2024-05-04 18:50:46, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NM_001107276 4899 bp mRNA linear ROD 22-MAR-2023 DEFINITION Rattus norvegicus piwi-like RNA-mediated gene silencing 2 (Piwil2), mRNA. ACCESSION NM_001107276 XM_001069687 XM_224334 VERSION NM_001107276.1 KEYWORDS RefSeq; RefSeq Select. SOURCE Rattus norvegicus (Norway rat) ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. REFERENCE 1 (bases 1 to 4899) AUTHORS Lu Y, Zheng X, Hu W, Bian S, Zhang Z, Tao D, Liu Y and Ma Y. TITLE Cancer/testis antigen PIWIL2 suppresses circadian rhythms by regulating the stability and activity of BMAL1 and CLOCK JOURNAL Oncotarget 8 (33), 54913-54924 (2017) PUBMED 28903391 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 4899) AUTHORS Wenda JM, Homolka D, Yang Z, Spinelli P, Sachidanandam R, Pandey RR and Pillai RS. TITLE Distinct Roles of RNA Helicases MVH and TDRD9 in PIWI Slicing-Triggered Mammalian piRNA Biogenesis and Function JOURNAL Dev Cell 41 (6), 623-637 (2017) PUBMED 28633017 REFERENCE 3 (bases 1 to 4899) AUTHORS Sivagurunathan S, Palanisamy K, Arunachalam JP and Chidambaram S. TITLE Possible role of HIWI2 in modulating tight junction proteins in retinal pigment epithelial cells through Akt signaling pathway JOURNAL Mol Cell Biochem 427 (1-2), 145-156 (2017) PUBMED 28025795 REFERENCE 4 (bases 1 to 4899) AUTHORS Barau J, Teissandier A, Zamudio N, Roy S, Nalesso V, Herault Y, Guillou F and Bourc'his D. TITLE The DNA methyltransferase DNMT3C protects male germ cells from transposon activity JOURNAL Science 354 (6314), 909-912 (2016) PUBMED 27856912 REFERENCE 5 (bases 1 to 4899) AUTHORS Yang Z, Chen KM, Pandey RR, Homolka D, Reuter M, Janeiro BK, Sachidanandam R, Fauvarque MO, McCarthy AA and Pillai RS. TITLE PIWI Slicing and EXD1 Drive Biogenesis of Nuclear piRNAs from Cytosolic Targets of the Mouse piRNA Pathway JOURNAL Mol Cell 61 (1), 138-152 (2016) PUBMED 26669262 REFERENCE 6 (bases 1 to 4899) AUTHORS Watanabe T, Totoki Y, Toyoda A, Kaneda M, Kuramochi-Miyagawa S, Obata Y, Chiba H, Kohara Y, Kono T, Nakano T, Surani MA, Sakaki Y and Sasaki H. TITLE Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes JOURNAL Nature 453 (7194), 539-543 (2008) PUBMED 18404146 REFERENCE 7 (bases 1 to 4899) AUTHORS Kuramochi-Miyagawa S, Watanabe T, Gotoh K, Totoki Y, Toyoda A, Ikawa M, Asada N, Kojima K, Yamaguchi Y, Ijiri TW, Hata K, Li E, Matsuda Y, Kimura T, Okabe M, Sakaki Y, Sasaki H and Nakano T. TITLE DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes JOURNAL Genes Dev 22 (7), 908-917 (2008) PUBMED 18381894 REFERENCE 8 (bases 1 to 4899) AUTHORS Aravin AA, Sachidanandam R, Girard A, Fejes-Toth K and Hannon GJ. TITLE Developmentally regulated piRNA clusters implicate MILI in transposon control JOURNAL Science 316 (5825), 744-747 (2007) PUBMED 17446352 REFERENCE 9 (bases 1 to 4899) AUTHORS Aravin A, Gaidatzis D, Pfeffer S, Lagos-Quintana M, Landgraf P, Iovino N, Morris P, Brownstein MJ, Kuramochi-Miyagawa S, Nakano T, Chien M, Russo JJ, Ju J, Sheridan R, Sander C, Zavolan M and Tuschl T. TITLE A novel class of small RNAs bind to MILI protein in mouse testes JOURNAL Nature 442 (7099), 203-207 (2006) PUBMED 16751777 REFERENCE 10 (bases 1 to 4899) AUTHORS Kuramochi-Miyagawa S, Kimura T, Ijiri TW, Isobe T, Asada N, Fujita Y, Ikawa M, Iwai N, Okabe M, Deng W, Lin H, Matsuda Y and Nakano T. TITLE Mili, a mammalian member of piwi family gene, is essential for spermatogenesis JOURNAL Development 131 (4), 839-849 (2004) PUBMED 14736746 COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473951.1. On or before Oct 4, 2007 this sequence version replaced XM_224334.4, XM_001069687.