LOCUS       NM_001107633            6526 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus GRIP and coiled-coil domain containing 2 (Gcc2),
            mRNA.
ACCESSION   NM_001107633 XM_001053446 XM_228197
VERSION     NM_001107633.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6526)
  AUTHORS   Ghosh D, Lippert D, Krokhin O, Cortens JP and Wilkins JA.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   2  (bases 1 to 6526)
  AUTHORS   Burguete AS, Fenn TD, Brunger AT and Pfeffer SR.
  TITLE     Rab and Arl GTPase family members cooperate in the localization of
            the golgin GCC185
  JOURNAL   Cell 132 (2), 286-298 (2008)
   PUBMED   18243103
REFERENCE   3  (bases 1 to 6526)
  AUTHORS   Efimov A, Kharitonov A, Efimova N, Loncarek J, Miller PM, Andreyeva
            N, Gleeson P, Galjart N, Maia AR, McLeod IX, Yates JR 3rd, Maiato
            H, Khodjakov A, Akhmanova A and Kaverina I.
  TITLE     Asymmetric CLASP-dependent nucleation of noncentrosomal
            microtubules at the trans-Golgi network
  JOURNAL   Dev Cell 12 (6), 917-930 (2007)
   PUBMED   17543864
REFERENCE   4  (bases 1 to 6526)
  AUTHORS   Derby MC, Lieu ZZ, Brown D, Stow JL, Goud B and Gleeson PA.
  TITLE     The trans-Golgi network golgin, GCC185, is required for
            endosome-to-Golgi transport and maintenance of Golgi structure
  JOURNAL   Traffic 8 (6), 758-773 (2007)
   PUBMED   17488291
REFERENCE   5  (bases 1 to 6526)
  AUTHORS   Reddy JV, Burguete AS, Sridevi K, Ganley IG, Nottingham RM and
            Pfeffer SR.
  TITLE     A functional role for the GCC185 golgin in mannose 6-phosphate
            receptor recycling
  JOURNAL   Mol Biol Cell 17 (10), 4353-4363 (2006)
   PUBMED   16885419
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474016.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_228197.4, XM_001053446.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132262,
                              SAMD00132285 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..6526
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q11"
     gene            1..6526
                     /gene="Gcc2"
                     /note="GRIP and coiled-coil domain containing 2"
                     /db_xref="GeneID:309798"
                     /db_xref="RGD:1305732"
     exon            1..67
                     /gene="Gcc2"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..5101
                     /gene="Gcc2"
                     /note="185 kDa Golgi coiled-coil protein; LIM and
                     senescent cell antigen-like domains 1"
                     /codon_start=1
                     /product="GRIP and coiled-coil domain-containing protein
                     2"
                     /protein_id="NP_001101103.1"
                     /db_xref="GeneID:309798"
                     /db_xref="RGD:1305732"
                     /translation="

