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Previous release (v1)
2025-04-20 02:29:07, GGRNA.v2 : RefSeq release 229 (Mar, 2025)
LOCUS NM_001108853 4046 bp mRNA linear ROD 03-APR-2024
DEFINITION Rattus norvegicus piwi-like RNA-mediated gene silencing 1 (Piwil1),
mRNA.
ACCESSION NM_001108853 XM_001078557 XM_017598411 XM_344105
VERSION NM_001108853.3
KEYWORDS RefSeq; RefSeq Select.
SOURCE Rattus norvegicus (Norway rat)
ORGANISM Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
REFERENCE 1 (bases 1 to 4046)
AUTHORS Gou,L.T., Kang,J.Y., Dai,P., Wang,X., Li,F., Zhao,S., Zhang,M.,
Hua,M.M., Lu,Y., Zhu,Y., Li,Z., Chen,H., Wu,L.G., Li,D., Fu,X.D.,
Li,J., Shi,H.J. and Liu,M.F.
TITLE Ubiquitination-Deficient Mutations in Human Piwi Cause Male
Infertility by Impairing Histone-to-Protamine Exchange during
Spermiogenesis
JOURNAL Cell 169 (6), 1090-1104 (2017)
PUBMED 28552346
REFERENCE 2 (bases 1 to 4046)
AUTHORS Tarabay,Y., Achour,M., Teletin,M., Ye,T., Teissandier,A., Mark,M.,
Bourc'his,D. and Viville,S.
TITLE Tex19 paralogs are new members of the piRNA pathway controlling
retrotransposon suppression
JOURNAL J Cell Sci 130 (8), 1463-1474 (2017)
PUBMED 28254886
REFERENCE 3 (bases 1 to 4046)
AUTHORS Zhao,P.P., Yao,M.J., Chang,S.Y., Gou,L.T., Liu,M.F., Qiu,Z.L. and
Yuan,X.B.
TITLE Novel function of PIWIL1 in neuronal polarization and migration via
regulation of microtubule-associated proteins
JOURNAL Mol Brain 8, 39 (2015)
PUBMED 26104391
REMARK GeneRIF: PIWIL1 regulates neuronal polarization and radial
migration partly via modulating the expression of
microtubule-associated proteins.
Erratum:[Mol Brain. 2016;9:21. PMID: 26907587]
Publication Status: Online-Only
REFERENCE 4 (bases 1 to 4046)
AUTHORS Rizzo,F., Hashim,A., Marchese,G., Ravo,M., Tarallo,R., Nassa,G.,
Giurato,G., Rinaldi,A., Cordella,A., Persico,M., Sulas,P.,
Perra,A., Ledda-Columbano,G.M., Columbano,A. and Weisz,A.
TITLE Timed regulation of P-element-induced wimpy testis-interacting RNA
expression during rat liver regeneration
JOURNAL Hepatology 60 (3), 798-806 (2014)
PUBMED 24930433
REMARK GeneRIF: RNAs encoding PIWIL2/HILI, PIWIL4/HIWI2 and other
components of the piRNA biogenesis pathways are identified in the
normal rat liver during regenerative proliferation.
REFERENCE 5 (bases 1 to 4046)
AUTHORS Zhao,S., Gou,L.T., Zhang,M., Zu,L.D., Hua,M.M., Hua,Y., Shi,H.J.,
Li,Y., Li,J., Li,D., Wang,E.D. and Liu,M.F.
TITLE piRNA-triggered MIWI ubiquitination and removal by APC/C in late
spermatogenesis
JOURNAL Dev Cell 24 (1), 13-25 (2013)
PUBMED 23328397
REFERENCE 6 (bases 1 to 4046)
AUTHORS Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
TITLE A germline-specific class of small RNAs binds mammalian Piwi
proteins
JOURNAL Nature 442 (7099), 199-202 (2006)
PUBMED 16751776
REFERENCE 7 (bases 1 to 4046)
AUTHORS Grivna,S.T., Beyret,E., Wang,Z. and Lin,H.
