LOCUS       NM_001270586            3113 bp    mRNA    linear   ROD 23-DEC-2022
DEFINITION  Rattus norvegicus solute carrier organic anion transporter family
            member 1B2 (Slco1b2), transcript variant 2, mRNA.
ACCESSION   NM_001270586
VERSION     NM_001270586.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3113)
  AUTHORS   Chen S, Li K, Jiang J, Wang X, Chai Y, Zhang C, Deng Q, Shuai L,
            Feng K, Ma K and Zhang L.
  TITLE     Low expression of organic anion-transporting polypeptide 1B3
            predicts a poor prognosis in hepatocellular carcinoma
  JOURNAL   World J Surg Oncol 18 (1), 127 (2020)
   PUBMED   32534581
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3113)
  AUTHORS   Ma X, Shang X, Qin X, Lu J, Liu M and Wang X.
  TITLE     Characterization of organic anion transporting polypeptide 1b2
            knockout rats generated by CRISPR/Cas9: a novel model for drug
            transport and hyperbilirubinemia disease
  JOURNAL   Acta Pharm Sin B 10 (5), 850-860 (2020)
   PUBMED   32528832
REFERENCE   3  (bases 1 to 3113)
  AUTHORS   Alam K, Farasyn T, Ding K and Yue W.
  TITLE     Characterization of Liver- and Cancer-type-Organic Anion
            Transporting Polypeptide (OATP) 1B3 Messenger RNA Expression in
            Normal and Cancerous Human Tissues
  JOURNAL   Drug Metab Lett 12 (1), 24-32 (2018)
   PUBMED   29577869
REFERENCE   4  (bases 1 to 3113)
  AUTHORS   Verboom MC, Kloth JSL, Swen JJ, van der Straaten T, Bovee JVMG,
            Sleijfer S, Reyners AKL, Mathijssen RHJ, Guchelaar HJ, Steeghs N
            and Gelderblom H.
  TITLE     Genetic polymorphisms in angiogenesis-related genes are associated
            with worse progression-free survival of patients with advanced
            gastrointestinal stromal tumours treated with imatinib
  JOURNAL   Eur J Cancer 86, 226-232 (2017)
   PUBMED   29054076
REFERENCE   5  (bases 1 to 3113)
  AUTHORS   Sun B, Chen Y, Xiang T, Zhang L, Chen Z, Zhang S, Zhou H and Chen
            S.
  TITLE     The Chinese Herb Jianpijiedu Contributes to the Regulation of
            OATP1B2 and ABCC2 in a Rat Model of Orthotopic Transplantation
            Liver Cancer Pretreated with Food Restriction and Diarrhea
  JOURNAL   Biomed Res Int 2015, 752850 (2015)
   PUBMED   26665149
REFERENCE   6  (bases 1 to 3113)
  AUTHORS   Cattori V, van Montfoort JE, Stieger B, Landmann L, Meijer DK,
            Winterhalter KH, Meier PJ and Hagenbuch B.
  TITLE     Localization of organic anion transporting polypeptide 4 (Oatp4) in
            rat liver and comparison of its substrate specificity with Oatp1,
            Oatp2 and Oatp3
  JOURNAL   Pflugers Arch 443 (2), 188-195 (2001)
   PUBMED   11713643
REFERENCE   7  (bases 1 to 3113)
  AUTHORS   Ismair MG, Stieger B, Cattori V, Hagenbuch B, Fried M, Meier PJ and
            Kullak-Ublick GA.
  TITLE     Hepatic uptake of cholecystokinin octapeptide by organic
            anion-transporting polypeptides OATP4 and OATP8 of rat and human
            liver
  JOURNAL   Gastroenterology 121 (5), 1185-1190 (2001)
   PUBMED   11677211
REFERENCE   8  (bases 1 to 3113)
  AUTHORS   Choudhuri S, Ogura K and Klaassen CD.
  TITLE     Cloning of the full-length coding sequence of rat liver-specific
            organic anion transporter-1 (rlst-1) and a splice variant and
            partial characterization of the rat lst-1 gene
  JOURNAL   Biochem Biophys Res Commun 274 (1), 79-86 (2000)
   PUBMED   10903899
REFERENCE   9  (bases 1 to 3113)
  AUTHORS   Cattori V, Hagenbuch B, Hagenbuch N, Stieger B, Ha R, Winterhalter
            KE and Meier PJ.
  TITLE     Identification of organic anion transporting polypeptide 4 (Oatp4)
            as a major full-length isoform of the liver-specific transporter-1
            (rlst-1) in rat liver
  JOURNAL   FEBS Lett 474 (2-3), 242-245 (2000)
   PUBMED   10838093
REFERENCE   10 (bases 1 to 3113)
  AUTHORS   Kakyo M, Unno M, Tokui T, Nakagomi R, Nishio T, Iwasashi H, Nakai
            D, Seki M, Suzuki M, Naitoh T, Matsuno S, Yawo H and Abe T.
  TITLE     Molecular characterization and functional regulation of a novel rat
            liver-specific organic anion transporter rlst-1
  JOURNAL   Gastroenterology 117 (4), 770-775 (1999)
   PUBMED   10500057
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF217450.2, AF147740.1 and JACYVU010000151.1.
            
