LOCUS       NM_001106928            3387 bp    mRNA    linear   ROD 22-DEC-2022
DEFINITION  Rattus norvegicus FER tyrosine kinase (Fer), transcript variant 1,
            mRNA.
ACCESSION   NM_001106928 XM_001062414 XM_001072397 XM_001072478 XM_001072523
            XM_217492
VERSION     NM_001106928.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3387)
  AUTHORS   Nizard P, Ezan F, Bonnier D, Le Meur N, Langouet S, Baffet G,
            Arlot-Bonnemains Y and Theret N.
  TITLE     Integrative analysis of high-throughput RNAi screen data identifies
            the FER and CRKL tyrosine kinases as new regulators of the
            mitogenic ERK-dependent pathways in transformed cells
  JOURNAL   BMC Genomics 15 (1), 1169 (2014)
   PUBMED   25540073
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3387)
  AUTHORS   Makovski A, Yaffe E, Shpungin S and Nir U.
  TITLE     Intronic promoter drives the BORIS-regulated expression of FerT in
            colon carcinoma cells
  JOURNAL   J Biol Chem 287 (9), 6100-6112 (2012)
   PUBMED   22223638
REFERENCE   3  (bases 1 to 3387)
  AUTHORS   Guo C and Stark GR.
  TITLE     FER tyrosine kinase (FER) overexpression mediates resistance to
            quinacrine through EGF-dependent activation of NF-kappaB
  JOURNAL   Proc Natl Acad Sci U S A 108 (19), 7968-7973 (2011)
   PUBMED   21518868
REFERENCE   4  (bases 1 to 3387)
  AUTHORS   Itoh T, Hasegawa J, Tsujita K, Kanaho Y and Takenawa T.
  TITLE     The tyrosine kinase Fer is a downstream target of the PLD-PA
            pathway that regulates cell migration
  JOURNAL   Sci Signal 2 (87), ra52 (2009)
   PUBMED   19738202
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3387)
  AUTHORS   Zoubeidi A, Rocha J, Zouanat FZ, Hamel L, Scarlata E, Aprikian AG
            and Chevalier S.
  TITLE     The Fer tyrosine kinase cooperates with interleukin-6 to activate
            signal transducer and activator of transcription 3 and promote
            human prostate cancer cell growth
  JOURNAL   Mol Cancer Res 7 (1), 142-155 (2009)
   PUBMED   19147545
REFERENCE   6  (bases 1 to 3387)
  AUTHORS   Iwanishi M, Czech MP and Cherniack AD.
  TITLE     The protein-tyrosine kinase fer associates with signaling complexes
            containing insulin receptor substrate-1 and phosphatidylinositol
            3-kinase
  JOURNAL   J Biol Chem 275 (50), 38995-39000 (2000)
   PUBMED   11006284
REFERENCE   7  (bases 1 to 3387)
  AUTHORS   Kim L and Wong TW.
  TITLE     Growth factor-dependent phosphorylation of the actin-binding
            protein cortactin is mediated by the cytoplasmic tyrosine kinase
            FER
  JOURNAL   J Biol Chem 273 (36), 23542-23548 (1998)
   PUBMED   9722593
REFERENCE   8  (bases 1 to 3387)
  AUTHORS   Kim L and Wong TW.
  TITLE     The cytoplasmic tyrosine kinase FER is associated with the
            catenin-like substrate pp120 and is activated by growth factors
  JOURNAL   Mol Cell Biol 15 (8), 4553-4561 (1995)
   PUBMED   7623846
REFERENCE   9  (bases 1 to 3387)
  AUTHORS   Hao QL, Ferris DK, White G, Heisterkamp N and Groffen J.
  TITLE     Nuclear and cytoplasmic location of the FER tyrosine kinase
  JOURNAL   Mol Cell Biol 11 (2), 1180-1183 (1991)
   PUBMED   1990274
REFERENCE   10 (bases 1 to 3387)
  AUTHORS   Letwin K, Yee SP and Pawson T.
