEQTKPLTDSQRVKFTKEIRGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLENGQAMECTVAQYFKQKYNLQLKYSHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLVKSNSVLGGPDPYLKEFGIVVHNEMTELMGRVLPAPMLQYGGRNKTVATPNQGVWDMRGKQFYAGIEIKVWAVACFAPQKQCREDLLKSFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFKHLKMTYVGLQLIVVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVVKTSPQTLSNLCLKINAKLGGINNVLVPHQRPSVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDGHPSRYCATVRVQTSRQEIAQELLFSQEVVQDLTSMARELLIQFYKSTRFKPTRIIYYRGGVSEGQMKQVAWPELIAIRKACISLEEDYRPGITYIVVQKRHHTRLFCADKTERVGKSGNVPAGTTVDSTITHPSEFDFYLCSHAGIQGTSRPSHYQVLWDDNCFTADELQLLTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKDHDSAEGSHVSGQSNGRDPQALAKAVQIHHDTQHTMYFA"
misc_feature 459..848 /gene="Ago4" /gene_synonym="Eif2c4" /note="N-terminal domain of argonaute; Region: ArgoN; pfam16486" /db_xref="CDD:435368" misc_feature 879..1031 /gene="Ago4" /gene_synonym="Eif2c4" /note="Argonaute linker 1 domain; Region: ArgoL1; pfam08699" /db_xref="CDD:430160" misc_feature 1032..1394 /gene="Ago4" /gene_synonym="Eif2c4" /note="PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846" /db_xref="CDD:239212" misc_feature order(1188..1190,1233..1235,1275..1277,1287..1289, 1341..1343,1362..1364,1368..1370) /gene="Ago4" /gene_synonym="Eif2c4" /note="nucleic acid-binding interface [nucleotide binding]; other site" /db_xref="CDD:239212" misc_feature 1533..2840 /gene="Ago4" /gene_synonym="Eif2c4" /note="PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the...; Region: Piwi_ago-like; cd04657" /db_xref="CDD:240015" misc_feature order(1944..1946,1956..1958,1992..2003,2010..2012, 2034..2036,2043..2045,2055..2057,2067..2069) /gene="Ago4" /gene_synonym="Eif2c4" /note="5' RNA guide strand anchoring site [active]" /db_xref="CDD:240015" misc_feature order(2148..2150,2154..2156,2394..2396,2808..2810) /gene="Ago4" /gene_synonym="Eif2c4" /note="active site" /db_xref="CDD:240015" exon 403..568 /gene="Ago4" /gene_synonym="Eif2c4" /inference="alignment:Splign:2.1.0" exon 569..689 /gene="Ago4" /gene_synonym="Eif2c4" /inference="alignment:Splign:2.1.0" exon 690..871 /gene="Ago4" /gene_synonym="Eif2c4" /inference="alignment:Splign:2.1.0" exon 872..1008 /gene="Ago4" /gene_synonym="Eif2c4" /inference="alignment:Splign:2.1.0" exon 1009..1143 /gene="Ago4" /gene_synonym="Eif2c4" /inference="alignment:Splign:2.1.0" exon 1144..1231 /gene="Ago4" /gene_synonym="Eif2c4" /inference="alignment:Splign:2.1.0" exon 1232..1379 /gene="Ago4" /gene_synonym="Eif2c4" /inference="alignment:Splign:2.1.0" exon 1380..1499 /gene="Ago4" /gene_synonym="Eif2c4" /inference="alignment:Splign:2.1.0" exon 1500..1628 /gene="Ago4" /gene_synonym="Eif2c4" /inference="alignment:Splign:2.1.0" exon 1629..1762 /gene="Ago4" /gene_synonym="Eif2c4" /inference="alignment:Splign:2.1.0" exon 1763..1947 /gene="Ago4" /gene_synonym="Eif2c4" /inference="alignment:Splign:2.1.0" exon 1948..2107 /gene="Ago4" /gene_synonym="Eif2c4" /inference="alignment:Splign:2.1.0" exon 2108..2423 /gene="Ago4" /gene_synonym="Eif2c4" /inference="alignment:Splign:2.1.0" exon 2424..2558 /gene="Ago4" /gene_synonym="Eif2c4" /inference="alignment:Splign:2.1.0" exon 2559..2660 /gene="Ago4" /gene_synonym="Eif2c4" /inference="alignment:Splign:2.1.0" exon 2661..2860 /gene="Ago4" /gene_synonym="Eif2c4" /inference="alignment:Splign:2.1.0" exon 2861..6622 /gene="Ago4" /gene_synonym="Eif2c4" /inference="alignment:Splign:2.1.0" ORIGIN