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMD00132266, SAMD00132270 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## FEATURES Location/Qualifiers source 1..4899 /organism="Rattus norvegicus" /mol_type="mRNA" /db_xref="taxon:10116" /chromosome="15" /map="15p11" gene 1..4899 /gene="Piwil2" /note="piwi-like RNA-mediated gene silencing 2" /db_xref="GeneID:306011" /db_xref="RGD:1306964" exon 1..138 /gene="Piwil2" /inference="alignment:Splign:2.1.0" exon 139..375 /gene="Piwil2" /inference="alignment:Splign:2.1.0" CDS 184..3099 /gene="Piwil2" /note="piwi like homolog 2; piwi-like 2" /codon_start=1 /product="piwi-like protein 2" /protein_id="NP_001100746.1" /db_xref="GeneID:306011" /db_xref="RGD:1306964" /translation="
MDPVRPLFRGPTPVHPSQCVRMPGCWPQAPRPLEPAWGRAGPAGRGLVFRKPEESSPPLQPVQKESVGLVSMFRGMGLDTALRAPSKREVPPLGRGVLGRGLSANVVRKDREESRSSLPDPSVLAAGDSKLAEASVGWSRMLGRGSSDVSLLPLGRAAGSIGRGVDKPPSAFGLTARDPPRLPQPPTLSPTSLHSSDPPPVLTIERKEKELLVKQGSKGTPQSLGLNLIKIQCHNEAVYQYHVTFSPNVECKSMRFGMLKDHQSVTGNVTAFDGSILYLPVKLQQLVELKSQRKTDDAEISIKIQLTKILEPCSDLCIPFYNVVFRRVMKLLDMKLVGRNFYDPTSAMVLQQHRLQIWPGYAASIRRTDGGLFLLADVSHKVIRNDSVLDVMHAIYQQNKEHFQDECSKLLVGSIVITRYNNRTYRIDDVDWNKTPKDSFVMSDGKEITFLEYYSKNYGITVKEDDQPLLIHRPSERQNNHGTLLKGEILLLPELSFMTGIPEKMKKDFRAMKDLTQQINLSPKQHHSALECLLQRISQNETANNELTRWGLSLQKDVHKIEGRLLPMERINLRNTSFVTSEDLNWVKEVTRDASILTIPMHFWALFYPKRAMDQARELVNMLEKIAGPIGMRISPPAWVELKDDRIETYIRTIQSLLGVEGKIQMVVCIIMGTRDDLYGAIKKLCCVQSPVPSQVINVRTIGQPTRLRSVAQKILLQMNCKLGGELWGVDIPLKQLMVIGMDVYHDPSRGMRSVVGFVASINLTLTKWYSRVVFQMPHQEIVDSLKLCLVGSLKKYYEVNHCLPEKIVVYRDGVSDGQLKTVANYEIPQLQKCFEAFDNYHPKMVVFVVQKKISTNLYLAAPDHFVTPSPGTVVDHTITSCEWVDFYLLAHHVRQGCGIPTHYICVLNTANLSPDHMQRLTFKLCHMYWNWPGTIRVPAPCKYAHKLAFLSGQILHHEPAIQLCENLFFL"
misc_feature 1192..1335 /gene="Piwil2" /note="Argonaute linker 1 domain; Region: ArgoL1; pfam08699" /db_xref="CDD:430160" misc_feature 1336..1689 /gene="Piwil2" /note="PAZ domain, Piwi_like subfamily. In multi-cellular organisms, the Piwi protein appears to be essential for the maintenance of germline stem cells. In the Drosophila male germline, Piwi was shown to be involved in the silencing of retrotransposons in the...; Region: PAZ_piwi_like; cd02845" /db_xref="CDD:239211" misc_feature order(1468..1470,1507..1509,1531..1533,1543..1545, 1597..1599,1648..1650,1654..1656) /gene="Piwil2" /note="nucleic acid-binding interface [nucleotide binding]; other site" /db_xref="CDD:239211" misc_feature 1711..3045 /gene="Piwil2" /note="PIWI domain, Piwi-like subfamily found in eukaryotes. This domain is found in Piwi and closely related proteins, where it is believed to perform a crucial role in germline cells, via RNA silencing. RNA silencing refers to a group of related...; Region: Piwi_piwi-like_Euk; cd04658" /db_xref="CDD:240016" misc_feature order(2218..2220,2230..2232,2266..2277,2284..2286, 2314..2316,2323..2325,2335..2337,2347..2349) /gene="Piwil2" /note="5' RNA guide strand anchoring site [active]" /db_xref="CDD:240016" misc_feature