LOCUS       NM_001107135            2023 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus claudin 15 (Cldn15), mRNA.
ACCESSION   NM_001107135 XM_001076934 XM_222085
VERSION     NM_001107135.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2023)
  AUTHORS   Cai,M., Shao,J., Wang,Y., Yung,B., Li,J.N., Zhang,H.H., Li,Y.T. and
            Yao,D.B.
  TITLE     Claudin 14/15 play important roles in early wallerian degeneration
            after rat sciatic nerve injury
  JOURNAL   Chin J Traumatol 24 (6), 374-382 (2021)
   PUBMED   33903003
  REMARK    GeneRIF: Claudin 14/15 play important roles in early wallerian
            degeneration after rat sciatic nerve injury.
REFERENCE   2  (bases 1 to 2023)
  AUTHORS   Krause,G., Winkler,L., Mueller,S.L., Haseloff,R.F., Piontek,J. and
            Blasig,I.E.
  TITLE     Structure and function of claudins
  JOURNAL   Biochim Biophys Acta 1778 (3), 631-645 (2008)
   PUBMED   18036336
  REMARK    Review article
REFERENCE   3  (bases 1 to 2023)
  AUTHORS   Fujita,H., Chiba,H., Yokozaki,H., Sakai,N., Sugimoto,K., Wada,T.,
            Kojima,T., Yamashita,T. and Sawada,N.
  TITLE     Differential expression and subcellular localization of claudin-7,
            -8, -12, -13, and -15 along the mouse intestine
  JOURNAL   J Histochem Cytochem 54 (8), 933-944 (2006)
   PUBMED   16651389
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Apr 3, 2024 this sequence version replaced NM_001107135.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.42782.1,
                                           SRR26643288.47323.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676786 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-428               JAXUCZ010000012.1  25343198-25343625   c
            429-593             JAXUCZ010000012.1  25339011-25339175   c
            594-675             JAXUCZ010000012.1  25336371-25336452   c
            676-792             JAXUCZ010000012.1  25336167-25336283   c
            793-2023            JAXUCZ010000012.1  25334849-25336079   c
FEATURES             Location/Qualifiers
     source          1..2023
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q12"
     gene            1..2023
                     /gene="Cldn15"
                     /note="claudin 15"
                     /db_xref="GeneID:304388"
                     /db_xref="RGD:1310678"
     exon            1..428
                     /gene="Cldn15"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    98..100
                     /gene="Cldn15"
                     /note="upstream in-frame stop codon"
     CDS             212..895
                     /gene="Cldn15"
                     /codon_start=1
                     /product="claudin-15"
                     /protein_id="NP_001100605.1"
                     /db_xref="GeneID:304388"
                     /db_xref="RGD:1310678"
                     /translation="

MSIAVETFGFFMSALGLLMLGVTLPNSYWRVSTVHGNVITTNTIFENLWYSCATDSLGVSNCWDFPSMLALSGYVQGCRALMITAILLGFLGLFLGMVGLRCTNVGNIDLSRKAKLLAIAGAFHILAGACGMVAISWYAVNITTDFFNPLYVGTKYELGSALYLGWSASLLSILGGICVFSTCCCDSKEDPATRVGLPYKPSTVVTARATSDESDVSFGKYGKNAYV"

