2024-05-04 22:49:24, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NM_001271133 3109 bp mRNA linear ROD 22-MAR-2023 DEFINITION Rattus norvegicus piwi-like RNA-mediated gene silencing 4 (Piwil4), mRNA. ACCESSION NM_001271133 XM_001072752 VERSION NM_001271133.1 KEYWORDS RefSeq; RefSeq Select. SOURCE Rattus norvegicus (Norway rat) ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. REFERENCE 1 (bases 1 to 3109) AUTHORS Henaoui IS, Jacovetti C, Guerra Mollet I, Guay C, Sobel J, Eliasson L and Regazzi R. TITLE PIWI-interacting RNAs as novel regulators of pancreatic beta cell function JOURNAL Diabetologia 60 (10), 1977-1986 (2017) PUBMED 28711973 REFERENCE 2 (bases 1 to 3109) AUTHORS Sivagurunathan S, Palanisamy K, Arunachalam JP and Chidambaram S. TITLE Possible role of HIWI2 in modulating tight junction proteins in retinal pigment epithelial cells through Akt signaling pathway JOURNAL Mol Cell Biochem 427 (1-2), 145-156 (2017) PUBMED 28025795 REFERENCE 3 (bases 1 to 3109) AUTHORS Yang Z, Chen KM, Pandey RR, Homolka D, Reuter M, Janeiro BK, Sachidanandam R, Fauvarque MO, McCarthy AA and Pillai RS. TITLE PIWI Slicing and EXD1 Drive Biogenesis of Nuclear piRNAs from Cytosolic Targets of the Mouse piRNA Pathway JOURNAL Mol Cell 61 (1), 138-152 (2016) PUBMED 26669262 REFERENCE 4 (bases 1 to 3109) AUTHORS Pastor WA, Stroud H, Nee K, Liu W, Pezic D, Manakov S, Lee SA, Moissiard G, Zamudio N, Bourc'his D, Aravin AA, Clark AT and Jacobsen SE. TITLE MORC1 represses transposable elements in the mouse male germline JOURNAL Nat Commun 5, 5795 (2014) PUBMED 25503965 REMARK Erratum:[Nat Commun. 2015;6:7604. PMID: 26159654] Publication Status: Online-Only REFERENCE 5 (bases 1 to 3109) AUTHORS Keam SP, Young PE, McCorkindale AL, Dang TH, Clancy JL, Humphreys DT, Preiss T, Hutvagner G, Martin DI, Cropley JE and Suter CM. TITLE The human Piwi protein Hiwi2 associates with tRNA-derived piRNAs in somatic cells JOURNAL Nucleic Acids Res 42 (14), 8984-8995 (2014) PUBMED 25038252 REFERENCE 6 (bases 1 to 3109) AUTHORS Shoji M, Tanaka T, Hosokawa M, Reuter M, Stark A, Kato Y, Kondoh G, Okawa K, Chujo T, Suzuki T, Hata K, Martin SL, Noce T, Kuramochi-Miyagawa S, Nakano T, Sasaki H, Pillai RS, Nakatsuji N and Chuma S. TITLE The TDRD9-MIWI2 complex is essential for piRNA-mediated retrotransposon silencing in the mouse male germline JOURNAL Dev Cell 17 (6), 775-787 (2009) PUBMED 20059948 REFERENCE 7 (bases 1 to 3109) AUTHORS Aravin AA, van der Heijden GW, Castaneda J, Vagin VV, Hannon GJ and Bortvin A. TITLE Cytoplasmic compartmentalization of the fetal piRNA pathway in mice JOURNAL PLoS Genet 5 (12), e1000764 (2009) PUBMED 20011505 REFERENCE 8 (bases 1 to 3109) AUTHORS Aravin AA, Sachidanandam R, Bourc'his D, Schaefer C, Pezic D, Toth KF, Bestor T and Hannon GJ. TITLE A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice JOURNAL Mol Cell 31 (6), 785-799 (2008) PUBMED 18922463 REFERENCE 9 (bases 1 to 3109) AUTHORS