  TITLE     Novel protein-tyrosine kinase cDNAs related to fps/fes and eph
            cloned using anti-phosphotyrosine antibody
  JOURNAL   Oncogene 3 (6), 621-627 (1988)
   PUBMED   2485255
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CH473997.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_217492.4, XM_001062414.1, XM_001072478.1, XM_001072523.1,
            XM_001072397.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3387
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q37"
     gene            1..3387
                     /gene="Fer"
                     /gene_synonym="Fert2; Flk; Flk_retired"
                     /note="FER tyrosine kinase"
                     /db_xref="GeneID:301737"
                     /db_xref="RGD:1306273"
     exon            1..95
                     /gene="Fer"
                     /gene_synonym="Fert2; Flk; Flk_retired"
                     /inference="alignment:Splign:2.1.0"
     exon            96..285
                     /gene="Fer"
                     /gene_synonym="Fert2; Flk; Flk_retired"
                     /inference="alignment:Splign:2.1.0"
     exon            286..460
                     /gene="Fer"
                     /gene_synonym="Fert2; Flk; Flk_retired"
                     /inference="alignment:Splign:2.1.0"
     exon            461..653
                     /gene="Fer"
                     /gene_synonym="Fert2; Flk; Flk_retired"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    510..512
                     /gene="Fer"
                     /gene_synonym="Fert2; Flk; Flk_retired"
                     /note="upstream in-frame stop codon"
     CDS             525..1886
                     /gene="Fer"
                     /gene_synonym="Fert2; Flk; Flk_retired"
                     /EC_number="2.7.10.2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     proto-oncogene tyrosine-protein kinase FER; tyrosine
                     protein kinase FLK; tyrosine-protein kinase Fer; c-FER;
                     p94-FER; fer (fms/fps related) protein kinase, testis
                     specific 2; proto-oncogene c-Fer; fer (fps/fes related)
                     tyrosine kinase"
                     /codon_start=1
                     /product="tyrosine-protein kinase Fer isoform 1"
                     /protein_id="NP_001100398.1"
                     /db_xref="GeneID:301737"
                     /db_xref="RGD:1306273"
                     /translation="

MEQSVECPHCEGDLEPDSDSKFCKKCSIPMSPGPSSSEIQRYQERKERLSKFESIRHSIAGIIKSPKSVLGSSTLSDVISVGEKPLAEHDWYHGAIPRIEAQELLKQQGDFLVRESHGKPGEYVLSVYSDGQRRHFIIQFVDNLYRFEGTGFSNIPQLIDHHFNTKQVITKKSGVVLLNPIPKDKKWVLNHEDVSLGELLGKGNFGEVYKGTLKDKTPVAVKTCKEDLPQELKIKFLQEAKILKQYDHPNIVKLIGVCTQRQPVYIIMELVPGGDFLSFLRKRKDELKLKQLVRFSLDVAAGMLYLEGKICIHRDLAARNCLVGENNTLKISDFGMSRQEDGGVYSSSGLKQIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQVERGYRMSAPQNCPEEIFTIMMKCWDYKPENRPKFSDLHKELTAIKKKIT"

     misc_feature    774..1031
                     /gene="Fer"
                     /gene_synonym="Fert2; Flk; Flk_retired"
                     /note="Src homology 2 (SH2) domain found in feline
                     sarcoma, Fujinami poultry sarcoma, and fes-related
                     (Fes/Fps/Fer) proteins; Region: SH2_Fps_family; cd10361"
                     /db_xref="CDD:198224"
     misc_feature    order(816..818,864..866,927..929,933..935)
                     /gene="Fer"
                     /gene_synonym="Fert2; Flk; Flk_retired"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]; other site"
                     /db_xref="CDD:198224"
     misc_feature    order(930..932,1008..1010)
                     /gene="Fer"
                     /gene_synonym="Fert2; Flk; Flk_retired"
                     /note="hydrophobic binding pocket [polypeptide binding];
                     other site"
                     /db_xref="CDD:198224"
     misc_feature    1113..1865
                     /gene="Fer"
                     /gene_synonym="Fert2; Flk; Flk_retired"
                     /note="Protein Kinases, catalytic domain; Region:
                     PKc_like; cl21453"
                     /db_xref="CDD:451246"
     misc_feature    order(1122..1133,1140..1142,1146..1148,1182..1184,
                     1188..1190,1278..1280,1326..1337,1467..1469,1479..1484,
                     1488..1490,1518..1523)
                     /gene="Fer"
                     /gene_synonym="Fert2; Flk; Flk_retired"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270870"
     exon            654..746
                     /gene="Fer"
                     /gene_synonym="Fert2; Flk; Flk_retired"
                     /inference="alignment:Splign:2.1.0"
     exon            747..950
                     /gene="Fer"