MEDSAQDAVTAAPSGTPKSKLETLPREDLIKFAKKQMMLLQKAKARCTELDKEVEELKSKPVDGGTDDMIKVLTERLDALLLEKAETEQQCLCLKKENIKMKQEVEDSVTKLEETQKEFEQSHRNYVREMESVKNELIAVHSEHSKEKAALQRDLEGAVHRQAELLEQLKSQSDSEDNVKKLQEEIQNITAAFEEQTSCLQKQLEATSDEKQQEIIHLQKVIEDNAQHYQKDINTFQEEIVQLRATHKEEVNELMSQMETLAKEHEAAVNKLKENRVTLCETSETIPENYQCESESLNEDTSDASQENQKCSVALQEDPFAEHTVYDKVRQLEDSLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQSYVVEKLKYEREDLNRQLCCTVEQHNKEIQRLQEHHQKEISELSETFMSGSEKEKLALMFEIQGLKEQCENLQHEKQEVVLNYESLREMMEILQTELGESAGKISQEFETMKQQQASDVHELQQKLRTAFNEKDALLETINRLQGENEKLLSQELVSELESTMKNLKADNSMYLASLGQKDTLLQELEAKISSLAEEKDDFISKIKTSREEIDDLHQKWEREQKLSVELREAAEQAAQHNSELRQRVSELTGKLDEILREKSQNDQNIMVQMKTMTEDQEALSSKIKSLYEENNRLHSEKVQLSRDLEALQSQQDFAYKEHVAEFEKKLQLMVEERDDLNKLLENEQLQKSFVKTQLYEFLKQMRPSILEDNEEEDVVTVLKAVGESLVTVKEEKHNLVFEYDARVLELERRIKCLQEESVVQCEELRALVRDSEQEKILLRKELDEVTSTKEALQCDILEMKNTNEKTSLENQTLSTRVEELSRSLHSKNEVHNEKDLVIEHENLRLSLEQRESELQDVRAELMLLKDSLEKSPSVKNDQLSLVKELEEKIESLEKESKDKDEKISKIKLVAVRAKKELDSNRKEAQTLRDELESVQSEKDRLSASMKEFIQGAESYKNLLLEYDKQSEQLDVEKERANNFEHHIEDLTKQLRDSTCQYEKLTSDNEDLLARIETLQANARLLEAQILEVQRAKGVVEKELEAEKLQKEQKIKEHVSTTNELEELQLQFQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNSKIEDLEQEMKIQKQKQETLQEEMTSLQSSVQHYEEKNAQIKQLLVKTKKELADAKQAETDHLLLQASLKGELEASQQQVEVYKIQLAEMTSEKHKIHEHLKTSAEQHQRTLSAYQQRVVALQEESRTAKAEQAAVTSEFENYKVRVHNVLKQQKNKSVSQAETEGAKQEREHLEMLIDQLKIKLQDSQNSLQISVSEFQTLQSEHDTLLERHNRMLQETVTKEAELREKLCSAQSENTMLKSEHAQTMCQLTSQNEALRNSFRDQVRHLQDEHRKTVETLQHQLSKVETQLFQLKSEPPTKSPASSHQPSKSLRERRTTDLPLLDMHTVTREEGEGMETTDSESVSSAGTHIQSLEQLLSSPDSKLERLTEASLWHTEFTKEELAEKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKSEIRRLERNQEREKSVANLEYLKNVLLRFIFLKPGSERERLLPVIDTMLQLSPEEKGKLATVAQGEEESASRSSGWASYLHSWSGLR"

     misc_feature    62..130
                     /gene="Gcc2"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZZL9.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    62..64
                     /gene="Gcc2"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:Q8IWJ2; propagated from
                     UniProtKB/Swiss-Prot (D3ZZL9.1); acetylation site"
     misc_feature    284..2551
                     /gene="Gcc2"
                     /note="chromosome segregation protein SMC, primarily
                     archaeal type; Region: SMC_prok_A; TIGR02169"
                     /db_xref="CDD:274009"
     misc_feature    <1445..3790
                     /gene="Gcc2"
                     /note="Chromosome segregation ATPase [Cell cycle control,
                     cell division, chromosome partitioning]; Region: Smc;
                     COG1196"
                     /db_xref="CDD:224117"
     misc_feature    3650..>4315
                     /gene="Gcc2"
                     /note="Uncharacterized conserved protein, contains DUF3084
                     domain [Function unknown]; Region: COG4372"
                     /db_xref="CDD:226809"
     misc_feature    4457..4627
                     /gene="Gcc2"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZZL9.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    4481..4483
                     /gene="Gcc2"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8IWJ2; propagated from
                     UniProtKB/Swiss-Prot (D3ZZL9.1); phosphorylation site"
     misc_feature    4493..4495
                     /gene="Gcc2"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8IWJ2; propagated from
                     UniProtKB/Swiss-Prot (D3ZZL9.1); phosphorylation site"
     misc_feature    4688..4882
                     /gene="Gcc2"
                     /note="Rab binding domain; Region: Rab_bind; pfam16704"
                     /db_xref="CDD:435531"
     misc_feature    4766..5098
                     /gene="Gcc2"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZZL9.1);
                     Region: Mediates interaction with RAB9A.
