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Previous release (v1)
2025-03-02 05:41:36, GGRNA.v2 : RefSeq release 228 (Jan, 2025)
LOCUS NM_001107633 6522 bp mRNA linear ROD 15-NOV-2024
DEFINITION Rattus norvegicus GRIP and coiled-coil domain containing 2 (Gcc2),
transcript variant 2, mRNA.
ACCESSION NM_001107633 XM_001053446 XM_228197
VERSION NM_001107633.2
KEYWORDS RefSeq.
SOURCE Rattus norvegicus (Norway rat)
ORGANISM Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
REFERENCE 1 (bases 1 to 6522)
AUTHORS Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
TITLE Defining the membrane proteome of NK cells
JOURNAL J Mass Spectrom 45 (1), 1-25 (2010)
PUBMED 19946888
REFERENCE 2 (bases 1 to 6522)
AUTHORS Burguete,A.S., Fenn,T.D., Brunger,A.T. and Pfeffer,S.R.
TITLE Rab and Arl GTPase family members cooperate in the localization of
the golgin GCC185
JOURNAL Cell 132 (2), 286-298 (2008)
PUBMED 18243103
REFERENCE 3 (bases 1 to 6522)
AUTHORS Efimov,A., Kharitonov,A., Efimova,N., Loncarek,J., Miller,P.M.,
Andreyeva,N., Gleeson,P., Galjart,N., Maia,A.R., McLeod,I.X.,
Yates,J.R. 3rd, Maiato,H., Khodjakov,A., Akhmanova,A. and
Kaverina,I.
TITLE Asymmetric CLASP-dependent nucleation of noncentrosomal
microtubules at the trans-Golgi network
JOURNAL Dev Cell 12 (6), 917-930 (2007)
PUBMED 17543864
REFERENCE 4 (bases 1 to 6522)
AUTHORS Derby,M.C., Lieu,Z.Z., Brown,D., Stow,J.L., Goud,B. and
Gleeson,P.A.
TITLE The trans-Golgi network golgin, GCC185, is required for
endosome-to-Golgi transport and maintenance of Golgi structure
JOURNAL Traffic 8 (6), 758-773 (2007)
PUBMED 17488291
REFERENCE 5 (bases 1 to 6522)
AUTHORS Reddy,J.V., Burguete,A.S., Sridevi,K., Ganley,I.G., Nottingham,R.M.
and Pfeffer,S.R.
TITLE A functional role for the GCC185 golgin in mannose 6-phosphate
receptor recycling
JOURNAL Mol Biol Cell 17 (10), 4353-4363 (2006)
PUBMED 16885419
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
JAXUCZ010000020.1.
On Nov 15, 2024 this sequence version replaced NM_001107633.1.
##Evidence-Data-START##
Transcript exon combination :: SRR26360194.162682.1,
SRR21887620.363518.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA5760383, SAMEA5760386
[ECO:0000348]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-64 JAXUCZ010000020.1 26790585-26790648
65-118 JAXUCZ010000020.1 26790905-26790958
119-203 JAXUCZ010000020.1 26791877-26791961
204-271 JAXUCZ010000020.1 26793152-26793219
272-376 JAXUCZ010000020.1 26799262-26799366
377-2818 JAXUCZ010000020.1 26800507-26802948
2819-2891 JAXUCZ010000020.1 26803568-26803640
2892-2992 JAXUCZ010000020.1 26805861-26805961
2993-3091 JAXUCZ010000020.1 26806053-26806151
3092-3211 JAXUCZ010000020.1 26807663-26807782
3212-3376 JAXUCZ010000020.1 26809409-26809573
3377-3481 JAXUCZ010000020.1 26809850-26809954
3482-3644 JAXUCZ010000020.1 26810725-26810887
3645-3745 JAXUCZ010000020.1 26815784-26815884
3746-3823 JAXUCZ010000020.1 26815971-26816048
3824-3961 JAXUCZ010000020.1 26816855-26816992