TITLE A novel class of small RNAs in mouse spermatogenic cells
JOURNAL Genes Dev 20 (13), 1709-1714 (2006)
PUBMED 16766680
REFERENCE 8 (bases 1 to 4046)
AUTHORS Kuramochi-Miyagawa,S., Kimura,T., Ijiri,T.W., Isobe,T., Asada,N.,
Fujita,Y., Ikawa,M., Iwai,N., Okabe,M., Deng,W., Lin,H., Matsuda,Y.
and Nakano,T.
TITLE Mili, a mammalian member of piwi family gene, is essential for
spermatogenesis
JOURNAL Development 131 (4), 839-849 (2004)
PUBMED 14736746
REFERENCE 9 (bases 1 to 4046)
AUTHORS Deng,W. and Lin,H.
TITLE miwi, a murine homolog of piwi, encodes a cytoplasmic protein
essential for spermatogenesis
JOURNAL Dev Cell 2 (6), 819-830 (2002)
PUBMED 12062093
REFERENCE 10 (bases 1 to 4046)
AUTHORS Kuramochi-Miyagawa,S., Kimura,T., Yomogida,K., Kuroiwa,A.,
Tadokoro,Y., Fujita,Y., Sato,M., Matsuda,Y. and Nakano,T.
TITLE Two mouse piwi-related genes: miwi and mili
JOURNAL Mech Dev 108 (1-2), 121-133 (2001)
PUBMED 11578866
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
JAXUCZ010000012.1.
On Apr 3, 2024 this sequence version replaced NM_001108853.2.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR26360181.703429.1,
SRR26360186.2962928.1 [ECO:0000332]
RNAseq introns :: mixed sample support SAMEA5760383,
SAMEA5760386 [ECO:0006172]
##Evidence-Data-END##
##RefSeq-Attributes-START##
RefSeq Select criteria :: based on conservation, expression
##RefSeq-Attributes-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-111 JAXUCZ010000012.1 33606473-33606583 c
112-188 JAXUCZ010000012.1 33605212-33605288 c
189-269 JAXUCZ010000012.1 33603607-33603687 c
270-384 JAXUCZ010000012.1 33603195-33603309 c
385-510 JAXUCZ010000012.1 33601834-33601959 c
511-725 JAXUCZ010000012.1 33601216-33601430 c
726-847 JAXUCZ010000012.1 33600779-33600900 c
848-928 JAXUCZ010000012.1 33599567-33599647 c
929-1126 JAXUCZ010000012.1 33598788-33598985 c
1127-1238 JAXUCZ010000012.1 33598414-33598525 c
1239-1365 JAXUCZ010000012.1 33597050-33597176 c
1366-1483 JAXUCZ010000012.1 33596840-33596957 c
1484-1598 JAXUCZ010000012.1 33596407-33596521 c
1599-1786 JAXUCZ010000012.1 33595163-33595350 c
1787-1859 JAXUCZ010000012.1 33594723-33594795 c
1860-2060 JAXUCZ010000012.1 33591611-33591811 c
2061-2164 JAXUCZ010000012.1 33591394-33591497 c
2165-2235 JAXUCZ010000012.1 33590901-33590971 c
2236-2389 JAXUCZ010000012.1 33590627-33590780 c
2390-2515 JAXUCZ010000012.1 33588931-33589056 c
2516-2663 JAXUCZ010000012.1 33587248-33587395 c
2664-4046 JAXUCZ010000012.1 33585747-33587129 c
FEATURES Location/Qualifiers
source 1..4046
/organism="Rattus norvegicus"
/mol_type="mRNA"
/strain="BN"
/db_xref="taxon:10116"
/chromosome="12"
/map="12q13"
gene 1..4046
/gene="Piwil1"
/note="piwi-like RNA-mediated gene silencing 1"