order(2410..2412,2416..2418,2620..2622,3019..3021) /gene="Piwil2" /note="active site" /db_xref="CDD:240016" exon 376..463 /gene="Piwil2" /inference="alignment:Splign:2.1.0" exon 464..602 /gene="Piwil2" /inference="alignment:Splign:2.1.0" exon 603..809 /gene="Piwil2" /inference="alignment:Splign:2.1.0" exon 810..920 /gene="Piwil2" /inference="alignment:Splign:2.1.0" exon 921..1038 /gene="Piwil2" /inference="alignment:Splign:2.1.0" exon 1039..1163 /gene="Piwil2" /inference="alignment:Splign:2.1.0" exon 1164..1244 /gene="Piwil2" /inference="alignment:Splign:2.1.0" exon 1245..1358 /gene="Piwil2" /inference="alignment:Splign:2.1.0" exon 1359..1547 /gene="Piwil2" /inference="alignment:Splign:2.1.0" exon 1548..1632 /gene="Piwil2" /inference="alignment:Splign:2.1.0" exon 1633..1722 /gene="Piwil2" /inference="alignment:Splign:2.1.0" exon 1723..1863 /gene="Piwil2" /inference="alignment:Splign:2.1.0" exon 1864..1977 /gene="Piwil2" /inference="alignment:Splign:2.1.0" exon 1978..2166 /gene="Piwil2" /inference="alignment:Splign:2.1.0" exon 2167..2268 /gene="Piwil2" /inference="alignment:Splign:2.1.0" exon 2269..2385 /gene="Piwil2" /inference="alignment:Splign:2.1.0" exon 2386..2474 /gene="Piwil2" /inference="alignment:Splign:2.1.0" exon 2475..2580 /gene="Piwil2" /inference="alignment:Splign:2.1.0" exon 2581..2834 /gene="Piwil2" /inference="alignment:Splign:2.1.0" exon 2835..2942 /gene="Piwil2" /inference="alignment:Splign:2.1.0" exon 2943..4899 /gene="Piwil2" /inference="alignment:Splign:2.1.0" ORIGIN
agtgtgttggaggaatgcgggtcctggaataggagggaaaggaggtggctcgaggagagagcgagcgagcactcgcttcggggctcagtggcacaagacctaaaaagaaatctaggcaagactccagttggtggaaaggtaacgaattggaacagaaccaacagtcatttctactgcctctcaatggatcctgtccggccattgttcagggggcctactccagtccacccatctcaatgtgttcggatgccaggctgttggccgcaagctcctagacctttggaaccagcttggggtagggcaggacctgcaggcagaggccttgtgtttagaaagccagaggaatccagcccaccactccagccagtacaaaaggagtctgtgggtttggtgtccatgtttcgtggcatgggtcttgacacagcattgcgggccccttcaaaacgagaagtgcctcctttaggcagaggagttctaggtcgaggcttgtctgctaacgtagtccgcaaggacagagaagaatcccgttcctctttgcctgatccttcggtgctggcagctggggacagcaagctggcagaggcttctgttggatggagtagaatgctgggaagaggtagttctgatgtctctttgttaccactgggaagagcagctggtagtataggcagaggagtggacaaacctcccagtgcctttggccttactgctcgggatccccctcggctgccccagcctccaactctgtctccaacttcactgcactcctctgatcctcctccagtcctgactatagagcgaaaggaaaaagagcttttggtcaagcaaggatcaaaaggaacacctcagtctttaggactgaacctcatcaaaatccagtgtcataacgaagcagtttatcaatatcatgtaactttcagccccaatgtggagtgcaaaagcatgaggtttggcatgttgaaggaccaccaatctgtcactggaaacgttactgcttttgatggctctattctttatcttcctgttaagcttcaacaacttgttgagttaaaaagccagagaaaaactgatgatgccgagatcagcatcaagattcagctgacaaagatcctggagccatgttccgacttgtgcattcccttctacaatgttgtcttccggcgggtaatgaaacttttggatatgaagcttgtggggagaaacttctatgatcctacaagtgccatggtactgcagcaacacagattgcagatctggcctggctatgcagctagtatccggaggacagatgggggtctcttcttgctcgctgatgtctctcataaggtcattcggaatgactctgtactggatgtcatgcatgctatctaccagcagaacaaggagcacttccaggacgagtgcagcaagcttctggtgggcagcattgtcatcacacgctacaacaaccgtacctaccgcattgacgatgtggactggaacaagacccctaaagacagctttgtaatgtcggatgggaaggagatcacattcctggagtactacagtaaaaactatgggatcacagttaaagaagatgaccagccgctgctcatccaccggcccagtgagagacagaataaccatggcacgttgctgaagggtgagatcctgctgctgcctgagctttccttcatgacggggattcctgagaagatgaagaaggacttcagggccatgaaggacttgactcagcagattaacctgagccccaagcagcaccacagtgctttggaatgcctgctgcagagaatttcacaaaatgagacagccaacaacgagctgacccgctgggggctcagtctgcaaaaagatgtccacaagatcgaaggccgtcttctaccaatggagaggattaacttaaggaatacttcatttgtcacatcggaggacctgaactgggttaaggaggtgaccagagatgcttccattctgactattcccatgcatttctgggcactcttttatccaaagagagcaatggaccaagccagagaactggttaacatgttggaaaagattgctggccccattggcatgcgcataagccccccagcctgggttgaactgaaggatgaccgaatagagacctatatcaggaccattcagtccttactgggagttgaggggaagatacaaatggtcgtttgcatcatcatgggcacacgggatgatctctatggggccatcaagaaactgtgctgtgtgcagtccccagtgccctcacaggtcatcaatgtccgaaccattggtcaacccaccaggcttcggagtgtggctcagaaaattttacttcagatgaactgtaaactgggtggtgagctctggggagtagatattccactgaaacaattaatggtgattgggatggatgtgtaccacgaccccagcagaggcatgcgctctgtggttggctttgttgccagcataaatctcacactcaccaaatggtactcgagggtggtgttccagatgccgcatcaggagattgtggacagcctgaagctctgcctggtgggctccttgaaaaagtattatgaggtgaaccactgtctcccagagaagattgtggtgtaccgagatggagtgtctgatggccagctaaagacagttgccaactatgagatccctcagctgcagaagtgctttgaagcctttgataactaccatcccaagatggtggtatttgtagttcagaagaaaatcagcaccaatctgtaccttgctgctcctgaccactttgtgaccccctcccctgggactgtggttgatcataccataaccagctgtgagtgggtggatttctaccttcttgctcatcatgtgcgacagggctgtggcatacctacacactacatctgtgttctgaacactgcaaatctgagccctgatcacatgcagaggctgactttcaaactatgccacatgtactggaattggcctggtaccatccgagttccagctccttgcaagtatgcccacaagctagctttcctgtccggacagattttgcatcatgaaccagccatccagctatgtgagaacctgttcttcctgtaactgggaacttggacaccagctgcaaggagcaactggattccagctcagctcattcttacagaatcaacagaaatggcagtggagttttacgtttgcattttctctttctccatccttgtagaattagatttctgttcttcttttaaccctgatattatagtagagtggtgtggtacatgcctgttactccagcacatgggagactgaagcagaaggatctttagttcaaggccagcctggactacatggaaagttccaagctagccaagattatagagtgagaccctatctcaaaagacaaaaccaaaccactgtccccacaaagcccacaacaaaaccaaagcctggtgtcaaggaagcaagtttctgagtagcagccagcagctgccttgatggagcagagtgatgttagcagtgccgctgctctgccgagcatgggcctacggacatgtccagtccccctaccaaataagtgaaggacataaaaaacagctcccaaggcagcatgagcatcagtttataaaccagagtttatgcctacaagatcatcctatttctgggccagaagtgacatgaatgaagtagtcattgcagatcttaaaggagagagttactatgttcagagagagttagtgtttcagagagagcagctgtttgcatgcatggaagatgtaggaaaaccagtgtaaggcacagtcaggtgagctgacttgacccaggccagtgagtttggccactccttggcctcctgagagtccagctagagctgcttttctggaccttttagtcatttacgaccatcagattgctttcctgcagcctgactgacacattcatgtgcacatacacacttttgatctttgtgactaatgtgaaataaattcagttaggacattcagcagacctaggaacattctggatggagtataggtttttttctgcaaaaatctgtaaatgagattatgcaagagtctcttccagctgtgggctggtgttgcttggaaattttcaaaatcccaaagtttcatgcttcccaaagttggcttggacaaatgtgatgctctcacctgagcctagacatgtaggaagttttcctagcgccagtgggcttctgtatttgggtgaagcactggttttctgcgttttttttttcccttctgtttcagaatcttcaagtttcttcaggcttaatgaaccatcccttgctttactgggttttaaaagctaattttacttaacctcttcaaatttgtgtgtatctatttatgttttggtgtggtggatggatggtaggggactgagcagaaattcagtgtgctaggagagcctcactgggaagtactgaagagccacagggtctgtgggagtcagtgttagcactcaccaagccaggccaggccttgggtttgaaggcaacaccagcaaagcctttagttcagtatagcacccagaggttggcgagggataagtgttggggtcttcaaatacaacccctggtgtttggagtctgtgaccaaggccagactgagacctgaaaggtaaaagccataggattaaacagagcagactgaaaaatgagtctttaggttgaacacattccactttctggatttctctgtgagtattttgagtttgtctttagacgttgctattcctagcactccttttctctttaggtagaacagacacttaaccataatgccagaatgtactttctatacctgatgtccttgccttgtttttcagtttcagggccaggtaattgggccctgtggtgtaaaataaaaacagtgtatgtgt
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Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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