LOCUS       NM_001108399            1384 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus PBX homeobox 4 (Pbx4), mRNA.
ACCESSION   NM_001108399 XM_001069955 XM_341418
VERSION     NM_001108399.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1384)
  AUTHORS   Yoshioka H, Geyer CB, Hornecker JL, Patel KT and McCarrey JR.
  TITLE     In vivo analysis of developmentally and evolutionarily dynamic
            protein-DNA interactions regulating transcription of the Pgk2 gene
            during mammalian spermatogenesis
  JOURNAL   Mol Cell Biol 27 (22), 7871-7885 (2007)
   PUBMED   17875925
REFERENCE   2  (bases 1 to 1384)
  AUTHORS   Wagner K, Mincheva A, Korn B, Lichter P and Popperl H.
  TITLE     Pbx4, a new Pbx family member on mouse chromosome 8, is expressed
            during spermatogenesis
  JOURNAL   Mech Dev 103 (1-2), 127-131 (2001)
   PUBMED   11335119
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474031.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_341418.3, XM_001069955.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1384
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..1384
                     /gene="Pbx4"
                     /gene_synonym="Edg4"
                     /note="PBX homeobox 4"
                     /db_xref="GeneID:361131"
                     /db_xref="RGD:1305100"
     exon            1..179
                     /gene="Pbx4"
                     /gene_synonym="Edg4"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    31..33
                     /gene="Pbx4"
                     /gene_synonym="Edg4"
                     /note="upstream in-frame stop codon"
     CDS             37..1176
                     /gene="Pbx4"
                     /gene_synonym="Edg4"
                     /note="endothelial differentiation, lysophosphatidic acid
                     G-protein-coupled receptor 4; pre-B-cell leukemia homeobox
                     4"
                     /codon_start=1
                     /product="pre-B-cell leukemia transcription factor 4"
                     /protein_id="NP_001101869.1"
                     /db_xref="GeneID:361131"
                     /db_xref="RGD:1305100"
                     /translation="

MAAPLRPVPPQPAPRRSPPTAPLGHDTSDVLQQIMAITDQSLDEAQARKHALNCHRMKSALFSVLSEIKGKTAVSVQTQEEDPPDAQLLRLDNMLLAEGVSRPEKRGRGGAAAGSTATPGGCPNDNSIEHSDYRAKLSQIRQIYHSELEKYEQACREFTTHVTNLLREQSRVRPVSSGEIEHMVSTIHSKFSAIQRQLKQSTCEAVMTLRSRFLDARRKRRNFSKQATEVLNEYFYSHLSNPYPSEETKEELARKGGITVSQVSNWFGNKRIRYKKNTGKFQEEATMYTGKTSTVTKTRVSGGQTSCQSTPSPDSCGPFPLTSGSDMVLTLRTLAFLQPPPGGVCLQPLAHGSWQRATTSQPSSSPAGDSGSFNSDASD"

     misc_feature    112..681
                     /gene="Pbx4"
                     /gene_synonym="Edg4"
                     /note="PBC domain; Region: PBC; pfam03792"
                     /db_xref="CDD:461052"
     misc_feature    685..867
                     /gene="Pbx4"
                     /gene_synonym="Edg4"
                     /note="Homeodomain; DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:238039"
     misc_feature    order(685..699,703..705,763..765,781..783,820..822,
                     826..831,838..843,847..855,859..864)
                     /gene="Pbx4"
                     /gene_synonym="Edg4"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     misc_feature    order(691..693,700..702,829..831,838..843,850..852)
                     /gene="Pbx4"
                     /gene_synonym="Edg4"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     exon            180..253
                     /gene="Pbx4"
                     /gene_synonym="Edg4"
                     /inference="alignment:Splign:2.1.0"
     exon            254..495
                     /gene="Pbx4"
                     /gene_synonym="Edg4"
                     /inference="alignment:Splign:2.1.0"
     exon            496..686
                     /gene="Pbx4"
                     /gene_synonym="Edg4"
                     /inference="alignment:Splign:2.1.0"
     exon            687..822
                     /gene="Pbx4"
                     /gene_synonym="Edg4"
                     /inference="alignment:Splign:2.1.0"
     exon            823..976
                     /gene="Pbx4"
                     /gene_synonym="Edg4"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1083
                     /gene="Pbx4"
                     /gene_synonym="Edg4"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1384
                     /gene="Pbx4"
                     /gene_synonym="Edg4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

ggacctgtccctctgcgctcgctcggcccgtagttcatggccgcccctctgcgtcccgtgccgccacagcccgccccgcgccgctcgccgcccacagctccactgggccatgacacgagcgacgtcctgcagcaaatcatggccatcaccgaccagagcctggacgaggctcaggccagaaagcatgccctgaactgccatcggatgaagtctgctctcttcagtgtgctcagcgagatcaaggggaagactgctgtgagcgtccagacgcaggaagaggaccctcccgatgcccagctgctgaggttggataacatgctgctggctgagggtgtgtccaggccagagaagcgaggacgaggaggagcagcggcaggcagcacagcaacaccaggtggctgcccaaatgacaatagcattgaacactcagactacagggccaagctgtcccagatccgacagatttaccactcagagctagagaagtatgaacaggcctgtcgtgagttcaccacgcacgtcaccaaccttctccgggaacagagtagggtgaggcccgtgtcctccggggagatcgagcacatggtgagcaccattcacagcaagttcagtgccatccagaggcagctgaaacagagcacctgtgaggctgtgatgaccctacgctcacggttcctggatgccaggcgcaagcggcggaatttcagcaagcaagccaccgaggtgctgaatgaatacttctattcccatctgagcaacccttaccccagtgaagagaccaaggaagagctggccaggaagggtggcatcacagtgtcccaggtctctaactggttcggcaacaaaagaatccggtacaaaaagaatacggggaaatttcaagaagaagccaccatgtacacggggaaaacatccacagtcactaagacccgggtctccgggggtcagaccagctgccagtccacacccagcccagactcctgtggccccttcccactgaccagtggaagtgacatggttctcaccctgcggaccctggccttcctccagcccccacccggaggagtctgcctacagcccctggcccatggtagctggcagagggccaccacctcacagccatcctcctcacctgccggagactccggcagcttcaactcagatgcgtctgactaaggttttggaacctggctgagtgctgtggatgtctggccctgggtcctgctgatcacctcagaagccctggctgtggctctgccctttccaggccactcacttccctgctttggcgcgatgttctttaaaacatgaattgagtggctggcagtggagtgttcgcctggggcttgttctgagcaccccattaaagttttgacctgtttgc

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