accccgccccctgcctcggacctgctcgctggaccctgcgcgtgccgggctgcgcacgcccccttcgccagccgggaccccggaccgcacgcgcctggcgccccctccctgcccggcgggcgcgcgccgcctcccgctcccgctccagctggcggcggcggcggcggcccggattgtttttgttgttgccgaggccggaagagccgtgagagagccgggtccctgtccccggaccgggcactgccgccgccccttgcccagcgctcgcgtcttcgcggcgccgcttcagcgccaatattccggagagcaagcgttacgcggcggcggcggggcccggagcgggaggcgccggggaccggggcgaggcggcccccgccgccgccatggaggcgctgggacccggacctccagccagcctcttccagccaccccggcgtcctggccttggcactgttgggaaaccaatccgactgttagccaatcattttcaggttcagattcctaaaatagatgtgtatcactatgatgtggatattaaaccggaaaaacggcctcgtagagtcaacagggaggtagtagacactatggtgcgacacttcaagatgcagatatttggagatcggcagcctggctatgatggcaaaagaaacatgtacacagcacatccactgccaatcggacgggatagggttgatatggaggtgaccctcccaggtgagggcaaggaccaaacgttcaaagtgtcagtgcaatgggtgtcagttgtgagccttcagctgcttttagaagctttagctggacacctgagtgaagtcccagatgactcagtacaagcccttgacgtgattacaaggcatctcccctctatgaggtacactccagtaggccggtcttttttctcacctcctgaaggttactaccaccctctgggagggggcagagaggtctggttcggctttcaccagtctgtgcgccctgccatgtggaagatgatgctcaacattgatgtatctgcaactgctttctaccgggctcagcccatcattgagttcatgtgtgaggttttagacatccagaacatcaacgagcagacgaaacctctaacagactcccagcgtgtcaagtttaccaaagaaatcaggggtcttaaagttgaggtgactcactgtggacagatgaaacgaaaatatcgagtttgtaatgtgacaagacgaccagccagtcatcaaaccttccctttgcagctagaaaatggtcaagctatggaatgtacagtagctcagtattttaagcaaaaatataatctgcagctgaaatactcccatcttccctgccttcaagtgggacaagagcaaaagcatacatacctgccacttgaggtctgtaatatagtagcagggcagagatgtataaagaagctcacagacaaccagacatccaccatgatcaaagccacagcgagatctgctcctgacagacaggaggaaatcagtagactggtgaagagcaacagcgtgctgggtggacctgacccatacctgaaggaatttgggatcgttgtgcacaatgagatgacggaactcatgggcagggtgcttccggcgccaatgctgcagtatggaggccggaataaaacagtagccacacccaaccagggtgtctgggacatgcgaggaaagcagttttatgctggcattgaaattaaagtatgggcagtggcttgttttgcgcctcagaaacaatgtagggaagatttgctaaagagcttcactgaccaacttcgtaaaatctccaaggatgcagggatgcccatccagggtcaaccatgtttctgcaaatatgctcaaggtgcagacagtgtggagcccatgtttaaacatctgaaaatgacatatgtgggcctgcagctaatagtggtgattttgcctgggaagacaccagtatatgcggaggtgaagcgtgttggagataccctcctaggtatggccacgcagtgtgtccaggtcaaaaatgttgtgaagacctcgccacaaaccctttccaacctttgtctgaagataaacgcaaagcttggaggaattaacaacgtacttgtgcctcatcaaaggccctcagtgttccagcagcctgtcatcttcctgggagcagatgtcactcatccacctgctggggatgggaagaagccttctattgcagcggtggtgggcagcatggatggccatcccagtcggtactgtgccactgtccgggtgcagacatctcgccaggagattgcccaggagctcctgttcagtcaggaggtcgtgcaggacctgacgagcatggctcgggagctgctgattcagttctataagtccacgcgcttcaagcccacgcgtatcatctactaccgcggaggggtatccgagggacagatgaaacaggtagcttggccagaactaatagcaattcgaaaggcatgtataagtctggaggaagactaccggccaggaataacctacattgtggtacaaaagcgacatcacacacgactcttctgtgcagataaaacagaaagggtggggaaaagtggcaatgtcccagcaggcactacggtggatagcaccatcacacatccatcggagtttgacttttacctctgcagtcatgcaggaattcagggaaccagtcgtccttcacattaccaggtcctgtgggatgacaactgctttaccgcggatgaactgcagctgctgacctaccagctctgccacacctacgtgaggtgcacacgctcagtctccattcctgcccctgcatattatgcccggcttgtagcattccgggcaaggtatcatttggtggacaaagatcatgacagtgcggaaggcagtcacgtgtcaggacagagcaacggccgggatcctcaagccttggctaaggcggtgcagatccaccatgatacccagcacactatgtattttgcctgagagtcttggaaaagaactcaaccaatttggcatcccacgcatcctcaaaatgtttcagatgcctactgcctctcttagtgcacagtgatttcaggtggtccctaccagcagctcagaaaagttgcactgaatctgtactctgtagccctgtctgatgcatcaacaaaatcgagcctttttttttttttaagaaatagatactcatagattatgttttctgatgcactgggcagaatttttacctcaacgtgcgaaggctgattagccttgactttctaaaggactttccaagaagggtttctgtggaatattttgctagctgtggtattcaccgcatctagtcttataagaggagtatttccttttttctgtgttattgactggagtgtgtacataagaacatttggaagagagaaaccaaacgacctggatcatttccatgtaactttttaattgagtgggtccgtagacttcttaatggagatttcttactttgccactgcaaatgcctttgaggagcattaagttttgaaagttttccagaactctgttaccttcactgcgttatctgactgacctctccgggcctgcgctgtagagtacaggctgcctggtgattgcactaatacttggctgagatttgaacaggcagctcccttccttggctggcttttgtgaatctgtgacataagcagatgtgatgtgtgtcacagggacagataacactgccaatggtaaaaagtacccatgttctccatatttgggaaaaaaaagaattagtttttagtatttttccacattttcaaaagtgcccattttatgctgctgtgtggtgtgttagatctaaacgatctttaaacttctctcatagaaaattaactttggcaataagcatttttaaggtctctgctctttttcctcctgacatagttttctagataagatttcagtatgattttatcaactatttcttgtatctcataactgggatattctgaaaccagtttataaagacatggatttccatgtcctttaaataattgtttttttaaaaaacaaaacaaacctattttatagtcagtgtcctgtcactttaaaaaaaaaaaaaagctggaaccaggatgctttctgattggtcaggctttgctgacgtataaggctcattgagcagtactgcacttgaaaagaaagtaccagccagtaaaaaaatagtttccctgggaatcaaggctgcacacacagctgcttacaagacagcctgaagtgtgcttggctttgcccatctctctctcaactaaaactctgtagaagttgatttttttttctctctctctgtaatagattctggattccctcacaggaagacaggacttcttttcttgtcgtaacaaagggagttgatgtaaagcaagtatcagttagaatgaagggaaaatgtatcctgtatttagtgtagatagtacttggtaaaggacaagcgttacatagtcaaggtagtcctacctgcggtttccagcgcacagttactccaacctggaagggtaaggagtgaaaggcaagaggctctatgtagagccacactcctcatggctgaggagggtgctgggaagagacagacgcaatatgctagagtcaattttgcagtctctctgtagaaaccgttggtgggaaacactgggtcagatgataaagggtgtttgcttgaaccctttagttggtccaaggtccaaatctgttaaacgggccctctcaatcccagcaatataaaacactgtttcccttcagtcttttaaacaagtgtgtagatacattaaatgtttacatttccgtgtgctgtcgtcgctcagcggtgccaccagtgtttgctgagactggtctccaagagagtttccaatgtccatctaatcctatagcacgtgagggtgggtgcagacccccttaatctgcagaccgtgggaaaaagcaagtcctgaggctgaagcacaacatagcagtgaagagacagcagacgtctgttctctgagattttccttttctgcaaatacctcacatggattatacaaatcaggacatgttgatgaatggctgactgccacttttattcacacctgttcagggaaagcacagaaaatactctgcagcccagccactctggacccaagaagagggaaaaaacaaaaggaagctttttcagaaaaaggaaaacttgcctggagtctgtgaggcgaagaaccaagagggggctggcagctagccagagggcaccgtacctgcactggagtgcctagggctcgcttgttaacaatacacagaagaaactcttgggatcttccgacataatggaacagtgagcaagccgtgtgcccagacgctccatccaccttcccgcagttggcttcgaggtttgcccatgaacaatgtatctgaatataccgtcagccctcgtatgcaaggccctgggttcggtccccagctccggaaaaaaagaaccaaaaaaaaaaaaaaaaaaaaaaaaaaaacaacagaattgcagtcataccatcgcaagccaatctgaatgcatagttttaattgaacaagagttggcaattcaaatagataccccccccccaaaactgactgaattgttatgcatgtgtcaatcaatgggaggtgtgcattctctagaagtagaattaggttgtttggttttttaaaacacagcctatttaggtcctgtcatatagcgaggaagatttcagtgtagcgactctaaggagtgactatttggggctaaggagcacaggaccttacggatgggaaaggcccagatgtcgaaccaattatgttttgttgttgttgatgtgttgtcgttagttgttgaaacccgagctgtttataaagggaagcagccggcttggtgtagccagtgttctgggcaggtgaaccacattcattctcgctgtaaattctacgtgctgcttccaaaggcgatggttcacaagcaggtgtggcctaagtggtctgtaccttaggatctggtgtctggcccatatcctacatgaaaacctgcccacctggctcagctacccactccttcccatggacaaagataaagcactgttttaaccaggctcaccccgtctcccccgccatggttaccctccctccgaggacgctctgagactcccttgcttagtacaaggtggctgctctgctttcattttgagaaagcagaggttagggcgggcgccatattaatactgcttcaacatcaaccattttcttaccccttcctgccgacactcacattctttctgcatccaccagccaaaagtgcttgtgttcatctgaccgatggtgtggtttctgtttctgtatgcttagacttgtaatgctttaaaatgcattttactaatttggactggatgtctgtctccagcgatgcgaggtactttctaagctatgaaggaagggtttgtatccttatgtgagatgagtaacggttgtttaaattttgcagaggttcttgttactgttactggtttggggttttttggtttttggggggggttttgtttgtttgtttgtttgtttgttttggcttgcagggatattttgtgttcatgtgtctgaaaagtggggaggggaataaatggcattcttgtgctaaa
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Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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