Kuramochi-Miyagawa S, Watanabe T, Gotoh K, Totoki Y, Toyoda A, Ikawa M, Asada N, Kojima K, Yamaguchi Y, Ijiri TW, Hata K, Li E, Matsuda Y, Kimura T, Okabe M, Sakaki Y, Sasaki H and Nakano T. TITLE DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes JOURNAL Genes Dev 22 (7), 908-917 (2008) PUBMED 18381894 REFERENCE 10 (bases 1 to 3109) AUTHORS Carmell MA, Girard A, van de Kant HJ, Bourc'his D, Bestor TH, de Rooij DG and Hannon GJ. TITLE MIWI2 is essential for spermatogenesis and repression of transposons in the mouse male germline JOURNAL Dev Cell 12 (4), 503-514 (2007) PUBMED 17395546 COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JACYVU010000189.1. On Sep 1, 2012 this sequence version replaced XM_001072752.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMEA5760383, SAMEA5760434 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation ##RefSeq-Attributes-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-103 JACYVU010000189.1 5659001-5659103 c 104-235 JACYVU010000189.1 5655196-5655327 c 236-450 JACYVU010000189.1 5652290-5652504 c 451-572 JACYVU010000189.1 5647814-5647935 c 573-653 JACYVU010000189.1 5646022-5646102 c 654-851 JACYVU010000189.1 5642329-5642526 c 852-963 JACYVU010000189.1 5640811-5640922 c 964-1087 JACYVU010000189.1 5633615-5633738 c 1088-1205 JACYVU010000189.1 5631727-5631844 c 1206-1317 JACYVU010000189.1 5629111-5629222 c 1318-1502 JACYVU010000189.1 5627324-5627508 c 1503-1575 JACYVU010000189.1 5624062-5624134 c 1576-1776 JACYVU010000189.1 5622565-5622765 c 1777-1880 JACYVU010000189.1 5621504-5621607 c 1881-1951 JACYVU010000189.1 5621266-5621336 c 1952-2105 JACYVU010000189.1 5620008-5620161 c 2106-2234 JACYVU010000189.1 5617826-5617954 c 2235-2382 JACYVU010000189.1 5617155-5617302 c 2383-3109 JACYVU010000189.1 5615862-5616588 c FEATURES Location/Qualifiers source 1..3109 /organism="Rattus norvegicus" /mol_type="mRNA" /strain="BN" /db_xref="taxon:10116" /chromosome="8" /map="8q12" gene 1..3109 /gene="Piwil4" /note="piwi-like RNA-mediated gene silencing 4" /db_xref="GeneID:689972" /db_xref="RGD:1311015" CDS 1..2499 /gene="Piwil4" /note="piwi-like 4" /codon_start=1 /product="piwi-like protein 4" /protein_id="NP_001258062.1" /db_xref="GeneID:689972" /db_xref="RGD:1311015" /translation="
MSGRARVRARGITTGHSAREVERAPRDLMVSASVYELGVSSGDGRRTLVEKRGNGRQDFVDLGVCTREKLTHVKDSKTGSSGIPVQLATNLFHLDLPQDWQLYQYHVTYSPDLASRRLRTALLYNHSILSDKAKAFDGTSLFLSEKLDHKVTELTSETQRGETVKITLTLTSELFPNSPMCIQFFNVIFRKIFKKLSMYQIGRNYYKPSEPVEIPQYKLSLWPGFAISVSRFESKLLFNADVNYKVLRNETVLEFMTDLCLRTDMSCFTETCHKQLVGLIVLTRYNNKTYRIDDIDWSVKPTHAFQKRDGSETTYVDYYKQQYDITLSDLNQPVLVSLLKRRRNDNSEPQMVHLIPELCFLTGLTSQATSDFRLMKAVAEETRLSPMGRQQQLARLADDIQRNQVTRFELETWGLHFGSQLSLTGRVVPSEKILLQDHTCQPAFAADWSKDMRSCKVLSSEPLNTWLIVCCSRAEHLIESFLSCLRRVGGSTGFSVGHPKIIKVDENPAAFLRAIQLHVNPDVQLVMCILPSNQKNYYDSIKRYLSSDCPVPSQCVLTRTLNKQGMMLSVATKIAMQMTCKLGGELWAVEIPLKSLMVVGIDICRDALSKDVAVVGFVASINSRITRWFSRCVLQRTAADIADCLKVCMTGALNKWYKHNHDLPARIIAYRDGVGNGQLKAVLEYEVPQLLSSVTECGSDARSCRLSVVVVRKRCLLRLFAESGHTLQNPPLGTVVDSEATRPEWYDFYLTSQTANRGTVSPTYYNVIYDDNALKPDHMQRLTFKLCHLYYNWQGVISVPAPCQYAHKLTFLVAQSIHKEPSLELANKLFYL"
