LOCUS       NM_001106524            3595 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus acyl-CoA synthetase short-chain family member 1
            (Acss1), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001106524 XM_215897
VERSION     NM_001106524.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3595)
  AUTHORS   Lakhter AJ, Hamilton J, Konger RL, Brustovetsky N, Broxmeyer HE and
            Naidu SR.
  TITLE     Glucose-independent Acetate Metabolism Promotes Melanoma Cell
            Survival and Tumor Growth
  JOURNAL   J Biol Chem 291 (42), 21869-21879 (2016)
   PUBMED   27539851
REFERENCE   2  (bases 1 to 3595)
  AUTHORS   Sakakibara I, Fujino T, Ishii M, Tanaka T, Shimosawa T, Miura S,
            Zhang W, Tokutake Y, Yamamoto J, Awano M, Iwasaki S, Motoike T,
            Okamura M, Inagaki T, Kita K, Ezaki O, Naito M, Kuwaki T, Chohnan
            S, Yamamoto TT, Hammer RE, Kodama T, Yanagisawa M and Sakai J.
  TITLE     Fasting-induced hypothermia and reduced energy production in mice
            lacking acetyl-CoA synthetase 2
  JOURNAL   Cell Metab 9 (2), 191-202 (2009)
   PUBMED   19187775
REFERENCE   3  (bases 1 to 3595)
  AUTHORS   Watkins PA, Maiguel D, Jia Z and Pevsner J.
  TITLE     Evidence for 26 distinct acyl-coenzyme A synthetase genes in the
            human genome
  JOURNAL   J Lipid Res 48 (12), 2736-2750 (2007)
   PUBMED   17762044
REFERENCE   4  (bases 1 to 3595)
  AUTHORS   Hallows WC, Lee S and Denu JM.
  TITLE     Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases
  JOURNAL   Proc Natl Acad Sci U S A 103 (27), 10230-10235 (2006)
   PUBMED   16790548
REFERENCE   5  (bases 1 to 3595)
  AUTHORS   Schwer B, Bunkenborg J, Verdin RO, Andersen JS and Verdin E.
  TITLE     Reversible lysine acetylation controls the activity of the
            mitochondrial enzyme acetyl-CoA synthetase 2
  JOURNAL   Proc Natl Acad Sci U S A 103 (27), 10224-10229 (2006)
   PUBMED   16788062
REFERENCE   6  (bases 1 to 3595)
  AUTHORS   Fujino T, Kondo J, Ishikawa M, Morikawa K and Yamamoto TT.
  TITLE     Acetyl-CoA synthetase 2, a mitochondrial matrix enzyme involved in
            the oxidation of acetate
  JOURNAL   J Biol Chem 276 (14), 11420-11426 (2001)
   PUBMED   11150295
REFERENCE   7  (bases 1 to 3595)
  AUTHORS   Barth,C., Sladek,M. and Decker,K.
  TITLE     The subcellular distribution of short-chain fatty acyl-CoA
            synthetase activity in rat tissues
  JOURNAL   Biochim Biophys Acta 248 (1), 24-33 (1971)
   PUBMED   4334748
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474050.2.
            
            On Oct 4, 2007 this sequence version replaced XM_215897.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed/partial sample support SAMEA5756307,
                              SAMEA5760383 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3595
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     gene            1..3595
                     /gene="Acss1"
                     /gene_synonym="Acas2l"
                     /note="acyl-CoA synthetase short-chain family member 1"
                     /db_xref="GeneID:296259"
                     /db_xref="RGD:1306246"
     exon            1..345
                     /gene="Acss1"
                     /gene_synonym="Acas2l"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..2081
                     /gene="Acss1"
                     /gene_synonym="Acas2l"
                     /EC_number="6.2.1.1"
                     /note="acetyl-Coenzyme A synthetase 2 (AMP forming)-like"
                     /codon_start=1
                     /product="acetyl-coenzyme A synthetase 2-like,
                     mitochondrial"
                     /protein_id="NP_001099994.1"
                     /db_xref="GeneID:296259"
                     /db_xref="RGD:1306246"
                     /translation="