            Transcript Variant: This variant (2, also known as rlst-1b) uses an
            alternate in-frame splice junction at the 3' end of an exon
            compared to variant 1. The resulting isoform (2) has the same N-
            and C-termini but is shorter compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AF147740.1 [ECO:0000331]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-114               AF217450.2         1-114
            115-2073            AF147740.1         1-1959
            2074-3113           JACYVU010000151.1  10936018-10937057
FEATURES             Location/Qualifiers
     source          1..3113
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q44"
     gene            1..3113
                     /gene="Slco1b2"
                     /gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
                     /note="solute carrier organic anion transporter family
                     member 1B2"
                     /db_xref="GeneID:58978"
                     /db_xref="RGD:69300"
     exon            1..40
                     /gene="Slco1b2"
                     /gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
                     /inference="alignment:Splign:2.1.0"
     exon            41..198
                     /gene="Slco1b2"
                     /gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    43..45
                     /gene="Slco1b2"
                     /gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
                     /note="upstream in-frame stop codon"
     CDS             115..2073
                     /gene="Slco1b2"
                     /gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
                     /note="isoform 2 is encoded by transcript variant 2;
                     solute carrier family 21 member 10; sodium-independent
                     organic anion-transporting polypeptide 4; solute carrier
                     organic anion transporter family, member 1b3; solute
                     carrier family 21 (organic anion transporter) member 10;
                     solute carrier family (organic anion transporter) member
                     10; organic anion transporting polypeptide 4;
                     liver-specific transporter-1; liver-specific organic anion
                     transporter 1"
                     /codon_start=1
                     /product="solute carrier organic anion transporter family
                     member 1B2 isoform 2"
                     /protein_id="NP_001257515.1"
                     /db_xref="GeneID:58978"
                     /db_xref="RGD:69300"
                     /translation="

MDHTQQSRKAAEAQPSRSKQTRFCDGFKLFLAALSFSYICKALGGVVMKSSITQIERRFDIPSSISGLIDGGFEIGNLLVIVFVSYFGSKLHRPKLIGIGCFIMGIGSILTALPHFFMGYYKYAKENDIGSLGNSTLTCFINQMTSPTGPSPEIVEKGCEKGLKSHMWIYVLMGNMLRGIGETPIVPLGISYLDDFAKEGHTSMHLGTLHTIAMIGPILGFIMSSVFAKIYVDVGYVDLNSVRITPNDARWVGAWWLSFIVNGLLCITSSIPFFFLPKIPKRSQEERKNSVSLHAPKTDEEKKHMTNLTKQEEQDPSNMTGFLRSLRSILTNEIYVIFLILTLLQVSGFIGSFTYLFKFIEQQFGRTASQANFLLGIITIPTMATAMFLGGYIVKKFKLTSVGIAKMNPVDSHIDVPLSYCNSDCSCDKNQWEPICGENGVTYISPCLAGCKSFRGDKKPNNTEFYDCSCISNSGNNSAHLGECPRYKCKTNYYFYIILQVTVSFFTAMGSPSLILILMKSVQPELKSLAMGFHSLIIRALGGILAPIYYGAFIDRTCIKWSVTSCGKRGACRLYNSRLFGFSYLGLNLALKTPPLFLYVVLIYFTKRKYKRNDNKTLENGRQFTDEGNPDSVNKNGYYCVPYDEQSNETPL"

     misc_feature    196..1674
                     /gene="Slco1b2"
                     /gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
                     /note="Major Facilitator Superfamily; Region: MFS;
                     cl28910"
                     /db_xref="CDD:452895"
     misc_feature    order(235..240,247..252,259..261,355..357,658..663,
                     667..675,682..684,742..744,751..756,763..765,1138..1140,
                     1147..1152,1159..1167,1174..1176,1261..1263,1273..1275,
                     1507..1509,1516..1521,1528..1530)
                     /gene="Slco1b2"
                     /gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]; other site"
                     /db_xref="CDD:349949"
     exon            199..340
                     /gene="Slco1b2"
                     /gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
                     /inference="alignment:Splign:2.1.0"
     exon            341..473
                     /gene="Slco1b2"
                     /gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
                     /inference="alignment:Splign:2.1.0"
     exon            474..586
                     /gene="Slco1b2"
                     /gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
                     /inference="alignment:Splign:2.1.0"
     exon            587..733
                     /gene="Slco1b2"
                     /gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
                     /inference="alignment:Splign:2.1.0"
     exon            734..832
                     /gene="Slco1b2"
                     /gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
                     /inference="alignment:Splign:2.1.0"
     exon            833..1075
                     /gene="Slco1b2"
                     /gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1240
                     /gene="Slco1b2"
                     /gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1331
                     /gene="Slco1b2"
                     /gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1503
                     /gene="Slco1b2"
                     /gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1673
                     /gene="Slco1b2"
                     /gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1738
                     /gene="Slco1b2"
                     /gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
                     /inference="alignment:Splign:2.1.0"
     exon            1739..1856
                     /gene="Slco1b2"
                     /gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
                     /inference="alignment:Splign:2.1.0"
     exon            1857..3113
                     /gene="Slco1b2"
                     /gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