3962-4083 JAXUCZ010000020.1 26818520-26818641
4084-4260 JAXUCZ010000020.1 26820155-26820331
4261-4478 JAXUCZ010000020.1 26822305-26822522
4479-4673 JAXUCZ010000020.1 26824180-26824374
4674-4825 JAXUCZ010000020.1 26825542-26825693
4826-5027 JAXUCZ010000020.1 26827814-26828015
5028-6522 JAXUCZ010000020.1 26835233-26836727
FEATURES Location/Qualifiers
source 1..6522
/organism="Rattus norvegicus"
/mol_type="mRNA"
/strain="BN"
/db_xref="taxon:10116"
/chromosome="20"
/map="20q11"
gene 1..6522
/gene="Gcc2"
/note="GRIP and coiled-coil domain containing 2"
/db_xref="GeneID:309798"
/db_xref="RGD:1305732"
exon 1..64
/gene="Gcc2"
/inference="alignment:Splign:2.1.0"
CDS 59..5098
/gene="Gcc2"
/note="isoform 2 is encoded by transcript variant 2; 185
kDa Golgi coiled-coil protein; LIM and senescent cell
antigen-like domains 1; GRIP and coiled-coil
domain-containing protein 2"
/codon_start=1
/product="GRIP and coiled-coil domain-containing protein 2
isoform 2"
/protein_id="NP_001101103.1"
/db_xref="GeneID:309798"
/db_xref="RGD:1305732"
/translation="
MEDSAQDAVTAAPSGTPKSKLETLPREDLIKFAKKQMMLLQKAKARCTELDKEVEELKSKPVDGGTDDMIKVLTERLDALLLEKAETEQQCLCLKKENIKMKQEVEDSVTKLEETQKEFEQSHRNYVREMESVKNELIAVHSEHSKEKAALQRDLEGAVHRQAELLEQLKSQSDSEDNVKKLQEEIQNITAAFEEQTSCLQKQLEATSDEKQQEIIHLQKVIEDNAQHYQKDINTFQEEIVQLRATHKEEVNELMSQMETLAKEHEAAVNKLKENRVTLCETSETIPENYQCESESLNEDTSDASQENQKCSVALQEDPFAEHTVYDKVRQLEDSLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQSYVVEKLKYEREDLNRQLCCTVEQHNKEIQRLQEHHQKEISELSETFMSGSEKEKLALMFEIQGLKEQCENLQHEKQEVVLNYESLREMMEILQTELGESAGKISQEFETMKQQQASDVHELQQKLRTAFNEKDALLETINRLQGENEKLLSQELVSELESTMKNLKADNSMYLASLGQKDTLLQELEAKISSLAEEKDDFISKIKTSREEIDDLHQKWEREQKLSVELREAAEQAAQHNSELRQRVSELTGKLDEILREKSQNDQNIMVQMKTMTEDQEALSSKIKSLYEENNRLHSEKVQLSRDLEALQSQQDFAYKEHVAEFEKKLQLMVEERDDLNKLLENEQLQKSFVKTQLYEFLKQMRPSILEDNEEEDVVTVLKAVGESLVTVKEEKHNLVFEYDARVLELERRIKCLQEESVVQCEELRALVRDSEQEKILLRKELDEVTSTKEALQCDILEMKNTNEKTSLENQTLSTRVEELSRSLHSKNEVHNEKDLVIEHENLRLSLEQRESELQDVRAELMLLKDSLEKSPSVKNDQLSLVKELEEKIESLEKESKDKDEKISKIKLVAVRAKKELDSNRKEAQTLRDELESVQSEKDRLSASMKEFIQGAESYKNLLLEYDKQSEQLDVEKERANNFEHHIEDLTKQLRDSTCQYEKLTSDNEDLLARIETLQANARLLEAQILEVQRAKGVVEKELEAEKLQKEQKIKEHVSTTNELEELQLQFQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNSKIEDLEQEMKIQKQKQETLQEEMTSLQSSVQHYEEKNAQIKQLLVKTKKELADAKQAETDHLLLQASLKGELEASQQQVEVYKIQLAEMTSEKHKIHEHLKTSAEQHQRTLSAYQQRVVALQEESRTAKAEQAAVTSEFENYKVRVHNVLKQQKNKSVSQAETEGAKQEREHLEMLIDQLKIKLQDSQNSLQISVSEFQTLQSEHDTLLERHNRMLQETVTKEAELREKLCSAQSENTMLKSEHAQTMCQLTSQNEALRNSFRDQVRHLQDEHRKTVETLQHQLSKVETQLFQLKSEPPTKSPASSHQPSKSLRERRTTDLPLLDMHTVTREEGEGMETTDSESVSSAGTHIQSLEQLLSSPDSKLERLTEASLWHTEFTKEELAEKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKSEIRRLERNQEREKSVANLEYLKNVLLRFIFLKPGSERERLLPVIDTMLQLSPEEKGKLATVAQGEEESASRSSGWASYLHSWSGLR"
misc_feature 59..127
/gene="Gcc2"
/note="propagated from UniProtKB/Swiss-Prot (D3ZZL9.1);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 59..61
/gene="Gcc2"
/note="N-acetylmethionine.
