LOCUS       NM_001106274            2289 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus retinaldehyde binding protein 1 (Rlbp1), mRNA.
ACCESSION   NM_001106274 XM_001064754 XM_006229396 XM_214973
VERSION     NM_001106274.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2289)
  AUTHORS   Daiger,S.P., Sullivan,L.S. and Bowne,S.J.
  TITLE     Genes and mutations causing retinitis pigmentosa
  JOURNAL   Clin Genet 84 (2), 132-141 (2013)
   PUBMED   23701314
  REMARK    Review article
REFERENCE   2  (bases 1 to 2289)
  AUTHORS   von Lintig,J., Kiser,P.D., Golczak,M. and Palczewski,K.
  TITLE     The biochemical and structural basis for trans-to-cis isomerization
            of retinoids in the chemistry of vision
  JOURNAL   Trends Biochem Sci 35 (7), 400-410 (2010)
   PUBMED   20188572
  REMARK    Review article
REFERENCE   3  (bases 1 to 2289)
  AUTHORS   Wright,A.F., Chakarova,C.F., Abd El-Aziz,M.M. and Bhattacharya,S.S.
  TITLE     Photoreceptor degeneration: genetic and mechanistic dissection of a
            complex trait
  JOURNAL   Nat Rev Genet 11 (4), 273-284 (2010)
   PUBMED   20212494
  REMARK    Review article
REFERENCE   4  (bases 1 to 2289)
  AUTHORS   Huang,J., Possin,D.E. and Saari,J.C.
  TITLE     Localizations of visual cycle components in retinal pigment
            epithelium
  JOURNAL   Mol Vis 15, 223-234 (2009)
   PUBMED   19180257
REFERENCE   5  (bases 1 to 2289)
  AUTHORS   Katsanis,N., Shroyer,N.F., Lewis,R.A., Cavender,J.C.,
            Al-Rajhi,A.A., Jabak,M. and Lupski,J.R.
  TITLE     Fundus albipunctatus and retinitis punctata albescens in a pedigree
            with an R150Q mutation in RLBP1
  JOURNAL   Clin Genet 59 (6), 424-429 (2001)
   PUBMED   11453974
REFERENCE   6  (bases 1 to 2289)
  AUTHORS   Burstedt,M.S., Forsman-Semb,K., Golovleva,I., Janunger,T.,
            Wachtmeister,L. and Sandgren,O.
  TITLE     Ocular phenotype of bothnia dystrophy, an autosomal recessive
            retinitis pigmentosa associated with an R234W mutation in the RLBP1
            gene
  JOURNAL   Arch Ophthalmol 119 (2), 260-267 (2001)
   PUBMED   11176989
REFERENCE   7  (bases 1 to 2289)
  AUTHORS   Maw,M.A., Kennedy,B., Knight,A., Bridges,R., Roth,K.E., Mani,E.J.,
            Mukkadan,J.K., Nancarrow,D., Crabb,J.W. and Denton,M.J.
  TITLE     Mutation of the gene encoding cellular retinaldehyde-binding
            protein in autosomal recessive retinitis pigmentosa
  JOURNAL   Nat Genet 17 (2), 198-200 (1997)
   PUBMED   9326942
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Jun 4, 2021 this sequence version replaced
            XM_006229396.4, NM_001106274.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.1036427.1,
                                           SRR26643298.3530.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840106 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-358               JAXUCZ010000001.1  142731264-142731621 c
            359-469             JAXUCZ010000001.1  142729481-142729591 c
            470-498             JAXUCZ010000001.1  142728769-142728797 c
            499-627             JAXUCZ010000001.1  142728461-142728589 c
            628-832             JAXUCZ010000001.1  142726015-142726219 c
            833-1011            JAXUCZ010000001.1  142723835-142724013 c
            1012-1170           JAXUCZ010000001.1  142720774-142720932 c
            1171-1281           JAXUCZ010000001.1  142719448-142719558 c
            1282-2289           JAXUCZ010000001.1  142718262-142719269 c
FEATURES             Location/Qualifiers
     source          1..2289
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q31"
     gene            1..2289
                     /gene="Rlbp1"
                     /note="retinaldehyde binding protein 1"
                     /db_xref="GeneID:293049"
                     /db_xref="RGD:1309649"
     exon            1..358
                     /gene="Rlbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            359..469
                     /gene="Rlbp1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    433..435
                     /gene="Rlbp1"
                     /note="upstream in-frame stop codon"
     exon            470..498
                     /gene="Rlbp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             487..1440
                     /gene="Rlbp1"
                     /codon_start=1
                     /product="retinaldehyde-binding protein 1"
                     /protein_id="NP_001099744.1"
                     /db_xref="GeneID:293049"
                     /db_xref="RGD:1309649"
                     /translation="