/db_xref="GeneID:363912"
/db_xref="RGD:1306980"
exon 1..111
/gene="Piwil1"
/inference="alignment:Splign:2.1.0"
exon 112..188
/gene="Piwil1"
/inference="alignment:Splign:2.1.0"
misc_feature 177..179
/gene="Piwil1"
/note="upstream in-frame stop codon"
exon 189..269
/gene="Piwil1"
/inference="alignment:Splign:2.1.0"
CDS 192..2780
/gene="Piwil1"
/note="piwi like homolog 1; piwi-like 1"
/codon_start=1
/product="piwi-like protein 1"
/protein_id="NP_001102323.1"
/db_xref="GeneID:363912"
/db_xref="RGD:1306980"
/translation="
MTGRARARARGRARGQETVQHVGAAASQQPGYIPPRPQQSPTEGDLVGRGRQRGMVVGATSKSQELQISAGFQELSLAERGGRRRDFHDLGVNTRQNLDHVKESKTGSSGIIVKLSTNHFRLTSRPQWALYQYHIDYNPLMEARRLRSALLFQHEDLIGRCHAFDGTILFLPKRLQHKVTEVFSQTRNGEHVRITITLTNELPPTSPTCLQFYNIIFRRLLKIMNLQQIGRNYYNPSDPIDIPNHRLVIWPGFTTSILQYENNIMLCTDVSHKVLRSETVLDFMFNLYQQTEEHKFQEQVSKELIGLIVLTKYNNKTYRVDDIDWDQNPKSTFKKADGSEVSFLEYYRKQYNQEITDLKQPVLVSQPKRRRGPGGTLPGPAMLIPELCYLTGLTDKMRNDFNVMKDLAVHTRLTPEQRQREVGRLIDYIHKDDNVQRELRDWGLSFDSNLLSFSGRILQSEKIHQGGKTFDYNPQFADWSKETRGAPLISVKPLDNWLLIYTRRNYEAANSLIQNLFKVTPAMGIQMKKAIMIEVDDRTEAYLRALQQKVTSDTQIVVCLLSSNRKDKYDAIKKYLCTDCPTPSQCVVARTLGKQQTVMAIATKIALQMNCKMGGELWRVDMPLKLAMIVGIDCYHDTTAGRRSIAGFVASINEGMTRWFSRCVFQDRGQELVDGLKVCLQAALRAWSGCNEYMPSRVIVYRDGVGDGQLKTLVNYEVPQFLDCLKSVGRGYNPRLTVIVVKKRVNARFFAQSGGRLQNPLPGTVIDVEVTRPEWYDFFIVSQAVRSGSVSPTHYNVIYDSSGLKPDHIQRLTYKLCHVYYNWPGVIRVPAPCQYAHKLAFLVGQSIHREPNLSLSNRLYYL"
misc_feature 237..512
/gene="Piwil1"
/note="GAGE protein; Region: GAGE; pfam05831"
/db_xref="CDD:461753"
misc_feature 876..1019
/gene="Piwil1"
/note="Argonaute linker 1 domain; Region: ArgoL1;
pfam08699"
/db_xref="CDD:462567"
misc_feature 1023..1439
/gene="Piwil1"
/note="This domain is named PAZ after the proteins Piwi
Argonaut and Zwille; Region: PAZ; smart00949"
/db_xref="CDD:198017"
misc_feature order(1155..1157,1194..1196,1218..1220,1230..1232,
1284..1286,1332..1334,1338..1340)
/gene="Piwil1"
/note="nucleic acid-binding interface [nucleotide
binding]; other site"
/db_xref="CDD:239211"
misc_feature 1395..2726
/gene="Piwil1"
/note="PIWI domain, Piwi-like subfamily found in
eukaryotes. This domain is found in Piwi and closely
related proteins, where it is believed to perform a
crucial role in germline cells, via RNA silencing. RNA
silencing refers to a group of related...; Region:
Piwi_piwi-like_Euk; cd04658"
/db_xref="CDD:240016"
misc_feature order(1896..1898,1908..1910,1944..1955,1962..1964,
1992..1994,2001..2003,2013..2015,2025..2027)
/gene="Piwil1"
/note="5' RNA guide strand anchoring site [active]"
/db_xref="CDD:240016"
misc_feature order(2088..2090,2094..2096,2298..2300,2700..2702)
/gene="Piwil1"
/note="active site"
/db_xref="CDD:240016"
exon 270..384