MAARSLGSGVGRLLRGLHGHSGQSGWLLSLSRWTTTRFLGSVPAAAQLGSYPALSAQAAQEPAAFWGPLARDTLVWDTPYHTVWDCDFRTGKIGWFLGGQLNVSVNCLDQHVQKSPDTIALIWERDEPGTEVRITYRELLETTCRLANTLKRHGVHRGDRVAIYMPVSPLAVAAMLACARIGAIHTVVFAGFSAESLAGRINDAKCKVVITFNQGLRGGRVVELKKIVDEAVKNCPTVQHVLVAHRTDTKVPMGNLDIPLEQEMANEAPVCTPESMNSEDMLFMLYTSGSTGTPKGLVHTQAGYLLYAAMTHKLVFDYHPGDVFGCVADIGWITGHSYVVYGPLCNGATTVLFESTPVYPDAGRYWETVQRLKINQFYGAPTAVRLLLKFGDAWVKKYDRSSLRTLGSVGEPINHEAWEWLHKVVGDGRCTLVDTWWQTETGGICIAPRPSEDGAEILPGMAMRPFFGIVPALMDEKGNVVEGGDVSGALCISQAWPGMARTIYGDHQRFVDAYFRTYPGYYFTGDGAHRTEGGYYQITGRMDDVINISGHRLGTAEIEDAMADHPAVPETAVIGYPHDIKGEAAFAFIVLKDDVRDANVVVNELKLAVATKIAKYAVPDQILVVKRLPKTRSGKVMRRLLRKIITSRGQDLGDTTTLEDPSVITEIMSAFREYEEQRAATN"

     misc_feature    165..2042
                     /gene="Acss1"
                     /gene_synonym="Acas2l"
                     /note="acetate--CoA ligase; Region: Ac_CoA_lig_AcsA;
                     TIGR02188"
                     /db_xref="CDD:274022"
     misc_feature    order(597..605,681..683,690..692,696..698,1014..1016,
                     1029..1034,1098..1106,1176..1181,1188..1190,1257..1268,
                     1332..1349,1608..1610,1644..1646,1653..1655,1677..1688,
                     1860..1862,1875..1880)
                     /gene="Acss1"
                     /gene_synonym="Acas2l"
                     /note="active site"
                     /db_xref="CDD:341270"
     misc_feature    order(597..605,681..683,690..692,696..698,1014..1016,
                     1032..1034,1098..1106,1176..1181,1188..1190,1677..1685,
                     1860..1862,1875..1877)
                     /gene="Acss1"
                     /gene_synonym="Acas2l"
                     /note="CoA binding site [chemical binding]; other site"
                     /db_xref="CDD:341270"
     misc_feature    order(882..884,891..908,912..917)
                     /gene="Acss1"
                     /gene_synonym="Acas2l"
                     /note="acyl-activating enzyme (AAE) consensus motif; other
                     site"
                     /db_xref="CDD:341270"
     misc_feature    order(1029..1034,1257..1268,1332..1349,1608..1610,
                     1644..1646,1653..1655,1686..1688)
                     /gene="Acss1"
                     /gene_synonym="Acas2l"
                     /note="AMP binding site [chemical binding]; other site"
                     /db_xref="CDD:341270"
     misc_feature    order(1029..1034,1257..1262,1341..1343)
                     /gene="Acss1"
                     /gene_synonym="Acas2l"
                     /note="acetate binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:341270"
     exon            346..442
                     /gene="Acss1"
                     /gene_synonym="Acas2l"
                     /inference="alignment:Splign:2.1.0"
     exon            443..642
                     /gene="Acss1"
                     /gene_synonym="Acas2l"
                     /inference="alignment:Splign:2.1.0"
     exon            643..818
                     /gene="Acss1"
                     /gene_synonym="Acas2l"
                     /inference="alignment:Splign:2.1.0"
     exon            819..971
                     /gene="Acss1"
                     /gene_synonym="Acas2l"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1119
                     /gene="Acss1"
                     /gene_synonym="Acas2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1257
                     /gene="Acss1"
                     /gene_synonym="Acas2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1350
                     /gene="Acss1"
                     /gene_synonym="Acas2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1463
                     /gene="Acss1"
                     /gene_synonym="Acas2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1590
                     /gene="Acss1"
                     /gene_synonym="Acas2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1718
                     /gene="Acss1"
                     /gene_synonym="Acas2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..1782
                     /gene="Acss1"
                     /gene_synonym="Acas2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..1901
                     /gene="Acss1"
                     /gene_synonym="Acas2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..3595
                     /gene="Acss1"
                     /gene_synonym="Acas2l"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