misc_feature 745..1095 /gene="Piwil4" /note="PAZ domain, Piwi_like subfamily. In multi-cellular organisms, the Piwi protein appears to be essential for the maintenance of germline stem cells. In the Drosophila male germline, Piwi was shown to be involved in the silencing of retrotransposons in the...; Region: PAZ_piwi_like; cd02845" /db_xref="CDD:239211" misc_feature order(880..882,919..921,943..945,955..957,1009..1011, 1054..1056,1060..1062) /gene="Piwil4" /note="nucleic acid-binding interface [nucleotide binding]; other site" /db_xref="CDD:239211" misc_feature 1117..2445 /gene="Piwil4" /note="PIWI domain, Piwi-like subfamily found in eukaryotes. This domain is found in Piwi and closely related proteins, where it is believed to perform a crucial role in germline cells, via RNA silencing. RNA silencing refers to a group of related...; Region: Piwi_piwi-like_Euk; cd04658" /db_xref="CDD:240016" misc_feature order(1612..1614,1624..1626,1660..1671,1678..1680, 1708..1710,1717..1719,1729..1731,1741..1743) /gene="Piwil4" /note="5' RNA guide strand anchoring site [active]" /db_xref="CDD:240016" misc_feature order(1804..1806,1810..1812,2014..2016,2419..2421) /gene="Piwil4" /note="active site" /db_xref="CDD:240016" exon 1..103 /gene="Piwil4" /inference="alignment:Splign:2.1.0" exon 104..235 /gene="Piwil4" /inference="alignment:Splign:2.1.0" exon 236..450 /gene="Piwil4" /inference="alignment:Splign:2.1.0" exon 451..572 /gene="Piwil4" /inference="alignment:Splign:2.1.0" exon 573..653 /gene="Piwil4" /inference="alignment:Splign:2.1.0" exon 654..851 /gene="Piwil4" /inference="alignment:Splign:2.1.0" exon 852..963 /gene="Piwil4" /inference="alignment:Splign:2.1.0" exon 964..1087 /gene="Piwil4" /inference="alignment:Splign:2.1.0" exon 1088..1205 /gene="Piwil4" /inference="alignment:Splign:2.1.0" exon 1206..1317 /gene="Piwil4" /inference="alignment:Splign:2.1.0" exon 1318..1502 /gene="Piwil4" /inference="alignment:Splign:2.1.0" exon 1503..1575 /gene="Piwil4" /inference="alignment:Splign:2.1.0" exon 1576..1776 /gene="Piwil4" /inference="alignment:Splign:2.1.0" exon 1777..1880 /gene="Piwil4" /inference="alignment:Splign:2.1.0" exon 1881..1951 /gene="Piwil4" /inference="alignment:Splign:2.1.0" exon 1952..2105 /gene="Piwil4" /inference="alignment:Splign:2.1.0" exon 2106..2234 /gene="Piwil4" /inference="alignment:Splign:2.1.0" exon 2235..2382 /gene="Piwil4" /inference="alignment:Splign:2.1.0" exon 2383..3109 /gene="Piwil4" /inference="alignment:Splign:2.1.0" ORIGIN