MSEGVGTFRMVPEEEQELRAQLEQLTTKDHGPVFGPCSQLPRHTLQKAKDELNEREETRDEAVRELQELVQAQAASGEELAVAVAERVQARDSAFLLRFIRARKFDVGRAYELLKGYVNFRLQYPELFDSLSMEALRCTIEAGYPGVLSSRDKYGRVVMLFNIENWHCEEVTFDEILQAYCFILEKLLENEETQINGFCIVENFKGFTMQQAAGLRPSDLKKMVDMLQDSFPARFKAIHFIHQPWYFTTTYNVVKPFLKNKLLQRVFVHGDDLDGFFQEIDENILPADFGGTLPKYDGKVVAEQLFGPRVEVENTAL"

     misc_feature    664..837
                     /gene="Rlbp1"
                     /note="CRAL/TRIO, N-terminal domain; Region: CRAL_TRIO_N;
                     smart01100"
                     /db_xref="CDD:215024"
     misc_feature    907..1362
                     /gene="Rlbp1"
                     /note="Sec14p-like lipid-binding domain; Region: SEC14;
                     cd00170"
                     /db_xref="CDD:469559"
     exon            499..627
                     /gene="Rlbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            628..832
                     /gene="Rlbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            833..1011
                     /gene="Rlbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1170
                     /gene="Rlbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1281
                     /gene="Rlbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..2289
                     /gene="Rlbp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

tcccaggctcccctgcctcccagtttgagaagagagagggcaggaaaatgagacggggctggcccagatcccagtgaagtagcttccacatggccgaacagagctccaagcaggagctcacaaagcagggctttgatggtggccctgcaggcccggcctctcccctctccctcagggtgcttcgcttggttcattctgggcctcccgtgagcctgattgaatgggaaacggtgggcctgagaagttccttgtgacaagctaatcccagcttgctgacctgaccacacctccaaaggaaacagcctcccgagctccagaacaattcaggcacccagtagccccaagaaagagctatcagggacggtcaaggctcgggtgaaatcacacagcttgcaagacaggattggaatccaagtcccatatcctgttccttagccgcttcttggtgcctacagaagtcacagcttagtgtcttcaagaggcagtatgtcagagggggtgggcacattccgaatggtccctgaagaggagcaggagctccgggcacagctagaacagctcacaaccaaggatcatggtcctgtctttggcccatgcagccagctgccccgccacactttgcagaaggctaaggatgagctgaatgaaagggaggaaacccgggatgaggcggtgagggagctacaggagctggtccaggcacaggcagcttctggggaagagttggccgtggcagtggctgagagggtgcaggcaagagacagcgccttcctcctgcgcttcatccgtgcccgaaagtttgatgtgggccgggcttatgagctgctcaaaggctatgtgaacttccggctccagtaccctgaactcttcgatagcctatctatggaggctctccgctgcactatcgaggccggttaccctggtgtcctttccagtcgggacaagtatggtcgagtggttatgctcttcaacattgaaaactggcactgtgaagaagtcacctttgatgagatcttacaggcatattgtttcattctggagaaactgctggagaacgaggaaacccaaatcaacggcttctgtattgtggagaacttcaagggcttcaccatgcagcaggccgcgggactccgcccctccgatctcaagaagatggtggacatgctccaggattcattcccagccaggttcaaagctatccacttcatccaccaaccatggtacttcaccaccacttacaatgtggtcaagcccttcttgaagaacaagttgctacagagggtcttcgttcatggagatgacctggacggcttcttccaggagattgatgagaatatcttgcctgctgactttgggggtacactgcccaagtatgacggcaaagttgtcgctgagcagctcttcggtccccgggttgaggttgagaacacagccttgtgaggagatgccctaccatgtgatcctcattagcatcccggcccttcctcagctttcctgaacccaaaacagggaacggaacgcctgaggtgactggtttccccagccttccctaggtttaggaccgctctagtggcatctcatcccaaaccgacctagaggacagtgaggcacaggcatgtctttttttttttttttttttttcctccatttttcttttcttcggagatggggaccgaacccaggaccttgcgcttgctaggcaagcgctctaccactgagctaaatccccaaccccacaggcatgtctttaataggagacttgtggggcagctaaattcccatcagcctttgcggttacagggcaatgactttgagagaagttaggatttcacagactaattaggtggcttctccgtgattgtctttgtaatcgctttgatacttagggtgtgaaggtgagtgagaagcttacttgcaattcagttaaaaaaagaaagagaggggcttaaagctctaatgatcttagcagcagtgggcagataaggggtttcccacctaagattccagggagggagtagcagccttagaacagttgtatttggggctgacttgcggatgaacgccctgcggatgaacgccctcgtagctaagagctctggactctgtccagggtagaagtcacgtcccttcctctccatccaccgtaggtgtgatttttggggccagggctcccattcactagatgctgtttgctttgttggatggtcttacttaaatgcacctttgacattgtccccagacactcttagtccttattagacaaataaaaccgttctttgtcttgtgtca

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