ggctcctgcacccgcgtggggcgtcgggcgagatggcggcgcgcagcctcggcagcggtgtggggcgactgctgcgtggcctgcacgggcactcgggacaatcggggtggttgctgagcctgtcccgctggaccaccacccgattcctgggcagtgttcctgcagcagcgcagctaggctcgtaccccgctttgagcgctcaggcagcccaggagccggccgccttctggggaccgctggcccgtgacacactagtttgggacactccttaccatactgtctgggactgcgacttcaggacgggcaagatcggctggttcctgggaggccagttgaatgtgtctgtcaactgcctggaccagcacgtgcagaagtctcccgacaccatagctttgatttgggagagagatgaacctgggacagaagtgaggatcacttacagggagcttctggagaccacatgccgcctggccaacacgctgaagaggcatggtgtgcaccgaggggaccgtgtggccatctacatgcctgtgtccccactggctgtggcagcgatgctggcctgtgccaggattggagctatccacacagtggtttttgctggctttagtgcagagtccttggccgggaggatcaatgatgccaagtgcaaggttgttatcaccttcaaccaaggactccggggagggcgtgtggtggagctgaagaaaatagtggacgaagctgtgaagaactgcccaacagtgcagcatgtcctagtggctcacaggacggacaccaaggttcccatggggaatctggacatcccccttgagcaggagatggccaatgaggcccctgtgtgtacccctgaaagcatgaacagtgaagatatgctcttcatgctctacacgtctgggagcactgggacacccaagggactcgttcatacacaggcaggctatctgctgtatgccgccatgacgcacaagctcgtgtttgactaccatccaggtgatgtctttggttgtgtggctgacatcggttggatcacaggacacagctatgtggtgtatggacccctctgcaatggagctaccacggtcctttttgagagcaccccagtttaccctgatgctggtcgttactgggagacagtacagaggctaaagatcaaccagttctatggtgccccgacagctgtccgactgctgctgaagttcggggatgcctgggtgaaaaagtatgaccgctcctccctgcgcacactggggtcagtgggagagcccatcaatcatgaggcctgggagtggctccacaaagtggtgggtgatggcagatgtaccctggtggacacttggtggcagacagaaactggaggcatctgcattgcaccacggccctcggaagatggggcagagatcctcccaggcatggccatgaggccgttttttggcattgtccctgcactcatggatgagaagggcaatgttgtggagggtggtgatgtctctggggccctgtgtatttcccaagcttggccaggcatggcaaggaccatctacggtgaccaccagaggttcgtagatgcctacttcagaacgtacccaggttactacttcactggagatggagctcaccggacggagggtggctattaccagatcacagggcgcatggatgatgtcatcaacatcagtggtcatcgcctggggactgcagagattgaggatgcaatggctgaccatcccgctgtcccagaaactgctgtcattgggtaccctcatgacatcaaaggagaagctgcgtttgccttcattgtactgaaagatgacgtccgtgatgcaaacgtggtggtaaatgagctcaagttggcagtggccaccaagatcgccaagtatgctgtgcctgaccagatcctggtggtgaagcgtctccccaaaaccaggtctgggaaggtgatgaggaggctgctgaggaagatcatcaccagcagggggcaggatctaggggacaccactaccctggaggaccccagtgtcatcacggagatcatgagtgcctttcgggagtacgaagagcagcgggctgccaccaactgagaggtgcacctctgtgttgcccagacaaagccgcacaggacccctggtcaccctcagggaaaggagcttcaaagctggcttgtttcatctgagcacatgacccatgtactgccctatttgcagctgaagcccctctttctttctcctggggcctcgagcgctgcctctggaaggggaggcctttgtcctacttctggtttccagaattaagtcataattggaactaaaccagcacggggtaaccagaggtcttagctccagaactgtcatgttttctccagatgtgtgtagatacaaaacacagaatattttatttttttgtactttttctatttggggagagtaacagaacatttgggtataatgtgaacatttagttttgcacgtgcgcgtgcgtatgcacacacacacacacacacacacacacacacacacacacacacacacacacactgtgggaaaatattcttgcctccccagggatgaggataacagaatgtgcttttttaaaaaaattatcattcagtgtgcttgaaattcaaaccatagatgtttgtgcctctgccacataactgtccccatcctactaatccaagtcgccatatccacctcctgtgtctatttcatatttggttcacttggtttattttgtgatagaacagactggacgattcttatatttacgtttcgcaccttagggattgcactcagggcctcctgaacactaggcaagcactctacctctgagctgcacaccagcacctttaatccccaagagacggagtgaatgtcctctcctttacttgtgaaatcatttgggttcgcttctctaagctgtgatctggaaggagcttctttccccagggaatatgacctcataggaggtcatattgcttcaaacgtgtggttgttcgtggcaaccggtgaaaactcaggtgtcttactaaggctctggtcccattggggctcttgaagactctgcctgccctttctcttgtgattggggcaacaagagccactgtggtccaatgacaacacttggtgctcttgagcgagttctctctcgatgtgccttaagtcctctggacactggtgagtgtcacaaaccgtgaagtctggaaaacgtattctgtagcttggttgtggctaagcatgggagggcttgaaggggtggcagctctgtgagcagggcccctgggggcagaggaagatggttctggctggtccacagaactcagctctatgggtgtttcttagttactgcacacctactgtctgtcctgacttcttgggtaatggggtaaatattctgatactcccgggaggtggagtggttgtagtatgcacaaatattaatagtcctttgttacagtcagcggtaaagagccatgtgatggatttacttggctgactacagttactttagggaatggcctaggtttccaggttactgatagaacctatcagaatgatttatagaaatattcaaataaagctttattttgttcagtgtc

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