/gene="Piwil1"
/inference="alignment:Splign:2.1.0"
exon 385..510
/gene="Piwil1"
/inference="alignment:Splign:2.1.0"
exon 511..725
/gene="Piwil1"
/inference="alignment:Splign:2.1.0"
exon 726..847
/gene="Piwil1"
/inference="alignment:Splign:2.1.0"
exon 848..928
/gene="Piwil1"
/inference="alignment:Splign:2.1.0"
exon 929..1126
/gene="Piwil1"
/inference="alignment:Splign:2.1.0"
exon 1127..1238
/gene="Piwil1"
/inference="alignment:Splign:2.1.0"
exon 1239..1365
/gene="Piwil1"
/inference="alignment:Splign:2.1.0"
exon 1366..1483
/gene="Piwil1"
/inference="alignment:Splign:2.1.0"
exon 1484..1598
/gene="Piwil1"
/inference="alignment:Splign:2.1.0"
exon 1599..1786
/gene="Piwil1"
/inference="alignment:Splign:2.1.0"
exon 1787..1859
/gene="Piwil1"
/inference="alignment:Splign:2.1.0"
exon 1860..2060
/gene="Piwil1"
/inference="alignment:Splign:2.1.0"
exon 2061..2164
/gene="Piwil1"
/inference="alignment:Splign:2.1.0"
exon 2165..2235
/gene="Piwil1"
/inference="alignment:Splign:2.1.0"
exon 2236..2389
/gene="Piwil1"
/inference="alignment:Splign:2.1.0"
exon 2390..2515
/gene="Piwil1"
/inference="alignment:Splign:2.1.0"
exon 2516..2663
/gene="Piwil1"
/inference="alignment:Splign:2.1.0"
exon 2664..4046
/gene="Piwil1"
/inference="alignment:Splign:2.1.0"
ORIGIN
gagaagcctgctgcagcgacccggcgtgaggagcctcaggggctgcggacctaagcgtgctgagcacggggccaagataggaccagacgctgctggaccacgacgatcagggcgcgaccacaccggcatccagcctgcgacacacgtaggattggaaggaggccaagctgaacacctgagctgactggaaaatgactggacgagcccgagcccgggcccgtggcagggcccgaggtcaggagacggtgcagcatgttggggctgctgcaagccagcaacctgggtacatcccgccgagaccccagcagtcgcccacagagggggacttggttggccgaggacgacagaggggaatggtagtcggagccacgtccaagtcacaagaactgcagatctcagccgggtttcaggagctgtcactggcagagagaggagggcgtcgccgagacttccatgaccttggtgtgaacaccagacagaaccttgaccatgtcaaagagtcaaagacaggctcctctggcatcattgtgaagctgagcaccaaccacttccggctgacctcgcgcccacagtgggccctgtaccagtaccacattgactataaccccctgatggaggcccgcaggctgcgctctgccctgctcttccagcacgaagacctcattggaaggtgtcatgctttcgacgggacaatattgtttttacctaagagactacagcacaaggtcacggaagtattcagtcagactcggaatggggaacacgtgcggattaccatcaccctgaccaacgagctgccgcccacctcacccacctgcctgcagttctataacatcatcttcaggaggctcttgaaaatcatgaatttgcaacaaattggacggaattattacaacccaagtgacccgattgatattccaaatcacaggttggtgatctggcccggcttcaccacctccatacttcaatatgagaacaacatcatgctttgcacagacgtcagccacaaggtcctccgcagcgagaccgttctagacttcatgttcaatctgtaccagcagacggaggagcacaagttccaggagcaagtgtccaaggagctcataggcctcatcgtcctcaccaagtacaacaacaagacctacagggtggatgacatcgactgggaccagaatccaaagagcaccttcaagaaggcagatggctcggaggtcagcttcctggagtactacaggaagcaatacaaccaggagatcacagacttgaagcagccagtgctagtgagccagcccaagcggaggagaggccctggcggcaccctgcctggcccagccatgctcatcccagagctctgctacctcacaggcctgactgataaaatgcgcaatgatttcaacgtgatgaaggacctggcggtgcacacacggctgacccctgagcagcggcagcgggaggtgggccgcctcatcgactacatccacaaggatgacaatgtgcagagagagcttcgagactggggcctaagcttcgattcgaacttgctgtccttctcaggaagaatcttacaatccgagaagatccaccagggtggaaagacgtttgattacaacccacaatttgcagactggtccaaagaaacgagaggcgcgccgctgatcagcgtgaagccgttggataactggctgctgatctatacccgcaggaattatgaagcggccaactcgctgatacagaacctgttcaaagtgactccggccatgggcatccagatgaaaaaggccatcatgatcgaggtggacgacagaacagaagcttatctgagagccttgcagcagaaggtgacatcagacactcagatagttgtctgtctcttgtcaagtaatcggaaggacaagtatgatgccatcaagaagtatttgtgcacagactgccccaccccaagtcagtgtgtggtggcccggacgctgggcaagcagcaaacagtcatggccattgccaccaagatcgccctgcagatgaactgcaagatgggaggcgagctctggcgggtggacatgcctctgaagctggcaatgatcgtgggcattgactgttaccatgacaccacagctgggcggaggtccatcgcaggattcgttgccagcatcaatgaagggatgacccgttggttctcccgctgcgtctttcaggaccgtggacaggagctggtagacggtctgaaggtgtgcttgcaagctgccctgagggcttggagtggctgcaatgaatatatgcccagccgagtcattgtgtaccgagacggtgtgggggacgggcagctgaagaccctggtcaattatgaggtcccacagttcctagactgcctcaagtcagtcgggagaggttacaacccaagactgaccgtgatcgtagtgaagaagcgagtcaatgccaggttttttgctcagtctgggggaagacttcagaaccctcttccggggacagtcatcgatgtggaagtcaccagaccagagtggtatgactttttcatcgtgagccaggcagtgagaagtgggagtgtgtccccaacacactacaatgtcatctacgacagcagtggcctgaagcccgaccacatccagcggctgacgtacaagctgtgtcacgtgtactacaattggcctggagtcatccgagtccctgcaccttgccagtatgcacacaagctggccttcctcgtgggccagagcatccacagagagccgaacctctccctgtccaaccgtctctactacctctaaccagcagcgagggcctacatgctggtttcctccagagctctgccaacctttagttctgtttctcatatgatgttgttctagcgggatgctgggggtgggggttgggggccgcggtttcgttttttttttttttttttagttggtttgtagtggttatagagttaactaaggttcactgtttgctttgtttctcatagagcgttgtgacaatttgcttggcagagtggtggcagggggccgtggtaccacagatagactttcctaaagcagccgagtcggcaggttctcggaggtgctcctgggagcacgtcctactgtacgctgcgctctctctctctctctctctctctctctctctctctctctctctctctctgcatgtttgaatttaaaggaggaaaagacgcaaggcaaaaatacccagagcatcctaggctgatgctatgtgggactctgaccctctgacacctcagatcctaaagataaaaaggccgggggtgcctctctgaatttcttttaagagttaggttatagggaatgaaaagaattgttgagggttggggatttagctcagtggtagagcgcttgcctagcaagcgcaaggccctgggttcggtccccagctccgaaaaaaaagaaaaaagaaaaaaaaataataattgttgaaagttttaaacttttctccatgaaagtgttttaagactgatgaggccggtggtggaacgagtgttgttttctttcgcaattttctcaccgagtgaaattagcgaccctcactttatttaaacagtttttagttttcgaaggcccgtgttttctttgtttttaaactgcagaagaccactctgggataggattccactcccgaaagtaaggtgtcgggcgtggtggcacacacctgtgatctcagcacttgggaggtgaagcccggggaaccccaagttcccggtcagcctaggctacatagtgagaccttgtcttaacaaacaggaaaataaaagaaaaatggagcagttatgagttatgggtgtcagtttctgcaggagactctgggagtaagagctgcccctgtccccagaggcagctggtgggccaattcaggtgccaggcaaggtatggccacatatgtttgtctggctctttggcagtgaaggaggcttggagttatgtcacgagagcagcttgaagtggctacagtgtgatgagttttacacaatggcagtgtgtgcccccggcacagctcaataaagtttctgtctcacttta
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
[Full Text]