ggttagacatgccacgcttgctctagaagcctgagctcagggtagacgaccatttcaaaagaaatatttatcaacagtgattgcagacgttcccatcacaaccactgttcagtcatggaccacactcagcagtcaaggaaagctgcagaggcccaaccttcacgatcaaagcaaacaaggttctgcgatggattcaagctatttttggcagccctctccttcagctacatatgcaaagcactaggtggagttgttatgaagagttccatcacccaaatcgaaagaagattcgacataccatcttccatttctggtttgattgatggaggctttgaaattgggaatttattagttattgtatttgtgagttactttggatccaaactacacaggccaaagctgattggaattggctgcttcatcatgggcattgggagcattttgacagcgttgccacatttcttcatgggatattacaagtatgcaaaagaaaacgacattggctctctaggcaactctacattgacctgtttcatcaatcaaatgacatcacccactggaccttcacctgagatagtggagaaaggttgtgaaaaggggttaaagtcacacatgtggatttatgtcttgatggggaacatgcttcgtgggataggggaaacaccaatagtgcccctgggaatttcctaccttgatgactttgcaaaagaagggcacacttccatgcacctaggtactctgcatactatagcaatgattggaccaatccttggctttatcatgtcatctgtgtttgctaagatatatgtagacgttggatatgtagacctgaacagtgtccgaataactcctaatgatgctcgttgggttggtgcctggtggctcagcttcattgtgaatggactattatgcattacttcttccatacccttcttttttctgcccaaaattccaaagaggtcacaggaggaaaggaaaaattcagtatctcttcatgcacccaaaacagatgaggagaagaaacacatgactaatttaacaaagcaagaggaacaagatccttccaacatgactggttttctaaggtctctgagaagcatccttaccaatgaaatatatgttatattcttgatactgacgttactacaagtcagcggcttcattggctcctttacttacctgttcaagttcatagagcagcagttcggccggacagcatctcaggccaacttcttgttaggaattataaccatacctactatggcaactgcaatgtttttaggaggatatattgttaaaaaattcaaattgacatcggttggaatcgccaaaatgaacccagtggactctcacatagatgtaccactttcttattgtaactcggactgcagttgtgataaaaatcaatgggaacccatctgtggggaaaatggagtcacttacatttcaccttgtctggcaggatgcaaatcttttcgtggtgataagaagccgaataacacagagttctatgactgcagttgtatcagcaactctggaaacaactcagcacatttgggtgaatgcccaagatacaaatgcaaaaccaactattacttttatataattcttcaagtcactgtgtcctttttcactgcaatgggaagcccatctttaatcttgattctgatgaagagcgtccaacctgaattgaaatcacttgcaatgggtttccattcactgattattcgagcactaggagggattctagctccaatctattatggggcattcattgacagaacgtgtattaagtggtctgtcaccagctgtggaaaacgtggtgcatgtaggctatataactccagattatttggattctcctacttgggtttgaacttagctttaaaaactccaccactttttttatatgttgtattaatttatttcacaaagagaaaatataaaagaaatgataacaagacattggaaaatggaagacagttcacagatgaaggaaacccagattctgtaaataaaaatggatactattgtgtaccttatgatgaacaaagcaatgaaacacctctttaaggaaagagaaagatacatctgttgctgtgttttcaaatacccccggggttctttcactgaaatttttcatactttatatgtaatagagaatttataaccctatgcatttataattaaacaaattgcaaatcaaaagaaataagagaacccttgttagggtatagctgtgcatttgtagctaaagatttggagatatataaacaggtattcgcttaagcatttataactcaataaaatagagaatggggcaaggatggacaaaggggaaagggactgtgaaaaattgttgtctttaaaaatcaaaatttgaatcgtactattcatgccagaagcttctgtgataggtgacttcatgatgtggcatattctggtatccccggtaagtcaaatatatatatatatatatatatatatatatatatatatatatatatatatatatttttttttttttttttggagctggggaccgaacccagagccttgcgcttgctaggcaagtgctctaccactgagttaaatccccaaccctaagtcatatatttttaattattaattttaaattgtgtttaatgacatatccatcttctttgtacatactgtacagaatattgagaataaaacagagacgtttaggatgtgagatatctctgtctatctctatctctacccctagcttcacctccttctctgtctccatctccctatctatctatctatctatctatctatctatctatctatcatctatctatccatctatgtatctgtctatctattatctatctatctatctatctatctatctatctatctatctatctatctatctacaatctccccaaatatctaaaattaagatagagtgaatgagacagatatctgtagacactgtattttcttgtgtgatcagatctagtgtggtggatgatagaagttgaacttgctttattgctatgtgttaaaatattttgtttgcattaaaatggcctattgaaatgcttttctgttcctataataaaataacctgatgaaaaagt

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