atgagtggacgggcccgtgtgagggcgcgaggcatcaccactggccacagtgccagggaagtggagcgggccccaagagacctcatggtgagtgcttctgtctatgagcttggcgtctcttctggtgatggtagacgtactctcgtggaaaaaagaggcaatggcagacaggacttcgtcgatttgggtgtctgtaccagggagaagttgactcacgtaaaagattctaaaacaggttctagcggaatacctgtgcagctggctacaaatctcttccatttagatttgccccaggattggcagctataccagtaccatgtcacatacagcccggatttagcctctaggaggctgaggactgctctgctgtataaccacagcatactctccgacaaggcaaaggcattcgacggcaccagccttttcctctcagaaaagctggaccacaaagtcacagaactgacaagtgaaacccaaagaggggagactgtgaagataactctcaccctgaccagtgagctgttcccaaactccccgatgtgcattcagtttttcaatgtcatcttcagaaagatctttaaaaagttgagcatgtaccagattggacggaactactataagccttcagagccagtggagatcccccagtacaaattgtccctgtggcctgggtttgccatttctgtgtctcgctttgaaagcaaactcctgttcaatgctgacgtaaactataaagtcctccgcaatgagactgttctggaattcatgactgatctctgcctcagaaccgacatgtcatgcttcactgagacgtgccacaaacagctagtggggctcattgtccttaccaggtacaacaacaaaacatatcgtatcgatgacattgactggtctgtgaagcccacacatgcctttcagaagcgggatggctcagagaccacgtatgtggattactacaagcagcaatatgatatcaccttatctgacctaaatcagccagtgcttgtcagtctgttgaaaagaaggagaaatgataactccgagcctcagatggtccacctgatcccggagctctgctttctcacgggcctgaccagccaagcaacctcagacttccgcttgatgaaggcagtcgctgaagaaactcggctcagtcctatgggaaggcagcagcaactagcccgactggcagatgacatccagagaaaccaagtgactcggtttgagcttgagacctggggattgcattttggaagccagctatccctgaccggccgggttgttccctctgaaaagatcctgctgcaggaccacacatgtcaacctgcatttgctgctgattggtccaaagatatgcgatcttgcaaggttctgagttctgagcctttgaatacatggttgatcgtgtgctgtagcagggctgagcatttgattgaatccttcctgagctgtctgaggagagttggaggttccacgggattcagtgtgggccacccaaaaatcataaaagtggatgaaaaccctgcagcgttccttcgagccatccagctgcacgtcaaccccgatgttcagttggtgatgtgcatcctgccttctaatcagaagaactattacgactccattaaaagatatttgagctccgactgcccggtcccaagccagtgtgtgctgacccggaccttgaacaaacagggaatgatgctgagtgtggccaccaagatcgccatgcaaatgacctgcaaactcgggggcgagctgtgggctgtggagatcccattgaagtcactgatggtcgtgggcatcgacatctgtagagacgccctcagcaaggatgtagcggtcgtcgggtttgtcgccagcattaactccaggatcaccaggtggttttcccgctgtgtcctccagagaacggcagctgatattgcagattgcctgaaagtctgcatgactggtgctctcaacaagtggtacaaacacaaccacgatttgccggcacggataatcgcgtaccgggatggtgtgggcaacggccagctaaaggcagttttggaatacgaagtcccacagctgctgagcagtgtgacagaatgtggctccgacgccaggagctgtagactgtcagtggtcgtggtcaggaagaggtgtctgctgcgtctctttgccgagtctggccatacgctacagaaccccccacttggcactgtcgtggactcagaagcaacacgtccagagtggtatgacttctacctgaccagccagactgctaaccgggggactgttagtcccacctactacaatgtcatctatgacgacaacgctctgaagcctgaccatatgcagcggctgaccttcaaactgtgccacctctactacaactggcagggcgtaatcagtgtccctgctccgtgccagtatgcacacaagctgaccttcctggtggcacaaagcatccacaaggaaccaagtctggaattagccaataagctcttctacctgtgacaagtgggccaatagcatggctcgatggagacgccaaaaagcggttgctatgctttgttcaaatctgcctaatgctcaaggctcctgctgcttaaaggagcttcagcctgattttaagtattgggaaggagagggttttttggtttttgtttttttgttttgttttgttttgttttttgttttctgggttttttttttgttgttgttgttgttgtttttaaagtcatctgaatcagttgaggacaaacctatggggatttttgtctcccctgtgtctaaaaacaacaatgacaaacaaacaaaaacccacagagtgatgggttttcttgtggctctgtcaggcgacattttactttgtcctggtttatcctcgtatttttttttttttaagtaaatgcttgaggtgaattctcacatggtatatacgtgatgatattgggatatatcatcacagctaactggattctaaaacaatattcgtgtggtattgtgatggtgtttaagaggggtttaacttctttcctgacattaccagggttgttctaagtatcgtagagcattttgtagagtgggttaagtaaatactgaaaataaagactccctgagcatc
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Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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