                     /evidence=ECO:0000250"
     misc_feature    4766..4885
                     /gene="Gcc2"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZZL9.1);
                     Region: Mediates interaction with RAB6A.
                     /evidence=ECO:0000250"
     misc_feature    4886..5014
                     /gene="Gcc2"
                     /note="GRIP domain; Region: GRIP; pfam01465"
                     /db_xref="CDD:426274"
     exon            68..121
                     /gene="Gcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            122..206
                     /gene="Gcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            207..274
                     /gene="Gcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            275..379
                     /gene="Gcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            380..2821
                     /gene="Gcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2822..2894
                     /gene="Gcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2895..2995
                     /gene="Gcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2996..3094
                     /gene="Gcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            3095..3214
                     /gene="Gcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            3215..3379
                     /gene="Gcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            3380..3484
                     /gene="Gcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            3485..3647
                     /gene="Gcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            3648..3748
                     /gene="Gcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            3749..3826
                     /gene="Gcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            3827..3964
                     /gene="Gcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            3965..4086
                     /gene="Gcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            4087..4263
                     /gene="Gcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            4264..4481
                     /gene="Gcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            4482..4676
                     /gene="Gcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            4677..4828
                     /gene="Gcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            4829..5030
                     /gene="Gcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            5031..6526
                     /gene="Gcc2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