/evidence=ECO:0000250|UniProtKB:Q8IWJ2; propagated from
UniProtKB/Swiss-Prot (D3ZZL9.1); acetylation site"
misc_feature 281..2548
/gene="Gcc2"
/note="RecF/RecN/SMC N terminal domain; Region: SMC_N;
cl47134"
/db_xref="CDD:481474"
misc_feature 1442..3745
/gene="Gcc2"
/note="chromosome segregation protein SMC, common
bacterial type; Region: SMC_prok_B; TIGR02168"
/db_xref="CDD:274008"
misc_feature <3284..>4873
/gene="Gcc2"
/note="Chromosome segregation ATPase Smc [Cell cycle
control, cell division, chromosome partitioning]; Region:
Smc; COG1196"
/db_xref="CDD:440809"
misc_feature 4454..4624
/gene="Gcc2"
/note="propagated from UniProtKB/Swiss-Prot (D3ZZL9.1);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 4478..4480
/gene="Gcc2"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:Q8IWJ2; propagated from
UniProtKB/Swiss-Prot (D3ZZL9.1); phosphorylation site"
misc_feature 4490..4492
/gene="Gcc2"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:Q8IWJ2; propagated from
UniProtKB/Swiss-Prot (D3ZZL9.1); phosphorylation site"
misc_feature 4685..4879
/gene="Gcc2"
/note="Rab binding domain; Region: Rab_bind; pfam16704"
/db_xref="CDD:435531"
misc_feature 4763..5095
/gene="Gcc2"
/note="propagated from UniProtKB/Swiss-Prot (D3ZZL9.1);
Region: Mediates interaction with RAB9A.
/evidence=ECO:0000250"
misc_feature 4763..4882
/gene="Gcc2"
/note="propagated from UniProtKB/Swiss-Prot (D3ZZL9.1);
Region: Mediates interaction with RAB6A.