     misc_feature    215..283
                     /gene="Cldn15"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZQJ0.1);
                     transmembrane region"
     misc_feature    221..742
                     /gene="Cldn15"
                     /note="PMP-22/EMP/MP20/Claudin family; Region:
                     PMP22_Claudin; cl21598"
                     /db_xref="CDD:473919"
     misc_feature    374..376
                     /gene="Cldn15"
                     /note="Important for Na(+)-selective paracellular ion
                     transport. /evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (D3ZQJ0.1); other site"
     misc_feature    401..403
                     /gene="Cldn15"
                     /note="Important for Na(+)-selective paracellular ion
                     transport. /evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (D3ZQJ0.1); other site"
     misc_feature    413..415
                     /gene="Cldn15"
                     /note="Important for the formation of tight-junction
                     strand-like structures. /evidence=ECO:0000250; propagated
                     from UniProtKB/Swiss-Prot (D3ZQJ0.1); other site"
     misc_feature    434..508
                     /gene="Cldn15"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZQJ0.1);
                     transmembrane region"
     misc_feature    542..544
                     /gene="Cldn15"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P56746; propagated from
                     UniProtKB/Swiss-Prot (D3ZQJ0.1); phosphorylation site"
     misc_feature    557..631
                     /gene="Cldn15"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZQJ0.1);
                     transmembrane region"
     misc_feature    647..652
                     /gene="Cldn15"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZQJ0.1);
                     Region: Important for the formation of tight-junction
                     strand-like structures. /evidence=ECO:0000250"
     misc_feature    689..757
                     /gene="Cldn15"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZQJ0.1);
                     transmembrane region"
     misc_feature    842..844
                     /gene="Cldn15"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (D3ZQJ0.1); phosphorylation site"
     misc_feature    851..853
                     /gene="Cldn15"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (D3ZQJ0.1); phosphorylation site"
     misc_feature    860..862
                     /gene="Cldn15"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (D3ZQJ0.1); phosphorylation site"
     exon            429..593
                     /gene="Cldn15"
                     /inference="alignment:Splign:2.1.0"
     exon            594..675
                     /gene="Cldn15"
                     /inference="alignment:Splign:2.1.0"
     exon            676..792
                     /gene="Cldn15"
                     /inference="alignment:Splign:2.1.0"
     exon            793..2023
                     /gene="Cldn15"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

attcctctgacctgccaggaagcagagcctcccagagaccgggcagaagcaatcagacctgacctccagaagacagcagacaagaaccgcagctggatgagcttcccttcaaccttctccctcctcagtcttccttagcatctcacctggaggagccacctctatcccaatccctggggctcaagcccccttgcgggacctgcatcccagcatgtcgatagctgtggagacctttggtttcttcatgtcagccctgggactgctgatgctgggggtgacccttccaaacagctactggagagtgtctaccgtccatgggaacgtcatcaccactaacaccatcttcgagaacctgtggtacagctgtgccaccgactccctgggagtctccaactgctgggacttcccgtccatgctggccctctctggctatgtccagggctgccgagctctcatgatcaccgccatcctcctgggcttcctgggcctctttctaggcatggtggggctccgctgcaccaacgtgggcaacatcgacctctccagaaaggccaagctgctggccattgcaggggccttccacatacttgctggagcctgtggcatggttgctatctcatggtatgctgtcaacatcaccaccgacttcttcaaccccctgtatgttggaaccaagtatgaactgggctctgccctctacttgggctggagcgcctctctgctctccatcctgggcggcatctgtgtcttctccacctgctgctgtgactccaaggaggacccagccaccagggtgggacttccctacaagccttctacggttgtgacagcccgagccacttccgatgaaagtgacgtcagctttggtaaatatggcaaaaatgcctacgtgtaggagctccggcctggtggacagcgtttcttgtcccactgtccccagcagaaaacgtccccaggacctgtgggaggactagtctccagttaataacctgaggacaggccaaatttccaggcctcagcctatgccgggaagccactacccactctgggcacaccttatctggcactccagtctctcccaggaacagaagcttcaggggcaacttgcatggcctcccacagctggactcaaggggacagaggtgtctgcagcatgtgactctatagaaatatgtgcataaatcaatgtatattgtgattgtacagggggctcctggggtcctgaagttacgaccacggaagggggtcattttcaagccatagactgtcaagtctgcccactttgggggctgtgtcatctagtgagacggtgggccagggagctggggacgtggctcagtgagtttagagtgtttgctacacaagtatgaggacctgagttcaaatccccagtacccgtgtgaaaagcgggccctggacacactcctgcagcccaagtgttgctagggaggggctctgaggctcactggcttccaacctcactccaggttctatgtgagttcaatctcaagggaatgaggtggagcacgatagagcagggtgctgggagccctcttccgacctttgcgggcacacagacttgtgcgtagaggacacacgcgtgcgcgcacacacacacacacacacattctcaataaaaggatttgaaagggggaaatcgctaacaactgctccgaatcacccacctcaggagactgttaatagctgggaagcttctggcccactgaaagttcctctctgttgacccctgacctattttctcacagcctcacaaaggggcagttgatttagaacgggcgggcattggtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtttaaagtcgatttggggtttaaaataaaggttttttttttttggttctttttttcggagctggggaccgaacccagggccttgcgcttcccaggcaagcgctctaccactgagctaaatccccaaccccaaaataaaggtatttttaaagatgca

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