ctcagaggcggagtacctaggacgcctgaaaaggccgaggtggccgcgggtcgctgccacgatggaggattctgctcaagatgctgtgactgcagcaccctccgggaccccgaaatccaagctagaaacattgcccagagaagatctcatcaagtttgccaagaagcagatgatgctcctacagaaagccaaagcaaggtgtacagaattagacaaagaagttgaagagctcaaatcaaaacctgttgacggaggaactgatgatatgattaaggtgctaactgaacgcttggatgctcttcttctggaaaaagcagagactgaacaacagtgtctgtgtctcaaaaaagaaaatattaaaatgaagcaagaggttgaggattctgtaactaaactggaagagacacaaaaagagtttgaacaatcacatagaaactacgtaagagaaatggaaagtgttaaaaatgaactgatagcagtacactcagagcacagcaaagaaaaggctgccttacaaagagacctggagggagcagtccataggcaagcagagctgttagaacagctcaagtctcagagcgactctgaagataatgttaaaaaactacaggaagagattcagaacattacagcagcatttgaggaacaaacgtcatgtctacaaaagcaattagaagctaccagtgatgaaaaacagcaagagattattcatctccagaaagtcattgaggacaacgctcagcactaccaaaaagatattaatactttccaagaagagattgtgcagctgagagctacacacaaagaagaagttaatgagctgatgtctcaaatggaaacattagctaaagaacatgaggcagcagtaaataagctaaaagagaacagagtgacactgtgtgagacaagtgagaccattccagagaattaccaatgtgaatcagaaagcttaaatgaagacacctcagatgcaagccaggagaatcaaaaatgctctgtggccttacaggaagatccttttgcagaacatacagtgtatgataaagtcagacaattggaagattcattaaaagaactggaatctcaacatagtatcttaaaagatgaagtgacttatatgaataatctcaagttaaaacttgaaatggatgcccagcatataaaggatgagtttttccatgaaagagaagacttggagtttaaaattaatgaactgttgctggccaaagaagaacagagctacgtagtagaaaaattaaaatatgagcgagaagatttaaataggcagctttgctgtactgtggaacaacataacaaagaaatacagcgtcttcaggagcaccatcagaaagaaatctctgaactaagtgagacatttatgtcaggttcagaaaaagaaaagttagcattaatgtttgaaatacagggacttaaggaacagtgtgaaaatctacaacatgaaaagcaagaggtagttctaaattatgagagtttacgagagatgatggaaattttacaaacggaacttggagaatctgctggaaaaataagtcaagagtttgaaacaatgaagcaacagcaagcatctgatgttcatgagcttcagcagaagctaagaactgcttttaacgaaaaagacgctcttcttgaaactataaatcgcctacaaggagaaaatgaaaaattattatcacaagaattggtatcagaactcgaaagtaccatgaagaaccttaaggcagataatagcatgtacttagccagccttggtcaaaaagataccctgttacaagaattagaagcaaagataagttctcttgctgaagaaaaagatgattttataagtaaaatcaaaacttcccgtgaagagatagatgatctccatcagaaatgggaaagggaacagaaactgtctgtagaactcagggaagcagcagagcaagccgcccagcacaacagtgaactgagacaaagagtaagtgaattaacaggaaaactagatgaaatattaagagaaaagagtcaaaatgaccaaaacattatggttcaaatgaaaaccatgacagaagaccaagaagcattgtcatctaaaatcaagtctctttatgaggaaaacaatagactgcattctgaaaaggtccagttgagtagagatttagaagctcttcagtctcaacaagattttgcctataaagagcatgttgctgaattcgaaaagaaactccagttaatggttgaagaacgagatgatttaaataaactgcttgaaaatgagcaacttcagaagtcatttgtcaaaactcagttgtacgagtttcttaagcaaatgaggccaagcattttagaagataatgaagaggaagatgttgtcacagttctaaaagctgtgggtgaatccttagtgacagtaaaggaagaaaagcataacttagtctttgaatatgatgcgagagtattagaattagaaaggaggattaagtgccttcaagaggagagtgtagttcagtgtgaagaactaagggctttagtaagagactctgaacaagagaaaattctcctaagaaaagaattagatgaagtcacatcaacaaaagaggccctgcagtgtgatattctagaaatgaagaatactaatgaaaaaacaagccttgaaaatcagactctttcaactcgggttgaagaattatcgcggtcattacacagcaaaaatgaagtccataatgaaaaggatcttgtcatagaacatgaaaacctgaggctatcgcttgagcagagggagtctgagctacaagatgtgagagcagaattgatgctgctgaaggattccttagagaaatcgccttctgtaaaaaatgatcaactttcattggtaaaagagctggaagaaaaaatagaaagtctggaaaaagaatccaaagacaaggatgagaaaatcagtaagataaaactagtcgctgtgagagcaaagaaagaactagattctaacaggaaagaggcccagacactacgggacgaactcgagtccgtacagtcagaaaaggaccgcttatctgcttctatgaaggagtttatccaaggagcagaaagctataagaatcttctgttagaatatgacaagcagtcagaacagctggatgtggaaaaagaacgtgctaataattttgaacatcacatagaagaccttaccaaacaattaagagattcgacttgccagtatgaaaaactaacttccgacaatgaggatctcctggctcgaattgagaccctgcaggctaatgccaggttattagaagcacagatcttagaggtccagagagccaaaggagtagtagaaaaagaactggaagctgaaaaacttcagaaagagcagaaaattaaggaacatgtcagtactacaaatgagcttgaagaacttcaactccaatttcaaaaggaaaagaagcagcttcagaaaacgatgcaagaattagaactggttaaaaaggatgcccaacagaccacgttgatgaatatggaaatagcagattacgaacgtttgatgaaagaattaaatcaaaagttaacaaataaaaacagtaagatagaagatttggagcaagaaatgaaaattcagaaacagaaacaagaaaccctacaagaagaaatgacttccctgcagtcttcagtacagcactacgaagaaaagaacgcccaaatcaagcagctgcttgtgaaaaccaaaaaggaactggcagatgcaaagcaagcagaaactgatcacttactactccaggcgtctttaaagggcgagctggaagcaagccagcagcaagtagaagtctataaaattcagctagctgagatgacatctgagaaacacaaaatccatgagcacctgaagacttctgcggaacagcaccagcgcacactaagtgcataccagcagagggtggtggccctgcaggaagagagccgcactgccaaggcagagcaagctgctgtcacctctgaatttgagaactacaaagtccgggttcataacgttctaaaacaacagaaaaataaatctgtgtctcaggctgaaactgagggagctaaacaagaaagggaacacctggaaatgctgattgaccaactgaaaatcaagttacaggacagccaaaacagcttacaaatcagtgtgtcagagttccagacactgcagtctgagcatgacactctgctagagaggcacaaccggatgctgcaggaaactgtgaccaaagaggcggaacttcgggaaaagttatgttcagctcaatctgagaacaccatgttgaagtctgaacacgcccagacaatgtgtcagctgacatcccagaatgaggccctccgtaacagcttccgagaccaagttcgacacttgcaggatgagcacagaaagacagtggagaccttgcagcaccagctctccaaggtggaaactcagctcttccagctcaagagtgagccacccacaaaaagccctgcttcttcccatcaaccttcaaaaagcctccgagaaagacggaccacagacctcccccttctggacatgcacactgtgacccgagaggagggggaagggatggagacaactgacagtgagtctgtgtcttcggccggcacacacattcagtccttggagcagctccttagctctcctgacagcaagcttgaacgtcttacagaggcctccttatggcatacagaatttaccaaagaagaattggctgagaagctcagttccaccacgaagagtgcagatcacttaaatggcctgcttcgggagacagaggctaccaacgccatccttatggagcaaattaagcttctcaaaagtgaaataagaagactggaaagaaaccaagagcgggagaagtctgtggctaacctggagtacttgaagaatgtcctactgcggttcattttcctgaagccgggtagtgaaagagagaggcttcttcctgtgatagacacgatgctgcagctcagccctgaagaaaagggaaagcttgccacagttgctcaaggtgaggaagaaagtgcctctcgttcctctggatgggcatcctaccttcatagctggtctggactgcgataggttgacagaaagaagattctttagtgatgcaacagaactcctttggaaaagctgggtatcatttgatcatgaagtgtgcatctctgttcacatcccctgatgattgtacatatgtatagcccatgtatatagaatctcatcttgtagtaaaaggacatcagcttgaagtagtggtaccaattgttcatggtcctctaactcagcatgtggcctcatggtctctgtgatctccacccacagaggaaacggttcattcctgcactctggaaccccaggagacactcatttctaagtagtattgtgaattttgatattgaactaaattttggtaccaaaccaactggggaatttaatcttttaaaataatgtttcaagattgaggaaatgctttattgataaggttgacatgtttattaaaagattatgaagtaaatatgctatggtttaattatgaggctaacttaaattgcaattcagtcagttactttaaaataaacctccctcccatttgtaattttcaaaattggccctagtcctggtaatgtgacactgacagaataggtgggctccacctcagctgatgtgttctgtggtgtctccaggcttgtttgctgccactcataagccatgagtctcttttgagaattccctacatctcaaaacagtgactgtcttactcagcattaaatctacatgtgaacctggtgcttccagtattgttcaagtattcttatttcctaagcaggaccccagagggctcagaccctctattggtgaacaagcctagctgggggagtgtctctgtccttatgtctctggaaatactatattgactagattaaaattgtgctcttaaatcagatttgggggttatattttaatatgtaatttgttaatgaatagtgctgtctggagtcttaagcttacgtttattctccagttgtcagtctcagcttgaaactgtcctttagtcactatgaatattggtttccaacctggtttgactgaaatttactgctgacatgttgagtttgttctcttaaagctgtttgactctcagtgttcgctctacctgtgttagaacagacctagcaagtgagtgtgctgattcaaacacatctctctcagctgactctttaaggtaaggttttctacctttataaactgtgaatgtgagtatgcccagcggaatcccatgtaatttcagtactatttaaataaactccatgttttctttgggcctaatatgccttttgaagtctgtataaacttgttttcaaatctaatctgttcatatgaatataataaaaataccttttgcatggtaaaaattactttgattacaaaagatatatatatgctttttgtgaccagcaataagaaactgtaatgactgatatttctattaaatgcacttaactatat

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