LOCUS       NM_001106942            1615 bp    mRNA    linear   ROD 21-MAR-2023
DEFINITION  Rattus norvegicus caudal type homeo box 4 (Cdx4), mRNA.
ACCESSION   NM_001106942 XM_001055316 XM_228569
VERSION     NM_001106942.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1615)
  AUTHORS   Bei L, Huang W, Wang H, Shah C, Horvath E and Eklund E.
  TITLE     HoxA10 activates CDX4 transcription and Cdx4 activates HOXA10
            transcription in myeloid cells
  JOURNAL   J Biol Chem 286 (21), 19047-19064 (2011)
   PUBMED   21471217
REFERENCE   2  (bases 1 to 1615)
  AUTHORS   Young T, Rowland JE, van de Ven C, Bialecka M, Novoa A, Carapuco M,
            van Nes J, de Graaff W, Duluc I, Freund JN, Beck F, Mallo M and
            Deschamps J.
  TITLE     Cdx and Hox genes differentially regulate posterior axial growth in
            mammalian embryos
  JOURNAL   Dev Cell 17 (4), 516-526 (2009)
   PUBMED   19853565
REFERENCE   3  (bases 1 to 1615)
  AUTHORS   van Nes J, de Graaff W, Lebrin F, Gerhard M, Beck F and Deschamps
            J.
  TITLE     The Cdx4 mutation affects axial development and reveals an
            essential role of Cdx genes in the ontogenesis of the placental
            labyrinth in mice
  JOURNAL   Development 133 (3), 419-428 (2006)
   PUBMED   16396910
REFERENCE   4  (bases 1 to 1615)
  AUTHORS   Niwa H, Toyooka Y, Shimosato D, Strumpf D, Takahashi K, Yagi R and
            Rossant J.
  TITLE     Interaction between Oct3/4 and Cdx2 determines trophectoderm
            differentiation
  JOURNAL   Cell 123 (5), 917-929 (2005)
   PUBMED   16325584
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473969.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_228569.2, XM_001055316.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN13663604,
                              SAMN13663613 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1615
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq22"
     gene            1..1615
                     /gene="Cdx4"
                     /gene_synonym="RGD1561529"
                     /note="caudal type homeo box 4"
                     /db_xref="GeneID:302400"
                     /db_xref="RGD:1561529"
     exon            1..684
                     /gene="Cdx4"
                     /gene_synonym="RGD1561529"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    141..143
                     /gene="Cdx4"
                     /gene_synonym="RGD1561529"
                     /note="upstream in-frame stop codon"
     CDS             171..1037
                     /gene="Cdx4"
                     /gene_synonym="RGD1561529"
                     /codon_start=1
                     /product="homeobox protein CDX-4"
                     /protein_id="NP_001100412.1"
                     /db_xref="GeneID:302400"
                     /db_xref="RGD:1561529"
                     /translation="

MYGSCLLEKEAGMYPGTLRNPGGGSTAGVGTSGGSGSPLPASNFTAAPVYPHYMGYPHMSNMDPHGPSLGAWSSPYSPPREDWSTYPGPSSTMGTVPMNDMTSSSPAFGSPDYSTLGPTGGAGGASNGGSLPDAASESLVSIDSGTSGGATSPSRSRHSPYAWMRKTVQVTGKTRTKEKYRVVYTDHQRLELEKEFHCNRYITIRRKSELAVNLGLSERQVKIWFQNRRAKERKMIKKKISQFENSGGSVQSDSGSISPGELPNAFFTTPSAVRGFQPIEIQQVIISE"

     misc_feature    207..692
                     /gene="Cdx4"
                     /gene_synonym="RGD1561529"
                     /note="Caudal like protein activation region; Region:
                     Caudal_act; pfam04731"
                     /db_xref="CDD:461413"
     misc_feature    705..872
                     /gene="Cdx4"
                     /gene_synonym="RGD1561529"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     exon            685..830
                     /gene="Cdx4"
                     /gene_synonym="RGD1561529"
                     /inference="alignment:Splign:2.1.0"
     exon            831..1615
                     /gene="Cdx4"
                     /gene_synonym="RGD1561529"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

ttagggtaggataggaaggttggagtagtccgagccgcccagaggagctggcagcacagcgagtgctgacccattcattgatagcctcttgcatctcaaactcgggttggcgctaagtttacagggtcctcaggatggcttagggggcaacttcttctatccaagccaccatgtatggaagctgccttttagaaaaagaagcgggaatgtacccaggcactctcaggaaccctggaggaggcagcacagccggagtgggcacctctgggggcagtggtagtcctctgcctgcctccaactttactgcagccccagtttacccacactacatggggtatccacatatgtccaacatggatcctcacgggccttcgctgggagcctggagctcaccctacagtccgccccgggaagactggagtacataccctgggccgtccagcacaatgggcacagtgcccatgaacgacatgacctcgagctccccagctttcggctccccagactacagcactctgggccccactggcggtgcaggcggtgcaagcaacggcggtagcctgccagacgcggccagcgagtcactggtttccatcgactcaggcacctctggcggcgccacttctcccagcaggagccgccacagcccctacgcgtggatgcgcaagactgtgcaggtgaccgggaaaaccaggacaaaagaaaagtatcgtgtggtctacacggatcatcaaaggctggagctggaaaaggaatttcactgcaatagatacattaccatccggaggaagtcagagctggcagttaacctgggcctttctgagagacaggtgaaaatctggtttcagaatcgcagagccaaggagaggaagatgatcaaaaagaaaatctcccagtttgagaacagtggaggttccgtgcaaagtgactctggctccatcagccccggagaactgcctaatgctttcttcaccactccatctgctgtccgtgggtttcagccaattgagatacagcaggtcataatttctgaatgaaacgggagcagagaaaccaacgcatccttcctgttacagtgtctctttggcctctaagataacagcagggcagttgagatcggatatacttccttataaggcacaattccaaacaagtagacacaccatgagttggagatatttcagaagactctaatattaagaaaaatcttatttcatgctgtcaaatgggcactgggcagaaagctgtgcgatacgtttttctacttaaagtctagattcaagagcccttgaaactttgtttacaatttcagaaactcatttgttcctatgctcttgtgtttgttatttgattctgagtatcttcctggtctttttaggggataggagtaaggtaagcatacatttctctatctggagacattgtttggagggagtaattaaaaaaccaccagtctttttaacaagctaactgtgtaaaacagcatcaagaagtgattacgaatctattggttaattacatgaagatcacttttccctttgaataatactcacttaccatcaattacctggtcatagaatttagaagatttatttcaaatcgtgtcaaaacaatg

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