/evidence=ECO:0000250"
misc_feature 4883..5011
/gene="Gcc2"
/note="GRIP domain; Region: GRIP; pfam01465"
/db_xref="CDD:460221"
exon 65..118
/gene="Gcc2"
/inference="alignment:Splign:2.1.0"
exon 119..203
/gene="Gcc2"
/inference="alignment:Splign:2.1.0"
exon 204..271
/gene="Gcc2"
/inference="alignment:Splign:2.1.0"
exon 272..376
/gene="Gcc2"
/inference="alignment:Splign:2.1.0"
exon 377..2818
/gene="Gcc2"
/inference="alignment:Splign:2.1.0"
exon 2819..2891
/gene="Gcc2"
/inference="alignment:Splign:2.1.0"
exon 2892..2992
/gene="Gcc2"
/inference="alignment:Splign:2.1.0"
exon 2993..3091
/gene="Gcc2"
/inference="alignment:Splign:2.1.0"
exon 3092..3211
/gene="Gcc2"
/inference="alignment:Splign:2.1.0"
exon 3212..3376
/gene="Gcc2"
/inference="alignment:Splign:2.1.0"
exon 3377..3481
/gene="Gcc2"
/inference="alignment:Splign:2.1.0"
exon 3482..3644
/gene="Gcc2"
/inference="alignment:Splign:2.1.0"
exon 3645..3745
/gene="Gcc2"
/inference="alignment:Splign:2.1.0"
exon 3746..3823
/gene="Gcc2"
/inference="alignment:Splign:2.1.0"
exon 3824..3961
/gene="Gcc2"
/inference="alignment:Splign:2.1.0"
exon 3962..4083
/gene="Gcc2"
/inference="alignment:Splign:2.1.0"
exon 4084..4260
/gene="Gcc2"
/inference="alignment:Splign:2.1.0"
exon 4261..4478
/gene="Gcc2"
/inference="alignment:Splign:2.1.0"
exon 4479..4673
/gene="Gcc2"
/inference="alignment:Splign:2.1.0"
exon 4674..4825
/gene="Gcc2"
/inference="alignment:Splign:2.1.0"
exon 4826..5027
/gene="Gcc2"
/inference="alignment:Splign:2.1.0"
exon 5028..6522
/gene="Gcc2"
/inference="alignment:Splign:2.1.0"
ORIGIN
agaggcggagtacctaggacgcctgaaaaggccgaggtggccgcgggtcgctgccacgatggaggattctgctcaagatgctgtgactgcagcaccctccgggaccccgaaatccaagctagaaacattgcccagagaagatctcatcaagtttgccaagaagcagatgatgctcctacagaaagccaaagcaaggtgtacagaattagacaaagaagttgaagagctcaaatcaaaacctgttgacggaggaactgatgatatgattaaggtgctaactgaacgcttggatgctcttcttctggaaaaagcagagactgaacaacagtgtctgtgtctcaaaaaagaaaatattaaaatgaagcaagaggttgaggattctgtaactaaactggaagagacacaaaaagagtttgaacaatcacatagaaactacgtaagagaaatggaaagtgttaaaaatgaactgatagcagtacactcagagcacagcaaagaaaaggctgccttacaaagagacctggagggagcagtccataggcaagcagagctgttagaacagctcaagtctcagagcgactctgaagataatgttaaaaaactacaggaagagattcagaacattacagcagcatttgaggaacaaacgtcatgtctacaaaagcaattagaagctaccagtgatgaaaaacagcaagagattattcatctccagaaagtcattgaggacaacgctcagcactaccaaaaagatattaatactttccaagaagagattgtgcagctgagagctacacacaaagaagaagttaatgagctgatgtctcaaatggaaacattagctaaagaacatgaggcagcagtaaataagctaaaagagaacagagtgacactgtgtgagacaagtgagaccattccagagaattaccaatgtgaatcagaaagcttaaatgaagacacctcagatgcaagccaggagaatcaaaaatgctctgtggccttacaggaagatccttttgcagaacatacagtgtatgataaagtcagacaattggaagattcattaaaagaactggaatctcaacatagtatcttaaaagatgaagtgacttatatgaataatctcaagttaaaacttgaaatggatgcccagcatataaaggatgagtttttccatgaaagagaagacttggagtttaaaattaatgaactgttgctggccaaagaagaacagagctacgtagtagaaaaattaaaatatgagcgagaagatttaaataggcagctttgctgtactgtggaacaacataacaaagaaatacagcgtcttcaggagcaccatcagaaagaaatctctgaactaagtgagacatttatgtcaggttcagaaaaagaaaagttagcattaatgtttgaaatacagggacttaaggaacagtgtgaaaatctacaacatgaaaagcaagaggtagttctaaattatgagagtttacgagagatgatggaaattttacaaacggaacttggagaatctgctggaaaaataagtcaagagtttgaaacaatgaagcaacagcaagcatctgatgttcatgagcttcagcagaagctaagaactgcttttaacgaaaaagacgctcttcttgaaactataaatcgcctacaaggagaaaatgaaaaattattatcacaagaattggtatcagaactcgaaagtaccatgaagaaccttaaggcagataatagcatgtacttagccagccttggtcaaaaagataccctgttacaagaattagaagcaaagataagttctcttgctgaagaaaaagatgattttataagtaaaatcaaaacttcccgtgaagagatagatgatctccatcagaaatgggaaagggaacagaaactgtctgtagaactcagggaagcagcagagcaagccgcccagcacaacagtgaactgagacaaagagtaagtgaattaacaggaaaactagatgaaatattaagagaaaagagtcaaaatgaccaaaacattatggttcaaatgaaaaccatgacagaagaccaagaagcattgtcatctaaaatcaagtctctttatgaggaaaacaatagactgcattctgaaaaggtccagttgagtagagatttagaagctcttcagtctcaacaagattttgcctataaagagcatgttgctgaattcgaaaagaaactccagttaatggttgaagaacgagatgatttaaataaactgcttgaaaatgagcaacttcagaagtcatttgtcaaaactcagttgtacgagtttcttaagcaaatgaggccaagcattttagaagataatgaagaggaagatgttgtcacagttctaaaagctgtgggtgaatccttagtgacagtaaaggaagaaaagcataacttagtctttgaatatgatgcgagagtattagaattagaaaggaggattaagtgccttcaagaggagagtgtagttcagtgtgaagaactaagggctttagtaagagactctgaacaagagaaaattctcctaagaaaagaattagatgaagtcacatcaacaaaagaggccctgcagtgtgatattctagaaatgaagaatactaatgaaaaaacaagccttgaaaatcagactctttcaactcgggttgaagaattatcgcggtcattacacagcaaaaatgaagtccataatgaaaaggatcttgtcatagaacatgaaaacctgaggctatcgcttgagcagagggagtctgagctacaagatgtgagagcagaattgatgctgctgaaggattccttagagaaatcgccttctgtaaaaaatgatcaactttcattggtaaaagagctggaagaaaaaatagaaagtctggaaaaagaatccaaagacaaggatgagaaaatcagtaagataaaactagtcgctgtgagagcaaagaaagaactagattctaacaggaaagaggcccagacactacgggacgaactcgagtccgtacagtcagaaaaggaccgcttatctgcttctatgaaggagtttatccaaggagcagaaagctataagaatcttctgttagaatatgacaagcagtcagaacagctggatgtggaaaaagaacgtgctaataattttgaacatcacatagaagaccttaccaaacaattaagagattcgacttgccagtatgaaaaactaacttccgacaatgaggatctcctggctcgaattgagaccctgcaggctaatgccaggttattagaagcacagatcttagaggtccagagagccaaaggagtagtagaaaaagaactggaagctgaaaaacttcagaaagagcagaaaattaaggaacatgtcagtactacaaatgagcttgaagaacttcaactccaatttcaaaaggaaaagaagcagcttcagaaaacgatgcaagaattagaactggttaaaaaggatgcccaacagaccacgttgatgaatatggaaatagcagattacgaacgtttgatgaaagaattaaatcaaaagttaacaaataaaaacagtaagatagaagatttggagcaagaaatgaaaattcagaaacagaaacaagaaaccctacaagaagaaatgacttccctgcagtcttcagtacagcactacgaagaaaagaacgcccaaatcaagcagctgcttgtgaaaaccaaaaaggaactggcagatgcaaagcaagcagaaactgatcacttactactccaggcgtctttaaagggcgagctggaagcaagccagcagcaagtagaagtctataaaattcagctagctgagatgacatctgagaaacacaaaatccatgagcacctgaagacttctgcggaacagcaccagcgcacactaagtgcataccagcagagggtggtggccctgcaggaagagagccgcactgccaaggcagagcaagctgctgtcacctctgaatttgagaactacaaagtccgggttcataacgttctaaaacaacagaaaaataaatctgtgtctcaggctgaaactgagggagctaaacaagaaagggaacacctggaaatgctgattgaccaactgaaaatcaagttacaggacagccaaaacagcttacaaatcagtgtgtcagagttccagacactgcagtctgagcatgacactctgctagagaggcacaaccggatgctgcaggaaactgtgaccaaagaggcggaacttcgggaaaagttatgttcagctcaatctgagaacaccatgttgaagtctgaacacgcccagacaatgtgtcagctgacatcccagaatgaggccctccgtaacagcttccgagaccaagttcgacacttgcaggatgagcacagaaagacagtggagaccttgcagcaccagctctccaaggtggaaactcagctcttccagctcaagagtgagccacccacaaaaagccctgcttcttcccatcaaccttcaaaaagcctccgagaaagacggaccacagacctcccccttctggacatgcacactgtgacccgagaggagggggaagggatggagacaactgacagtgagtctgtgtcttcggccggcacacacattcagtccttggagcagctccttagctctcctgacagcaagcttgaacgtcttacagaggcctccttatggcatacagaatttaccaaagaagaattggctgagaagctcagttccaccacgaagagtgcagatcacttaaatggcctgcttcgggagacagaggctaccaacgccatccttatggagcaaattaagcttctcaaaagtgaaataagaagactggaaagaaaccaagagcgggagaagtctgtggctaacctggagtacttgaagaatgtcctactgcggttcattttcctgaagccgggtagtgaaagagagaggcttcttcctgtgatagacacgatgctgcagctcagccctgaagaaaagggaaagcttgccacagttgctcaaggtgaggaagaaagtgcctctcgttcctctggatgggcatcctaccttcatagctggtctggactgcgataggttgacagaaagaagattctttagtgatgcaacagaactcctttggaaaagctgggtatcatttgatcatgaagtgtgcatctctgttcacatcccctgatgattgtacatatgtatagcccatgtatatagaatctcatcttgtagtaaaaggacatcagcttgaagtagtggtaccaattgttcatggtcctctaactcagcatgtggcctcatggtctctgtgatctccacccacagaggaaacggttcattcctgcactctggaaccccaggagacactcatttctaagtagtattgtgaattttgatattgaactaaattttggtaccaaaccaactggggaatttaatcttttaaaataatgtttcaagattgaggaaatgctttattgataaggttgacatgtttattaaaagattatgaagtaaatatgctatggtttaattatgaggctaacttaaattgcaattcagtcagttactttaaaataaacctccctcccatttgtaattttcaaaattggccctagtcctggtaatgtgacactgacagaataggtgggctccacctcagctgatgtgttctgtggtgtctccaggcttgtttgctgccactcataagccatgagtctcttttgagaattccctacatctcaaaacagtgactgtcttactcagcattaaatctacatgtgaacctggtgcttccagtattgttcaagtattcttatttcctaagcaggaccccagagggctcagaccctctattggtgaacaagcctagctgggggagtgtctctgtccttatgtctctggaaatactatattgactagattaaaattgtgctcttaaatcagatttgggggttatattttaatatgtaatttgttaatgaatagtgctgtctggagtcttaagcttacgtttattctccagttgtcagtctcagcttgaaactgtcctttagtcactatgaatattggtttccaacctggtttgactgaaatttactgctgacatgttgagtttgttctcttaaagctgtttgactctcagtgttcgctctacctgtgttagaacagacctagcaagtgagtgtgctgattcaaacacatctctctcagctgactctttaaggtaaggttttctacctttataaactgtgaatgtgagtatgcccagcggaatcccatgtaatttcagtactatttaaataaactccatgttttctttgggcctaatatgccttttgaagtctgtataaacttgttttcaaatctaatctgttcatatgaatataataaaaataccttttgcatggtaaaaattactttgattacaaaagatatatatatgctttttgtgaccagcaataagaaactgtaatgactgatatttctattaaatgcacttaactata
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
[Full Text]