                     /gene_synonym="Fert2; Flk; Flk_retired"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1073
                     /gene="Fer"
                     /gene_synonym="Fert2; Flk; Flk_retired"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1130
                     /gene="Fer"
                     /gene_synonym="Fert2; Flk; Flk_retired"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1246
                     /gene="Fer"
                     /gene_synonym="Fert2; Flk; Flk_retired"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1341
                     /gene="Fer"
                     /gene_synonym="Fert2; Flk; Flk_retired"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1465
                     /gene="Fer"
                     /gene_synonym="Fert2; Flk; Flk_retired"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1620
                     /gene="Fer"
                     /gene_synonym="Fert2; Flk; Flk_retired"
                     /inference="alignment:Splign:2.1.0"
     exon            1621..1743
                     /gene="Fer"
                     /gene_synonym="Fert2; Flk; Flk_retired"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..3387
                     /gene="Fer"
                     /gene_synonym="Fert2; Flk; Flk_retired"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gtaccgttaatggccccagagtctggctgctctgtagagctgggacgtttggctgaccacagcgggctctagctgctcagcagggggaggtactgcattgtgcttcttctgggccaaaagcaggcacttgaagagctgaaacagtcagtccagcaattgcgatgcactgaggcaaagtgcgcagcacagaaagaattgctggagcaaaaagtacaggaaaatgatgggaaagagccacctcctgtggtgaattacgaagaagatgcgcggtcagtcacatctatggtcctattaagcttatttgtaaatgcagaatagacttacctgtcagtcacctcaggtcacctggagggcacttcagcagccacccatagagtcagaagacaaaaagctcttctcttgccttcaaaactgaaaggacagactgaagttgtttttatccctgggagacagcaggaagacaggatgatctgtggacacactgacttctgcgtgcataccgttagctctagttaagatttgagatggagcagagtgtggagtgtccccactgtgagggtgacctggagcctgactctgactccaagttctgtaaaaaatgctctataccgatgagccctgggccttcctcatcagagatccagagataccaggaaagaaaggagaggctatccaaatttgagtctattcgtcattcaattgctggaataattaagtctccaaagtcggtcctcggctcttcaacgctctctgacgtgatctctgtgggtgagaagcccctggcggagcatgactggtaccacggtgccatccccaggatagaggcacaagaactgctgaagcagcagggagacttcctggtgcgagagagccatgggaaacctggtgaatatgtcctttctgtatattctgacggacaaaggaggcactttatcatacagtttgttgataatctatatcgatttgagggcaccggcttttcaaatatccctcaacttatagatcaccacttcaatacaaagcaagtcatcaccaagaagtcgggggtggttctgctgaatcctattccaaaggataagaaatgggttctcaatcatgaagatgtttcattgggagaattactgggcaaggggaattttggtgaggtgtacaagggcacactgaaggataaaacccctgttgctgttaaaacgtgcaaggaagacctgcctcaggaactaaaaataaagtttttacaggaagccaaaattctcaagcaatatgatcaccccaatattgtcaaacttataggcgtgtgcacacaaagacagcctgtctacatcattatggaactggtcccaggaggtgattttctgtcctttctgaggaagaggaaggacgagctaaagttgaagcagttggtgaggttttccttggacgttgctgctggcatgctgtatctcgagggcaagatctgcattcacagggacctggctgcacggaactgcctggtaggtgaaaataatactctgaaaatcagtgactttgggatgtctcggcaagaagacggtggagtgtattcatcttctggcttaaagcagattcccattaagtggacagcaccagaagcactgaattatgggagatacagctctgaaagtgacgtgtggagcttcggcatcctgctctgggagactttcagcctgggagtctgtccgtaccctgggatgacaaaccagcaagcacgggaacaagtggagagagggtatcggatgtcagccccacagaactgtcccgaggaaatttttacaatcatgatgaagtgctgggattacaagcctgaaaaccgccctaagttcagtgaccttcacaaagagctcacggccatcaagaagaaaatcacatagtgccacccagggctagactccacctgcgggactctgtcctcagtcaccctgactttataccaccttactgcaaccatctttgaaggttatgttttttattaactgggtttttaaagtatgttccactttaaatatgttaaaggcaaatttattcaagaaataaatagtcctacccagggccgtattagctaaccacaacaaccctgccatttgatgcccctgtacagagaagagcaaggcctcccaggaaggtaaaagatatctttaataccgaagaacattggtgttctgccaaagttttctactccgggcacagcctctgggctgctgtcttctgccgtcggccctcctcagttggtgctataaacagccttggtagcccatgttttgcacaacacgtgcccaccacagttggctttccactctgccaaggcaagattctatctataaatagaatcatatgttgggaatcgcttggacctcctcgggcttctctcttctttcctgtgagaacatcacacaaccatgtcgtttgcctttcgcttccctcagccaggccacagaaaatggtgtgtggaaaattcccagagagcccaggggacagaggtagttgcttctgcggaacagtgcagaggacaggggtgacaaggagcatgtgtgaccaggagggcaggttgggaaaagagcaggtagccagtgctcaccagggagaagaaagcaagagcgcccccttcctcccagctttccaccttcacagaacccgtgtctgggtctcgattcactaacaaggtctaagaaagttttcaggattcattgagcccatgcaaactgtcttaaagacactgaagcccacagaagaacagcatgattctggttgtgtatcttcatcctaggagacaatcccagaatgggattcccttcacttgtaccagtttctgggtcttcagaatccctgattcacatttacaaacacatccacccatatctactgaagtgcagggcggctatgaatgaaatagatgggccaggcgccaagtcagtgttaatgaagaaaatctatagggatgcccacatctccatttcctcttccccctaaagccactcgctggaaatgttactgagaacgcagcggtatgcaagcagccattaaggtgaaggcaggtaagagcagggtgtggctgagctgcctcttagctgcctcggggaacttcccatggtctgcgcagttgtctcagaaccagtgtggcccagagatggtctcctcccttcctggccgtgtagagcgtggatcagactttgaaggaggcagctgaagagagaaggactctgttctattatttcaacctccttgctaattttatacacatttaatggttcctacatgcaggctgaaataaaggcacactgagcctgcccgcagcagtacactgcagcacacaaagcagctccctcctccgcgggcacagccctcccacgggtccgaccctgtaaataagcagag

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